DE69939945D1 - Verfahren zur isolierung von stammzellen - Google Patents

Verfahren zur isolierung von stammzellen

Info

Publication number
DE69939945D1
DE69939945D1 DE69939945T DE69939945T DE69939945D1 DE 69939945 D1 DE69939945 D1 DE 69939945D1 DE 69939945 T DE69939945 T DE 69939945T DE 69939945 T DE69939945 T DE 69939945T DE 69939945 D1 DE69939945 D1 DE 69939945D1
Authority
DE
Germany
Prior art keywords
stem cells
isolating stem
isolating
present
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939945T
Other languages
English (en)
Inventor
Clayton A Smith
Michael Colvin
Robert W Storms
Susan M Ludeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Application granted granted Critical
Publication of DE69939945D1 publication Critical patent/DE69939945D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
DE69939945T 1998-12-07 1999-12-07 Verfahren zur isolierung von stammzellen Expired - Lifetime DE69939945D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11119598P 1998-12-07 1998-12-07
PCT/US1999/028769 WO2000034507A1 (en) 1998-12-07 1999-12-07 A method of isolating stem cells

Publications (1)

Publication Number Publication Date
DE69939945D1 true DE69939945D1 (de) 2009-01-02

Family

ID=22337091

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69942185T Expired - Lifetime DE69942185D1 (de) 1998-12-07 1999-12-07 BODIPY Aminoacetaldehyd Diethyl Acetal
DE69939945T Expired - Lifetime DE69939945D1 (de) 1998-12-07 1999-12-07 Verfahren zur isolierung von stammzellen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69942185T Expired - Lifetime DE69942185D1 (de) 1998-12-07 1999-12-07 BODIPY Aminoacetaldehyd Diethyl Acetal

Country Status (12)

Country Link
US (3) US6627759B1 (de)
EP (2) EP1975243B1 (de)
JP (1) JP4498614B2 (de)
AT (2) ATE462014T1 (de)
AU (1) AU774566B2 (de)
CA (1) CA2353701C (de)
CY (2) CY1111042T1 (de)
DE (2) DE69942185D1 (de)
DK (2) DK1975243T3 (de)
ES (2) ES2317707T3 (de)
PT (2) PT1137798E (de)
WO (1) WO2000034507A1 (de)

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CA2441688C (en) 2001-03-27 2014-01-21 Vertex Pharmaceuticals Incorporated Compositions and methods useful for hcv infection
US20030049836A1 (en) * 2001-08-15 2003-03-13 Phi-Wilson Janette T. Cell separation system
WO2004005496A1 (ja) * 2002-07-05 2004-01-15 Kirin Beer Kabushiki Kaisha 臍帯血、骨髄、末梢血等に含まれる新規な未分化幹細胞集団
EP1718735A1 (de) * 2004-02-11 2006-11-08 Aldagen, Inc. Stammzellpopulationen und verwendungsverfahren
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US8765119B2 (en) * 2004-05-06 2014-07-01 University Of South Florida Treating amyotrophic lateral sclerosis (ALS)with isolated aldehyde dehydrogenase-positive umbilical cord blood cells
JP2006349658A (ja) * 2005-02-21 2006-12-28 Hisamitsu Pharmaceut Co Inc 神経系癌幹細胞の検出試薬、神経系癌幹細胞を分離する方法、神経系癌幹細胞、及び神経芽腫の予後診断薬。
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
WO2007033331A2 (en) * 2005-09-14 2007-03-22 Duke University Stem cells
US20090220462A1 (en) * 2005-09-14 2009-09-03 Duke University Stem cells
ATE552837T1 (de) * 2005-12-02 2012-04-15 Univ Johns Hopkins Verwendung von hochdosierten oxazaphosphorin- arzneimitteln zur behandlung von immunstörungen
EP2019858B1 (de) * 2006-04-17 2012-06-13 BioE LLC Differenzierung von vorläuferzellen mit mehreren abstammungslinien in respiratorischen epithelzellen
JP2009537137A (ja) * 2006-05-17 2009-10-29 コグネート セラピューティクス，インコーポレーテッド 脂肪吸引後の脂肪吸引物からの造血幹細胞の単離および精製
WO2008034076A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclophosphamide in combination with immune therapeutics
WO2008034074A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclosphosphamide in combination with anti-idiotypic vaccines
WO2008034071A2 (en) * 2006-09-15 2008-03-20 The Johns Hopkins University Method of identifying patients suitable for high-dose cyclophosphamide treatment
WO2008036419A2 (en) * 2006-09-22 2008-03-27 The Regents Of The University Of Michigan Aldehyde dehydrogenase 1(aldh1) as a cancer stem cell marker
US20080226608A1 (en) * 2007-01-15 2008-09-18 Washington University Methods of Isolating and Using Enriched Subpopulations of Bone Marrow Progenitors for the Treatment of Diabetes
CA2693827A1 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US9026372B2 (en) * 2007-11-21 2015-05-05 Accentia Biopharmaceuticals, Inc. Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen
WO2009067690A2 (en) * 2007-11-21 2009-05-28 Accentia Biopharmaceuticals, Inc. Methods for safe and effective treatment using oxazaphosphorine drugs
EP2294187A2 (de) * 2008-05-21 2011-03-16 BioE LLC Differenzierung von mehrlinien-vorläuferzellen zu pankreaszellen
WO2011159797A2 (en) 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. A compendium of ready-built stem cell models for interrogation of biological response
EP2591093B1 (de) 2010-07-07 2018-11-28 FUJIFILM Cellular Dynamics, Inc. Endothelzellenproduktion durch programmierung
WO2012071012A2 (en) 2010-11-24 2012-05-31 National University Of Singapore Bodipy structure fluorescence dye for neural stem cell probe
JP6005666B2 (ja) 2011-02-08 2016-10-12 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる造血前駆細胞の生産
CN103193841A (zh) 2012-01-06 2013-07-10 维瑞斯特姆有限公司 治疗性化合物及相关使用方法
US8715529B1 (en) 2012-01-23 2014-05-06 Arrowhead Center, Inc. Synthesis and applications of triazaborolopyridinium compounds and substituted triazaborolopyridinium compounds and methods of use
WO2014130834A1 (en) 2013-02-21 2014-08-28 The Johns Hopkins University Red fluorescent aldehyde dehydrogenase (aldh) substrate
AU2014218807A1 (en) 2013-02-22 2015-09-03 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US20160008493A1 (en) * 2013-03-15 2016-01-14 The Johns Hopkins University Radioactive substrates for aldehyde dehydrogenase
JP6602288B2 (ja) 2013-04-03 2019-11-06 フジフィルム セルラー ダイナミクス，インコーポレイテッド 浮遊液中で内胚葉前駆細胞を培養するための方法および組成物
US20170107486A1 (en) 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
FR3054564B1 (fr) 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN109916866B (zh) * 2019-03-04 2021-06-29 三峡大学 一种七元氟硼荧光染料的新用途
CN111172109A (zh) * 2019-12-20 2020-05-19 广州海润康华生物科技有限公司 一种免疫细胞培养方法及其应用
EP4334437A1 (de) 2021-05-03 2024-03-13 Astellas Institute for Regenerative Medicine Verfahren zur erzeugung reifer hornhautendothelzellen
BR112023022181A2 (pt) 2021-05-07 2024-02-06 Astellas Inst For Regenerative Medicine Métodos de geração de hepatócitos maduros
WO2024044134A1 (en) 2022-08-23 2024-02-29 Astellas Institute For Regenerative Medicine Photoreceptor rescue cell (prc) compositions and methods for treatment of ocular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5274113A (en) * 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5876956A (en) 1995-05-15 1999-03-02 Johns Hopkins University School Of Medicine Methods for identification or purification of cells containing an enzymatic intracellular marker

Also Published As

Publication number Publication date
EP1975243A1 (de) 2008-10-01
EP1137798B1 (de) 2008-11-19
US7754480B2 (en) 2010-07-13
JP4498614B2 (ja) 2010-07-07
US6627759B1 (en) 2003-09-30
DE69942185D1 (de) 2010-05-06
PT1975243E (pt) 2010-06-24
DK1975243T3 (da) 2010-06-28
PT1137798E (pt) 2009-02-20
US20060051833A1 (en) 2006-03-09
ATE462014T1 (de) 2010-04-15
CA2353701C (en) 2014-06-03
EP1137798A1 (de) 2001-10-04
CY1111042T1 (el) 2015-06-11
AU774566B2 (en) 2004-07-01
ES2343222T3 (es) 2010-07-26
CY1111098T1 (el) 2015-06-11
ATE414783T1 (de) 2008-12-15
DK1137798T3 (da) 2009-04-14
JP2002531139A (ja) 2002-09-24
CA2353701A1 (en) 2000-06-15
EP1137798A4 (de) 2003-06-25
AU2165200A (en) 2000-06-26
US6991897B2 (en) 2006-01-31
WO2000034507A1 (en) 2000-06-15
US20040023318A1 (en) 2004-02-05
EP1975243B1 (de) 2010-03-24
ES2317707T3 (es) 2009-04-16

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