BR9908499A - Linhagens celulares embrionárias ousemelhantes a tronco produzidas portransplante nuclear de espécies cruzado - Google Patents

Linhagens celulares embrionárias ousemelhantes a tronco produzidas portransplante nuclear de espécies cruzado

Info

Publication number
BR9908499A
BR9908499A BR9908499-6A BR9908499A BR9908499A BR 9908499 A BR9908499 A BR 9908499A BR 9908499 A BR9908499 A BR 9908499A BR 9908499 A BR9908499 A BR 9908499A
Authority
BR
Brazil
Prior art keywords
embryonic
cells
stem
cell
transplantation
Prior art date
Application number
BR9908499-6A
Other languages
English (en)
Inventor
James Robl
Jose Cibelli
Steven L Stice
Original Assignee
Univ Massachusetts Public Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Massachusetts Public Inst filed Critical Univ Massachusetts Public Inst
Publication of BR9908499A publication Critical patent/BR9908499A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: "LINHAGENS CéLULARESEMBRIONáRIAS OU SEMELHANTES A TRONCO PRODUZIDASPOR TRANSPLANTE NUCLEAR DE ESPéCIES CRUZADO". éfornecido um processo melhorado de transferência nuclear queenvolve o transplante de núcleos de células doadorasdiferenciadas em oócitos enucleados de uma espécie diferente dacélula doadora. As unidades de transferência nuclear resultantessão úteis para a produção de células tronco embrionáriasisogênicas, em particular células embrionárias ou tronco isogênicashumanas. Estas células embrionárias ou semelhantes a tronco sãoúteis para a produção de células diferenciadas desejadas e paraintrodução, remoção ou modificação, de genes desejados, porexemplo, em sítios específicos do genoma de tais células porrecombinação homóloga. Estas células, que podem conter umgene heterólogo, são especialmente úteis nas terapias detransplante de célula e para o estudo in vitro da diferenciaçãocelular. Ainda, são fornecidos processos para melhorar a eficiênciada transferência nuclear pela alteração genética das célulasdoadoras para inibir a apoptose, selecionar um ciclo celularespecífico e/ou aumentar o crescimento e o desenvolvimentoembrionário.
BR9908499-6A 1998-03-02 1999-03-02 Linhagens celulares embrionárias ousemelhantes a tronco produzidas portransplante nuclear de espécies cruzado BR9908499A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3294598A 1998-03-02 1998-03-02
PCT/US1999/004608 WO1999045100A1 (en) 1998-03-02 1999-03-02 Embryonic or stem-like cell lines produced by cross-species nuclear transplantation

Publications (1)

Publication Number Publication Date
BR9908499A true BR9908499A (pt) 2001-12-26

Family

ID=21867727

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908499-6A BR9908499A (pt) 1998-03-02 1999-03-02 Linhagens celulares embrionárias ousemelhantes a tronco produzidas portransplante nuclear de espécies cruzado

Country Status (9)

Country Link
EP (1) EP1060243A4 (pt)
JP (1) JP2002505100A (pt)
CN (1) CN1299408A (pt)
AU (1) AU759322B2 (pt)
BR (1) BR9908499A (pt)
CA (1) CA2323094A1 (pt)
IL (1) IL138201A0 (pt)
NZ (1) NZ506808A (pt)
WO (1) WO1999045100A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0013999A (pt) * 1999-09-14 2002-05-21 Univ Massachusetts Public Inst Linhagens de célula embriÈnicas ou semelhantes a células tronco produzidas por transplante nuclear de espécies cruzadas e métodos para melhorar o desenvolvimento embriÈnico por alteração genética de células doadoras ou por condições de cultura de tecido
AU782385B2 (en) * 1999-10-15 2005-07-21 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
AU784731B2 (en) * 1999-12-20 2006-06-08 University Of Massachusetts Embryonic or stem-like cells produced by cross species nuclear transplantation
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6921665B2 (en) 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
WO2002062131A2 (en) * 2001-02-02 2002-08-15 Infigen, Inc. Method of cloning transgenic mammalian animals using pseudonuclei
US20050066379A1 (en) * 2001-11-06 2005-03-24 Huizhen Sheng Preparing somatic embryo by utilizing rabbit oocyte
JP2005523685A (ja) * 2001-11-06 2005-08-11 上海第二医科大学 体細胞由来胚幹細胞及びそれらの分化子孫
EP1490487A4 (en) * 2002-04-01 2007-08-29 Gtc Biotherapeutics Inc METHOD FOR SELECTING CELLULAR LINES SUITABLE FOR CORE TRANSFER IN MAMMAL SPECIES
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013177228A1 (en) 2012-05-22 2013-11-28 Loma Linda University Generation of integration/transgene-free stem cells
CN113249297A (zh) * 2014-05-28 2021-08-13 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905042A (en) * 1996-04-01 1999-05-18 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from bovine or porcine embryos
IL128348A (en) * 1996-08-19 2008-08-07 Univ Massachusetts Method of producing embryonic or stem like cell lines by transplantation of cell nuclei from animal or mammal, such cells and uses thereof
AU745334B2 (en) * 1997-03-06 2002-03-21 Advanced Cell Technology, Inc. Method of cloning animals
AU8587598A (en) * 1997-07-26 1999-02-16 Wisconsin Alumni Research Foundation Trans-species nuclear transfer

Also Published As

Publication number Publication date
CN1299408A (zh) 2001-06-13
CA2323094A1 (en) 1999-09-10
JP2002505100A (ja) 2002-02-19
AU759322B2 (en) 2003-04-10
WO1999045100A1 (en) 1999-09-10
EP1060243A1 (en) 2000-12-20
AU2979599A (en) 1999-09-20
EP1060243A4 (en) 2005-03-09
NZ506808A (en) 2003-12-19
IL138201A0 (en) 2001-10-31

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 10 (VIII), 18 (III), 24 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.