MA58991A1 - Nucléosides et nucléotides avec groupe de blocage acétal 3' - Google Patents
Nucléosides et nucléotides avec groupe de blocage acétal 3'Info
- Publication number
- MA58991A1 MA58991A1 MA58991A MA58991A MA58991A1 MA 58991 A1 MA58991 A1 MA 58991A1 MA 58991 A MA58991 A MA 58991A MA 58991 A MA58991 A MA 58991A MA 58991 A1 MA58991 A1 MA 58991A1
- Authority
- MA
- Morocco
- Prior art keywords
- blocking group
- nucleotide
- nucleoside
- nucleosides
- nucleotides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/117—Modifications characterised by incorporating modified base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/101—Sanger sequencing method, i.e. oligonucleotide sequencing using primer elongation and dideoxynucleotides as chain terminators
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne un nucléoside ou un nucléotide comprenant une nucléobase attachée à une étiquette détectable par l'intermédiaire d'un lieur clivable, le nucléoside ou le nucléotide comprenant une fraction ribose ou 2' désoxyribose et un groupe de blocage 3'-oh, et le lieur clivable comprenant une fraction de la structure (i), chacun de x et y étant indépendamment o ou s ; et chacun de r1a , r2b, r2, r3a et r3b représentant indépendamment h, l'halogène, l'alkyle en c1-c6 substitué ou non substitué ou l'haloalkyle en c1-c6. La présente invention concerne également des procédés de préparation de ces molécules de nucléotides et de nucléosides, et les utilisations de nucléotides entièrement fonctionnalisés contenant le groupe de blocage acétal 3' pour des applications de séquençage.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063042240P | 2020-06-22 | 2020-06-22 | |
PCT/EP2021/066886 WO2021259881A1 (fr) | 2020-06-22 | 2021-06-21 | Nucléosides et nucléotides avec groupe de blocage acétal 3' |
Publications (1)
Publication Number | Publication Date |
---|---|
MA58991A1 true MA58991A1 (fr) | 2023-03-31 |
Family
ID=76765108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA58991A MA58991A1 (fr) | 2020-06-22 | 2021-06-21 | Nucléosides et nucléotides avec groupe de blocage acétal 3' |
Country Status (16)
Country | Link |
---|---|
US (2) | US11787831B2 (fr) |
EP (1) | EP4168421A1 (fr) |
JP (1) | JP2023531009A (fr) |
KR (1) | KR20230031837A (fr) |
CN (1) | CN115867560A (fr) |
AU (1) | AU2021295081A1 (fr) |
BR (1) | BR112022026056A2 (fr) |
CA (1) | CA3177293A1 (fr) |
CL (1) | CL2022003661A1 (fr) |
CO (1) | CO2022018487A2 (fr) |
IL (1) | IL297992A (fr) |
MA (1) | MA58991A1 (fr) |
MX (1) | MX2022016492A (fr) |
PE (1) | PE20230492A1 (fr) |
WO (1) | WO2021259881A1 (fr) |
ZA (1) | ZA202211847B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL308173A (en) * | 2021-05-20 | 2024-01-01 | Illumina Inc | Compositions and methods for genetic sequencing by synthesis |
AU2022424380A1 (en) | 2021-12-29 | 2024-01-18 | Illumina, Inc. | Methods of nucleic acid sequencing using surface-bound primers |
WO2023229884A2 (fr) | 2022-05-27 | 2023-11-30 | Illumina, Inc. | Nucléotides bloqués en 3', leurs procédés de déblocage et procédés de synthèse de polynucléotides y faisant appel |
US20240141427A1 (en) | 2022-09-30 | 2024-05-02 | Illumina, Inc. | Polymerases, compositions, and methods of use |
WO2024077410A1 (fr) * | 2022-10-09 | 2024-04-18 | 深圳市真迈生物科技有限公司 | Procédé de réduction de groupe azide méthoxy, procédé de séquençage et kit |
Family Cites Families (102)
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TWI698530B (zh) * | 2015-11-06 | 2020-07-11 | 美商齊亞雋科學公司 | 核苷酸類似物 |
EP3473637A4 (fr) * | 2016-06-21 | 2020-01-22 | Genedesign, Inc. | Procédé de synthèse de monomère de h-phosphonate d'acide ribonucléique, et procédé de synthèse d'oligonucléotide mettant en uvre ce monomère |
EP3491001A1 (fr) * | 2016-07-27 | 2019-06-05 | Roche Innovation Center Copenhagen A/S | Nucléotides et oligonucléotides de 5's-lna |
US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
DK3794012T3 (da) | 2018-05-15 | 2024-01-08 | Illumina Inc | Sammensætninger og fremgangsmåder til kemisk spaltning og afbeskyttelse af overfladebundne oligonukleotider |
JP2022503427A (ja) | 2018-10-31 | 2022-01-12 | イラミーナ インコーポレーテッド | ポリメラーゼ、組成物、および使用方法 |
KR20210098844A (ko) | 2018-12-05 | 2021-08-11 | 일루미나, 인코포레이티드 | 중합효소, 조성물, 및 사용 방법 |
AU2019411266A1 (en) | 2018-12-17 | 2021-01-07 | Illumina Cambridge Limited | Compositions for use in polyunucleotide sequencing |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
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- 2021-06-21 WO PCT/EP2021/066886 patent/WO2021259881A1/fr active Application Filing
- 2021-06-21 EP EP21737355.4A patent/EP4168421A1/fr active Pending
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CN115867560A (zh) | 2023-03-28 |
IL297992A (en) | 2023-01-01 |
US11787831B2 (en) | 2023-10-17 |
US20210403500A1 (en) | 2021-12-30 |
BR112022026056A2 (pt) | 2023-03-07 |
MX2022016492A (es) | 2023-03-06 |
PE20230492A1 (es) | 2023-03-23 |
CA3177293A1 (fr) | 2021-12-30 |
CO2022018487A2 (es) | 2023-03-07 |
JP2023531009A (ja) | 2023-07-20 |
US20240132532A1 (en) | 2024-04-25 |
KR20230031837A (ko) | 2023-03-07 |
EP4168421A1 (fr) | 2023-04-26 |
WO2021259881A1 (fr) | 2021-12-30 |
ZA202211847B (en) | 2024-02-28 |
AU2021295081A1 (en) | 2022-12-08 |
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