SG11201810907UA - Target reporter constructs and uses thereof - Google Patents

Target reporter constructs and uses thereof

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Publication number
SG11201810907UA
SG11201810907UA SG11201810907UA SG11201810907UA SG11201810907UA SG 11201810907U A SG11201810907U A SG 11201810907UA SG 11201810907U A SG11201810907U A SG 11201810907UA SG 11201810907U A SG11201810907U A SG 11201810907UA SG 11201810907U A SG11201810907U A SG 11201810907UA
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SG
Singapore
Prior art keywords
international
trcs
houston
target
pct
Prior art date
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SG11201810907UA
Inventor
Michael Metzker
Christopher Weier
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Redvault Biosciences Lp
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Publication date
Application filed by Redvault Biosciences Lp filed Critical Redvault Biosciences Lp
Publication of SG11201810907UA publication Critical patent/SG11201810907UA/en

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT ill~~~~~~~~ 011101tIIl two Hol olo om olo Imo oimIE (10) International Publication Number WO 2017/214127 Al (51) International Patent Classification: C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) (21) International Application Number: PCT/US2017/036129 (22) International Filing Date: 06 June 2017 (06.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/346,334 06 June 2016 (06.06.2016) US (71) Applicant: REDVAULT BIOSCIENCES, LP [US/US]; 3900 Essex Lane, Suite 1030, Houston, TX 77027 (US). (72) Inventors: METZKER, Michael, L.; 12015 Surrey Lane, Houston, TX 77024 (US). WEIER, Christopher, August; 3805 West Alabama, #8105, Houston, TX 77027 (US). (74) Agent: VOGES, Mark, H.; Parker Highlander PLLC, 1120 S. Capital Of Texas Highway, Building One, Suite 200, Austin, TX 78746 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: TARGET REPORTER CONSTRUCTS AND USES THEREOF Tomo Sequences Bridge Segue am ACCOSSO , Y SOIUMCOS ••••••• W O 20 17 / 214127 Al FIG. ID (57) : Provided herein are methods and compositions for the detection of target nucleic acids using target reporter constructs (TRCs) which comprise target sequences complementary to the target nucleic acid. Further provided are methods of replicating the TRCs using rolling circle replication and/or rolling circle amplification to produce replicated TRCs which can be detected using probe sequences within the replicated TRCs. [Continued on next page] WO 2017/214127 Al MIDEDIMOMMIDIRMEMODI10101HIDIOHNEVOIS Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201810907UA 2016-06-06 2017-06-06 Target reporter constructs and uses thereof SG11201810907UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662346334P 2016-06-06 2016-06-06
PCT/US2017/036129 WO2017214127A1 (en) 2016-06-06 2017-06-06 Target reporter constructs and uses thereof

Publications (1)

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SG11201810907UA true SG11201810907UA (en) 2019-01-30

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US (2) US11299769B2 (en)
EP (1) EP3464628B1 (en)
AU (1) AU2017278350B2 (en)
CA (1) CA3026193A1 (en)
SG (1) SG11201810907UA (en)
WO (1) WO2017214127A1 (en)

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CN108273056A (en) * 2018-02-01 2018-07-13 中国科学院长春应用化学研究所 A kind of modified gold nano-material/nucleic acid probe nanometer system and preparation method thereof, application
US11125743B2 (en) * 2018-02-20 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Detection of norovirus using norovirus-specific toehold switches
CN108665451B (en) * 2018-05-04 2022-02-25 江西理工大学 Circle detection method based on ternary Gaussian difference evolution algorithm
AU2019364418A1 (en) * 2018-10-25 2021-04-22 Illumina, Inc. Methods and compositions for identifying ligands on arrays using indexes and barcodes
CN109371136B (en) * 2018-12-28 2021-07-02 青岛泱深生物医药有限公司 Lung adenocarcinoma-related lncRNA and application thereof
KR102599718B1 (en) * 2019-03-01 2023-11-09 메르시 바이오애널리틱스, 인코포레이티드 Systems, compositions and methods for detecting target entities
CN110004213B (en) * 2019-03-04 2023-01-03 山东师范大学 Method for detecting miRNA (micro ribonucleic acid) based on Toehold mediated strand displacement reaction initiated rolling circle amplification and FRET (fluorescence resonance energy transfer)
CN112501304A (en) * 2020-12-17 2021-03-16 浙江清华长三角研究院 Application of miRNA-424 as pituitary tumor diagnosis marker

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WO2017214127A1 (en) 2017-12-14
CA3026193A1 (en) 2017-12-14
US20220307076A1 (en) 2022-09-29
EP3464628A1 (en) 2019-04-10
EP3464628B1 (en) 2024-01-31
AU2017278350A1 (en) 2019-01-03
AU2017278350B2 (en) 2023-10-19
US20170349939A1 (en) 2017-12-07
US11299769B2 (en) 2022-04-12

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