CN1416320A - 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 - Google Patents
通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生 Download PDFInfo
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- CN1416320A CN1416320A CN01806451A CN01806451A CN1416320A CN 1416320 A CN1416320 A CN 1416320A CN 01806451 A CN01806451 A CN 01806451A CN 01806451 A CN01806451 A CN 01806451A CN 1416320 A CN1416320 A CN 1416320A
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Abstract
Description
mL培养基 | FAME(%TFA) | DHA(%干重) | 生物量(g/L) | 终点pH | DO(%饱和度) |
50 | 16.5 | 7.4 | 4.2 | 7.4 | 31 |
100 | 17.0 | 6.5 | 3.9 | 7.2 | 29 |
150 | 22.4 | 9.2 | 2.7 | 7.0 | 11 |
200 | 35.9 | 14.5 | 1.8 | 6.9 | 3 |
批次 | 菌龄(Hrs) | 产量1(g/L) | DHA2(%) | FAME3(%) | 生产力4 |
1 | 100.3 | 160.7 | 17.8 | 49.5 | 0.285 |
2 | 99.8 | 172.4 | 19.4 | 51.3 | 0.335 |
3 | 84.7 | 148.7 | 14.4 | 41.4 | 0.253 |
4 | 90.2 | 169.5 | 19.7 | 53.9 | 0.370 |
5 | 99.0 | 164.1 | 12.5 | 38.9 | 0.207 |
6 | 113.0 | 187.1 | 19.7 | 47.2 | 0.326 |
7 | 97.0 | 153.5 | 13.7 | 41.0 | 0.217 |
8 | 92.8 | 174.8 | 16.4 | 48.6 | 0.309 |
Aver.5 | 97.1 | 166.4 | 16.7 | 46.5 | 0.288 |
Std.6 | 8.4 | 12.3 | 2.9 | 5.4 | 0.058 |
CV7(%) | 8.7 | 7.4 | 17.3 | 11.7 | 20.2 |
批次 | DHA相对于FAME的% | 以重量计算的总脂质% |
1 | 36.0 | 72.3 |
2 | 37.8 | 70.3 |
3 | 34.8 | 61.5 |
4 | 36.5 | 74.8 |
5 | 32.1 | 52.8 |
6 | 41.7 | 67.7 |
7 | 33.4 | 49.9 |
8 | 33.7 | 61.4 |
平均值 | 35.8 | 63.8 |
Std.Deviation3 | 3.0 | 9.1 |
CV4(%) | 8.5 | 14.2 |
批次 | 菌龄(Hrs) | 产量(g/L) | %DHA | %FAME | %DHA相对于FAME | DHA生产力(gDHA/L/hr) |
1 | 82.0 | 179.3 | 21.7 | 52.4 | 41.4 | 0.474 |
2 | 99.0 | 183.1 | 22.3 | 55.0 | 40.5 | 0.412 |
3 | 72.0 | 159.3 | - | - | 40.9 | - |
4 | 77.0 | 161.3 | - | - | 43.2 | - |
5 | 100.0 | 173.0 | 23.9 | 53.3 | 44.9 | 0.413 |
6 | 102.0 | 183.3 | 21.6 | 50.8 | 42.6 | 0.388 |
7 | 104.0 | 185.1 | 23.7 | 55.0 | 43.1 | 0.422 |
8 | 88.0 | 179.3 | 22.3 | 52.6 | 42.4 | 0.454 |
9 | 100.0 | 166.4 | 22.5 | 53.5 | 42.1 | 0.374 |
10 | 97.0 | 182.6 | 22.8 | 51.6 | 44.1 | 0.429 |
11 | 87.5 | 176.5 | 19.8 | 45.6 | 43.5 | 0.399 |
12 | 67.0 | 170.8 | 18.8 | 48.1 | 39.1 | 0.479 |
13 | 97.0 | 184.9 | 23.2 | 52.7 | 44.0 | 0.442 |
14 | 102.0 | 181.9 | 23.6 | 52.9 | 44.6 | 0.421 |
15 | 102.0 | 186.9 | 19.9 | 47.8 | 41.8 | 0.365 |
16 | 97.0 | 184.4 | 19.6 | 45.5 | 43.0 | 0.373 |
17 | 98.0 | 174.7 | 19.7 | 45.1 | 43.7 | 0.351 |
18 | 103.5 | 178.8 | 18.3 | 44.5 | 41.2 | 0.316 |
19 | 102.0 | 173.7 | 15.8 | 43.1 | 36.7 | 0.269 |
20 | 94.0 | 190.4 | 19.3 | 46.9 | 41.1 | 0.391 |
21 | 72.0 | 172.5 | 22.8 | 52.8 | 43.2 | 0.546 |
22 | 75.0 | 173.1 | 21.0 | 51.7 | 40.8 | 0.485 |
23 | 75.0 | 152.7 | 20.3 | 50.3 | 40.4 | 0.413 |
24 | 75.5 | 172.5 | 21.9 | 51.7 | 42.3 | 0.500 |
25 | 61.0 | 156.4 | 17.3 | 45.7 | 37.8 | 0.444 |
26 | 74.5 | 150.6 | 20.2 | 50.1 | 40.2 | 0.408 |
27 | 70.5 | 134.3 | 14.8 | 40.6 | 36.6 | 0.282 |
28 | 75.5 | 146.1 | 21.3 | 49.7 | 42.8 | 0.412 |
29 | 82.0 | 174.3 | 21.4 | 50.4 | 42.5 | 0.455 |
30 | 105.0 | 182.3 | 21.7 | 50.7 | 42.8 | 0.377 |
31 | 66.0 | 146.2 | 16.4 | 44.6 | 36.7 | 0.363 |
Avg | 87.2 | 171.5 | 20.6 | 49.5 | 41.6 | 0.409 |
Std | 13.9 | 14.1 | 2.4 | 3.8 | 2.3 | 0.061 |
CV | 16.0% | 8.2% | 11.6% | 7.7% | 5.5% | 15.0% |
批次 | 菌龄(Hrs) | 产量(g/L) | %DHA | %FAME | %DHA相对于FAME | DHA生产力(gDHA/L/hr) |
1 | 75.0 | 116.1 | 17.3 | 46.1 | 37.4 | 0.268 |
2 | 99.0 | 159.3 | 17.4 | 47.0 | 37.1 | 0.280 |
3 | 103.0 | 152.6 | 16.0 | 47.2 | 33.8 | 0.237 |
4 | 68.0 | 136.8 | 17.9 | 45.9 | 39.1 | 0.360 |
5 | 84.0 | 142.0 | 17.5 | 47.0 | 37.2 | 0.296 |
Avg | 85.8 | 141.4 | 17.2 | 46.6 | 36.9 | 0.288 |
Std | 15.1 | 16.6 | 0.7 | 0.6 | 1.9 | 0.046 |
CV | 17.5% | 11.8 | 4.2% | 1.3% | 5.2% | 15.8% |
菌龄(hrs) | 产量(g/L) | 生物量生产力 | 转化效率 | DHA含量 | FAME含量 | DHA左产力 |
目标葡萄糖:7g/L,碱性pH设定点:5.5,酸性pH设定点:7.3,1.0XNH3 | ||||||
48 | 178 | 3.71g/L/hr | 51.5% | 10.7% | 37.8% | 0.40g/L/hr |
60 | 185 | 3.08g/L/hr | 46.9% | 16.3% | 47.2% | 0.50g/L/hr |
72 | 205 | 2.85g/L/hr | 45.2% | 17.4% | 47.4% | 0.50g/L/hr |
84 | 219 | 2.61g/L/hr | 43.8% | 17.1% | 45.5% | 0.45g/L/hr |
90 | 221 | 2.46g/L/hr | 44.1% | 18.4% | 48.9% | 0.45g/L/hr |
目标葡萄糖:7g/L,碱性pH设定点:5.5,酸性pH设定点:7.3,1.15XNH3 | ||||||
48 | 171 | 3.56g/L/hr | 55.6% | 12.0% | 36.3% | 0.43g/L/hr |
60 | 197 | 3.28g/L/hr | 54.6% | 9.4% | 38.4% | 0.31g/L/hr |
72 | 191 | 2.65g/L/hr | 52.8% | 9.4% | 40.0% | 0.25g/L/hr |
84 | 190 | 2.26g/L/hr | 52.5% | 10.0% | 42.5% | 0.23g/L/hr |
90 | 189 | 2.10g/L/hr | 52.2% | 9.2% | 43.3% | 0.19g/L/hr |
目标葡萄糖:7g/L,碱性pH设定点:5.5,酸性pH设定点:7.3,1.25XNH3 | ||||||
48 | 178 | 3.71g/L/hr | 56.4% | 11.5% | 33.7% | 0.43g/L/hr |
60 | 179 | 2.98g/L/hr | 48.6% | 10.3% | 36.0% | 0.31g/L/hr |
72 | 180 | 2.50g/L/hr | 48.8% | 12.0% | 37.6% | 0.30g/L/hr |
84 | 181 | 2.15g/L/hr | 46.1% | 13.6% | 40.1% | 0.29g/L/hr |
90 | 185 | 2.06g/L/hr | 45.7% | 12.6% | 40.7% | 0.26g/L/hr |
目标葡萄糖:7g/L,碱性pH设定点:5.5,酸性pH设定点:7.3,1.0XNH3 | ||||||
48 | 158 | 3.29g/L/hr | 55.7% | 13.1% | 36.5% | 0.43g/L/hr |
60 | 174 | 2.90g/L/hr | 48.9% | 17.9% | 39.2% | 0.52g/L/hr |
72 | 189 | 2.63g/L/hr | 45.7% | 21.0% | 39.4% | 0.55g/L/hr |
84 | 196 | 2.33g/L/hr | 44.1% | 22.4% | 40.1% | 0.52g/L/hr |
90 | 206 | 2.29g/L/hr | 44.8% | 22.1% | 40.3% | 0.51g/L/hr |
菌龄(hrs) | 产量(g/L) | 生物量生产力 | 转化效率 | %DHA含量 | %FAME含量 | DHA生产力 |
24 | 118 | 4.92g/L/hr | 78.2% | 7.4 | 18.8 | 0.36g/L/hr |
30 | 138 | 4.60g/L/hr | 60.3% | 10.6 | 30.9 | 0.49g/L/hr |
36 | 138 | 3.83g/L/hr | 46.6% | 11.6 | 36.5 | 0.44g/L/hr |
42 | 175 | 4.17g/L/hr | 49.8% | 13.4 | 41.7 | 0.56g/L/hr |
48 | 178 | 3.71g/L/hr | 45.1% | 18.7 | 52.8 | 0.69g/L/hr |
48* | 164 | 3.42g/L/hr | 41.5% | 15.3 | 33.1 | 0.52g/L/hr |
54 | 196 | 3.63g/L/hr | 45.7% | 16.6 | 51.2 | 0.60g/L/hr |
60 | 190 | 3.17g/L/hr | 41.7% | 16.9 | 33.9 | 0.54g/L/hr |
72 | 189 | 2.62g/L/hr | 39.1% | 15.6 | 31.8 | 0.41g/L/hr |
84 | 195 | 2.32g/L/hr | 38.5% | 16.4 | 32.7 | 0.38g/L/hr |
90 | 200 | 2.22g/L/hr | 39.0% | 18.8 | 33.3 | 0.42g/L/hr |
90 | 171 | 1.90g/L/hr | 33.3% | 22.2 | 61.6 | 0.42g/L/hr** |
菌龄(hrs) | 产量(g/L) | 碳源量 | 转化效率 | %DHA含量 | %FAME含量 | 生产力(g/L/hr) |
90 | 171 | 51.3% | 33.3% | 22.2 | 61.6 | 0.42 |
94 | 122 | 40.5% | 30.1% | 19.1 | 57.3 | 0.25 |
59 | 73 | 20.0% | 36.5% | 11.9 | 40.8 | 0.15 |
限制性营养 | 生物量1(g/l) | Yx/s 2 | RCS3(g/l) | 脂含量4(%) | DHA含量5(%) |
葡萄糖 | 18.7 | 46.8 | 0.0 | 19.8 | 7.3 |
氮 | 14.5 | 36.3 | 0.6 | 47.5 | 10.3 |
磷酸盐 | 17.8 | 44.5 | 0.8 | 37.0 | 8.2 |
硫胺素 | 7.5 | 18.8 | 7.7 | 11.1 | 4.0 |
锌 | 16.0 | 40.0 | 1.3 | 27.8 | 7.2 |
铜 | 14.0 | 35.0 | 10.4 | 13.8 | 5.3 |
钴 | 14.5 | 36.3 | 0.0 | 22.2 | 6.9 |
镍 | 17.8 | 44.5 | 0.0 | 21.9 | 8.0 |
铁 | 15.9 | 39.8 | 3.5 | 18.5 | 7.2 |
锰 | 12.5 | 31.3 | 3.4 | 26.1 | 8.0 |
镁 | 13.9 | 34.8 | 5.3 | 18.7 | 6.4 |
钙 | 16.7 | 41.8 | 4.3 | 18.7 | 6.4 |
维生素B12 | 19.6 | 49.0 | 0.0 | 17.5 | 6.3 |
钼 | 18.9 | 47.3 | 0.0 | 19.3 | 7.0 |
泛酸盐 | 19.2 | 48.0 | 0.0 | 20.4 | 6.7 |
钠 | 17.9 | 44.8 | 1.8 | 21.8 | 8.2 |
钾 | 13.0 | 32.5 | 8.8 | 14.1 | 5.3 |
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2009
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2011
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2012
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2013
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2014
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2015
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2016
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- 2016-11-07 US US15/344,960 patent/US20170049132A1/en not_active Abandoned
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