HUP0105052A2 - Eljárások nukleinsav amplifikálására és szekvenálására - Google Patents

Eljárások nukleinsav amplifikálására és szekvenálására

Info

Publication number
HUP0105052A2
HUP0105052A2 HU0105052A HUP0105052A HUP0105052A2 HU P0105052 A2 HUP0105052 A2 HU P0105052A2 HU 0105052 A HU0105052 A HU 0105052A HU P0105052 A HUP0105052 A HU P0105052A HU P0105052 A2 HUP0105052 A2 HU P0105052A2
Authority
HU
Hungary
Prior art keywords
sequencing
nucleic acid
acid amplification
methods
study
Prior art date
Application number
HU0105052A
Other languages
English (en)
Inventor
Céline Adessi
Eric Kawashima
Pascal Mayer
Jean-Jacques Mermod
Gerardo Turcatti
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of HUP0105052A2 publication Critical patent/HUP0105052A2/hu
Publication of HUP0105052A3 publication Critical patent/HUP0105052A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

A tal lm ny t rgya nukleinsav-amplifik l s és -szekven l s. A tal lmny t rgy t k"zelebbről elj r sok képezik nukleinsav amplifik l s ra ésszekven l s ra, valamint nukleinsavak nagy mennyiségű, nagy hatékonysgú amplifik l s ra és szekven l s ra szolg ló berendezés ésreagenskészletek. Ó
HU0105052A 1998-09-30 1999-09-30 Methods of nucleic acid amplification and sequencing HUP0105052A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98307985 1998-09-30
PCT/GB1999/003248 WO2000018957A1 (en) 1998-09-30 1999-09-30 Methods of nucleic acid amplification and sequencing

Publications (2)

Publication Number Publication Date
HUP0105052A2 true HUP0105052A2 (hu) 2002-04-29
HUP0105052A3 HUP0105052A3 (en) 2003-12-29

Family

ID=8235083

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105052A HUP0105052A3 (en) 1998-09-30 1999-09-30 Methods of nucleic acid amplification and sequencing

Country Status (25)

Country Link
US (4) US7115400B1 (hu)
EP (2) EP1117827B8 (hu)
JP (1) JP2002525125A (hu)
KR (1) KR20010085860A (hu)
CN (1) CN1325458A (hu)
AR (1) AR021833A1 (hu)
AT (1) ATE311474T1 (hu)
AU (1) AU771073B2 (hu)
BG (1) BG105363A (hu)
BR (1) BR9914159A (hu)
CA (1) CA2344575A1 (hu)
CZ (1) CZ20011183A3 (hu)
DE (1) DE69928683T2 (hu)
EA (1) EA004271B1 (hu)
EE (1) EE200100195A (hu)
HK (1) HK1042525A1 (hu)
HU (1) HUP0105052A3 (hu)
IL (1) IL142178A0 (hu)
NO (1) NO20011303L (hu)
NZ (1) NZ510599A (hu)
PL (1) PL347125A1 (hu)
SK (1) SK4292001A3 (hu)
TR (1) TR200100911T2 (hu)
WO (1) WO2000018957A1 (hu)
ZA (1) ZA200102420B (hu)

Families Citing this family (808)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6846698A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid amplification
US20100130368A1 (en) * 1998-07-30 2010-05-27 Shankar Balasubramanian Method and system for sequencing polynucleotides
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE10027040A1 (de) * 2000-06-02 2001-12-06 Basf Lynx Bioscience Ag Verfahren zur Herstellung von DNA-Arrays
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
ES2305289T3 (es) 2001-04-20 2008-11-01 The Penn State Research Foundation Metodo de manipulacion de acidos nucleicos.
US7195908B2 (en) * 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
WO2004083443A1 (en) * 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
EP2159285B1 (en) 2003-01-29 2012-09-26 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
EP3175914A1 (en) 2004-01-07 2017-06-07 Illumina Cambridge Limited Improvements in or relating to molecular arrays
EP1758981A4 (en) 2004-05-28 2013-01-16 Wafergen Inc APPARATUS AND METHODS FOR PERFORMING MULTIPLEX ANALYZES
WO2006064199A1 (en) * 2004-12-13 2006-06-22 Solexa Limited Improved method of nucleotide detection
GB0427236D0 (en) 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
EP2233582A1 (en) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
JP2008528040A (ja) 2005-02-01 2008-07-31 アジェンコート バイオサイエンス コーポレイション ビーズベースの配列決定のための試薬、方法およびライブラリー
GB0514936D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
EP1963530B1 (en) * 2005-12-22 2011-07-27 Pacific Biosciences of California, Inc. Active surface coupled polymerases
CA2641851A1 (en) 2006-02-08 2007-08-16 Eric Hans Vermaas Method for sequencing a polynucleotide template
WO2007107710A1 (en) * 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
WO2008002502A2 (en) 2006-06-23 2008-01-03 Illumina, Inc. Devices and systems for creation of dna cluster arrays
US9328378B2 (en) * 2006-07-31 2016-05-03 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
JP2009545316A (ja) * 2006-07-31 2009-12-24 ワンリ ビ 可逆的に修飾されたオリゴヌクレオチドを使用する核酸増幅
JPWO2008018355A1 (ja) * 2006-08-08 2009-12-24 シャープ株式会社 バイオセンサ及びその製造方法並びに当該バイオセンサを用いた検出方法
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US7754429B2 (en) * 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2008045158A1 (en) 2006-10-10 2008-04-17 Illumina, Inc. Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
US20110045462A1 (en) * 2006-11-14 2011-02-24 The Regents Of The University Of California Digital analysis of gene expression
JP2010516285A (ja) 2007-01-26 2010-05-20 イルミナ インコーポレイテッド 核酸配列決定システムおよび方法
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
JP2010529862A (ja) * 2007-06-16 2010-09-02 スカラブ ゲノミクス， エルエルシー 核酸パッケージングシステム
WO2008157640A2 (en) 2007-06-18 2008-12-24 Illumina, Inc. Microfabrication methods for the optimal patterning of substrates
JP2009000070A (ja) * 2007-06-22 2009-01-08 Hitachi Ltd 大規模並列核酸分析方法
US8222040B2 (en) * 2007-08-28 2012-07-17 Lightspeed Genomics, Inc. Nucleic acid sequencing by selective excitation of microparticles
US8759077B2 (en) * 2007-08-28 2014-06-24 Lightspeed Genomics, Inc. Apparatus for selective excitation of microparticles
WO2009032167A1 (en) * 2007-08-29 2009-03-12 Illumina Cambridge Method for sequencing a polynucleotide template
JP2010537643A (ja) 2007-08-29 2010-12-09 アプライド バイオシステムズ， エルエルシー 代替的な核酸配列決定法
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
JP2009178159A (ja) * 2007-11-05 2009-08-13 Hitachi Plant Technologies Ltd 核酸配列の検出方法及び核酸配列検出基板
US8202691B2 (en) 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
US12060554B2 (en) 2008-03-10 2024-08-13 Illumina, Inc. Method for selecting and amplifying polynucleotides
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
EP2294214A2 (en) * 2008-05-07 2011-03-16 Illumina, Inc. Compositions and methods for providing substances to and from an array
US8407012B2 (en) * 2008-07-03 2013-03-26 Cold Spring Harbor Laboratory Methods and systems of DNA sequencing
WO2010004695A1 (ja) 2008-07-09 2010-01-14 パナソニック株式会社 シークエンサー
US20100069250A1 (en) * 2008-08-16 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Digital PCR Calibration for High Throughput Sequencing
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
AU2009319907B2 (en) 2008-11-03 2015-10-01 The Regents Of The University Of California Methods for detecting modification resistant nucleic acids
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
EP4335932A3 (en) 2008-11-07 2024-06-26 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
WO2010068702A2 (en) * 2008-12-10 2010-06-17 Illumina, Inc. Methods and compositions for hybridizing nucleic acids
WO2010075188A2 (en) 2008-12-23 2010-07-01 Illumina Inc. Multibase delivery for long reads in sequencing by synthesis protocols
US8685898B2 (en) 2009-01-15 2014-04-01 Imdaptive, Inc. Adaptive immunity profiling and methods for generation of monoclonal antibodies
DK2398915T3 (en) 2009-02-20 2016-12-12 Synthetic Genomics Inc Synthesis of nucleic acids sequence verified
JP5600880B2 (ja) * 2009-03-03 2014-10-08 東洋紡株式会社 改良された増幅試薬
JP5239978B2 (ja) * 2009-03-23 2013-07-17 パナソニック株式会社 センサおよびシーケンサー
US20100285970A1 (en) * 2009-03-31 2010-11-11 Rose Floyd D Methods of sequencing nucleic acids
CN104404134B (zh) * 2009-04-03 2017-05-10 莱弗斯基因股份有限公司 多重核酸检测方法和系统
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
AU2010242073C1 (en) 2009-04-30 2015-12-24 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2248914A1 (en) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
CA2765949C (en) 2009-06-25 2016-03-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
WO2011011175A2 (en) 2009-07-24 2011-01-27 Illumina, Inc. Method for sequencing a polynucleotide template
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
CN102625838B (zh) * 2009-08-14 2016-01-20 阿霹震中科技公司 用于生成rRNA除尽的样本或者用于从样本分离rRNA的方法、组合物和试剂盒
SI2669387T1 (sl) 2009-08-25 2017-01-31 Illumina, Inc. Metode za izbiro in pomnoževanje polinukleotidov
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
WO2011037990A1 (en) * 2009-09-22 2011-03-31 President And Fellows Of Harvard College Entangled mate sequencing
EP2488656B1 (en) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Multiple displacement amplification
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
CN102648295B (zh) 2009-12-07 2017-08-08 伊鲁米那股份有限公司 用于多重基因分型的多样品索引
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
EP2526415B1 (en) 2010-01-19 2017-05-03 Verinata Health, Inc Partition defined detection methods
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
ES2704701T3 (es) 2010-01-19 2019-03-19 Verinata Health Inc Nuevo protocolo de preparación de bibliotecas de secuenciación
AU2011207544A1 (en) 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
EP2526207A4 (en) * 2010-01-22 2013-10-09 Univ California COMPOSITIONS AND METHODS FOR CHEMICAL SCREENING AT SIGNATURE BASE
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8759037B2 (en) 2010-02-23 2014-06-24 Illumina Cambridge Limited Amplification methods to minimise sequence specific bias
DE202011003570U1 (de) 2010-03-06 2012-01-30 Illumina, Inc. Systeme und Vorrichtungen zum Detektieren optischer Signale aus einer Probe
US8502867B2 (en) 2010-03-19 2013-08-06 Lightspeed Genomics, Inc. Synthetic aperture optics imaging method using minimum selective excitation patterns
US9465228B2 (en) 2010-03-19 2016-10-11 Optical Biosystems, Inc. Illumination apparatus optimized for synthetic aperture optics imaging using minimum selective excitation patterns
PT2556171E (pt) 2010-04-05 2015-12-21 Prognosys Biosciences Inc Ensaios biológicos codificados espacialmente
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CN103003449A (zh) * 2010-05-06 2013-03-27 艾比斯生物科学公司 集成样品制备系统和稳定的酶混合物
EP4219759A3 (en) 2010-05-06 2023-09-06 Adaptive Biotechnologies Corporation Monitoring health and disease status using clonotype profiles
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
EP2854057B1 (en) 2010-05-18 2018-03-07 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
WO2011156387A2 (en) 2010-06-07 2011-12-15 Esoterix Genetic Laboratories, Llc Enumeration of nucleic acids
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
EP2596127A2 (en) 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Identification of differentially represented fetal or maternal genomic regions and uses thereof
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
EP2426214A1 (en) 2010-09-01 2012-03-07 Koninklijke Philips Electronics N.V. Method for amplifying nucleic acids
US20120070830A1 (en) 2010-09-16 2012-03-22 lbis Biosciences, Inc. Stabilization of ozone-labile fluorescent dyes by thiourea
WO2012040387A1 (en) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
WO2012050920A1 (en) 2010-09-29 2012-04-19 Illumina, Inc. Compositions and methods for sequencing nucleic acids
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
EA022475B1 (ru) * 2010-10-19 2016-01-29 Ооо "Центр Инновационных Технологий-Нано" Способ секвенирования днк
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US8753816B2 (en) 2010-10-26 2014-06-17 Illumina, Inc. Sequencing methods
US9096899B2 (en) 2010-10-27 2015-08-04 Illumina, Inc. Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
US8575071B2 (en) 2010-11-03 2013-11-05 Illumina, Inc. Reducing adapter dimer formation
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2012074855A2 (en) 2010-11-22 2012-06-07 The Regents Of The University Of California Methods of identifying a cellular nascent rna transcript
CN110079588B (zh) 2010-12-17 2024-03-15 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
US20120152743A1 (en) * 2010-12-17 2012-06-21 General Electric Company Method for electroeluting genetic material from dried samples
JP5616773B2 (ja) 2010-12-21 2014-10-29 株式会社日立ハイテクノロジーズ 核酸分析用反応デバイス、及び核酸分析装置
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012092265A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9217132B2 (en) 2011-01-20 2015-12-22 Ibis Biosciences, Inc. Microfluidic transducer
JP6017458B2 (ja) 2011-02-02 2016-11-02 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 大量並列連続性マッピング
US20130344540A1 (en) * 2011-02-03 2013-12-26 Mark T. Reed Methods for minimizing sequence specific bias
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
EP3345922A1 (en) 2011-03-09 2018-07-11 Cell Signaling Technology, Inc. Methods and reagents for creating monoclonal antibodies
DK3567124T3 (da) 2011-04-12 2022-03-07 Verinata Health Inc Opløsning af genomfraktioner ved anvendelse af polymorfisme-optællinger
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
CN110016499B (zh) 2011-04-15 2023-11-14 约翰·霍普金斯大学 安全测序系统
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
KR102003660B1 (ko) 2011-07-13 2019-07-24 더 멀티플 마이얼로머 리서치 파운데이션, 인크. 데이터 수집 및 분배 방법
WO2013022778A1 (en) 2011-08-05 2013-02-14 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
PT3623481T (pt) 2011-09-23 2021-10-15 Illumina Inc Composições para sequenciação de ácidos nucleicos
WO2013049135A1 (en) 2011-09-26 2013-04-04 Gen-Probe Incorporated Algorithms for sequence determinations
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
GB2497838A (en) 2011-10-19 2013-06-26 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2013063308A1 (en) 2011-10-25 2013-05-02 University Of Massachusetts An enzymatic method to enrich for capped rna, kits for performing same, and compositions derived therefrom
AU2012328662B2 (en) 2011-10-28 2015-12-17 Illumina, Inc. Microarray fabrication system and method
CN103890161A (zh) 2011-10-31 2014-06-25 株式会社日立高新技术 核酸扩增方法、核酸基板、核酸分析方法及核酸分析装置
EP2788509B1 (en) 2011-12-09 2018-07-11 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US20130189679A1 (en) 2011-12-20 2013-07-25 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
WO2013096838A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
WO2013096819A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
EP3211100A1 (en) 2011-12-22 2017-08-30 Ibis Biosciences, Inc. Amplification primers and methods
EP3269820A1 (en) 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit for the amplification of a sequence from a ribonucleic acid
WO2013102091A1 (en) 2011-12-28 2013-07-04 Ibis Biosciences, Inc. Nucleic acid ligation systems and methods
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
WO2013102081A2 (en) 2011-12-29 2013-07-04 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
US9855559B2 (en) 2011-12-30 2018-01-02 Abbott Molecular Inc. Microorganism nucleic acid purification from host samples
US9822417B2 (en) 2012-01-09 2017-11-21 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
CN104334739A (zh) 2012-01-13 2015-02-04 Data生物有限公司 通过新一代测序进行基因分型
EP4372084A3 (en) 2012-01-26 2024-08-14 Tecan Genomics, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
LT3363901T (lt) 2012-02-17 2021-04-12 Fred Hutchinson Cancer Research Center Kompozicijos ir būdai, skirti tiksliam mutacijų nustatymui
CN104220876A (zh) 2012-02-21 2014-12-17 奥斯陆大学医院 用于宫颈癌的检测和预后的方法和生物标志物
WO2013134162A2 (en) 2012-03-05 2013-09-12 Sequenta, Inc. Determining paired immune receptor chains from frequency matched subunits
NO2694769T3 (hu) 2012-03-06 2018-03-03
US20150111758A1 (en) 2012-03-06 2015-04-23 Oslo Universitetssykehus Hf Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US20130261984A1 (en) 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
EP2834370B1 (en) 2012-04-03 2019-01-02 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and crohn's disease
EP4219012A1 (en) 2012-04-03 2023-08-02 Illumina, Inc. Method of imaging a substrate comprising fluorescent features and use of the method in nucleic acid sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
ES2683978T3 (es) 2012-05-02 2018-10-01 Ibis Biosciences, Inc. Secuenciación de ADN
EP3783111A1 (en) 2012-05-02 2021-02-24 Ibis Biosciences, Inc. Dna sequencing
EP2844767A4 (en) 2012-05-02 2015-11-18 Ibis Biosciences Inc SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
WO2013166303A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
SG10201507700VA (en) 2012-05-08 2015-10-29 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
CN104619894B (zh) 2012-06-18 2017-06-06 纽亘技术公司 用于非期望核酸序列的阴性选择的组合物和方法
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
WO2014008448A1 (en) 2012-07-03 2014-01-09 Sloan Kettering Institute For Cancer Research Quantitative assessment of human t-cell repertoire recovery after allogeneic hematopoietic stem cell transplantation
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US9092401B2 (en) 2012-10-31 2015-07-28 Counsyl, Inc. System and methods for detecting genetic variation
WO2014015084A2 (en) 2012-07-17 2014-01-23 Counsyl, Inc. System and methods for detecting genetic variation
US9977861B2 (en) 2012-07-18 2018-05-22 Illumina Cambridge Limited Methods and systems for determining haplotypes and phasing of haplotypes
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US9422602B2 (en) 2012-08-15 2016-08-23 Bio-Rad Laboratories, Inc. Methods and compositions for determining nucleic acid degradation
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
AU2013306373B2 (en) 2012-08-20 2017-09-07 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
PL2897978T3 (pl) 2012-09-19 2017-08-31 Abbvie Biotherapeutics Inc. Sposoby identyfikacji przeciwciał o obniżonej immunogenności
ES2660027T3 (es) 2012-10-01 2018-03-20 Adaptive Biotechnologies Corporation Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad
JP6510978B2 (ja) 2012-10-16 2019-05-08 アボツト・モレキユラー・インコーポレイテツド 核酸を配列決定する方法および装置
USRE50065E1 (en) 2012-10-17 2024-07-30 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9365896B2 (en) 2012-10-19 2016-06-14 Agilent Technologies, Inc. Addition of an adaptor by invasive cleavage
JP6338221B2 (ja) 2012-10-24 2018-06-06 タカラ バイオ ユーエスエー， インコーポレイテッド 核酸生成物を生成するための、テンプレートスイッチに基づく方法
ES2701742T3 (es) 2012-10-29 2019-02-25 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
CA2892043C (en) 2012-11-21 2022-01-11 Courtagen Life Sciences Inc. A method of removing amplicons of a non-target nucleic acid having one or more methylated cytosines from a sample
EP2931919B1 (en) 2012-12-14 2019-02-20 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9128861B2 (en) 2013-01-17 2015-09-08 Personalis, Inc. Methods and systems for genetic analysis
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
CN108299275A (zh) 2013-03-08 2018-07-20 伊鲁米纳剑桥有限公司 多次甲基化合物和其作为荧光标记物的用途
EP2964624B1 (en) 2013-03-08 2017-01-04 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
WO2014142841A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Multilayer fluidic devices and methods for their fabrication
WO2014160233A1 (en) 2013-03-13 2014-10-02 Abbott Molecular Inc. Systems and methods for isolating nucleic acids
WO2014142850A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Methods and compositions for nucleic acid sequencing
ES2732012T3 (es) 2013-03-14 2019-11-20 Abbott Molecular Inc Minimización de errores utilizando uracil-ADN-N-glicosilasa
WO2014160117A1 (en) 2013-03-14 2014-10-02 Abbott Molecular Inc. Multiplex methylation-specific amplification systems and methods
WO2014152937A1 (en) 2013-03-14 2014-09-25 Ibis Biosciences, Inc. Nucleic acid control panels
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
ES2716094T3 (es) 2013-03-15 2019-06-10 Ibis Biosciences Inc Métodos para analizar la contaminación en la secuenciación del ADN
WO2014150851A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Nucleotide analogs for sequencing
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
US10767221B2 (en) 2013-03-15 2020-09-08 Illumina, Inc. Enzyme-linked nucleotides
CA2905410A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
WO2014171898A2 (en) 2013-04-17 2014-10-23 Agency For Science, Technology And Research Method for generating extended sequence reads
EP2986762B1 (en) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP3005200A2 (en) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Methods and systems for storing sequence read data
DK3013984T3 (da) 2013-06-25 2023-06-06 Prognosys Biosciences Inc Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve
PT3017065T (pt) 2013-07-01 2018-12-18 Illumina Inc Funcionalização de superfícies sem catalisador e enxerto de polímeros
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
CA2914248C (en) 2013-07-03 2021-09-07 Illumina, Inc. Sequencing by orthogonal synthesis
WO2015013465A2 (en) 2013-07-25 2015-01-29 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
KR102160389B1 (ko) 2013-08-05 2020-09-28 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
KR101869090B1 (ko) 2013-08-08 2018-06-20 일루미나, 인코포레이티드 플로우 셀로의 시약 전달을 위한 유체 시스템
WO2015026853A2 (en) 2013-08-19 2015-02-26 Abbott Molecular Inc. Next-generation sequencing libraries
EP3965111A1 (en) 2013-08-30 2022-03-09 Personalis, Inc. Methods and systems for genomic analysis
CA2920390A1 (en) 2013-08-30 2015-03-05 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
EP3058092B1 (en) 2013-10-17 2019-05-22 Illumina, Inc. Methods and compositions for preparing nucleic acid libraries
WO2015057319A1 (en) * 2013-10-17 2015-04-23 Clontech Laboratories, Inc. Methods for adding adapters to nucleic acids and compositions for practicing the same
EP3058096A1 (en) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US10174381B2 (en) 2013-10-18 2019-01-08 The Regents Of The University Of Michigan Systems and methods for determining a treatment course of action
US10415083B2 (en) 2013-10-28 2019-09-17 The Translational Genomics Research Institute Long insert-based whole genome sequencing
CA2929596C (en) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
AU2014364180B2 (en) 2013-12-09 2021-03-04 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
AU2014364006B2 (en) 2013-12-10 2019-07-11 Illumina, Inc. Biosensors for biological or chemical analysis and methods of manufacturing the same
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
WO2015094861A1 (en) 2013-12-17 2015-06-25 Clontech Laboratories, Inc. Methods for adding adapters to nucleic acids and compositions for practicing the same
US10768181B2 (en) 2013-12-17 2020-09-08 The Brigham And Women's Hospital, Inc. Detection of an antibody against a pathogen
CA3171807A1 (en) 2013-12-19 2015-06-25 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
WO2015095226A2 (en) 2013-12-20 2015-06-25 Illumina, Inc. Preserving genomic connectivity information in fragmented genomic dna samples
WO2015103225A1 (en) 2013-12-31 2015-07-09 Illumina, Inc. Addressable flow cell using patterned electrodes
KR102001554B1 (ko) 2014-01-16 2019-07-18 일루미나, 인코포레이티드 고형 지지체 상에서의 앰플리콘 제조 방법 및 시퀀싱
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
WO2015107430A2 (en) 2014-01-16 2015-07-23 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
WO2015126766A1 (en) 2014-02-18 2015-08-27 Illumina, Inc. Methods and compositions for dna profiling
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
SG11201610168YA (en) 2014-05-16 2017-01-27 Illumina Inc Nucleic acid synthesis techniques
EP3148697A1 (en) 2014-05-27 2017-04-05 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
DK3151964T3 (da) 2014-06-05 2020-04-14 Illumina Inc Systemer og metoder inklusive en rotationsventil for mindst en prøveforberedelse eller prøveanalyse
GB201410022D0 (en) * 2014-06-05 2014-07-16 Orion Diagnostica Oy Method
WO2015188178A1 (en) 2014-06-06 2015-12-10 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
EP3155125A1 (en) 2014-06-13 2017-04-19 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
GB201410646D0 (en) 2014-06-14 2014-07-30 Illumina Cambridge Ltd Methods of increasing sequencing accuracy
CA2953362A1 (en) 2014-06-23 2015-12-30 The General Hospital Corporation Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
CN114214314A (zh) 2014-06-24 2022-03-22 生物辐射实验室股份有限公司 数字式pcr条码化
EP4235677A3 (en) 2014-06-26 2023-11-22 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
WO2016003814A1 (en) 2014-06-30 2016-01-07 Illumina, Inc. Methods and compositions using one-sided transposition
ES2962636T3 (es) 2014-07-24 2024-03-20 Abbott Molecular Inc Métodos para la detección y análisis de mycobacterium tuberculosis
WO2016019360A1 (en) 2014-08-01 2016-02-04 Dovetail Genomics Llc Tagging nucleic acids for sequence assembly
JP6803327B2 (ja) 2014-08-06 2020-12-23 ニューゲン テクノロジーズ， インコーポレイテッド 標的化されたシークエンシングからのデジタル測定値
AU2015302059B2 (en) 2014-08-12 2020-02-06 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
US10174383B2 (en) 2014-08-13 2019-01-08 Vanadis Diagnostics Method of estimating the amount of a methylated locus in a sample
EP3183577B1 (en) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible surface functionalization
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
US10550428B2 (en) 2014-09-17 2020-02-04 Ibis Biosciences, Inc. Sequencing by synthesis using pulse read optics
JP6802154B2 (ja) 2014-09-18 2020-12-16 イラミーナ インコーポレーテッド 核酸シーケンシングデータを解析するための方法およびシステム
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス， インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
EP3204148B1 (en) 2014-10-09 2020-07-08 Illumina, Inc. Method and device for separating immiscible liquids to effectively isolate at least one of the liquids
RU2709655C2 (ru) 2014-10-17 2019-12-19 Иллумина Кембридж Лимитед Транспозиция с сохранением сцепления генов
EP3715455A1 (en) 2014-10-29 2020-09-30 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
EP3212807B1 (en) 2014-10-29 2020-09-02 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
EP4026913A1 (en) 2014-10-30 2022-07-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
CN107108822B (zh) 2014-10-31 2020-02-07 伊鲁米纳剑桥有限公司 聚合物以及dna共聚物涂层
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
EP3215846B1 (en) 2014-11-05 2020-03-11 Nirmidas Biotech, Inc. Metal composites for enhanced imaging
US10030268B2 (en) 2014-11-11 2018-07-24 Abbott Molecular Inc. Hybridization probes and methods
EP3218513B1 (en) 2014-11-11 2018-10-31 Illumina, Inc. Polynucleotide amplification using crispr-cas systems
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016081712A1 (en) 2014-11-19 2016-05-26 Bigdatabio, Llc Systems and methods for genomic manipulations and analysis
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
US11066705B2 (en) 2014-11-25 2021-07-20 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
US20180127804A1 (en) 2014-12-05 2018-05-10 Amyris, Inc. High-throughput sequencing of polynucleotides
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
WO2016126987A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
AU2016219480B2 (en) 2015-02-09 2021-11-11 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
AU2016220404B2 (en) 2015-02-17 2021-05-27 Mgi Tech Co., Ltd. DNA sequencing using controlled strand displacement
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
EP3822361A1 (en) 2015-02-20 2021-05-19 Takara Bio USA, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
EP3591074B1 (en) 2015-02-24 2024-10-23 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
CA3225867A1 (en) 2015-03-24 2016-09-29 Illumina, Inc. Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
EP3277839B1 (en) 2015-03-31 2020-12-02 Illumina Cambridge Limited Surface concatamerization of templates
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
KR20170136555A (ko) 2015-04-15 2017-12-11 더 제너럴 하스피탈 코포레이션 Lna-기반 돌연변이체 농축 차세대 서열분석 검정
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
US11220705B2 (en) 2015-04-24 2022-01-11 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on solid support
WO2016170182A1 (en) 2015-04-24 2016-10-27 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on a solid support
CA2983819A1 (en) * 2015-04-24 2016-10-27 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
DK3822365T3 (da) 2015-05-11 2023-02-06 Illumina Inc Platform til opdagelse og analyse af terapeutiske midler
EP4428863A2 (en) 2015-05-11 2024-09-11 Natera, Inc. Methods and compositions for determining ploidy
EP3298168A4 (en) * 2015-05-18 2019-02-20 10X Genomics, Inc. STABILIZED REDUCING AGENTS AND METHODS OF USE
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
CA2987397C (en) 2015-05-29 2022-03-01 Illumina, Inc. Sample carrier and assay system for conducting designated reactions
US11274333B2 (en) 2015-05-29 2022-03-15 Molecular Cloning Laboratories (MCLAB) LLC Compositions and methods for preparing sequencing libraries
JP6609641B2 (ja) 2015-05-29 2019-11-20 イルミナ ケンブリッジ リミテッド クラスターにおける表面プライマーの高度な利用
US10808282B2 (en) 2015-07-07 2020-10-20 Illumina, Inc. Selective surface patterning via nanoimprinting
EP3988658A1 (en) 2015-07-14 2022-04-27 Abbott Molecular Inc. Purification of nucleic acids using copper-titanium oxides
EP3322483A4 (en) 2015-07-14 2019-01-02 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
EP3325648B1 (en) 2015-07-17 2023-03-29 Illumina, Inc. Polymer sheets for sequencing applications
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
JP6712606B2 (ja) 2015-07-30 2020-06-24 イラミーナ インコーポレーテッド ヌクレオチドのオルトゴナルな脱ブロッキング
US11929149B2 (en) 2015-08-06 2024-03-12 Arc Bio, Llc Systems and methods for genomic analysis
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
US10976334B2 (en) 2015-08-24 2021-04-13 Illumina, Inc. In-line pressure accumulator and flow-control system for biological or chemical assays
EP3344389B1 (en) 2015-09-02 2020-06-10 Illumina Cambridge Limited Method of fixing defects in a hydrophobic surface of a droplet actuator
CN107922929A (zh) 2015-09-09 2018-04-17 凯杰有限公司 聚合酶
WO2017044843A1 (en) 2015-09-11 2017-03-16 The General Hospital Corporation Full interrogation of nuclease dsbs and sequencing (find-seq)
EP3350314A4 (en) 2015-09-18 2019-02-06 Twist Bioscience Corporation BANKS OF OLIGONUCLEIC ACID VARIANTS AND SYNTHESIS THEREOF
KR20180058772A (ko) 2015-09-22 2018-06-01 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
CA3000762A1 (en) 2015-09-30 2017-04-06 The General Hospital Corporation Comprehensive in vitro reporting of cleavage events by sequencing (circle-seq)
WO2017087724A1 (en) 2015-11-17 2017-05-26 Omniome, Inc. Methods for determining sequence profiles
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
CN115369161A (zh) 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
KR20190090081A (ko) 2015-12-07 2019-07-31 지머젠 인코포레이티드 Htp 게놈 공학 플랫폼에 의한 미생물 균주 개량
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CA3007635A1 (en) 2015-12-07 2017-06-15 Zymergen Inc. Promoters from corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US10730030B2 (en) 2016-01-08 2020-08-04 Bio-Rad Laboratories, Inc. Multiple beads per droplet resolution
KR20180108578A (ko) 2016-01-11 2018-10-04 일루미나, 인코포레이티드 마이크로 형광 측정기, 유체 시스템, 및 플로우 셀 래치 클램프 모듈을 구비하는 검출 장치
WO2017139260A1 (en) 2016-02-08 2017-08-17 RGENE, Inc. Multiple ligase compositions, systems, and methods
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
US20190062827A1 (en) 2016-03-14 2019-02-28 RGENE, Inc. HYPER-THERMOSTABLE LYSINE-MUTANT ssDNA/RNA LIGASES
EP3433373B1 (en) 2016-03-22 2022-01-12 Myriad Women's Health, Inc. Combinatorial dna screening
DK3377226T3 (da) 2016-03-28 2021-04-26 Illumina Inc Mikrorækker i flere niveauer
EP3442706A4 (en) 2016-04-13 2020-02-19 NextGen Jane, Inc. SAMPLE COLLECTION AND PRESERVATION DEVICES, SYSTEMS AND METHODS
EP4269611A3 (en) 2016-05-11 2024-01-17 Illumina, Inc. Polynucleotide enrichment and amplification using argonaute systems
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2017201302A1 (en) 2016-05-18 2017-11-23 The University Of Chicago Btk mutation and ibrutinib resistance
EP3458913B1 (en) 2016-05-18 2020-12-23 Illumina, Inc. Self assembled patterning using patterned hydrophobic surfaces
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
SG11201810907UA (en) 2016-06-06 2019-01-30 Redvault Biosciences Lp Target reporter constructs and uses thereof
US11708574B2 (en) 2016-06-10 2023-07-25 Myriad Women's Health, Inc. Nucleic acid sequencing adapters and uses thereof
CN109642252A (zh) 2016-06-17 2019-04-16 加州理工学院 核酸反应及相关方法和组合物
KR102345898B1 (ko) 2016-06-30 2022-01-03 지머젠 인코포레이티드 글루코오스 투과 효소 라이브러리를 생성하는 방법 및 이의 용도
WO2018005655A2 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
WO2018013509A1 (en) 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
CN106086203A (zh) * 2016-07-12 2016-11-09 深圳绿倍生态科技有限公司 一种小球藻核酸模板的制备方法及其应用
EP3875603A1 (en) 2016-07-12 2021-09-08 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
JP7075394B2 (ja) 2016-07-21 2022-05-25 タカラ バイオ ユーエスエー， インコーポレイテッド マルチウェルデバイスを用いたマルチｚ撮像及び分注
US11535883B2 (en) 2016-07-22 2022-12-27 Illumina, Inc. Single cell whole genome libraries and combinatorial indexing methods of making thereof
BR112019003577A2 (pt) 2016-08-22 2019-05-21 Biolumic Ltd métodos de tratamento da semente e produtos resultantes
CA3034769A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
US11543417B2 (en) 2016-08-29 2023-01-03 Oslo Universitetssykehus Hf ChIP-seq assays
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
ES2937782T3 (es) * 2016-10-03 2023-03-31 Illumina Inc Detección fluorescente de aminas e hidrazinas y métodos de ensayo de las mismas
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
MY194951A (en) 2016-10-14 2022-12-28 Illumina Inc Cartridge assembly
BR112019009949A2 (pt) 2016-11-16 2019-08-20 Illumina Inc método implantado por computador para validar chamadas de variante e sistema para validar chamadas de variante
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
GB2573069A (en) 2016-12-16 2019-10-23 Twist Bioscience Corp Variant libraries of the immunological synapse and synthesis thereof
CN110139932B (zh) 2016-12-19 2024-05-17 生物辐射实验室股份有限公司 液滴加标的相邻性保留的标签化dna
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4257596A3 (en) 2016-12-22 2023-12-06 Illumina Cambridge Limited Coumarin compounds and their uses as fluorescent labels
WO2018129214A1 (en) 2017-01-04 2018-07-12 Complete Genomics, Inc. Stepwise sequencing by non-labeled reversible terminators or natural nucleotides
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
EP3889962A1 (en) 2017-01-18 2021-10-06 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
EP3354746B1 (en) 2017-01-30 2019-05-29 Gregor Mendel Institute of Molecular Plant Biology GmbH Novel spike-in oligonucleotides for normalization of sequence data
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10968447B2 (en) 2017-01-31 2021-04-06 Myriad Women's Health, Inc. Methods and compositions for enrichment of target polynucleotides
US10752946B2 (en) 2017-01-31 2020-08-25 Myriad Women's Health, Inc. Methods and compositions for enrichment of target polynucleotides
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
WO2018148724A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from pyrococcus furiosus
WO2018148727A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from 9°n
WO2018148726A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from phage t4
WO2018148723A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from pyrococcus abyssi
US20200002689A1 (en) 2017-02-13 2020-01-02 Qiagen Sciences, Llc Polymerase enzyme from 9°n
US11492666B2 (en) 2017-02-15 2022-11-08 Pacific Biosciences Of California, Inc. Distinguishing sequences by detecting polymerase dissociation
CA3054303A1 (en) 2017-02-22 2018-08-30 Twist Bioscience Corporation Nucleic acid based data storage
US10894959B2 (en) 2017-03-15 2021-01-19 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
CN110446787A (zh) 2017-03-24 2019-11-12 生物辐射实验室股份有限公司 通用发夹引物
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
WO2018187013A1 (en) 2017-04-04 2018-10-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
CA3060979C (en) 2017-04-23 2023-07-11 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018259206B2 (en) 2017-04-23 2024-07-11 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
WO2018197945A1 (en) 2017-04-23 2018-11-01 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
CA3059952C (en) 2017-04-23 2023-04-18 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG11201909697TA (en) 2017-05-01 2019-11-28 Illumina Inc Optimal index sequences for multiplex massively parallel sequencing
DK3622089T3 (da) 2017-05-08 2024-10-14 Illumina Inc Fremgangsmåde til sekventering under anvendelse af universelle korte adaptere til indeksering af polynukleotidprøver
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的系统和方法
WO2018213796A1 (en) 2017-05-19 2018-11-22 Zymergen Inc. Genomic engineering of biosynthetic pathways leading to increased nadph
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
EP4230746A3 (en) 2017-05-26 2023-11-01 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3635110A2 (en) 2017-06-06 2020-04-15 Zymergen, Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
WO2018226900A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
CN110869502A (zh) 2017-06-06 2020-03-06 齐默尔根公司 高通量转座子诱变
WO2018226880A1 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving escherichia coli
KR102628035B1 (ko) 2017-06-07 2024-01-22 오레곤 헬스 앤드 사이언스 유니버시티 메틸화 서열결정을 위한 단일 세포 전체 게놈 라이브러리
US11834653B2 (en) 2017-06-08 2023-12-05 The Brigham And Women's Hospital, Inc. Methods and compositions for identifying epitopes
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
AU2018284227B2 (en) 2017-06-12 2024-05-02 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
EP3642363A1 (en) 2017-06-20 2020-04-29 Bio-Rad Laboratories, Inc. Mda using bead oligonucleotide
JP7390285B2 (ja) 2017-06-26 2023-12-01 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン 老化細胞を検出するための新規バイオマーカー
GB201711219D0 (en) 2017-07-12 2017-08-23 Illumina Cambridge Ltd Short pendant arm linkers for nucleotides in sequencing applications
WO2019018366A1 (en) 2017-07-18 2019-01-24 Omniome, Inc. METHOD OF CHEMICAL MODIFICATION OF PLASTIC SURFACES
WO2019027767A1 (en) 2017-07-31 2019-02-07 Illumina Inc. SEQUENCING SYSTEM COMPRISING AGGREGATION OF MULTIPLEXED BIOLOGICAL SAMPLES
FI3663407T3 (fi) 2017-08-01 2023-04-18 Mgi Tech Co Ltd Nukleiinihapon sekvensointimenetelmä
US11352668B2 (en) 2017-08-01 2022-06-07 Illumina, Inc. Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
NZ759924A (en) 2017-08-01 2023-07-28 Illumina Inc Hydrogel beads for nucleotide sequencing
AU2018313286B2 (en) 2017-08-11 2024-09-12 Atila Biosystems Incorporated Digital amplification with primers of limited nucleotide composition
US10858701B2 (en) 2017-08-15 2020-12-08 Omniome, Inc. Scanning apparatus and method useful for detection of chemical and biological analytes
WO2019038594A2 (en) 2017-08-21 2019-02-28 Biolumic Limited TRANSGENIC PLANTS WITH HIGH GROWTH AND HIGH RUSTICITY
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
WO2019060640A1 (en) 2017-09-20 2019-03-28 Guardant Health, Inc. METHODS AND SYSTEMS FOR DIFFERENTIATING SOMATIC VARIANTS AND GERMINAL LINE VARIANTS
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
CA3077085A1 (en) 2017-10-06 2019-04-11 Oncotherapy Science, Inc. Screening of t lymphocytes for cancer-specific antigens
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
AU2018350891B9 (en) 2017-10-16 2022-05-19 Illumina, Inc. Deep learning-based techniques for training deep convolutional neural networks
KR102526103B1 (ko) 2017-10-16 2023-04-26 일루미나, 인코포레이티드 심층 학습 기반 스플라이스 부위 분류
CA3079411C (en) 2017-10-19 2023-12-05 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
GB2583590A (en) 2017-10-20 2020-11-04 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
EP3700672B1 (en) 2017-10-27 2022-12-28 10X Genomics, Inc. Methods for sample preparation and analysis
WO2019089959A1 (en) 2017-11-02 2019-05-09 Bio-Rad Laboratories, Inc. Transposase-based genomic analysis
JP7019200B2 (ja) 2017-11-13 2022-02-15 ザ マルチプル ミエローマ リサーチ ファウンデーション， インコーポレイテッド 統合された、分子、オーミクス、免疫療法、代謝、エピジェネティック、および臨床のデータベース
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
AU2018372906A1 (en) 2017-11-22 2020-06-11 The Regents Of The University Of Michigan Compositions and methods for treating cancer
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
WO2019126789A1 (en) 2017-12-22 2019-06-27 10X Genomics, Inc. Systems and methods for processing nucleic acid molecules from one or more cells
JP2021509024A (ja) 2018-01-02 2021-03-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 多数の液滴の捕捉
AU2019205269A1 (en) 2018-01-04 2020-07-30 Twist Bioscience Corporation DNA-based digital information storage
DK3622272T3 (da) 2018-01-08 2021-11-15 Illumina Inc Indretninger til højgennemløbssekventering med halvlederbaseret detektering
WO2019136376A1 (en) 2018-01-08 2019-07-11 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
SG11201911805VA (en) 2018-01-15 2020-01-30 Illumina Inc Deep learning-based variant classifier
US11366303B2 (en) 2018-01-30 2022-06-21 Rebus Biosystems, Inc. Method for detecting particles using structured illumination
WO2019152395A1 (en) 2018-01-31 2019-08-08 Bio-Rad Laboratories, Inc. Methods and compositions for deconvoluting partition barcodes
WO2019152543A1 (en) 2018-01-31 2019-08-08 Dovetail Genomics, Llc Sample prep for dna linkage recovery
EP3752832A1 (en) 2018-02-12 2020-12-23 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
DK3752634T3 (da) 2018-02-13 2022-10-24 Illumina Inc DNA Sequencing Using Hydrogel Beads / DNA-sekventering ved anvendelse af hydrogelkorn
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
WO2019169028A1 (en) 2018-02-28 2019-09-06 10X Genomics, Inc. Transcriptome sequencing through random ligation
KR20200132870A (ko) 2018-03-20 2020-11-25 지머젠 인코포레이티드 중국 햄스터 난소 세포의 유전자 조작을 위한 htp 플랫폼
WO2019183188A1 (en) 2018-03-22 2019-09-26 Illumina, Inc. Preparation of nucleic acid libraries from rna and dna
AU2019247652A1 (en) 2018-04-02 2020-10-15 Enumera Molecular, Inc. Methods, systems, and compositions for counting nucleic acid molecules
JP6974504B2 (ja) 2018-04-02 2021-12-01 イルミナ インコーポレイテッド 配列に基づく遺伝子試験のための対照を作製するための組成物及び方法
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
EP3553182A1 (en) 2018-04-11 2019-10-16 Université de Bourgogne Detection method of somatic genetic anomalies, combination of capture probes and kit of detection
US20190318806A1 (en) 2018-04-12 2019-10-17 Illumina, Inc. Variant Classifier Based on Deep Neural Networks
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
US20190338352A1 (en) 2018-04-19 2019-11-07 Omniome, Inc. Accuracy of base calls in nucleic acid sequencing methods
CA3067181A1 (en) 2018-04-20 2019-10-24 Illumina, Inc. Methods of encapsulating single cells, the encapsulated cells and uses thereof
CA3098296A1 (en) 2018-04-26 2019-10-31 Omniome, Inc. Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
EP3788377A1 (en) 2018-05-04 2021-03-10 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
FI3794012T3 (fi) 2018-05-15 2024-01-08 Illumina Inc Koostumuksia ja menetelmiä pintaan sitoutuneiden oligonukleotidien kemiallista pilkkomista ja suojauksen poistoa varten
BR112020005982A2 (pt) 2018-05-17 2020-12-08 Illumina, Inc. Sequenciamento de células únicas com alto rendimento com viés de amplificação reduzido
CN112639130B (zh) 2018-05-18 2024-08-09 特韦斯特生物科学公司 用于核酸杂交的多核苷酸、试剂和方法
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
JP2021525078A (ja) 2018-05-31 2021-09-24 オムニオム インコーポレイテッドＯｍｎｉｏｍｅ， Ｉｎｃ． 核酸配列決定におけるシグナル対ノイズの増加
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
WO2019236478A1 (en) 2018-06-04 2019-12-12 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free nucleic acids
SG11202000905PA (en) 2018-06-04 2020-02-27 Illumina Inc High-throughput single-cell transcriptome libraries and methods of making and of using
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN110684829A (zh) * 2018-07-05 2020-01-14 深圳华大智造科技有限公司 一种高通量的单细胞转录组测序方法和试剂盒
US12073922B2 (en) 2018-07-11 2024-08-27 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
CA3107983A1 (en) 2018-07-23 2020-01-30 Guardant Health, Inc. Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
EP3827097A1 (en) 2018-07-24 2021-06-02 Omniome, Inc. Serial formation of ternary complex species
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
WO2020036991A1 (en) 2018-08-15 2020-02-20 Illumina, Inc. Compositions and methods for improving library enrichment
CN118406747A (zh) 2018-08-20 2024-07-30 生物辐射实验室股份有限公司 通过分区中条码珠共定位生成核苷酸序列
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
EP3844304B1 (en) 2018-08-28 2024-10-02 10X Genomics, Inc. Methods for generating spatially barcoded arrays
JP2021536232A (ja) 2018-08-30 2021-12-27 ガーダント ヘルス， インコーポレイテッド 試料間の汚染を検出するための方法およびシステム
AU2019328344A1 (en) 2018-08-31 2021-04-08 Guardant Health, Inc. Microsatellite instability detection in cell-free DNA
US20200075124A1 (en) 2018-09-04 2020-03-05 Guardant Health, Inc. Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples
PL3814533T3 (pl) 2018-09-20 2022-01-31 Tamirna Gmbh Sygnatury mikro-rna do przewidywania dysfunkcji wątroby
CN113705585A (zh) 2018-10-15 2021-11-26 因美纳有限公司 基于神经网络实现的方法和系统
EP3870704A4 (en) 2018-10-25 2023-01-11 Illumina, Inc. METHODS AND COMPOSITIONS FOR IDENTIFYING LIGANDS ON NETWORKS USING INDICES AND BARCODES
WO2020086843A1 (en) 2018-10-26 2020-04-30 Illumina, Inc. Modulating polymer beads for dna processing
SG11202103486YA (en) 2018-10-31 2021-05-28 Guardant Health Inc Methods, compositions and systems for calibrating epigenetic partitioning assays
US10768173B1 (en) * 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US10876148B2 (en) 2018-11-14 2020-12-29 Element Biosciences, Inc. De novo surface preparation and uses thereof
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
EP3887540B1 (en) 2018-11-30 2023-08-23 Illumina, Inc. Analysis of multiple analytes using a single assay
EP3891304A1 (en) 2018-12-04 2021-10-13 Omniome, Inc. Mixed-phase fluids for nucleic acid sequencing and other analytical assays
SG11202012762WA (en) 2018-12-05 2021-01-28 Illumina Cambridge Ltd Methods and compositions for cluster generation by bridge amplification
US20220002798A1 (en) * 2018-12-07 2022-01-06 Bgi Shenzhen Nanopore sequencing method
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
SG11202012748TA (en) 2018-12-14 2021-01-28 Illumina Cambridge Ltd Decreasing phasing with unlabeled nucleotides during sequencing
CA3103744A1 (en) 2018-12-17 2020-06-25 Pietro GATTI-LAFRANCONI Compositions for use in polynucleotide sequencing
CA3103750A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Primer oligonucleotide for sequencing
WO2020126602A1 (en) 2018-12-18 2020-06-25 Illumina Cambridge Limited Methods and compositions for paired end sequencing using a single surface primer
JP2022512264A (ja) 2018-12-19 2022-02-03 イラミーナ インコーポレーテッド ポリヌクレオチドクラスターのクローナリティを改善するための方法
WO2020132350A2 (en) 2018-12-20 2020-06-25 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
CA3119980A1 (en) 2018-12-20 2020-06-25 Guardant Health, Inc. Methods, compositions, and systems for improving recovery of nucleic acid molecules
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US20220081714A1 (en) 2019-01-04 2022-03-17 Northwestern University Storing temporal data into dna
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
US20220112557A1 (en) 2019-01-10 2022-04-14 Iovance Biotherapeutics, Inc. System and methods for monitoring adoptive cell therapy clonality and persistence
CN113661249A (zh) 2019-01-31 2021-11-16 夸登特健康公司 用于分离无细胞dna的组合物和方法
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
WO2020168013A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Methods for processing nucleic acid molecules
EP3924513B1 (en) 2019-02-14 2023-04-12 Pacific Biosciences of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
EP3927467A4 (en) 2019-02-20 2022-12-14 Pacific Biosciences of California, Inc. SCANNING APPARATUS AND METHODS FOR DETECTING CHEMICAL OR BIOLOGICAL ANALYTES
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
JP2022522668A (ja) 2019-02-26 2022-04-20 ツイスト バイオサイエンス コーポレーション 抗体を最適化するための変異体核酸ライブラリ
WO2020176678A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
KR20210134210A (ko) 2019-03-01 2021-11-09 일루미나 케임브리지 리미티드 삼차 아민 치환된 쿠마린 화합물 및 형광 표지로서의 이의 용도
US20220033805A1 (en) 2019-03-01 2022-02-03 Sanjay Srivatsan High-throughput single-nuclei and single-cell libraries and methods of making and of using
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
MX2020013384A (es) 2019-03-01 2021-04-28 Illumina Cambridge Ltd Compuestos de comarina sustituidos con amina exocíclica y sus usos como etiquetas fluorescentes.
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
EP3938537A1 (en) 2019-03-11 2022-01-19 10X Genomics, Inc. Systems and methods for processing optically tagged beads
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
WO2020191387A1 (en) 2019-03-21 2020-09-24 Illumina, Inc. Artificial intelligence-based base calling
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
US11347965B2 (en) 2019-03-21 2022-05-31 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
US11579217B2 (en) 2019-04-12 2023-02-14 Western Digital Technologies, Inc. Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
US11738336B2 (en) 2019-04-12 2023-08-29 Western Digital Technologies, Inc. Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11609208B2 (en) 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
AU2020276115A1 (en) 2019-05-16 2021-01-07 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP3976822A1 (en) 2019-05-31 2022-04-06 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
CA3144644A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
BR112021012755A2 (pt) 2019-07-12 2022-04-26 Illumina Cambridge Ltd Composições e métodos para preparar bibliotecas de sequenciamento de ácidos nucleicos usando crispr/cas9 imobilizadas em um suporte sólido
WO2021011803A1 (en) 2019-07-16 2021-01-21 Omniome, Inc. Synthetic nucleic acids having non-natural structures
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
WO2021026228A1 (en) 2019-08-05 2021-02-11 Mission Bio, Inc. Method and apparatus for single-cell analysis for determining a cell trajectory
WO2021050681A1 (en) 2019-09-10 2021-03-18 Omniome, Inc. Reversible modification of nucleotides
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
BR112021026562A2 (pt) 2019-09-20 2022-11-29 Illumina Inc Métodos e composições para identificar ligantes em arranjos com o uso de índices e códigos de barras
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US11111507B2 (en) 2019-09-23 2021-09-07 Zymergen Inc. Method for counterselection in microorganisms
AU2020356471A1 (en) 2019-09-23 2022-04-21 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
US11788137B2 (en) 2019-09-30 2023-10-17 Diagenode S.A. Diagnostic and/or sequencing method and kit
CN118186063A (zh) 2019-10-18 2024-06-14 加利福尼亚太平洋生物科学股份有限公司 用于对核酸加帽的方法和组合物
EP3812472B1 (en) 2019-10-21 2022-11-23 Albert-Ludwigs-Universität Freiburg A truly unbiased in vitro assay to profile off-target activity of one or more target-specific programmable nucleases in cells (abnoba-seq)
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
US11747329B2 (en) 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
CA3157560A1 (en) 2019-11-26 2021-06-03 Dustin Howard HITE Methods, compositions and systems for improving the binding of methylated polynucleotides
EP4065646A1 (en) 2019-11-27 2022-10-05 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
CA3134746A1 (en) 2019-12-19 2021-06-24 Illumina, Inc. High-throughput single-cell libraries and methods of making and of using
US11747262B2 (en) 2019-12-23 2023-09-05 Singular Genomics Systems, Inc. Flow cell carrier and methods of use
US11498078B2 (en) 2019-12-23 2022-11-15 Singular Genomics Systems, Inc. Flow cell receiver and methods of use
WO2021133842A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
EP4424843A3 (en) 2019-12-23 2024-09-25 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
US20210189483A1 (en) 2019-12-23 2021-06-24 Mgi Tech Co. Ltd. Controlled strand-displacement for paired end sequencing
IL294459A (en) 2019-12-31 2022-09-01 Singular Genomics Systems Inc Polynucleotide barcodes for long read sequencing
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
WO2021158511A1 (en) 2020-02-04 2021-08-12 Omniome, Inc. Flow cells and methods for their manufacture and use
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
CN115349128A (zh) 2020-02-13 2022-11-15 齐默尔根公司 宏基因组文库和天然产物发现平台
JPWO2021162028A1 (hu) * 2020-02-14 2021-08-19
CN115136244A (zh) 2020-02-20 2022-09-30 因美纳有限公司 基于人工智能的多对多碱基判读
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
KR20220151101A (ko) 2020-03-09 2022-11-14 일루미나, 인코포레이티드 폴리뉴클레오티드를 서열분석하는 방법
WO2021180724A1 (en) 2020-03-09 2021-09-16 Illumina, Inc. Improvements in nucleic acid sequencing
US20230129228A1 (en) 2020-03-18 2023-04-27 Mgi Tech Co. Ltd. Restoring phase in massively parallel sequencing
AU2021240092A1 (en) 2020-03-20 2022-10-27 Mission Bio, Inc. Single cell workflow for whole genome amplification
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
CN115916999A (zh) 2020-04-22 2023-04-04 10X基因组学有限公司 用于使用靶向rna耗竭进行空间分析的方法
CA3177127A1 (en) 2020-04-30 2021-11-04 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
CN115836135A (zh) 2020-05-05 2023-03-21 加利福尼亚太平洋生物科学股份有限公司 用于修饰聚合酶-核酸复合物的组合物和方法
JP2023526062A (ja) 2020-05-12 2023-06-20 イルミナ インコーポレイテッド 組換え末端デオキシヌクレオチジルトランスフェラーゼを使用して修飾塩基を有する核酸の生成
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
EP4150113A1 (en) 2020-05-14 2023-03-22 Guardant Health, Inc. Homologous recombination repair deficiency detection
EP4414459A3 (en) 2020-05-22 2024-09-18 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283184A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
EP4165207B1 (en) 2020-06-10 2024-09-25 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
JP2023531009A (ja) 2020-06-22 2023-07-20 イルミナ ケンブリッジ リミテッド ３’アセタールブロッキング基を有するヌクレオシド及びヌクレオチド
EP4450639A2 (en) 2020-06-25 2024-10-23 10X Genomics, Inc. Spatial analysis of dna methylation
EP4172364A1 (en) 2020-06-30 2023-05-03 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
CN115843315A (zh) 2020-07-02 2023-03-24 伊鲁米纳公司 用于校准流通池中核酸文库接种效率的方法
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
JP2023532905A (ja) 2020-07-08 2023-08-01 イルミナ インコーポレイテッド トランスポソーム担体としてのビーズ
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
EP4407042A3 (en) 2020-07-10 2024-09-18 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
EP4153606A4 (en) 2020-07-13 2024-10-02 Singular Genomics Systems Inc METHODS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
US11946044B2 (en) 2020-07-30 2024-04-02 Guardant Health, Inc. Methods for isolating cell-free DNA
IL300112A (en) 2020-08-06 2023-03-01 Illumina Inc Preparation of RNA and DNA sequencing libraries using bead-linked transpososomes
US20220059187A1 (en) 2020-08-07 2022-02-24 Oxford Nanopore Technologies Limited Methods of detecting nucleic acid barcodes
WO2022040176A1 (en) 2020-08-18 2022-02-24 Illumina, Inc. Sequence-specific targeted transposition and selection and sorting of nucleic acids
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
WO2022046947A1 (en) 2020-08-25 2022-03-03 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
WO2022053610A1 (en) 2020-09-11 2022-03-17 Illumina Cambridge Limited Methods of enriching a target sequence from a sequencing library using hairpin adaptors
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
EP4222278A1 (en) 2020-09-30 2023-08-09 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease
IL302207A (en) 2020-10-21 2023-06-01 Illumina Inc Sequencing templates that include several additions and compositions and methods to improve sequencing output
WO2022087485A1 (en) 2020-10-22 2022-04-28 Singular Genomics Systems, Inc. Nucleic acid circularization and amplification on a surface
US12084715B1 (en) 2020-11-05 2024-09-10 10X Genomics, Inc. Methods and systems for reducing artifactual antisense products
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4267757A1 (en) 2020-12-23 2023-11-01 Guardant Health, Inc. Methods and systems for analyzing methylated polynucleotides
CN117043352A (zh) 2021-01-29 2023-11-10 伊鲁米纳公司 使用多核苷酸改善流通池的接种效率的方法、组合物和试剂盒
MX2023009046A (es) 2021-02-04 2023-08-10 Illumina Inc Generacion de lectura unida indexada prolongada en globulos unidos con transposomas.
US11486001B2 (en) 2021-02-08 2022-11-01 Singular Genomics Systems, Inc. Methods and compositions for sequencing complementary polynucleotides
WO2022174054A1 (en) 2021-02-13 2022-08-18 The General Hospital Corporation Methods and compositions for in situ macromolecule detection and uses thereof
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
AU2022227563A1 (en) 2021-02-23 2023-08-24 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
WO2022187862A1 (en) 2021-03-05 2022-09-09 Guardant Health, Inc. Methods and related aspects for analyzing molecular response
US20220344004A1 (en) 2021-03-09 2022-10-27 Guardant Health, Inc. Detecting the presence of a tumor based on off-target polynucleotide sequencing data
WO2022197754A1 (en) 2021-03-16 2022-09-22 Illumina Software, Inc. Neural network parameter quantization for base calling
EP4301870A1 (en) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
CN117222747A (zh) 2021-03-22 2023-12-12 伊鲁米纳剑桥有限公司 用于改善核酸簇克隆性的方法
JP2024511766A (ja) 2021-03-29 2024-03-15 イルミナ インコーポレイテッド 改善されたライブラリ調製方法
EP4314328A1 (en) 2021-03-29 2024-02-07 Illumina, Inc. Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias
IL307172A (en) 2021-03-30 2023-11-01 Illumina Inc Improved methods of isothermal complementary DNA and library preparation
JP2024511760A (ja) 2021-03-31 2024-03-15 イルミナ インコーポレイテッド エラー補正のための固有分子識別子を有するトランスポゾンベースの技術を使用した指向性タグメンテーション配列決定ライブラリーの調製方法
US20220336054A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures
JP2024516191A (ja) 2021-05-05 2024-04-12 イルミナ ケンブリッジ リミテッド ビス－ホウ素縮合複素環を含有する蛍光色素及び配列決定における使用
BR112023024130A2 (pt) 2021-05-20 2024-01-30 Illumina Cambridge Ltd Composições e métodos para sequenciamento por síntese
EP4347879A1 (en) 2021-06-03 2024-04-10 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US20230016633A1 (en) 2021-06-15 2023-01-19 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
US11220707B1 (en) 2021-06-17 2022-01-11 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US11859241B2 (en) 2021-06-17 2024-01-02 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US20220411864A1 (en) 2021-06-23 2022-12-29 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
JP2024527306A (ja) 2021-06-29 2024-07-24 イルミナ インコーポレイテッド オリゴ配列を使用して訓練された自己学習ベースコーラ
WO2023278184A1 (en) 2021-06-29 2023-01-05 Illumina, Inc. Methods and systems to correct crosstalk in illumination emitted from reaction sites
US20230027409A1 (en) 2021-07-13 2023-01-26 Illumina, Inc. Methods and systems for real time extraction of crosstalk in illumination emitted from reaction sites
KR20240031968A (ko) 2021-07-19 2024-03-08 일루미나, 인코포레이티드 염기 호출에 대한 보간 및 적응을 갖는 강도 추출
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
JP2024526921A (ja) 2021-07-21 2024-07-19 ディーエヌエイイー ダイアグノスティックス リミテッド 標的ポリヌクレオチドを配列決定するための組成物、キット及び方法
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
KR20240037882A (ko) 2021-07-28 2024-03-22 일루미나, 인코포레이티드 염기 호출 시스템의 품질 점수 보정
KR20240035413A (ko) 2021-08-03 2024-03-15 일루미나, 인코포레이티드 다중 염기 호출자 모델을 사용한 염기 호출
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023035003A1 (en) 2021-09-03 2023-03-09 Elegen Corp. Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
WO2023056328A2 (en) 2021-09-30 2023-04-06 Illumina, Inc. Solid supports and methods for depleting and/or enriching library fragments prepared from biosamples
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
EP4430206A1 (en) 2021-11-10 2024-09-18 Encodia, Inc. Methods for barcoding macromolecules in individual cells
WO2023086635A1 (en) 2021-11-15 2023-05-19 Vir Biotechnology, Inc. Virological and molecular surrogates of response to sars-cov-2 neutralizing antibody sotrovimab
AU2022409487A1 (en) 2021-12-16 2024-01-18 Illumina, Inc. Hybrid clustering
CA3222829A1 (en) 2021-12-16 2023-06-22 Gabriele CANZI Methods for metal directed cleavage of surface-bound polynucleotides
WO2023114394A1 (en) 2021-12-17 2023-06-22 Illumina, Inc. Orthogonal hybridization
CA3222842A1 (en) 2021-12-20 2023-06-29 Oliver MILLER Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
WO2023122491A1 (en) 2021-12-20 2023-06-29 Illumina Cambridge Limited Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
AU2022424380A1 (en) 2021-12-29 2024-01-18 Illumina, Inc. Methods of nucleic acid sequencing using surface-bound primers
WO2023135485A1 (en) 2022-01-13 2023-07-20 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
WO2023141154A1 (en) 2022-01-20 2023-07-27 Illumina Cambridge Limited Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
EP4341435A1 (en) 2022-03-15 2024-03-27 Illumina, Inc. Methods of base calling nucleobases
WO2023175040A2 (en) 2022-03-15 2023-09-21 Illumina, Inc. Concurrent sequencing of forward and reverse complement strands on concatenated polynucleotides for methylation detection
CA3223115A1 (en) 2022-03-28 2023-10-05 Xiaolin Wu Labeled avidin and methods for sequencing
AU2023246772A1 (en) 2022-03-29 2024-01-18 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
WO2023186872A1 (en) 2022-03-30 2023-10-05 Illumina Cambridge Limited Methods for chemical cleavage of surface-bound polynucleotides
AU2023246851A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2023187061A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Paired-end re-synthesis using blocked p5 primers
AU2023244351A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use
US20230348967A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
US20230360725A1 (en) 2022-05-09 2023-11-09 Guardant Health, Inc. Detecting degradation based on strand bias
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
US20230392201A1 (en) 2022-06-06 2023-12-07 Element Biosciences, Inc. Methods for assembling and reading nucleic acid sequences from mixed populations
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024057280A1 (en) 2022-09-16 2024-03-21 Illumina Cambridge Limited Nanoparticle with polynucleotide binding site and method of making thereof
WO2024061799A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Deformable polymers comprising immobilised primers
US20240102067A1 (en) 2022-09-26 2024-03-28 Illumina, Inc. Resynthesis Kits and Methods
US20240110234A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Amplification Compositions and Methods
AU2023348238A1 (en) 2022-09-30 2024-10-03 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
US20240124914A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Thermophilic compositions for nucleic acid amplification
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
US20240124929A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Mesophilic compositions for nucleic acid amplification
US20240110221A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of modulating clustering kinetics
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
GB202215624D0 (en) 2022-10-21 2022-12-07 Dnae Diagnostics Ltd Clonal amplification
WO2024107599A1 (en) 2022-11-15 2024-05-23 Guardant Health, Inc. Method of predicting non-small cell lung cancer (nsclc) patient drug response or time until death or cancer progression from circulating tumor dna (ctdna) utilizing signals from both baseline ctdna level and longitudinal change of ctdna level over time
WO2024118903A1 (en) 2022-11-30 2024-06-06 Illumina, Inc. Chemoenzymatic correction of false positive uracil transformations
WO2024123917A1 (en) 2022-12-07 2024-06-13 Illumina, Inc. Monoclonal clustering using double stranded dna size exclusion with patterned seeding
WO2024123866A1 (en) 2022-12-09 2024-06-13 Illumina, Inc. Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers
WO2024129672A1 (en) 2022-12-12 2024-06-20 The Broad Institute, Inc. Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy
WO2024129969A1 (en) 2022-12-14 2024-06-20 Illumina, Inc. Systems and methods for capture and enrichment of clustered beads on flow cell substrates
WO2024137682A1 (en) 2022-12-21 2024-06-27 Guardant Health, Inc. Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
AU2023419253A1 (en) 2022-12-27 2024-10-03 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
WO2024147904A1 (en) 2023-01-06 2024-07-11 Illumina, Inc. Reducing uracils by polymerase
WO2024182219A1 (en) 2023-02-27 2024-09-06 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
US20240327910A1 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
US20240327909A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
EP0224126A3 (en) 1985-11-25 1989-02-01 The University of Calgary Covalently linked complementary oligodeoxynucleotides as universal nucleic acid sequencing primer linkers
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US6107023A (en) * 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
GB8818020D0 (en) 1988-07-28 1988-09-01 Ici Plc Method for amplification of nucleotide sequences
CA2004326A1 (en) 1988-12-23 1990-06-23 Nanibushan Dattagupta Assay of sequences using amplified genes
US5629158A (en) * 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
CA2036946C (en) * 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
ATE175997T1 (de) 1991-08-10 1999-02-15 Medical Res Council Behandlung von zellpopulationen
WO1993004199A2 (en) 1991-08-20 1993-03-04 Scientific Generics Limited Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids
EP0543484B1 (en) * 1991-08-30 2001-01-31 Research Development Corporation of Japan A method of DNA amplification
EP1382386A3 (en) * 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
DE69327326T2 (de) * 1992-07-24 2001-08-16 Diatech Pty. Ltd., Brisbane Vervielfältigungs- und detektionsprozess
RU2048522C1 (ru) * 1992-10-14 1995-11-20 Институт белка РАН Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления
US5436142A (en) * 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
JPH07203998A (ja) 1994-01-26 1995-08-08 Hamamatsu Photonics Kk 核酸塩基配列決定方法
DE69527355T2 (de) * 1994-05-28 2003-03-06 Tepnel Medical Ltd., Manchester Herstellung von nukleinsaeurekopien
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US6060288A (en) * 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports
EP0830460A1 (en) 1995-04-11 1998-03-25 Trustees Of Boston University Solid phase sequencing of biopolymers
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
AU714486B2 (en) 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5939291A (en) * 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US6218142B1 (en) * 1997-03-05 2001-04-17 Michael Wassenegger Nucleic acid molecules encoding polypeptides having the enzymatic activity of an RNA-directed RNA polymerase (RDRP)
AU6846698A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid amplification
JP2001517948A (ja) 1997-04-01 2001-10-09 グラクソ、グループ、リミテッド 核酸配列決定法
CA2256563A1 (en) 1997-04-04 1998-10-15 Innogenetics N.V. Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
EP1496120B1 (en) 1997-07-07 2007-03-28 Medical Research Council In vitro sorting method
US6326489B1 (en) * 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US6124120A (en) * 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
US6511803B1 (en) * 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6248558B1 (en) * 1998-03-31 2001-06-19 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
AR021833A1 (es) * 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
WO2000041524A2 (en) 1999-01-11 2000-07-20 President And Fellows Of Harvard College Isothermal amplification of dna
US6300070B1 (en) * 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
JP6049051B2 (ja) 2011-07-29 2016-12-21 日東電工株式会社 両面真空成膜方法

Also Published As

Publication number Publication date
AR021833A1 (es) 2002-08-07
AU6108899A (en) 2000-04-17
EP1634963B1 (en) 2013-06-19
EA200100402A1 (ru) 2001-10-22
CA2344575A1 (en) 2000-04-06
HUP0105052A3 (en) 2003-12-29
WO2000018957A1 (en) 2000-04-06
EP1117827B8 (en) 2010-06-02
US7115400B1 (en) 2006-10-03
HK1042525A1 (zh) 2002-08-16
KR20010085860A (ko) 2001-09-07
NO20011303D0 (no) 2001-03-14
SK4292001A3 (en) 2001-12-03
IL142178A0 (en) 2002-03-10
NO20011303L (no) 2001-05-22
US9297006B2 (en) 2016-03-29
JP2002525125A (ja) 2002-08-13
CN1325458A (zh) 2001-12-05
EP1117827A1 (en) 2001-07-25
AU771073B2 (en) 2004-03-11
EP1634963A1 (en) 2006-03-15
CZ20011183A3 (cs) 2001-09-12
NZ510599A (en) 2003-06-30
ZA200102420B (en) 2001-09-26
ATE311474T1 (de) 2005-12-15
PL347125A1 (en) 2002-03-25
DE69928683T2 (de) 2006-08-24
TR200100911T2 (tr) 2001-07-23
US8652810B2 (en) 2014-02-18
BR9914159A (pt) 2001-06-26
EP1117827B1 (en) 2005-11-30
US20140228254A1 (en) 2014-08-14
EA004271B1 (ru) 2004-02-26
EE200100195A (et) 2002-06-17
US10370652B2 (en) 2019-08-06
DE69928683D1 (de) 2006-01-05
BG105363A (bg) 2001-12-31
US20080160580A1 (en) 2008-07-03
US20160319274A1 (en) 2016-11-03

Similar Documents

Publication Publication Date Title
HUP0105052A2 (hu) Eljárások nukleinsav amplifikálására és szekvenálására
EP1032705A4 (en) PROBE ARRANGEMENTS AND THEIR USES FOR METHODS FOR DNA DISTINCTION
ATA165999A (de) Medium zur protein- und serumfreien kultivierung von zellen
MX9703063A (es) Compuestos de ester y acido boronico, su sintesis y usos.
DE69939945D1 (de) Verfahren zur isolierung von stammzellen
DK0610474T3 (da) Dyrecellekultur
DK0474790T3 (da) Medier til cellevækst og fremgangsmåde til fremstilling deraf
DK0799058T3 (da) Forbedringer af eller med hensyn til endometriefunktion
ES2076944T3 (es) Procedimiento para el cultivo de bacterias.
AU2003223660A8 (en) Comparative phenotype analysis of cells, including testing of biologically active compounds
CA2437962A1 (en) Method of extracting virus from cell culture
HUP0302600A2 (hu) Eljárás petefészektüszők in vitro tenyésztésére
AU2001226929A1 (en) Assessment method
DE60107718T8 (de) Konservierung von zellen
DE60035515D1 (de) Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit
HUP0102413A1 (hu) Vektorok nukleinsavak bevitelére, ezeket tartalmazó készítmények és alkalmazásuk
ATE449162T1 (de) Herstellung von tcr gamma delta t-zellen
DE69940352D1 (de) Verfahren zur herstellung von gamma delta t zellen
TR200100013T2 (tr) N-tert-butilhidroksilaminin yeni tuzları.
WO2001083822A3 (en) Use of representations of dna for genetic analysis
DK1238057T3 (da) Fremgangsmåde til produktion af vedhæftende dyreceller
ATE288476T1 (de) Herstellung von proteinen
HUP0002281A2 (hu) Eljárás sejtfelszíni fehérjék elleni vakcinák termelésére
Stepanov et al. Energy Consumption Analysis of Cu Production
JPS52156981A (en) Cultivation of d-cysteine-synthesizing enzyme-producing microorganisms