BR0012099A - Transferência citoplásmica para de-diferenciar células recipientes - Google Patents
Transferência citoplásmica para de-diferenciar células recipientesInfo
- Publication number
- BR0012099A BR0012099A BR0012099-5A BR0012099A BR0012099A BR 0012099 A BR0012099 A BR 0012099A BR 0012099 A BR0012099 A BR 0012099A BR 0012099 A BR0012099 A BR 0012099A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- methods
- differentiate
- cytoplasm
- cytoplasmic transfer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"TRANSFERêNCIA CITOPLáSMICA PARA DE-DIFERENCIAR CéLULAS RECIPIENTES". Métodos para de-diferenciação ou alteração da vida útil de células "recipientes" desejadas, por exemplo, células somáticas humanas, através de introdução de citoplasma de um tipo de célula menos diferenciado mais primitivo, por exemplo, oócito ou blastómero, são proporcionados. Esses métodos podem ser usados para produzir células do tronco embriónico e aumentar a eficiência da terapia genética permitindo que células desejadas sejam submetidas a modificações genéticas múltiplas sem se tornarem senescentes. Tal citoplasma pode ser fracionado e/ou submetido à hibridização subtrativa e os materiais ativos (suficientes para de-diferenciação) identificados e produzidos por meio de métodos recombinantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14125099P | 1999-06-30 | 1999-06-30 | |
PCT/US2000/018063 WO2001000650A1 (en) | 1999-06-30 | 2000-06-30 | Cytoplasmic transfer to de-differentiate recipient cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012099A true BR0012099A (pt) | 2003-07-29 |
Family
ID=22494867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012099-5A BR0012099A (pt) | 1999-06-30 | 2000-06-30 | Transferência citoplásmica para de-diferenciar células recipientes |
Country Status (11)
Country | Link |
---|---|
US (4) | US20020001842A1 (pt) |
EP (1) | EP1196426A4 (pt) |
JP (1) | JP2003503071A (pt) |
CN (1) | CN1362965A (pt) |
AU (1) | AU782286B2 (pt) |
BR (1) | BR0012099A (pt) |
CA (1) | CA2377515C (pt) |
IL (2) | IL147179A0 (pt) |
MX (1) | MXPA01013450A (pt) |
NZ (1) | NZ516236A (pt) |
WO (1) | WO2001000650A1 (pt) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
MXPA01013450A (es) | 1999-06-30 | 2003-09-04 | Advanced Cell Tech Inc | Transferencia citoplasmica para celulas receptoras de-diferenciacion. |
BR0013844A (pt) * | 1999-09-07 | 2002-05-14 | Advanced Cell Tech Inc | Restauração de telÈmero e extensão de perìodo de vida da célula em animais clonados de células somáticas senescentes |
AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
IL152741A0 (en) | 2000-05-17 | 2003-06-24 | Geron Corp | Neural progenitor cell populations |
US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
US20020142397A1 (en) | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
ATE502106T1 (de) * | 2000-12-22 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
EP1370132A2 (en) * | 2001-03-21 | 2003-12-17 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
EP1385935A4 (en) | 2001-03-29 | 2004-09-15 | Ixion Biotechnology Inc | METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLS IN THE PANCREAS DIFFERENTIATION PATHWAY |
GB0118984D0 (en) * | 2001-08-03 | 2001-09-26 | Intercytex Ltd | Fusion of cells |
WO2003018760A2 (en) * | 2001-08-24 | 2003-03-06 | Advanced Cell Technology, Inc. | Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy |
WO2003018780A1 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
AU2002365162A1 (en) | 2001-11-14 | 2003-07-09 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
AU2003215280A1 (en) | 2002-02-15 | 2003-09-09 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
US7462448B2 (en) | 2002-08-02 | 2008-12-09 | Stratatech Corporation | Species specific DNA detection |
EP1391503A1 (en) * | 2002-08-12 | 2004-02-25 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | A method of cell re-programming by cytoplasmic transfer |
US7534761B1 (en) | 2002-08-21 | 2009-05-19 | North Western University | Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom |
NZ539459A (en) * | 2002-11-08 | 2009-02-28 | Kirin Pharma Kk | Transgenic ungulates having reduced prion protein activity and uses thereof |
US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
WO2004046167A2 (en) | 2002-11-14 | 2004-06-03 | Northwestern University | Synthesis and self-assembly of abc triblock bola peptide |
NZ541718A (en) | 2003-02-11 | 2008-04-30 | Univ Northwestern | Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon |
AU2004232917A1 (en) * | 2003-04-21 | 2004-11-04 | University Of Massachusetts | Reprogramming nuclear function with somatic cell cytoplasm |
WO2004111195A2 (en) * | 2003-06-10 | 2004-12-23 | Trustees Of The University Of Pennsylvania | Methods and use of zona-free therapeutic cloning |
GB0316089D0 (en) * | 2003-07-09 | 2003-08-13 | Xo Bioscience Ltd | Differentiation method |
US7823789B2 (en) | 2004-12-21 | 2010-11-02 | Cognex Technology And Investment Corporation | Low profile illumination for direct part mark readers |
FR2861997A1 (fr) * | 2003-11-06 | 2005-05-13 | Fred Zacouto | Stimulateur cardiaque orthorythmique inotrope |
MXPA06006388A (es) | 2003-12-05 | 2006-09-04 | Univ Northwestern | Peptidos anfifilicos de auto-ensamble y metodos relacionados para el suministro del factor de crecimiento. |
WO2005056576A2 (en) | 2003-12-05 | 2005-06-23 | Northwestern University | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
US20050214257A1 (en) | 2003-12-23 | 2005-09-29 | Northwestern University | Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation |
CN101014715A (zh) | 2004-04-22 | 2007-08-08 | 麒麟麦酒株式会社 | 转基因动物及其用途 |
KR20070108555A (ko) | 2005-03-04 | 2007-11-12 | 노오쓰웨스턴 유니버시티 | 혈관신생 헤파린 결합 펩티드 양친매성 화합물 |
FR2885368A1 (fr) * | 2005-05-04 | 2006-11-10 | Fred Zacouto | Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees |
WO2007026255A2 (en) * | 2005-06-22 | 2007-03-08 | Universitetet I Oslo | Dedifferentiated cells and methods of making and using dedifferentiated cells |
EP2302034B1 (en) | 2005-08-03 | 2020-10-14 | Astellas Institute for Regenerative Medicine | Improved methods of reprogramming animal somatic cells |
US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
US8114843B2 (en) * | 2005-11-18 | 2012-02-14 | The Regents Of The University Of California | Photoreactive regulator of protein function and methods of use thereof |
EP3190178A1 (en) | 2007-02-23 | 2017-07-12 | Astellas Institute for Regenerative Medicine | Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells |
US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
JP2009024027A (ja) * | 2008-09-16 | 2009-02-05 | Tadashi Goino | 生理活性組成物 |
WO2010084275A1 (fr) * | 2009-01-26 | 2010-07-29 | Fred Zacouto | Procédé simplifié de reprogrammation génétique et épigénétique partielle de cellules. |
CN101798569B (zh) * | 2009-02-09 | 2012-11-21 | 北京瑞途之星科技有限公司 | 以卵裂后的发育胚胎替代卵母细胞的治疗性克隆新方法 |
EP2419116A1 (en) | 2009-04-13 | 2012-02-22 | North Western University | Novel peptide-based scaffolds for cartilage regeneration and methods for their use |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
LT3590949T (lt) | 2010-10-01 | 2022-07-25 | Modernatx, Inc. | Ribonukleorūgštys, kurių sudėtyje yra n1-metil-pseudouracilų, ir jų naudojimas |
EP2630232A4 (en) | 2010-10-22 | 2014-04-02 | Biotime Inc | METHOD FOR MODIFYING TRANSCRIPTIONAL REGULATORY NETWORKS IN STEM CELLS |
JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
CN102266350A (zh) * | 2011-07-20 | 2011-12-07 | 黄必录 | 逆转干细胞衰老的方案 |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CN102321571A (zh) * | 2011-09-21 | 2012-01-18 | 王跃嗣 | 从分化细胞制备自体造血干细胞的方法 |
MX354267B (es) | 2011-10-03 | 2018-02-21 | Moderna Therapeutics Inc Star | Nucléosidos, nucleótidos, y ácidos nucleicos modificados, y usos de los mismos. |
US20130156849A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
CA2868996A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
US10961531B2 (en) | 2013-06-05 | 2021-03-30 | Agex Therapeutics, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
WO2016044721A1 (en) | 2014-09-19 | 2016-03-24 | Regenerative Medical Solutions, Inc. | Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells |
US9828634B2 (en) | 2015-01-22 | 2017-11-28 | Regenerative Medical Solutions, Inc. | Markers for differentiation of stem cells into differentiated cell populations |
PT3274710T (pt) | 2015-03-23 | 2021-07-06 | Astellas Inst For Regenerative Medicine | Ensaios melhorados para potência de células de epitélio pigmentar da retina (rpe) humana e de progenitoras de fotorrecetores |
CN106755113B (zh) * | 2016-12-29 | 2020-06-19 | 赛业(苏州)生物科技有限公司 | Es细胞基因打靶技术制备基因修饰小鼠的改进方法 |
WO2023038999A1 (en) * | 2021-09-07 | 2023-03-16 | Yuva Biosciences, Inc. | Compositions and methods for treating ovarian aging, ovarian diseases and conditions, and symptoms thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6344526A (ja) * | 1986-08-12 | 1988-02-25 | Kingo Yoshida | 幼若細胞の細胞質・ミトコンドリア・イントロン他注入による若返り長寿法 |
US5480772A (en) | 1993-02-03 | 1996-01-02 | Brandeis University | In vitro activation of a nucleus |
US5830651A (en) | 1995-06-01 | 1998-11-03 | Signal Pharmaceuticals, Inc. | Human oligodendroglial progenitor cell line |
GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
WO1997035967A2 (en) | 1996-03-28 | 1997-10-02 | Cold Spring Harbor Laboratory | Transgenic organisms with altered telomerase activity |
NZ334016A (en) * | 1996-08-19 | 2000-08-25 | Univ Massachusetts | Embryonic stem cell lines produced by cross species nuclear transplantation |
US20010012513A1 (en) | 1996-08-19 | 2001-08-09 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
AU8587598A (en) * | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
GB9809178D0 (en) * | 1998-04-29 | 1998-07-01 | Univ Edinburgh | Nuclear reprogramming of somatic cells |
EP1204790A4 (en) * | 1999-04-23 | 2004-08-04 | Monica Palacios-Boyce | MICROELECTROMECHANICAL DEVICE FOR HANDLING CELLS OR EMBRYONS, KITS THEREFOR, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE USE THEREOF |
MXPA01013450A (es) | 1999-06-30 | 2003-09-04 | Advanced Cell Tech Inc | Transferencia citoplasmica para celulas receptoras de-diferenciacion. |
US20040199935A1 (en) | 1999-06-30 | 2004-10-07 | Chapman Karen B. | Cytoplasmic transfer to de-differentiate recipient cells |
CA2394614A1 (en) * | 1999-12-20 | 2001-06-28 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Embryonic or stem-like cells produced by cross species nuclear transplantation |
WO2003018780A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
-
2000
- 2000-06-30 MX MXPA01013450A patent/MXPA01013450A/es not_active Application Discontinuation
- 2000-06-30 WO PCT/US2000/018063 patent/WO2001000650A1/en active IP Right Grant
- 2000-06-30 BR BR0012099-5A patent/BR0012099A/pt not_active IP Right Cessation
- 2000-06-30 IL IL14717900A patent/IL147179A0/xx unknown
- 2000-06-30 EP EP00945032A patent/EP1196426A4/en not_active Withdrawn
- 2000-06-30 CA CA2377515A patent/CA2377515C/en not_active Expired - Lifetime
- 2000-06-30 AU AU59028/00A patent/AU782286B2/en not_active Ceased
- 2000-06-30 NZ NZ516236A patent/NZ516236A/xx not_active IP Right Cessation
- 2000-06-30 JP JP2001507057A patent/JP2003503071A/ja active Pending
- 2000-06-30 CN CN00809800A patent/CN1362965A/zh active Pending
- 2000-12-15 US US09/736,268 patent/US20020001842A1/en not_active Abandoned
-
2001
- 2001-12-19 IL IL147179A patent/IL147179A/en not_active IP Right Cessation
-
2012
- 2012-09-14 US US13/617,988 patent/US20130104253A1/en not_active Abandoned
-
2014
- 2014-06-11 US US14/302,384 patent/US9580683B2/en not_active Expired - Fee Related
-
2017
- 2017-02-17 US US15/436,545 patent/US20170226475A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ516236A (en) | 2004-12-24 |
US20020001842A1 (en) | 2002-01-03 |
JP2003503071A (ja) | 2003-01-28 |
MXPA01013450A (es) | 2003-09-04 |
EP1196426A1 (en) | 2002-04-17 |
IL147179A (en) | 2015-01-29 |
CN1362965A (zh) | 2002-08-07 |
AU782286B2 (en) | 2005-07-14 |
AU5902800A (en) | 2001-01-31 |
WO2001000650A1 (en) | 2001-01-04 |
IL147179A0 (en) | 2002-08-14 |
US20170226475A1 (en) | 2017-08-10 |
CA2377515C (en) | 2013-09-03 |
US9580683B2 (en) | 2017-02-28 |
US20130104253A1 (en) | 2013-04-25 |
US20150132853A1 (en) | 2015-05-14 |
EP1196426A4 (en) | 2003-09-03 |
CA2377515A1 (en) | 2001-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0012099A (pt) | Transferência citoplásmica para de-diferenciar células recipientes | |
SG147468A1 (en) | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences | |
BRPI0514778A (pt) | meio e cultivo das células tronco embriÈnica | |
HUP0105052A2 (hu) | Eljárások nukleinsav amplifikálására és szekvenálására | |
MXPA03000634A (es) | Metodos para el reemplazo, el desplazamiento y acumulacion de adn en genomas eucarioticos. | |
BR0015633A (pt) | Planta, polinucleotìdeo, vetor, célula, composição, polipeptìdeo, métodos para produzir uma planta e para identificar um fator que é modulado por, ou interage com, um polipeptìdeo codificado por um polinucleotìdeo, uma molécula que module a atividade ou a expressão de um polinucleotìdeo ou polipeptìdeo de interesse e uma sequência similar ou homóloga a um ou mais polinucleotìdeos, e, sistema integrado, meio computadorizado ou legìvel em computador | |
CA2338541A1 (en) | Genetically modified cd34-negative adherently growing stem cells and their use in gene therapy | |
HUP0100787A2 (hu) | Pollen fajlagos promóter | |
BR0015374A (pt) | Diferenciação hematopoiética de troncocélulas embriÈnicas humanas | |
BR0010496A (pt) | Regulação da expressão genica viral | |
BR0009550A (pt) | Bactéria methylophilus, métodos para produzir um l-aminoácido e para produzir células bacterianas de uma bactéria methylophilus com um teor aumentado de um l-aminoácido, e, dna | |
BR0209989A (pt) | Plataformas baseadas em cromossomas | |
BR0115096A (pt) | Métodos para modificar geneticamente um gene endógeno ou local cromossÈmico em células eucarióticas, e em células-tronco embriÈnicas de camundongos, gene endógeno ou local cromossÈmico geneticamente modificado, célula eucariótica e célula-tronco embriÈnica geneticamente modificadas, organismo não humano, camundongo, e, uso da célula e célula-tronco embriÈnica geneticamente modificadas | |
BRPI0411874A (pt) | potencial de staygreen controlado em plantas por gene simples obtido por engenharia genética | |
GB2429211A (en) | Feeder independent extended culture of embryonic stem cells | |
MX244498B (es) | Recombinacion especifica de la secuencia de adn en celulas eucarioticas. | |
BR0003943A (pt) | Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma | |
Rabarivola et al. | Cytogenetic and molecular characteristics of a new species of sportive lemur from Northern Madagascar | |
BR0314402A (pt) | Expansão ex-vivo de populações de células raìzes em culturas celulares mononucleares | |
ATE386130T1 (de) | Adenovirale vektoren für die gentherapie | |
BR0016561A (pt) | Células embrionárias ou similares a células tronco produzidas por transplantes nuclear em espécie cruzadas | |
BR9908499A (pt) | Linhagens celulares embrionárias ousemelhantes a tronco produzidas portransplante nuclear de espécies cruzado | |
AR023987A1 (es) | Vides resistentes a un patogeno | |
BR9801085A (pt) | Processo para a preparação de moenomicina a. | |
van der Oost et al. | Molecular biology of hyperthermophilic Archaea |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/0735 (2010.01), A61K 48/00 (2006.01), C12N |