PT3623481T - Composições para sequenciação de ácidos nucleicos - Google Patents

Composições para sequenciação de ácidos nucleicos

Info

Publication number
PT3623481T
PT3623481T PT191899277T PT19189927T PT3623481T PT 3623481 T PT3623481 T PT 3623481T PT 191899277 T PT191899277 T PT 191899277T PT 19189927 T PT19189927 T PT 19189927T PT 3623481 T PT3623481 T PT 3623481T
Authority
PT
Portugal
Prior art keywords
compositions
methods
nucleic acid
acid sequencing
sequencing
Prior art date
Application number
PT191899277T
Other languages
English (en)
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46964103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3623481(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of PT3623481T publication Critical patent/PT3623481T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
PT191899277T 2011-09-23 2012-09-21 Composições para sequenciação de ácidos nucleicos PT3623481T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161538294P 2011-09-23 2011-09-23
US201261619878P 2012-04-03 2012-04-03

Publications (1)

Publication Number Publication Date
PT3623481T true PT3623481T (pt) 2021-10-15

Family

ID=46964103

Family Applications (2)

Application Number Title Priority Date Filing Date
PT171805831T PT3290528T (pt) 2011-09-23 2012-09-21 Métodos e composições para sequenciamento de ácido nucleico
PT191899277T PT3623481T (pt) 2011-09-23 2012-09-21 Composições para sequenciação de ácidos nucleicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT171805831T PT3290528T (pt) 2011-09-23 2012-09-21 Métodos e composições para sequenciamento de ácido nucleico

Country Status (15)

Country Link
US (5) US9453258B2 (pt)
EP (4) EP2768972B2 (pt)
CA (2) CA3104322C (pt)
CY (1) CY1125261T1 (pt)
DK (3) DK3623481T3 (pt)
ES (3) ES2639938T5 (pt)
HK (2) HK1201079A1 (pt)
HR (1) HRP20211523T1 (pt)
HU (1) HUE056246T2 (pt)
LT (1) LT3623481T (pt)
PL (2) PL3623481T3 (pt)
PT (2) PT3290528T (pt)
RS (1) RS62530B1 (pt)
SI (1) SI3623481T1 (pt)
WO (1) WO2013044018A1 (pt)

Families Citing this family (275)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
USRE49362E1 (en) 2006-05-18 2023-01-10 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US9163053B2 (en) * 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
CN105385756B (zh) 2010-04-05 2020-12-25 普罗格诺西斯生物科学公司 空间编码的生物学测定
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9096899B2 (en) 2010-10-27 2015-08-04 Illumina, Inc. Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
ES2639938T5 (es) 2011-09-23 2021-05-07 Illumina Inc Métodos y composiciones para la secuenciación de ácidos nucleicos
EP2814953B1 (en) * 2012-02-15 2017-06-07 Pacific Biosciences Of California, Inc. Polymerase enzyme substrates with protein shield
EP2909337B1 (en) 2012-10-17 2019-01-09 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
AU2013338393C1 (en) 2012-10-29 2024-07-25 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
KR102230831B1 (ko) 2013-03-15 2021-03-22 일루미나 케임브리지 리미티드 변형된 뉴클레오사이드 또는 뉴클레오타이드
DK3013984T3 (da) 2013-06-25 2023-06-06 Prognosys Biosciences Inc Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve
CN105358715B (zh) 2013-07-03 2018-09-18 伊鲁米那股份有限公司 正交合成测序
CN108441405B (zh) 2013-08-08 2021-09-10 伊鲁米那股份有限公司 用于向流动池的试剂输送的流体系统
HUE050641T2 (hu) 2013-12-03 2020-12-28 Illumina Inc Eljárások és rendszerek képadat elemzésére
RS61976B1 (sr) 2014-02-18 2021-07-30 Illumina Inc Postupci i kompozicije za određivanje dnk profila
CN106459869B (zh) 2014-03-11 2020-01-21 伊鲁米那股份有限公司 一次性的集成微流体盒及其制备和使用的方法
DK3143161T3 (da) * 2014-05-16 2021-06-21 Illumina Inc Nukleinsyresynteseteknikker
WO2015183871A1 (en) 2014-05-27 2015-12-03 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201414098D0 (en) * 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
ES2803079T3 (es) 2014-09-12 2021-01-22 Illumina Inc Métodos para detectar la presencia de subunidades de polímeros usando quimioluminiscencia
US9897791B2 (en) 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
GB201418718D0 (en) * 2014-10-21 2014-12-03 Cambridge Epigenetix Ltd Improved nucleic acid re-sequencing using a reduced number of identified bases
CN107074904B (zh) 2014-10-23 2022-12-23 深圳华大智造科技股份有限公司 信号约束测序(scs)和用于信号约束测序的核苷酸类似物
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
CN107250358B (zh) 2014-11-05 2021-03-30 伊卢米纳剑桥有限公司 在样品制备和测序期间使用铁载体螯合剂减少dna损伤
CA2967525A1 (en) 2014-11-11 2016-05-19 Illumina Cambridge Ltd. Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid
JP6767978B2 (ja) 2014-12-03 2020-10-14 アイソプレキシス コーポレイション 細胞分泌プロファイルの分析およびスクリーニング
US10576471B2 (en) 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
EP3783109B1 (en) 2015-03-31 2024-05-29 Illumina Cambridge Limited Surface concatamerization of templates
ES2972835T3 (es) 2015-04-10 2024-06-17 10X Genomics Sweden Ab Análisis multiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos
IL255446B2 (en) 2015-05-12 2024-01-01 Illumina Inc Field effect device and method for sequencing amino acids
EP3303584B1 (en) 2015-05-29 2019-10-09 Epicentre Technologies Corporation Methods of analyzing nucleic acids
CN107849598B (zh) 2015-05-29 2021-12-14 伊卢米纳剑桥有限公司 簇中的表面引物的增强利用
CN107922966B (zh) 2015-07-06 2022-06-28 伊卢米纳剑桥有限公司 用于核酸扩增的样品制备
ES2888626T3 (es) 2015-07-27 2022-01-05 Illumina Inc Cartografiado espacial de información de secuencia de ácidos nucleicos
US11155864B2 (en) 2015-07-30 2021-10-26 Illumina, Inc. Orthogonal deblocking of nucleotides
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
IL295355B2 (en) 2015-08-14 2023-11-01 Illumina Inc System and methods for determining genetic characteristics using magnetically responsive sensors
CN105112516A (zh) * 2015-08-14 2015-12-02 深圳市瀚海基因生物科技有限公司 一种单分子靶向测序方法、装置、系统及应用
CN108474805A (zh) 2015-08-24 2018-08-31 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制系统
CN114989235A (zh) 2015-09-28 2022-09-02 哥伦比亚大学董事会 用作dna合成测序的可逆终止物的基于新的二硫键接头的核苷酸的设计与合成
EP3377113A4 (en) * 2015-11-18 2019-06-19 Synergy Pharmaceuticals, Inc. COMPOSITIONS AND METHODS OF TREATMENT AND DETECTION OF CANCER
CN108474744B (zh) 2016-03-24 2019-11-05 伊鲁米那股份有限公司 在发光成像中使用的基于光子超晶格的设备和组成物及其使用方法
JP6953430B2 (ja) 2016-04-22 2021-10-27 イラミーナ インコーポレーテッド ピクセル内における複数部位の発光性造影に使用するためのフォトニック構造をベースとしたデバイス及び組成物、並びにその使用方法
CN109790196B (zh) * 2016-04-22 2022-09-27 深圳华大智造科技股份有限公司 可逆封闭的核苷类似物及其用途
WO2018018008A1 (en) 2016-07-22 2018-01-25 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
AU2017313718B2 (en) 2016-08-15 2023-09-14 Pacific Biosciences Of California, Inc. Method and system for sequencing nucleic acids
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
WO2018089910A2 (en) 2016-11-11 2018-05-17 IsoPlexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
CN110226084A (zh) 2016-11-22 2019-09-10 伊索普莱克西斯公司 用于细胞捕获的系统、装置和方法,以及其制造方法
CN109476674B (zh) 2016-12-22 2021-12-10 伊鲁米纳剑桥有限公司 香豆素化合物及其作为荧光标记物的用途
US11466318B2 (en) 2016-12-27 2022-10-11 Egi Tech (Shen Zhen) Co., Limited Single fluorescent dye-based sequencing method
RS63419B1 (sr) * 2017-01-04 2022-08-31 Mgi Tech Co Ltd Sekvenciranje nukleinske kiseline upotrebom afinitetnih reagenasa
ES2917403T3 (es) 2017-01-06 2022-07-08 Illumina Inc Corrección de ajuste de fase
CN110178184B (zh) 2017-01-17 2024-04-19 Illumina公司 致癌剪接变体确定
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
CN110709089A (zh) 2017-03-28 2020-01-17 哥伦比亚大学董事会 用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3’-o-改性的核苷酸类似物
EP3913053A1 (en) 2017-04-23 2021-11-24 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG11201911730XA (en) 2017-06-07 2020-01-30 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
US11542540B2 (en) * 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
EP3642362A1 (en) 2017-06-20 2020-04-29 Illumina, Inc. Methods and compositions for addressing inefficiencies in amplification reactions
CN109207571B (zh) * 2017-06-30 2022-01-04 深圳华大生命科学研究院 一种检测核酸内切酶酶切位点的方法
EP3662482A1 (en) 2017-07-31 2020-06-10 Illumina Inc. Sequencing system with multiplexed biological sample aggregation
EP3662083B1 (en) 2017-08-01 2024-08-28 Illumina, Inc. Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
WO2019067092A1 (en) 2017-08-07 2019-04-04 The Johns Hopkins University METHODS AND SUBSTANCES FOR THE EVALUATION AND TREATMENT OF CANCER
AU2018359670B2 (en) * 2017-11-06 2021-08-26 Illumina, Inc. Nucleic acid indexing techniques
NL2020636B1 (en) * 2017-12-28 2019-07-08 Illumina Inc Light energy fluorescence excitation
EP3619521B1 (en) 2018-01-08 2021-07-07 Illumina Inc. High-throughput sequencing with semiconductor-based detection
WO2019136388A1 (en) 2018-01-08 2019-07-11 Illumina, Inc. Systems and devices for high-throughput sequencing with semiconductor-based detection
WO2019161253A1 (en) * 2018-02-16 2019-08-22 Ultima Genomics, Inc. Methods for sequencing with single frequency detection
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
CA3097583A1 (en) 2018-04-19 2019-10-24 Omniome, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
CA3067435C (en) 2018-05-17 2023-09-12 Illumina, Inc. High-throughput single-cell sequencing with reduced amplification bias
US11180794B2 (en) 2018-05-31 2021-11-23 Omniome, Inc. Methods and compositions for capping nucleic acids
JP2021525078A (ja) 2018-05-31 2021-09-24 オムニオム インコーポレイテッドOmniome, Inc. 核酸配列決定におけるシグナル対ノイズの増加
MX2019015262A (es) 2018-06-04 2023-01-25 Illumina Inc Bibliotecas de transcriptomas de celulas individuales de alto rendimiento y metodos de fabricacion y uso.
NL2021258B1 (en) 2018-06-14 2019-12-20 Illumina Inc Device for luminescent imaging
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047005A1 (en) 2018-08-28 2020-03-05 10X Genomics, Inc. Resolving spatial arrays
WO2020047010A2 (en) 2018-08-28 2020-03-05 10X Genomics, Inc. Increasing spatial array resolution
KR20210088637A (ko) 2018-11-07 2021-07-14 이지아이 테크 (센젠) 컴퍼니 리미티드 폴리뉴클레오티드의 시퀀싱 방법
CA3103736A1 (en) 2018-12-05 2020-06-11 Illumina Cambridge Limited Methods and compositions for cluster generation by bridge amplification
WO2020123311A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Resolving spatial arrays using deconvolution
CN112639126A (zh) 2018-12-14 2021-04-09 伊卢米纳剑桥有限公司 降低测序期间用未标记的核苷酸的定相
AU2019411266A1 (en) 2018-12-17 2021-01-07 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
KR20210104554A (ko) 2018-12-18 2021-08-25 일루미나 케임브리지 리미티드 단일 표면 프라이머를 사용하는 페어드 엔드 서열분석을 위한 방법 및 조성물
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CN112673034B (zh) 2019-01-14 2023-03-28 伊鲁米那股份有限公司 包含杂聚物的流动池
EP3702474A1 (en) * 2019-02-26 2020-09-02 QIAGEN GmbH Sequencing method and kit
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
AU2020230955A1 (en) 2019-03-01 2021-01-07 Illumina Cambridge Limited Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
JP2022522917A (ja) 2019-03-01 2022-04-21 イルミナ インコーポレイテッド ハイスループット単一核及び単一細胞ライブラリー、並びに製造及び使用方法
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11676685B2 (en) 2019-03-21 2023-06-13 Illumina, Inc. Artificial intelligence-based quality scoring
EP3887542A1 (en) 2019-03-22 2021-10-06 10X Genomics, Inc. Three-dimensional spatial analysis
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
WO2020210370A1 (en) 2019-04-12 2020-10-15 Roche Sequencing Solutions, Inc. Nucleic acid sequencing by synthesis using magnetic sensor arrays
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
US11609208B2 (en) 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11579217B2 (en) 2019-04-12 2023-02-14 Western Digital Technologies, Inc. Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11738336B2 (en) 2019-04-12 2023-08-29 Western Digital Technologies, Inc. Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
MX2021013983A (es) * 2019-05-15 2022-02-10 Egi Tech Shen Zhen Co Ltd Metodo de secuenciacion monocanal basado en autoluminiscencia.
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
EP3969884B1 (en) 2019-05-16 2024-04-17 Illumina, Inc. Systems and methods for characterization and performance analysis of pixel-based sequencing
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020243077A1 (en) 2019-05-31 2020-12-03 Illumina, Inc. Flow cell with one or more barrier features
SG11202012810TA (en) 2019-05-31 2021-01-28 Illumina Inc System and method for storage
US20210147833A1 (en) 2019-05-31 2021-05-20 Illumina, Inc. Systems and methods for information storage and retrieval using flow cells
SG11202012827VA (en) 2019-05-31 2021-01-28 Illumina Inc Obtaining information from a biological sample in a flow cell
WO2020243072A1 (en) 2019-05-31 2020-12-03 Illumina, Inc. Flow cell with selective deposition or activation of nucleotides
US11282588B2 (en) 2019-05-31 2022-03-22 Illumina, Inc. Storage device, system, and method
US20220372061A1 (en) * 2019-07-09 2022-11-24 The Trustees Of Columbia University In The City Of New York Novel nucleotide analogues and methods for use
US20230242979A1 (en) * 2019-08-20 2023-08-03 Egi Tech (Shen Zhen) Co., Limited Method for sequencing polynucleotides based on optical signal kinetics of luminescent labels and secondary luminescent signals
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021102039A1 (en) 2019-11-21 2021-05-27 10X Genomics, Inc, Spatial analysis of analytes
US11747329B2 (en) 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
MX2021011847A (es) 2019-12-19 2021-11-17 Illumina Inc Genotecas de celulas unicas de alto rendimiento y metodos para elaborarlas y usarlas.
FI3891300T3 (fi) 2019-12-23 2023-05-10 10X Genomics Inc Menetelmät spatiaalista analyysiä varten rna-templatoitua ligaatiota käyttäen
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US12112833B2 (en) 2020-02-04 2024-10-08 10X Genomics, Inc. Systems and methods for index hopping filtering
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US20210254140A1 (en) 2020-02-17 2021-08-19 10X Genomics, Inc. Situ analysis of chromatin interaction
BR112022016415A2 (pt) 2020-02-20 2022-10-11 Illumina Inc Múltiplas chamadas de base à base de inteligência artificial
CN115698324A (zh) 2020-02-21 2023-02-03 10X基因组学有限公司 用于整合原位空间测定的方法和组合物
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
GB2608318A (en) * 2020-03-13 2022-12-28 Apton Biosystems Inc Densely-packed analyte layers and detection methods
EP4121559A4 (en) * 2020-03-18 2024-03-27 Pacific Biosciences of California, Inc. SYSTEMS AND METHODS FOR DETECTING TIGHTLY PACKED ANALYTES
WO2021216627A1 (en) * 2020-04-21 2021-10-28 Roche Sequencing Solutions, Inc. High-throughput nucleic acid sequencing with single-molecule sensor arrays
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
CN115916967A (zh) 2020-05-12 2023-04-04 伊鲁米纳公司 使用重组末端脱氧核苷酸转移酶生成具有经修饰的碱基的核酸
EP4153775B1 (en) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186A3 (en) 2020-06-08 2024-09-18 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
PE20230492A1 (es) * 2020-06-22 2023-03-23 Illumina Cambridge Ltd Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3'
EP4172362B1 (en) 2020-06-25 2024-09-18 10X Genomics, Inc. Spatial analysis of dna methylation
JP2023532231A (ja) 2020-06-30 2023-07-27 イルミナ インコーポレイテッド 傷なしdnaを生成するための触媒的に制御された合成による配列決定
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
IL299042A (en) 2020-07-08 2023-02-01 Illumina Inc Beads as transpososome carriers
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
EP4121557A4 (en) 2020-08-06 2024-05-01 Singular Genomics Systems, Inc. SPATIAL SEQUENCING
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022094415A1 (en) 2020-10-30 2022-05-05 Singular Genomics Systems, Inc. Methods and compositions for reducing nucleotide impurities
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4012046A1 (en) 2020-12-11 2022-06-15 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
US20220195516A1 (en) * 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
WO2022164809A1 (en) 2021-01-26 2022-08-04 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
EP4301873A1 (en) 2021-03-03 2024-01-10 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
WO2022197754A1 (en) 2021-03-16 2022-09-22 Illumina Software, Inc. Neural network parameter quantization for base calling
US20220319641A1 (en) 2021-04-02 2022-10-06 Illumina, Inc. Machine-learning model for detecting a bubble within a nucleotide-sample slide for sequencing
US20220336054A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures
WO2022243480A1 (en) 2021-05-20 2022-11-24 Illumina, Inc. Compositions and methods for sequencing by synthesis
US20220380838A1 (en) 2021-06-01 2022-12-01 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
EP4347880A1 (en) 2021-06-02 2024-04-10 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
EP4347879A1 (en) 2021-06-03 2024-04-10 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
WO2022272260A1 (en) 2021-06-23 2022-12-29 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
EP4359129A1 (en) 2021-06-25 2024-05-01 Illumina, Inc. Linear fourier fiducial
EP4359122A1 (en) 2021-06-25 2024-05-01 Illumina, Inc. Fiducials for use in registration of a patterned surface
EP4364154A1 (en) 2021-06-29 2024-05-08 Illumina, Inc. Signal-to-noise-ratio metric for determining nucleotide-base calls and base-call quality
WO2023278184A1 (en) * 2021-06-29 2023-01-05 Illumina, Inc. Methods and systems to correct crosstalk in illumination emitted from reaction sites
US20220415443A1 (en) 2021-06-29 2022-12-29 Illumina, Inc. Machine-learning model for generating confidence classifications for genomic coordinates
AU2022302056A1 (en) 2021-06-29 2024-01-18 Illumina, Inc. Self-learned base caller, trained using organism sequences
WO2023288225A1 (en) 2021-07-13 2023-01-19 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
KR20240031968A (ko) 2021-07-19 2024-03-08 일루미나, 인코포레이티드 염기 호출에 대한 보간 및 적응을 갖는 강도 추출
US20230021577A1 (en) 2021-07-23 2023-01-26 Illumina Software, Inc. Machine-learning model for recalibrating nucleotide-base calls
IL309786A (en) 2021-07-28 2024-02-01 Illumina Inc Quality score calibration of BASECALLING systems
EP4326900B1 (en) 2021-07-30 2024-09-04 10X Genomics, Inc. Methods and compositions for synchronizing reactions in situ
CN118043476A (zh) 2021-08-03 2024-05-14 10X基因组学有限公司 核酸多联体及其稳定和/或压缩方法
WO2023014741A1 (en) 2021-08-03 2023-02-09 Illumina Software, Inc. Base calling using multiple base caller models
EP4326898B1 (en) 2021-08-16 2024-07-31 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
EP4396376A1 (en) 2021-09-01 2024-07-10 Illumina, Inc. Amplitude modulation for accelerated base calling
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
JP2024535663A (ja) 2021-09-17 2024-10-02 イルミナ インコーポレイテッド ヌクレオチド配列決定における塩基コールエラーパターンからの障害ソースの自動的特定
CN117546243A (zh) 2021-09-21 2024-02-09 因美纳有限公司 使用推算的单倍型的图参考基因组和碱基检出方法
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
WO2023102354A1 (en) 2021-12-02 2023-06-08 Illumina Software, Inc. Generating cluster-specific-signal corrections for determining nucleotide-base calls
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230207050A1 (en) 2021-12-28 2023-06-29 Illumina Software, Inc. Machine learning model for recalibrating nucleotide base calls corresponding to target variants
CA3242624A1 (en) 2021-12-29 2023-07-06 Shannon Whitmore Automatically switching variant analysis model versions for genomic analysis applications
WO2023141588A1 (en) 2022-01-21 2023-07-27 10X Genomics, Inc. Multiple readout signals for analyzing a sample
US20240254537A1 (en) 2022-02-23 2024-08-01 Insitro, Inc. Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
CN118871994A (zh) 2022-02-25 2024-10-29 因美纳有限公司 核苷酸测序的校准序列
US20230313271A1 (en) 2022-02-25 2023-10-05 Illumina, Inc. Machine-learning models for detecting and adjusting values for nucleotide methylation levels
AU2023234670A1 (en) 2022-03-15 2024-01-18 Illumina, Inc. Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection
WO2023175041A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Concurrent sequencing of forward and reverse complement strands on concatenated polynucleotides
AU2023246676A1 (en) * 2022-03-28 2024-01-18 Illumina Inc. Labeled avidin and methods for sequencing
AU2023246772A1 (en) 2022-03-29 2024-01-18 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
AU2023243205A1 (en) 2022-04-01 2024-09-19 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023196526A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods for multiplex cell analysis
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
US20230340571A1 (en) 2022-04-26 2023-10-26 Illumina, Inc. Machine-learning models for selecting oligonucleotide probes for array technologies
WO2023209606A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
US20240002902A1 (en) 2022-05-06 2024-01-04 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20230368866A1 (en) 2022-05-10 2023-11-16 Illumina Software, Inc. Adaptive neural network for nucelotide sequencing
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
WO2023245190A1 (en) 2022-06-17 2023-12-21 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
US20230420080A1 (en) 2022-06-24 2023-12-28 Illumina Software, Inc. Split-read alignment by intelligently identifying and scoring candidate split groups
WO2024006705A1 (en) 2022-06-27 2024-01-04 Illumina Software, Inc. Improved human leukocyte antigen (hla) genotyping
US20230420075A1 (en) 2022-06-27 2023-12-28 Illumina Software, Inc. Accelerators for a genotype imputation model
WO2024006769A1 (en) 2022-06-27 2024-01-04 Illumina Software, Inc. Generating and implementing a structural variation graph genome
US20240038327A1 (en) 2022-07-26 2024-02-01 Illumina Software, Inc. Rapid single-cell multiomics processing using an executable file
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
US12116626B2 (en) 2022-08-16 2024-10-15 10X Genomics, Inc. AP50 polymerases and uses thereof
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024059852A1 (en) 2022-09-16 2024-03-21 Illumina, Inc. Cluster segmentation and conditional base calling
WO2024061799A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Deformable polymers comprising immobilised primers
WO2024072799A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Flow cell based motion system calibration and control methods
WO2024073516A1 (en) 2022-09-29 2024-04-04 Illumina, Inc. A target-variant-reference panel for imputing target variants
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
US20240120027A1 (en) 2022-09-30 2024-04-11 Illumina, Inc. Machine-learning model for refining structural variant calls
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
AU2023348238A1 (en) 2022-09-30 2024-10-03 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
WO2024077096A1 (en) 2022-10-05 2024-04-11 Illumina, Inc. Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture
US20240127906A1 (en) 2022-10-11 2024-04-18 Illumina, Inc. Detecting and correcting methylation values from methylation sequencing assays
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
WO2024102736A1 (en) 2022-11-08 2024-05-16 10X Genomics, Inc. Immobilization methods and compositions for in situ detection
WO2024107887A1 (en) 2022-11-16 2024-05-23 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
WO2024118791A1 (en) 2022-11-30 2024-06-06 Illumina, Inc. Accurately predicting variants from methylation sequencing data
US20240218437A1 (en) 2022-12-16 2024-07-04 10X Genomics, Inc. Methods and compositions for assessing performance
US20240218424A1 (en) 2022-12-21 2024-07-04 10X Genomics, Inc. Methods for tethering ribonucleic acids in biological samples
US20240212791A1 (en) 2022-12-21 2024-06-27 Illumina, Inc. Context-dependent base calling
AU2023409138A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
AU2023409219A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
US20240271206A1 (en) 2022-12-27 2024-08-15 Illumina, Inc. Methods of sequencing using 3' allyl blocked nucleotides
US20240263219A1 (en) 2023-01-06 2024-08-08 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
US20240266003A1 (en) 2023-02-06 2024-08-08 Illumina, Inc. Determining and removing inter-cluster light interference
WO2024206394A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing
WO2024206848A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Tandem repeat genotyping
WO2024216159A1 (en) * 2023-04-13 2024-10-17 Esbiolab Llc Methods and compositions for nucleic acid sequencing using labeled nucleotides
WO2024216163A1 (en) * 2023-04-13 2024-10-17 Esbiolab Llc Methods and compositions for nucleic acid sequencing using predominantly unlabeled nucleotides

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US781650A (en) 1904-08-15 1905-02-07 William Heap Commutator-brush holder.
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
EP3034626A1 (en) 1997-04-01 2016-06-22 Illumina Cambridge Limited Method of nucleic acid sequencing
WO1998044152A1 (en) 1997-04-01 1998-10-08 Glaxo Group Limited Method of nucleic acid sequencing
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
EP0994960A1 (en) 1997-06-25 2000-04-26 Orchid Biocomputer, Inc. Methods for the detection of multiple single nucleotide polymorphisms in a single reaction
PT1801214E (pt) 1997-07-07 2011-01-20 Medical Res Council Método de triagem in vitro
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US7071324B2 (en) 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
NO986133D0 (no) 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
WO2001023610A2 (en) * 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002072892A1 (en) * 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
AU2003224836A1 (en) * 2002-04-12 2003-10-27 Stratagene Dual-labeled nucleotides
DK3363809T3 (da) 2002-08-23 2020-05-04 Illumina Cambridge Ltd Modificerede nukleotider til polynukleotidsekvensering
US7414116B2 (en) * 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
DK1560838T3 (da) 2002-08-23 2009-09-07 Illumina Cambridge Ltd M rkede nuklotider
WO2004069849A2 (en) 2003-01-29 2004-08-19 454 Corporation Bead emulsion nucleic acid amplification
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
GB0324456D0 (en) * 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
US7276338B2 (en) 2003-11-17 2007-10-02 Jacobson Joseph M Nucleotide sequencing via repetitive single molecule hybridization
PL1740100T3 (pl) 2004-04-13 2017-09-29 Biosearch Technologies, Inc. Barwniki ksantenowe
JP2008526877A (ja) * 2005-01-05 2008-07-24 エージェンコート パーソナル ジェノミクス 可逆的ヌクレオチドターミネーターおよびその使用
GB0507835D0 (en) 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
EP2463386B1 (en) 2005-06-15 2017-04-12 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US20060287833A1 (en) 2005-06-17 2006-12-21 Zohar Yakhini Method and system for sequencing nucleic acid molecules using sequencing by hybridization and comparison with decoration patterns
US7514952B2 (en) 2005-06-29 2009-04-07 Altera Corporation I/O circuitry for reducing ground bounce and VCC sag in integrated circuit devices
GB0517097D0 (en) * 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
EP2495337A1 (en) 2006-02-24 2012-09-05 Callida Genomics, Inc. High throughput genome sequencing on DNA arrays
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
WO2007107710A1 (en) 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
EP3722409A1 (en) 2006-03-31 2020-10-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
USRE49362E1 (en) 2006-05-18 2023-01-10 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
US7553949B2 (en) * 2006-06-30 2009-06-30 Applied Biosystems, Llc Reversible terminator nucleotides and methods of use
WO2008043426A2 (de) * 2006-09-20 2008-04-17 Genovoxx Gmbh Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
US8399188B2 (en) * 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
EP2126765B1 (en) * 2007-01-26 2011-08-24 Illumina Inc. Nucleic acid sequencing system and method
EP4310194A3 (en) * 2007-10-19 2024-10-16 The Trustees of Columbia University in the City of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
DK2725107T3 (da) * 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
US8617811B2 (en) * 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US7771903B2 (en) 2008-05-28 2010-08-10 Promos Technologies Pte. Ltd. Photolithography with optical masks having more transparent features surrounded by less transparent features
US20100092960A1 (en) 2008-07-25 2010-04-15 Pacific Biosciences Of California, Inc. Helicase-assisted sequencing with molecular beacons
US8772473B2 (en) * 2009-03-30 2014-07-08 The Regents Of The University Of California Mostly natural DNA sequencing by synthesis
CN101565746B (zh) 2009-06-03 2012-08-08 东南大学 带奇偶校验的信号组合编码dna连接测序方法
CN101570784B (zh) * 2009-06-03 2011-11-23 东南大学 基于信号组合编码的dna连接测序方法
US9309569B2 (en) * 2010-08-26 2016-04-12 Intelligent Bio-Systems, Inc. Methods and compositions for sequencing nucleic acid using charge
ES2639938T5 (es) * 2011-09-23 2021-05-07 Illumina Inc Métodos y composiciones para la secuenciación de ácidos nucleicos
ES2683978T3 (es) 2012-05-02 2018-10-01 Ibis Biosciences, Inc. Secuenciación de ADN

Also Published As

Publication number Publication date
US9453258B2 (en) 2016-09-27
CA2859660C (en) 2021-02-09
HUE056246T2 (hu) 2022-02-28
ES2639938T3 (es) 2017-10-30
EP3981886A1 (en) 2022-04-13
US20240141428A1 (en) 2024-05-02
WO2013044018A1 (en) 2013-03-28
DK3290528T3 (da) 2019-11-04
PL3623481T3 (pl) 2022-01-17
ES2752653T3 (es) 2020-04-06
CY1125261T1 (el) 2023-03-24
SI3623481T1 (sl) 2022-01-31
EP2768972B2 (en) 2020-07-22
US20210139978A1 (en) 2021-05-13
CA3104322C (en) 2023-06-13
HK1201079A1 (en) 2015-08-21
LT3623481T (lt) 2021-09-27
CA3104322A1 (en) 2013-03-28
EP3290528B1 (en) 2019-08-14
EP3623481B1 (en) 2021-08-25
CA2859660A1 (en) 2013-03-28
ES2639938T5 (es) 2021-05-07
DK2768972T3 (en) 2017-09-25
EP3290528A1 (en) 2018-03-07
US10287629B2 (en) 2019-05-14
US20170022559A1 (en) 2017-01-26
US20130079232A1 (en) 2013-03-28
EP2768972A1 (en) 2014-08-27
PT3290528T (pt) 2019-10-14
EP2768972B1 (en) 2017-07-12
DK3623481T3 (da) 2021-11-15
EP3623481A1 (en) 2020-03-18
HK1247254A1 (zh) 2018-09-21
RS62530B1 (sr) 2021-11-30
ES2895184T3 (es) 2022-02-17
US11827932B2 (en) 2023-11-28
US20190264279A1 (en) 2019-08-29
HRP20211523T1 (hr) 2021-12-24
PL3290528T3 (pl) 2020-03-31
US10900077B2 (en) 2021-01-26

Similar Documents

Publication Publication Date Title
HK1247254A1 (zh) 核酸測序的方法和組合物
HK1211260A1 (en) Method and kit for nucleic acid sequencing
EP2702175A4 (en) METHOD AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS
HK1219503A1 (zh) 用於核酸測序的方法和組合物
HK1226105B (zh) 核酸測序的改進方法
GB2499340B (en) Methods for sequencing nucleic acids
SG11201401628WA (en) Compositions and methods for directional nucleic acid amplification and sequencing
EP2798089A4 (en) METHOD AND COMPOSITIONS FOR CARRYING OUT NUCLEIC ACID AMPLIFICATION REACTIONS
EP2576836A4 (en) COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING PURPOSES
EP2673380A4 (en) ANALYSIS OF NUCLEIC ACIDS
EP2729182A4 (en) NUCLEIC COMPLEX
EP2831283A4 (en) METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS
EP2764112A4 (en) DIRECT NUCLEIC ACID ANALYSIS
GB2503856B (en) Methods for nucleic acid purification
HK1199065A1 (en) Compositions and methods for detecting bv-associated bacterial nucleic acid bv
EP2740804A4 (en) PROCESS FOR NUCLEIC ACID ANALYSIS
LT2993232T (lt) Nukleorūgščių gavimo būdas
IL226170A0 (en) Compositions and methods for delivery of nucleic acids based on nanopolymers
EP2700414A4 (en) SELF-GELATINABLE NUCLEIC ACID
HUE038608T2 (hu) Kompozíciók és eljárások nukleinsav-hibridizáltatáshoz
EP2682462A4 (en) (Nucleic acid) polysaccharide COMPLEX
EP2702999A4 (en) FUNCTIONAL NUCLEIC ACID TARGETING THE BRAIN AND USE THEREOF
HK1205532A1 (en) Compositions and methods for improving nanopore sequencing
GB201107286D0 (en) Nucleic acid preparation
GB201118815D0 (en) Methods and compositions for identifying nucleic acids