PE20230492A1 - Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3' - Google Patents
Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3'Info
- Publication number
- PE20230492A1 PE20230492A1 PE2022002971A PE2022002971A PE20230492A1 PE 20230492 A1 PE20230492 A1 PE 20230492A1 PE 2022002971 A PE2022002971 A PE 2022002971A PE 2022002971 A PE2022002971 A PE 2022002971A PE 20230492 A1 PE20230492 A1 PE 20230492A1
- Authority
- PE
- Peru
- Prior art keywords
- blocking group
- nucleosides
- nucleotides
- nucleoside
- acetal blocking
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/117—Modifications characterised by incorporating modified base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/101—Sanger sequencing method, i.e. oligonucleotide sequencing using primer elongation and dideoxynucleotides as chain terminators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Esta referido a un nucleosido o nucleotido que comprende una nucleobase unida a una etiqueta detectable a traves de un enlazador escindible, en donde el nucleosido o nucleotido comprende una ribosa o desoxirribosa 2' y un grupo de bloqueo OH 3', y en donde el enlazador escindible comprende un compuesto con la formula detallada a continuacion, en donde cada uno de X y Y es O o S; y cada uno de R1a, R1b, R2, R3a y R3b es H, halogeno, alquilo C1-C6 no sustituido o sustituido, o haloalquilo C1-C6. Estos nucleotidos completamente funcionalizados que contienen el grupo de bloqueo acetal 3' se emplean para aplicaciones de secuenciacion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063042240P | 2020-06-22 | 2020-06-22 | |
PCT/EP2021/066886 WO2021259881A1 (en) | 2020-06-22 | 2021-06-21 | Nucleosides and nucleotides with 3' acetal blocking group |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20230492A1 true PE20230492A1 (es) | 2023-03-23 |
Family
ID=76765108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022002971A PE20230492A1 (es) | 2020-06-22 | 2021-06-21 | Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3' |
Country Status (15)
Country | Link |
---|---|
US (1) | US11787831B2 (es) |
EP (1) | EP4168421A1 (es) |
JP (1) | JP2023531009A (es) |
KR (1) | KR20230031837A (es) |
CN (1) | CN115867560A (es) |
AU (1) | AU2021295081A1 (es) |
BR (1) | BR112022026056A2 (es) |
CA (1) | CA3177293A1 (es) |
CL (1) | CL2022003661A1 (es) |
CO (1) | CO2022018487A2 (es) |
IL (1) | IL297992A (es) |
MA (1) | MA58991A1 (es) |
MX (1) | MX2022016492A (es) |
PE (1) | PE20230492A1 (es) |
WO (1) | WO2021259881A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022243480A1 (en) * | 2021-05-20 | 2022-11-24 | Illumina, Inc. | Compositions and methods for sequencing by synthesis |
US20230212667A1 (en) | 2021-12-29 | 2023-07-06 | Illumina Cambridge Limited | Methods of nucleic acid sequencing using surface-bound primers |
WO2023229884A2 (en) | 2022-05-27 | 2023-11-30 | Illumina, Inc. | 3'-blocked nucleotides, methods of deblocking the same, and methods of synthesizing polynucleotides using the same |
WO2024068971A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Polymerases, compositions, and methods of use |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936696A (ja) | 1982-08-20 | 1984-02-28 | Taiho Yakuhin Kogyo Kk | 2′―デオキシ―5―置換ウリジン誘導体及びそれを含有する抗腫瘍剤 |
EP0104857A1 (en) | 1982-09-28 | 1984-04-04 | Beecham Group Plc | Deoxyuridine compounds, methods for preparing them and their use in medicine |
US4772691A (en) | 1985-06-05 | 1988-09-20 | The Medical College Of Wisconsin, Inc. | Chemically cleavable nucleotides |
DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
US5242796A (en) | 1986-07-02 | 1993-09-07 | E. I. Du Pont De Nemours And Company | Method, system and reagents for DNA sequencing |
GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
EP0450060A1 (en) | 1989-10-26 | 1991-10-09 | Sri International | Dna sequencing |
DK0604552T3 (da) | 1991-09-18 | 1997-08-04 | Affymax Tech Nv | Fremgangsmåde til syntese af forskellige samlinger af oligomerer |
EP0916396B1 (en) | 1991-11-22 | 2005-04-13 | Affymetrix, Inc. (a Delaware Corporation) | Combinatorial strategies for polymer synthesis |
ATE278807T1 (de) | 1992-02-19 | 2004-10-15 | New York Health Res Inst | Neue anordnungen von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzierung und manipulieren von nukleinsäuren |
US5583211A (en) | 1992-10-29 | 1996-12-10 | Beckman Instruments, Inc. | Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides |
WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6232465B1 (en) | 1994-09-02 | 2001-05-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
WO1996027025A1 (en) | 1995-02-27 | 1996-09-06 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
EP0852004B1 (en) | 1995-10-11 | 2011-01-19 | Luminex Corporation | Multiplexed analysis of clinical specimens |
US5658734A (en) | 1995-10-17 | 1997-08-19 | International Business Machines Corporation | Process for synthesizing chemical compounds |
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
US6297006B1 (en) | 1997-01-16 | 2001-10-02 | Hyseq, Inc. | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments |
WO1998033939A1 (fr) | 1997-01-31 | 1998-08-06 | Hitachi, Ltd. | Procede pour determiner une sequence de base d'acide nucleique et appareil correspondant |
ATE364718T1 (de) | 1997-04-01 | 2007-07-15 | Solexa Ltd | Verfahren zur vervielfältigung von nukleinsäure |
ATE269908T1 (de) | 1997-04-01 | 2004-07-15 | Manteia S A | Methode zur sequenzierung von nukleinsäuren |
US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
JP4294740B2 (ja) | 1997-05-23 | 2009-07-15 | ソレクサ・インコーポレイテッド | 分析物の系列的プロセシングのためのシステムおよび装置 |
US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
JP2001519538A (ja) | 1997-10-10 | 2001-10-23 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 核酸アレイのレプリカ増幅 |
US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
US6287776B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Method for detecting and classifying nucleic acid hybridization |
JP3944996B2 (ja) | 1998-03-05 | 2007-07-18 | 株式会社日立製作所 | Dnaプローブアレー |
US6031078A (en) | 1998-06-16 | 2000-02-29 | Millennium Pharmaceuticals, Inc. | MTbx protein and nucleic acid molecules and uses therefor |
US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
CA2339121A1 (en) | 1998-07-30 | 2000-02-10 | Shankar Balasubramanian | Arrayed biomolecules and their use in sequencing |
AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
US6277628B1 (en) | 1998-10-02 | 2001-08-21 | Incyte Genomics, Inc. | Linear microarrays |
US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
US6255476B1 (en) * | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
DK1159453T3 (da) | 1999-03-10 | 2008-10-06 | Asm Scient Inc | Fremgangsmåde til direkte nukleinsyresekventering |
EP1196630B2 (en) | 1999-04-20 | 2018-10-17 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
US6770441B2 (en) | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
US7001792B2 (en) | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
GB0013276D0 (en) | 2000-06-01 | 2000-07-26 | Amersham Pharm Biotech Uk Ltd | Nucleotide analogues |
WO2002004680A2 (en) | 2000-07-07 | 2002-01-17 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
AU2001279244A1 (en) | 2000-08-09 | 2002-02-18 | Motorola, Inc. | The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
ATE356222T1 (de) | 2000-10-06 | 2007-03-15 | Univ Columbia | Massives parallelverfahren zur dekodierung von dna und rna |
EP1354064A2 (en) | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
HUE032483T2 (en) | 2002-08-23 | 2017-09-28 | Illumina Cambridge Ltd | Marked nucleotides |
SI3587433T1 (sl) | 2002-08-23 | 2020-08-31 | Illumina Cambridge Limited | Modificirani nukleotidi |
GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
JP2007525571A (ja) | 2004-01-07 | 2007-09-06 | ソレクサ リミテッド | 修飾分子アレイ |
GB2423819B (en) | 2004-09-17 | 2008-02-06 | Pacific Biosciences California | Apparatus and method for analysis of molecules |
US8623628B2 (en) | 2005-05-10 | 2014-01-07 | Illumina, Inc. | Polymerases |
GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
CA2648149A1 (en) | 2006-03-31 | 2007-11-01 | Solexa, Inc. | Systems and devices for sequence by synthesis analysis |
US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
WO2008051530A2 (en) | 2006-10-23 | 2008-05-02 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
CN101669026B (zh) | 2006-12-14 | 2014-05-07 | 生命技术公司 | 利用大规模fet阵列测量分析物的方法和装置 |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
DK2725107T3 (da) | 2007-10-19 | 2019-01-02 | Univ Columbia | DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer |
US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
WO2012162429A2 (en) | 2011-05-23 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using raman and infrared spectroscopy detection |
ES2639938T5 (es) | 2011-09-23 | 2021-05-07 | Illumina Inc | Métodos y composiciones para la secuenciación de ácidos nucleicos |
US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
US9593373B2 (en) * | 2013-03-15 | 2017-03-14 | Illumina Cambridge Limited | Modified nucleosides or nucleotides |
GB201414098D0 (en) | 2014-08-08 | 2014-09-24 | Illumina Cambridge Ltd | Modified nucleotide linkers |
KR102454782B1 (ko) * | 2015-11-06 | 2022-10-13 | 퀴아젠 사이언시스, 엘엘씨 | 뉴클레오티드 유사체 |
CN105315318B (zh) | 2015-11-06 | 2019-04-19 | 山东大学 | 一种α‐L‐鼠李糖苷酶在制备5-氟-2’-脱氧脲苷衍生物中的应用 |
US11174279B2 (en) * | 2016-06-21 | 2021-11-16 | National Institute Of Advanced Industrial Science And Technology | Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used |
WO2018019748A1 (en) * | 2016-07-27 | 2018-02-01 | F. Hoffmann-La Roche Ag | 5's-lna nucleotides and oligonucleotides |
US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
FI3794012T3 (fi) | 2018-05-15 | 2024-01-08 | Illumina Inc | Koostumuksia ja menetelmiä pintaan sitoutuneiden oligonukleotidien kemiallista pilkkomista ja suojauksen poistoa varten |
SG11202012493WA (en) | 2018-10-31 | 2021-01-28 | Illumina Inc | Polymerases, compositions, and methods of use |
CN112639090A (zh) | 2018-12-05 | 2021-04-09 | 亿明达股份有限公司 | 聚合酶、组合物及使用方法 |
KR102594019B1 (ko) | 2018-12-17 | 2023-10-26 | 일루미나 케임브리지 리미티드 | 폴리뉴클레오타이드 서열분석에 사용하기 위한 조성물 |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
-
2021
- 2021-06-21 MX MX2022016492A patent/MX2022016492A/es unknown
- 2021-06-21 EP EP21737355.4A patent/EP4168421A1/en active Pending
- 2021-06-21 PE PE2022002971A patent/PE20230492A1/es unknown
- 2021-06-21 US US17/353,512 patent/US11787831B2/en active Active
- 2021-06-21 JP JP2022578720A patent/JP2023531009A/ja active Pending
- 2021-06-21 IL IL297992A patent/IL297992A/en unknown
- 2021-06-21 AU AU2021295081A patent/AU2021295081A1/en active Pending
- 2021-06-21 MA MA58991A patent/MA58991A1/fr unknown
- 2021-06-21 CN CN202180044416.1A patent/CN115867560A/zh active Pending
- 2021-06-21 KR KR1020227045221A patent/KR20230031837A/ko unknown
- 2021-06-21 CA CA3177293A patent/CA3177293A1/en active Pending
- 2021-06-21 WO PCT/EP2021/066886 patent/WO2021259881A1/en active Application Filing
- 2021-06-21 BR BR112022026056A patent/BR112022026056A2/pt unknown
-
2022
- 2022-12-20 CO CONC2022/0018487A patent/CO2022018487A2/es unknown
- 2022-12-20 CL CL2022003661A patent/CL2022003661A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP4168421A1 (en) | 2023-04-26 |
CL2022003661A1 (es) | 2023-06-09 |
BR112022026056A2 (pt) | 2023-03-07 |
WO2021259881A1 (en) | 2021-12-30 |
CN115867560A (zh) | 2023-03-28 |
US20210403500A1 (en) | 2021-12-30 |
KR20230031837A (ko) | 2023-03-07 |
AU2021295081A1 (en) | 2022-12-08 |
CO2022018487A2 (es) | 2023-03-07 |
MA58991A1 (fr) | 2023-03-31 |
IL297992A (en) | 2023-01-01 |
CA3177293A1 (en) | 2021-12-30 |
US11787831B2 (en) | 2023-10-17 |
MX2022016492A (es) | 2023-03-06 |
JP2023531009A (ja) | 2023-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20230492A1 (es) | Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3' | |
MX2020013454A (es) | Nucleósidos y nucleótidos con grupos de bloqueo 3'-hidroxi y su uso en métodos de secuenciación de polinucleótidos. | |
ES2620131T3 (es) | Nucleótidos marcados | |
WO2008016909A3 (en) | Nucleotide analogs | |
CY1123971T1 (el) | Επισημασμενα νουκλεοτιδια | |
FI4140491T3 (fi) | Menetelmä 5’-huputettujen RNA:iden syntetisoimiseksi | |
AR053739A1 (es) | Compuestos espiro condensados como inhibidores de la aldosterona sintasa | |
ATE538127T1 (de) | 6-disubstituierte bicyclische nukleinsäureanaloga | |
ECSP034683A (es) | Derivados amida de acido tiazolilico, oxazolilico, pirrolilico e imidazolilico utiles como inhibidores de las isozimas pde4 | |
CR9066A (es) | Nuevos derivados de aminopirimidina que tiene accion inhibitoria selectiva de la aurora a | |
CL2013003053A1 (es) | Compuesto que comprende un oligonucleotido modificado que consiste en de 10 a 30 nucleósidos unidos y definidos por un grupo de secuencias específicas; composicion que comprende dicho compuesto; uso para tratar enfermedades relacionadas con el virus de la hepatitis b (vhb). | |
PE20071285A1 (es) | Composicion para inducir la tolerancia de plantas contra bacteriosis | |
AR082066A2 (es) | Metodo y uso de analogos de nucleosidos fluorados modificados | |
PE20120257A1 (es) | Analogos carba-nucleosidicos para tratamiento antiviral | |
AR066626A1 (es) | Oligonucleotidos de clase a con potencia inmunoestimuladora | |
PT1152009E (pt) | Novos analogos de nucleosidos e oligonucleotidos | |
PE20061220A1 (es) | Bifenilsulfonamidas y proceso para su preparacion | |
MX2021011019A (es) | Ligadores de brazo colgante corto para nucleotidos en aplicaciones de secuenciacion. | |
RU2018113811A (ru) | КРОСС-СШИТАЯ НУКЛЕИНОВАЯ КИСЛОТА GuNA, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ | |
AR076340A1 (es) | Derivados de rifamicina | |
BR112017023749A8 (pt) | Um método para marcação especificamente de micro-organismos vivos que compreende o uso de compostos monossacarídicos modificados | |
BRPI0900727A2 (pt) | sistema de lançamento de mìssil, e um elemento suspensor para suspender o mìssil em um trilho de lançamento | |
GB2581044A (en) | Novel use | |
GT200300275A (es) | Derivados de nucleosido antivirales | |
Ashton et al. | An expedient synthesis of N6-substituted-5′-modified adenosines |