AR066626A1 - Oligonucleotidos de clase a con potencia inmunoestimuladora - Google Patents

Oligonucleotidos de clase a con potencia inmunoestimuladora

Info

Publication number
AR066626A1
AR066626A1 ARP080102108A ARP080102108A AR066626A1 AR 066626 A1 AR066626 A1 AR 066626A1 AR P080102108 A ARP080102108 A AR P080102108A AR P080102108 A ARP080102108 A AR P080102108A AR 066626 A1 AR066626 A1 AR 066626A1
Authority
AR
Argentina
Prior art keywords
oligonucleotides
class
immune stimulating
nucleotide
stimulating power
Prior art date
Application number
ARP080102108A
Other languages
English (en)
Original Assignee
Coley Pharm Group Inc
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Group Inc, Coley Pharm Gmbh filed Critical Coley Pharm Group Inc
Publication of AR066626A1 publication Critical patent/AR066626A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Abstract

Se proporciona un ácido nucleico inmunoestimulador que comprende motivos CpG y procedimientos de usar el mismo para estimular la inmunidad. Reivindicacion 1: Un oligonucleotido inmunoestimulador de la formula 5'-(Z1)k X1Y1R1X2Y2R2X3Y3R3(Z2)L(G)N(Z3)m-3' (SEC ID N.° :70) en el que X1 es cualquier nucleotido excepto dG, X2 y X3 son cualquier nucleotido Y1, Y2 y Y3 son dC, 5-metil-dC, 5-hidroxi-dC o 5-fluoro-dC, R1, R2 y R3 son dG, dl, 6-tío-dG, o 7-desaza-dG, y Z1, Z2 y Z3 son cualquier nucleotido, y en el que K, L, y M cada uno independientemente representan 0-10, N es 4-10 y en el que el oligonucleotido inmunoestimulador tiene menos de 16 nucleotidos de longitud.
ARP080102108A 2007-05-17 2008-05-16 Oligonucleotidos de clase a con potencia inmunoestimuladora AR066626A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93058007P 2007-05-17 2007-05-17

Publications (1)

Publication Number Publication Date
AR066626A1 true AR066626A1 (es) 2009-09-02

Family

ID=39720158

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102108A AR066626A1 (es) 2007-05-17 2008-05-16 Oligonucleotidos de clase a con potencia inmunoestimuladora

Country Status (15)

Country Link
US (1) US20100285041A1 (es)
EP (1) EP2160199A2 (es)
JP (1) JP2009035530A (es)
KR (1) KR20100010509A (es)
CN (1) CN101678098A (es)
AR (1) AR066626A1 (es)
AU (1) AU2008252577A1 (es)
BR (1) BRPI0811621A2 (es)
CA (1) CA2687441A1 (es)
IL (1) IL202096A0 (es)
MX (1) MX2009012482A (es)
RU (1) RU2009142211A (es)
TW (1) TW200916115A (es)
WO (1) WO2008142509A2 (es)
ZA (1) ZA200908062B (es)

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US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
CA2480775C (en) 2002-04-04 2016-05-31 Coley Pharmaceutical Gmbh Immunostimulatory g,u-containing oligoribonucleotides
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
CN1753687A (zh) 2002-10-29 2006-03-29 科勒制药集团股份有限公司 Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用
SG122973A1 (en) 2003-10-30 2006-06-29 Coley Pharm Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
PT2078080E (pt) 2006-09-27 2015-09-18 Coley Pharm Gmbh Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
MX347471B (es) * 2010-05-28 2017-04-24 Zoetis Belgium S A Vacunas que comprenden colesterol y cpg como moleculas portadoras-adyuvantes unicas.
EP2471926A3 (en) 2010-12-30 2012-07-11 Intervet International BV Immunostimulatory oligodeoxynucleotides
ES2938087T3 (es) 2014-12-25 2023-04-04 Nat Inst Biomedical Innovation Health & Nutrition Oligonucleótidos inmunoestimuladores no agregantes
JP6698069B2 (ja) * 2015-03-20 2020-05-27 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途
KR102273071B1 (ko) * 2018-06-12 2021-07-05 주식회사 에이엠사이언스 B형 간염 예방 또는 치료용 조성물
WO2019240504A1 (en) * 2018-06-12 2019-12-19 Am Sciences Co., Ltd. Modified oligonucleotides for inhibition of target gene expression
WO2023034853A2 (en) * 2021-08-31 2023-03-09 City Of Hope Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof
CN113517062B (zh) * 2021-09-14 2021-12-10 青岛未来移动医疗科技有限公司 一种智能疫苗雾化系统及使用方法

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US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
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US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
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CA2560114A1 (en) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
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Also Published As

Publication number Publication date
BRPI0811621A2 (pt) 2014-10-21
US20100285041A1 (en) 2010-11-11
MX2009012482A (es) 2009-12-02
WO2008142509A3 (en) 2009-03-05
RU2009142211A (ru) 2011-05-27
EP2160199A2 (en) 2010-03-10
JP2009035530A (ja) 2009-02-19
IL202096A0 (en) 2010-06-16
TW200916115A (en) 2009-04-16
CA2687441A1 (en) 2008-11-27
AU2008252577A1 (en) 2008-11-27
CN101678098A (zh) 2010-03-24
WO2008142509A2 (en) 2008-11-27
ZA200908062B (en) 2010-06-30
KR20100010509A (ko) 2010-02-01

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