CA2807552A1 - Engineered nucleic acids and methods of use thereof - Google Patents
Engineered nucleic acids and methods of use thereof Download PDFInfo
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- CA2807552A1 CA2807552A1 CA2807552A CA2807552A CA2807552A1 CA 2807552 A1 CA2807552 A1 CA 2807552A1 CA 2807552 A CA2807552 A CA 2807552A CA 2807552 A CA2807552 A CA 2807552A CA 2807552 A1 CA2807552 A1 CA 2807552A1
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- mrna
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| PCT/US2011/046861 WO2012019168A2 (en) | 2010-08-06 | 2011-08-05 | Engineered nucleic acids and methods of use thereof |
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| US (6) | US8822663B2 (de) |
| EP (2) | EP2600901B1 (de) |
| CA (1) | CA2807552A1 (de) |
| WO (1) | WO2012019168A2 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| US9181321B2 (en) | 2013-03-14 | 2015-11-10 | Shire Human Genetic Therapies, Inc. | CFTR mRNA compositions and related methods and uses |
| US9308281B2 (en) | 2011-06-08 | 2016-04-12 | Shire Human Genetic Therapies, Inc. | MRNA therapy for Fabry disease |
| US9629804B2 (en) | 2013-10-22 | 2017-04-25 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger RNA |
| US9668980B2 (en) | 2014-07-02 | 2017-06-06 | Rana Therapeutics, Inc. | Encapsulation of messenger RNA |
| US9850269B2 (en) | 2014-04-25 | 2017-12-26 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US9943595B2 (en) | 2014-12-05 | 2018-04-17 | Translate Bio, Inc. | Messenger RNA therapy for treatment of articular disease |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| US10087247B2 (en) | 2013-03-14 | 2018-10-02 | Translate Bio, Inc. | Methods and compositions for delivering mRNA coded antibodies |
| US10130649B2 (en) | 2013-03-15 | 2018-11-20 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
| US10138213B2 (en) | 2014-06-24 | 2018-11-27 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| US10143758B2 (en) | 2009-12-01 | 2018-12-04 | Translate Bio, Inc. | Liver specific delivery of messenger RNA |
| US10144942B2 (en) | 2015-10-14 | 2018-12-04 | Translate Bio, Inc. | Modification of RNA-related enzymes for enhanced production |
| US10172924B2 (en) | 2015-03-19 | 2019-01-08 | Translate Bio, Inc. | MRNA therapy for pompe disease |
| US10208295B2 (en) | 2013-10-22 | 2019-02-19 | Translate Bio, Inc. | MRNA therapy for phenylketonuria |
| US10245229B2 (en) | 2012-06-08 | 2019-04-02 | Translate Bio, Inc. | Pulmonary delivery of mRNA to non-lung target cells |
| US10266843B2 (en) | 2016-04-08 | 2019-04-23 | Translate Bio, Inc. | Multimeric coding nucleic acid and uses thereof |
| US10780052B2 (en) | 2013-10-22 | 2020-09-22 | Translate Bio, Inc. | CNS delivery of MRNA and uses thereof |
| US10835583B2 (en) | 2016-06-13 | 2020-11-17 | Translate Bio, Inc. | Messenger RNA therapy for the treatment of ornithine transcarbamylase deficiency |
| US11167043B2 (en) | 2017-12-20 | 2021-11-09 | Translate Bio, Inc. | Composition and methods for treatment of ornithine transcarbamylase deficiency |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| US11173190B2 (en) | 2017-05-16 | 2021-11-16 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR |
| US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
| US11253605B2 (en) | 2017-02-27 | 2022-02-22 | Translate Bio, Inc. | Codon-optimized CFTR MRNA |
| US11254936B2 (en) | 2012-06-08 | 2022-02-22 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
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|---|---|---|---|---|
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2014
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2015
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2016
- 2016-08-26 US US15/248,053 patent/US9937233B2/en active Active
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2018
- 2018-03-07 US US15/914,615 patent/US20190030129A1/en not_active Abandoned
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3578205A1 (de) | 2019-12-11 |
| US20140243399A1 (en) | 2014-08-28 |
| US9937233B2 (en) | 2018-04-10 |
| US20120065252A1 (en) | 2012-03-15 |
| US8822663B2 (en) | 2014-09-02 |
| US20160024171A1 (en) | 2016-01-28 |
| WO2012019168A3 (en) | 2012-07-05 |
| US20170143796A1 (en) | 2017-05-25 |
| US20190030129A1 (en) | 2019-01-31 |
| US9181319B2 (en) | 2015-11-10 |
| US9447164B2 (en) | 2016-09-20 |
| EP2600901B1 (de) | 2019-03-27 |
| EP2600901A4 (de) | 2014-07-16 |
| EP2600901A2 (de) | 2013-06-12 |
| US20220273766A1 (en) | 2022-09-01 |
| WO2012019168A2 (en) | 2012-02-09 |
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| EEER | Examination request |
Effective date: 20160719 |
|
| EEER | Examination request |
Effective date: 20160719 |
|
| EEER | Examination request |
Effective date: 20160719 |
|
| EEER | Examination request |
Effective date: 20160719 |
|
| EEER | Examination request |
Effective date: 20160719 |
|
| FZDE | Discontinued |
Effective date: 20240304 |