DK2194379T3 - Apparat og fremgangsmåder for tilvejebringelse af kønssorteret dyresæd - Google Patents
Apparat og fremgangsmåder for tilvejebringelse af kønssorteret dyresæd Download PDFInfo
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- DK2194379T3 DK2194379T3 DK09014407.2T DK09014407T DK2194379T3 DK 2194379 T3 DK2194379 T3 DK 2194379T3 DK 09014407 T DK09014407 T DK 09014407T DK 2194379 T3 DK2194379 T3 DK 2194379T3
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Claims (15)
1. Gennemløbscytometrisystem til sortering af en blanding af partikler, herunder partikler med en karakteristik A og partikler med en karakteristik B, hvilket system omfatter et fluidleveringssystem til levering af et fluid indeholdende partiklerne, et gennemløbscytometriapparat til at optage fluidet, danne det til en strøm og anvende gennemløbscytometri til at klassificere partiklerne i henhold til karakteristikkerne, og et sorteringssystem til sortering af partiklerne i henhold til klassifikationen og i henhold til en sorteringsstrategi for at tilvejebringe mindst en population indeholdende ønskede partikler, hvilken forbedring omfatter en styring, som reagerer på information modtaget fra gennemløbscytometriapparatet for at: A) styre sorteringssystemet for at variere dets sorteringsstrategi som en funktion af både: (1) renheden af den mindst ene population med hensyn til enten karakteristik A partikler eller karakteristik B partikler, og (2) mængden af karakteristik A partikler eller karakteristik B partikler i den mindst ene population i forhold til den samlede mængde af karakteristik A partikler eller karakteristik B partikler i strømmen, og/eller B) styre fluidleveringssystemet til at variere den rate, med hvilken fluidet leveres, som funktion af mængden af karakteristik A partikler eller karakteristik B partikler i den mindst ene population i forhold til den samlede mængde karakteristik A partikler eller karakteristik B partikler i strømmen.
2. System ifølge krav 1, kendetegnet ved, at styringen er en processor, som implementerer en styringstrategi, som er en række algoritmer, som styrer systemvariable, såsom fluidleveringsrate og/eller sorteringsparametre.
3. System ifølge krav 1 eller 2, kendetegnet ved, at partiklerne er sædceller, og at karakteristik A er betegnende for en levende X sædcelle.
4. System ifølge ethvert af de foregående krav, kendetegnet ved, at styringen er til for at øge fluidleveringsraten, når renheden er større ende en ønsket renhed, og for at mindske fluidleveringsraten, når renheden er mindre end den ønskede renhed. b. Fremgangsmåde til anvendelse at et gennemløbscytometrisystem ifølge krav i til sortering af en blanding af partikler med en karakteristik A og partikler med en karakteristik B.
6. Fremgangsmåde ifølge krav 5, kendetegnet ved, at styringen er en processor, som implementerer en styringstrategi, som er en række algoritmer, som styrer systemvariable, såsom fluidleveringsrate og/eller sorteringsparametre.
7. Fremgangsmåde ifølge krav 5 eller 6, kendetegnet ved, at partiklerne er sædceller, og at karakteristik A er betegnende for en levende X sædcelle.
8. Fremgangsmåde ifølge ethvert af krav 5 til 7, kendetegnet ved, at styringen er til for at øge fluidleveringsraten, når renheden er større ende en ønsket renhed, og for at mindske fluidleveringsraten, når renheden er mindre end den ønskede renhed.
9. System til sortering af en blanding af partikler, herunder partikler med en karakteristik A og partikler med en karakteristik B, hvilket system omfatter: - et fluidleveringssystem til levering af en fluidstrøm indeholdende partiklerne, - et gennemløbscytometriapparat til at optage fluidet, danne dråber indeholdende partiklerne og sortere dråberne i forskellige populationer i henhold til en sorteringsstrategi, hvilke dråber omfatter første dråber, der hver indeholder en eller flere partikler med karakteristik A, andre dråber, der hver indeholder en eller flere partikler med karakteristik B, og tredje dråber, der hver indeholder en eller flere partikler med karakteristik A og en eller flere partikler med karakteristik B, og - en styring, som reagerer på information modtaget fra gennemløbscytometriap-paratet for at A) styre gennemløbscytometriapparatet for at variere sorteringsstrategien som en funktion af både: (1) renheden af den mindst ene dråbepopulation med hensyn til enten karakteristik A partikler eller karakteristik B partikler, og (2) mængden af karakteristik A partikler eller karakteristik B partikler i mindst en dråbepopulation i forhold til den samlede mængde af karakteristik A partikler eller karakteristik B partikler i strømmen og/eller B) styre fluidleveringssystemet til at variere den rate, med hvilken fluidet leveres, som funktion af mængden af karakteristik A partikler eller karakteristik B partikler i mindst en drabepopulation i forhold til den samlede mængde karakteristik A partikler eller karakteristik B partikler i strømmen.
10. System ifølge krav 9, kendetegnet ved, at styringen er en processor, som implementerer en styringstrategi, som er en række algoritmer, som styrer systemvariable, såsom fluidleveringsrate og/eller sorteringsparametre.
11. System ifølge krav 9 eller 10, kendetegnet ved, at styringen er til for at styre fluidleveringssystemet for at vedligeholde den rate, ved hvilken fluidet leveres, som konstant, og at styringen er til for at variere sorteringsstrategien.
12. System ifølge krav 11, kendetegnet ved, at styringen er til for at variere sorteringsstrategien for at variere andelen af tredje dråber i en af dråbepopulationerne.
13. System ifølge krav 9 eller 10, kendetegnet ved, at styringen er til for at styre fluidleveringssystemet for at variere den rate, ved hvilken fluidet leveres, som funktion af mængden af karakteristik A partikler i den mindst ene dråbepopulation i forhold til den samlede mængde af karakteristik A partikler i strømmen.
14. System ifølge ethvert af krav 9 til 13, kendetegnet ved, at partiklerne er sædceller, og at karakteristik A er betegnende for en levende X sædcelle.
15. System ifølge ethvert af krav 9 til 14, kendetegnet ved, at forholdet af karakteristik A partikler til karakteristik B partikler i blandingen er et kendt forhold, og hvori styringen kan virke til at klassificere nogle af partiklerne som havende karakteristik A eller karakteristik B, og for at variere fluidleveringsraten som funktion af forholdet af klassificerede partikler til det kendte forhold.
16. System ifølge ethvert af krav 9 til 15, kendetegnet ved, at styringen er til for at bestemme en renhed af de sorterede partikler baseret på udgangssignaler fra gennemløbscytometriapparatet, hvilket system yderligere omfatter et operatørinput til styringen for at angive en ønsket renhed, og hvori styringen er til for at for variere raten, så renheden af den mindst ene dråbepopulation svarer til den ønskede renhed. 1/. i-remgangsmade til sortering at en blanding at partikler, nerunder partikler med en karakteristik A og partikler med en karakteristik B, hvilken fremgangsmåde omfatter: - levering af en fluidstrøm indeholdende partiklerne, - dannelse af dråber, der indeholder partiklerne, - sortering af dråberne i forskellige populationer i henhold til en sorteringsstrategi, hvilke dråber omfatter første dråber, der hver indeholder en eller flere partikler med karakteristik A, andre dråber, der hver indeholder en eller flere partikler med karakteristik B, og tredje dråber, der hver indeholder en eller flere partikler med karakteristik A og en eller flere partikler med karakteristik B, og A) variering af sorteringsstrategien som en funktion af både: (1) renheden af den mindst ene dråbepopulation med hensyn til enten karakteristik A partikler eller karakteristik B partikler, og (2) mængden af karakteristik A partikler eller karakteristik B partikler i mindst en dråbepopulation i forhold til den samlede mængde af karakteristik A partikler eller karakteristik B partikler i strømmen, og/eller B) variering af den rate, med hvilken fluidet leveres, som funktion af mængden af karakteristik A partikler eller karakteristik B partikler i mindst en dråbepopulation i forhold til den samlede mængde karakteristik A partikler eller karakteristik B partikler i strømmen.
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