|
US513030A
(en)
|
|
1894-01-16 |
|
Machine for waxing or coating paper |
|
US2878264A
(en)
|
|
1959-03-17 |
|
Substituted amino alcohols |
|
CH372667A
(de)
|
1957-09-26 |
1963-10-31 |
Robins Co Inc A H |
Verfahren zur Herstellung von 3-Aryl-3-pyrrolidinolen
|
|
US3135766A
(en)
|
1961-10-03 |
1964-06-02 |
Mead Johnson & Co |
3-substituted-3-pyrrolidinols
|
|
US3484473A
(en)
|
1967-05-12 |
1969-12-16 |
Buckman Labor Inc |
Methylene bisesters of thiolsulfonic acids
|
|
DE1934150A1
(de)
|
1968-07-10 |
1970-01-15 |
Pennwalt Corp |
Neue 1-Alkanoyloxy-1,2,4,5-tetrahydro-3H,3-benzazepine
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US3745162A
(en)
|
1970-08-31 |
1973-07-10 |
Robins Co Inc A H |
1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides
|
|
GB1448437A
(en)
|
1973-02-24 |
1976-09-08 |
Beecham Group Ltd |
Diphenylpropylamines
|
|
US4022791A
(en)
|
1975-06-03 |
1977-05-10 |
Pfizer Inc. |
2-Aminomethyl-3,4-dihydronaphthalenes
|
|
GB1504424A
(en)
|
1975-08-09 |
1978-03-22 |
Beecham Group Ltd |
Isoquinoline-derived aminoethers
|
|
BR7807288A
(pt)
|
1977-11-08 |
1979-06-12 |
Genentech Inc |
Processo para sintese de polinucleotidos
|
|
DD133885B1
(de)
|
1978-01-04 |
1981-02-25 |
Hans Lehmann |
Mittel zur bekaempfung von phytopathogenen bakterien und pilzen
|
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US4542142A
(en)
|
1982-11-22 |
1985-09-17 |
Roussel Uclaf |
Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain
|
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
FR2576898B1
(fr)
|
1985-02-01 |
1988-01-08 |
Lafon Labor |
Derives de 3-phenyl-tetrahydropyridine, procede de preparation et utilisation en therapeutique
|
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
|
US4735949A
(en)
|
1986-02-18 |
1988-04-05 |
Warner-Lambert Company |
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
|
|
US4840956A
(en)
|
1986-02-18 |
1989-06-20 |
Warner-Lambert Company |
Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
|
|
IL83663A0
(en)
|
1986-10-27 |
1988-01-31 |
Robins Co Inc A H |
Preparation of 3-pyrrolidinols
|
|
CA1340032C
(en)
|
1987-06-24 |
1998-09-08 |
Jim Haralambidis |
Lucleoside derivatives
|
|
US5200553A
(en)
|
1987-07-30 |
1993-04-06 |
Kupat Holim Health Insurance Institution Of The General Federation Of Labor |
Biologically active carboxylic acid esters
|
|
US4923901A
(en)
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US4943629A
(en)
|
1988-08-12 |
1990-07-24 |
American Cyanamid Company |
Antidiabetic alpha-substituted phosphonates
|
|
US4945158A
(en)
|
1988-08-12 |
1990-07-31 |
American Cyanamid Company |
Antidiabetic phosphonates
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
CA2029273A1
(en)
|
1989-12-04 |
1991-06-05 |
Christine L. Brakel |
Modified nucleotide compounds
|
|
WO1991009594A1
(en)
|
1989-12-28 |
1991-07-11 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
DE69133405T2
(de)
|
1990-01-11 |
2005-07-07 |
Isis Pharmaceutical, Inc., Carlsbad |
Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression
|
|
US5635488A
(en)
|
1991-10-15 |
1997-06-03 |
Isis Pharmaceuticals, Inc. |
Compounds having phosphorodithioate linkages of high chiral purity
|
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
|
US5212295A
(en)
|
1990-01-11 |
1993-05-18 |
Isis Pharmaceuticals |
Monomers for preparation of oligonucleotides having chiral phosphorus linkages
|
|
US5620963A
(en)
|
1991-10-15 |
1997-04-15 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5506212A
(en)
|
1990-01-11 |
1996-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides with substantially chirally pure phosphorothioate linkages
|
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US5852188A
(en)
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US5036964A
(en)
|
1990-03-28 |
1991-08-06 |
Dana Corporation |
Armature assembly for an electromagnetic coupling
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
US5292875A
(en)
|
1990-04-20 |
1994-03-08 |
Lynx Therapeutics, Inc. |
Method of synthesizing sulfurized oligonucleotide analogs
|
|
JPH06500075A
(ja)
|
1990-05-23 |
1994-01-06 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
Ｒｎａの５´キャップ構造の修飾によりｒｎａ活性を変調させるための組成物および方法
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
WO1994022886A1
(en)
|
1993-03-30 |
1994-10-13 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US6121433A
(en)
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
|
US5792844A
(en)
|
1990-07-27 |
1998-08-11 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent nitrogen atoms
|
|
WO1992002258A1
(en)
|
1990-07-27 |
1992-02-20 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
US5834607A
(en)
|
1990-07-27 |
1998-11-10 |
Isis Pharmaceuticals, Inc. |
Amines and methods of making and using the same
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
|
US6087482A
(en)
|
1990-07-27 |
2000-07-11 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5783682A
(en)
|
1990-07-27 |
1998-07-21 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide mimics having nitrogen-containing linkages
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
US5512668A
(en)
*
|
1991-03-06 |
1996-04-30 |
Polish Academy Of Sciences |
Solid phase oligonucleotide synthesis using phospholane intermediates
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
US20020183502A1
(en)
|
1991-05-21 |
2002-12-05 |
Mesmaeker Alain De |
Backbone-modified oligonucleotide analogs and methods for using same
|
|
US6414112B1
(en)
|
1991-05-24 |
2002-07-02 |
Ole Buchardt |
Peptide nucleic acids having 2,6-diaminopurine nucleobases
|
|
AU659649B2
(en)
|
1991-06-10 |
1995-05-25 |
Lucky Limited |
Hepatitis C diagnostics and vaccines
|
|
US5646267A
(en)
|
1991-08-05 |
1997-07-08 |
Polish Academy Of Sciences |
Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
|
|
US5359052A
(en)
|
1991-08-05 |
1994-10-25 |
Polish Academy Of Sciences |
Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
|
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
|
ATE221127T1
(de)
|
1991-10-15 |
2002-08-15 |
Isis Pharmaceuticals Inc |
Über chirale phosphoratome gebundene oligonukleotide
|
|
US5654284A
(en)
|
1991-10-15 |
1997-08-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
EP0538194B1
(de)
|
1991-10-17 |
1997-06-04 |
Novartis AG |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
DK1695979T3
(da)
|
1991-12-24 |
2011-10-10 |
Isis Pharmaceuticals Inc |
Gappede modificerede oligonukleotider
|
|
GB9213601D0
(en)
|
1992-06-26 |
1992-08-12 |
Mastico Robert A |
Protein based delivery system
|
|
US7067497B2
(en)
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
|
US6005107A
(en)
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
|
US6444656B1
(en)
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
|
DK0677056T3
(da)
|
1993-01-25 |
1996-08-05 |
Hybridon Inc |
Oligonukleotid-alkylphosphonater og -alkylphosphonothioater
|
|
AU6449294A
(en)
|
1993-03-31 |
1994-10-24 |
Sterling Winthrop Inc. |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
|
HU9501978D0
(en)
|
1993-03-31 |
1995-09-28 |
Sterling Winthorp Inc |
Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
|
|
US5955591A
(en)
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
|
EP0628394B1
(en)
|
1993-06-10 |
1998-08-26 |
Idemitsu Petrochemical Co. Ltd. |
Injection molding die
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5643989A
(en)
|
1993-10-29 |
1997-07-01 |
Azdel, Inc. |
Fiber reinforced functionalized polyolefin composites
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
DE4435728A1
(de)
|
1994-01-19 |
1995-07-20 |
Boehringer Mannheim Gmbh |
Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
|
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
|
WO1995022615A1
(en)
|
1994-02-22 |
1995-08-24 |
Novo Nordisk A/S |
A method of preparing a variant of a lipolytic enzyme
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
HUT75368A
(en)
|
1994-05-11 |
1997-05-28 |
Novo Nordisk As |
An enzyme with endo-1,3(4)-beta-glucanase activity
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
HRP950288A2
(en)
|
1994-05-31 |
1997-08-31 |
Bayer Ag |
Oxalylamino-benzofuran- and benzothienyl-derivatives
|
|
ES2127966T3
(es)
|
1994-05-31 |
1999-05-01 |
Bayer Ag |
Derivados de amino-benzofurilo y -benzotienilo.
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
ES2366201T3
(es)
|
1994-07-15 |
2011-10-18 |
University Of Iowa Research Foundation |
Oligonucleótidos inmunmoduladores.
|
|
CA2199464A1
(en)
|
1994-09-07 |
1996-03-14 |
Radhakrishnan Iyer |
Oligonucleotide prodrugs
|
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
|
EP0807171A1
(en)
|
1994-12-22 |
1997-11-19 |
HYBRIDON, Inc. |
Synthesis of stereospecific oligonucleotide phosphorothioates
|
|
GB9501465D0
(en)
|
1995-01-25 |
1995-03-15 |
King S College London |
Nucleoside phosphorothioate derivatives,synthesis and use thereof
|
|
EP0813539B1
(en)
|
1995-03-06 |
2006-05-24 |
Isis Pharmaceuticals, Inc. |
Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
|
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
|
EP0739983B1
(en)
|
1995-04-27 |
2009-12-30 |
Takara Bio Inc. |
Gene encoding lacto-n-biosidase
|
|
US6004813A
(en)
|
1995-05-11 |
1999-12-21 |
Applied Research Systems Ars Holding N.V. |
Il-6 activity inhibitor
|
|
CA2221589A1
(en)
|
1995-05-19 |
1996-11-21 |
Glycomed Incorporated |
Collection of activated glycoside compounds and their biological use
|
|
AU5871196A
(en)
|
1995-05-23 |
1996-12-24 |
Hybridon, Inc. |
Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
|
|
DK0836612T3
(da)
|
1995-05-23 |
2000-10-30 |
Hybridon Inc |
Nye synthoner til stereoselektiv oligonucleotidsyntese
|
|
EP0831854A4
(en)
*
|
1995-06-06 |
2001-01-24 |
Isis Pharmaceuticals Inc |
OLIGONUCLEOTIDS WITH PHOSPHOROTHIOATE BINDINGS OF HIGH CHIRAL PURITY
|
|
US5932450A
(en)
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
|
EP0751222B1
(en)
|
1995-06-29 |
2006-03-01 |
Takara Bio Inc. |
Gene encoding endoglycoceramidase
|
|
US5824503A
(en)
|
1995-06-29 |
1998-10-20 |
Takara Shuzo Co, Ltd. |
Gene encoding endoglycoceramidase activator
|
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
|
US5936080A
(en)
|
1996-05-24 |
1999-08-10 |
Genta Incorporated |
Compositions and methods for the synthesis of organophosphorus derivatives
|
|
WO1997009443A1
(en)
|
1995-09-05 |
1997-03-13 |
Michigan State University |
PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
|
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
|
CA2246503A1
(en)
|
1996-02-15 |
1997-08-21 |
National Institutes Of Health |
Rnase l activators and antisense oligonucleotides effective to treat rsv infections
|
|
US6214805B1
(en)
|
1996-02-15 |
2001-04-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
|
US5824669A
(en)
|
1996-03-22 |
1998-10-20 |
Nitromed, Inc. |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
|
|
DK0898618T3
(da)
|
1996-05-10 |
2008-02-25 |
Novozymes As |
Fremgangsmåde til tilvejebringelse af hidtil ukendte DNA-sekvenser
|
|
US5856465A
(en)
|
1996-05-24 |
1999-01-05 |
Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych |
Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
DE19622783A1
(de)
|
1996-06-07 |
1997-12-11 |
Hoechst Ag |
Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung
|
|
ATE339514T1
(de)
|
1996-07-16 |
2006-10-15 |
Gen Probe Inc |
Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
|
|
DE69734783T2
(de)
|
1996-07-24 |
2006-08-17 |
Buchardt, Dorte |
Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit
|
|
AU4156197A
(en)
|
1996-08-21 |
1998-03-06 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
GB9621522D0
(en)
|
1996-10-16 |
1996-12-04 |
Biocompatibles Ltd |
Synthesis of phosphorus compounds
|
|
US6639062B2
(en)
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
|
US6369237B1
(en)
|
1997-03-07 |
2002-04-09 |
President And Fellows Of Harvard College |
DNA glycosylase inhibitors, and uses related thereto
|
|
US6015887A
(en)
|
1997-04-11 |
2000-01-18 |
Isis Pharmaceuticals, Inc. |
Chiral peptide nucleic acids and methods for preparing same
|
|
US6468983B2
(en)
|
1997-04-21 |
2002-10-22 |
The Cleveland Clinic Foundation |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
|
|
PL184612B1
(pl)
|
1997-04-25 |
2002-11-29 |
Pan |
Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
|
|
NZ501289A
(en)
|
1997-05-28 |
2001-06-29 |
Nielsen Peter E |
Conjugated peptide nucleic acids having enhanced cellular uptake
|
|
JP2002507212A
(ja)
|
1997-06-27 |
2002-03-05 |
ザ、プロクター、エンド、ギャンブル、カンパニー |
プロ芳香性環状アセタール
|
|
WO1999005160A2
(en)
|
1997-07-25 |
1999-02-04 |
Hybridon, Inc. |
Oligonuclotides having 3' terminal stereospecific phosphorothioates
|
|
US6767739B2
(en)
|
2001-07-30 |
2004-07-27 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microsomal triglyceride transfer protein expression
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
GB9717158D0
(en)
|
1997-08-13 |
1997-10-22 |
King S College London |
Solution synthesis of oligonucleotides and their phosphorothioate analogues
|
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
DE19741715A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
|
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
|
US6080543A
(en)
|
1997-12-08 |
2000-06-27 |
E. & J. Gallo Winery |
Detection of fungal pathogens
|
|
US6582936B1
(en)
|
1997-12-12 |
2003-06-24 |
The Regents Of The University Of California |
Methods for making nucleic acids
|
|
US6248519B1
(en)
|
1998-03-11 |
2001-06-19 |
E & J Gallo Winery |
Detection of fermentation-related microorganisms
|
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
|
WO1999056755A1
(en)
|
1998-05-06 |
1999-11-11 |
University Of Iowa Research Foundation |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
|
EP1078053B1
(en)
|
1998-05-14 |
2005-09-28 |
Coley Pharmaceutical GmbH |
METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6242589B1
(en)
*
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
JP2002521489A
(ja)
|
1998-07-27 |
2002-07-16 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
ＣｐＧオリゴヌクレオチドの立体異性体および関連する方法
|
|
JP4620251B2
(ja)
|
1998-08-10 |
2011-01-26 |
アンチジェニックス・インコーポレイテッド |
Ｃｐｇおよびサポニンアジュバントの組成物並びにその方法
|
|
WO2000023444A1
(en)
|
1998-10-21 |
2000-04-27 |
Abbott Laboratories |
5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
|
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
|
US6451524B1
(en)
|
1998-11-25 |
2002-09-17 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
AU1742600A
(en)
|
1998-11-25 |
2000-06-13 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
AU1853600A
(en)
|
1999-01-06 |
2000-07-24 |
Choong-Chin Liew |
Method for the detection of gene transcripts in blood and uses thereof
|
|
US6265172B1
(en)
|
1999-02-08 |
2001-07-24 |
University Of Kentucky |
Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
|
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6506594B1
(en)
|
1999-03-19 |
2003-01-14 |
Cornell Res Foundation Inc |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
|
GB9907245D0
(en)
|
1999-03-29 |
1999-05-26 |
Goldsborough Andrew |
Cleavage of nucleic acids from solid supports
|
|
JP3072345B1
(ja)
|
1999-03-31 |
2000-07-31 |
農林水産省家畜衛生試験場長 |
豚丹毒菌の組換えサブユニットワクチン
|
|
US5998148A
(en)
|
1999-04-08 |
1999-12-07 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microtubule-associated protein 4 expression
|
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6300069B1
(en)
|
1999-05-03 |
2001-10-09 |
Qiagen Gmbh |
Generation and amplification of nucleic acids from ribonucleic acids
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6066500A
(en)
|
1999-06-25 |
2000-05-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Beta catenin expression
|
|
US6271004B1
(en)
|
1999-06-25 |
2001-08-07 |
Display Systems Biotech A/S |
Method for improved reverse transcription at high temperatures
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US20030092647A1
(en)
|
2001-08-08 |
2003-05-15 |
Crooke Rosanne M. |
Antisense modulation of cholesteryl ester transfer protein expression
|
|
US6147200A
(en)
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US7264932B2
(en)
|
1999-09-24 |
2007-09-04 |
Applera Corporation |
Nuclease inhibitor cocktail
|
|
DK1221955T3
(da)
|
1999-09-25 |
2006-01-30 |
Univ Iowa Res Found |
Immunstimulerende nukleinsyre
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
JP2003510290A
(ja)
|
1999-09-27 |
2003-03-18 |
コーリー ファーマシューティカル グループ，インコーポレイテッド |
免疫刺激核酸誘導インターフェロンに関する方法
|
|
US20020082227A1
(en)
|
1999-09-30 |
2002-06-27 |
Scott Henry |
Use of oligonucleotides for inhibition of complement activation
|
|
AU7863200A
(en)
|
1999-10-06 |
2001-05-10 |
Quark Biotech, Inc. |
Method for enrichment of natural antisense messenger rna
|
|
GB9924285D0
(en)
|
1999-10-14 |
1999-12-15 |
Avecia Ltd |
Process
|
|
US20010055761A1
(en)
|
1999-10-29 |
2001-12-27 |
Agilent Technologies |
Small scale dna synthesis using polymeric solid support with functionalized regions
|
|
FR2800750B1
(fr)
|
1999-11-05 |
2003-01-31 |
Centre Nat Rech Scient |
Proteines membranaires ctl (choline transporter like) impliquees dans le transport de la choline
|
|
AU1656601A
(en)
|
1999-11-12 |
2001-06-12 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6322985B1
(en)
|
1999-12-27 |
2001-11-27 |
Technion Research And Development Foundation Ltd. |
Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
|
|
WO2001050349A1
(en)
|
1999-12-30 |
2001-07-12 |
Rutgers, The State University Of New Jersey |
Electronic document customization and transformation utilizing user feedback
|
|
JP2004510953A
(ja)
|
1999-12-30 |
2004-04-08 |
キャボット コーポレイション |
改良された性質を有するセンサー
|
|
US6649750B1
(en)
|
2000-01-05 |
2003-11-18 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotide compounds
|
|
US6159697A
(en)
|
2000-01-19 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad7 expression
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
EP1130091A3
(en)
|
2000-03-01 |
2001-11-14 |
Message Pharmaceuticals, Inc. |
Bacterial RNaseP Proteins and their use in identifying antibacterial compounds
|
|
GB0004889D0
(en)
|
2000-03-01 |
2000-04-19 |
Avecia Ltd |
Synthesis of oligonucleotides
|
|
JP2003528068A
(ja)
|
2000-03-17 |
2003-09-24 |
コリクサ コーポレイション |
新規両親媒性アルデヒドならびにアジュバントおよび免疫エフェクターとしてのそれらの使用
|
|
CA2404464C
(en)
|
2000-04-20 |
2008-03-11 |
F. Hoffmann-La Roche Ag |
Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders
|
|
DE10019756A1
(de)
|
2000-04-20 |
2001-10-25 |
Bayer Ag |
Verfahren zur Herstellung von superabsorbierenden Polymeren aus Polyacrylnitrilen
|
|
AU2001259706A1
(en)
|
2000-05-09 |
2001-11-20 |
Reliable Biopharmaceutical, Inc. |
Polymeric compounds useful as prodrugs
|
|
US6492171B2
(en)
|
2000-05-16 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of TERT expression
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
WO2002012263A1
(en)
|
2000-08-03 |
2002-02-14 |
Roche Diagnostics Gmbh |
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
|
|
US6725412B1
(en)
|
2000-08-15 |
2004-04-20 |
Dolby Laboratories Licensing Corporation |
Low latency data encoder
|
|
US6809195B1
(en)
|
2000-08-16 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotides
|
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
|
JP2005500806A
(ja)
|
2000-09-15 |
2005-01-13 |
コーリー ファーマシューティカル ゲーエムベーハー |
ＣｐＧに基づく免疫アゴニスト／免疫アンタゴニストの高スループットスクリーニングのためのプロセス
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
GB0024752D0
(en)
|
2000-10-10 |
2000-11-22 |
Univ Belfast |
Oxidative halogenation of aromatic compounds
|
|
IL155282A0
(en)
|
2000-10-18 |
2003-11-23 |
Glaxosmithkline Biolog Sa |
Vaccines
|
|
US6372492B1
(en)
|
2000-10-30 |
2002-04-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of talin expression
|
|
US6682889B1
(en)
|
2000-11-08 |
2004-01-27 |
Becton, Dickinson And Company |
Amplification and detection of organisms of the Chlamydiaceae family
|
|
NL1016978C2
(nl)
|
2000-12-22 |
2002-06-25 |
Robert Jan Colenbrander |
Inrichting en werkwijze voor het verpakken en bereiden van voedsel en werkwijze voor het vervaardigen van een dergelijke inrichting.
|
|
DZ3487A1
(fr)
|
2001-01-22 |
2002-07-25 |
Merck Sharp & Dohme |
Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant
|
|
DE60239386D1
(de)
|
2001-01-25 |
2011-04-21 |
Evolva Ltd |
Zellbibliothek
|
|
US8008459B2
(en)
|
2001-01-25 |
2011-08-30 |
Evolva Sa |
Concatemers of differentially expressed multiple genes
|
|
WO2002059294A1
(en)
|
2001-01-26 |
2002-08-01 |
Commonwealth Scientific And Industrial Research O Rganisation |
Methods and means for producing efficient silencing construct using recombinational cloning
|
|
US20050277133A1
(en)
|
2001-05-18 |
2005-12-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US20030207804A1
(en)
|
2001-05-25 |
2003-11-06 |
Muthiah Manoharan |
Modified peptide nucleic acids
|
|
GB0113523D0
(en)
|
2001-06-04 |
2001-07-25 |
Torotrak Dev Ltd |
An Hydraulic control circuit for a continuosly variable transmission
|
|
US20030069410A1
(en)
*
|
2001-06-14 |
2003-04-10 |
Isis Pharmaceuticals, Inc. |
Methods for preparing oligonucleotides having chiral phosphorothioate linkages
|
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
NZ530632A
(en)
|
2001-06-29 |
2007-04-27 |
Chiron Corp |
HCV E1E2 vaccine compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or CpG oligonucleotides
|
|
CA2452458A1
(en)
|
2001-07-03 |
2003-01-16 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
|
US6440739B1
(en)
|
2001-07-17 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glioma-associated oncogene-2 expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US6455308B1
(en)
|
2001-08-01 |
2002-09-24 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of serum amyloid A4 expression
|
|
US7888324B2
(en)
|
2001-08-01 |
2011-02-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
|
WO2003020884A2
(en)
|
2001-08-14 |
2003-03-13 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services |
Method for rapid generation of mature dendritic cells
|
|
CA2458393A1
(en)
|
2001-08-24 |
2003-03-06 |
Massachusetts Institute Of Technology |
Reagents that facilitate the purification of compounds synthesized on a solid support
|
|
US7049122B2
(en)
|
2001-09-21 |
2006-05-23 |
Academia Sinica |
Mutant-type lipases and applications thereof
|
|
US6933288B2
(en)
|
2002-02-04 |
2005-08-23 |
Isis Pharmaceuticals, Inc. |
Pyranosyl cytosines: pharmaceutical formulations and methods
|
|
JP4348044B2
(ja)
|
2002-02-12 |
2009-10-21 |
株式会社キラルジェン |
立体規則性の高いジヌクレオシドホスホロチオエートの製造法
|
|
US20040149587A1
(en)
|
2002-02-15 |
2004-08-05 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US20030159938A1
(en)
|
2002-02-15 |
2003-08-28 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
AU2003217863B9
(en)
|
2002-02-28 |
2009-10-29 |
Biota Scientific Management Pty Ltd |
Nucleotide mimics and their prodrugs
|
|
EP1485396A2
(en)
|
2002-02-28 |
2004-12-15 |
Biota, Inc. |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
|
US7288376B2
(en)
|
2002-03-22 |
2007-10-30 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis
|
|
US20040102394A1
(en)
|
2002-11-23 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of huntingtin interacting protein 2 expression
|
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
|
AU2003237875A1
(en)
|
2002-05-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
|
WO2003099840A1
(en)
|
2002-05-24 |
2003-12-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
AU2003241621A1
(en)
|
2002-05-24 |
2003-12-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
|
WO2003106477A1
(en)
|
2002-06-01 |
2003-12-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
BR0311995A
(pt)
|
2002-06-20 |
2005-04-05 |
Cytos Biotechnology Ag |
Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso
|
|
WO2004003228A1
(en)
|
2002-07-01 |
2004-01-08 |
Unisearch Limited |
Genotyping method
|
|
CA2489174C
(en)
|
2002-07-10 |
2013-02-05 |
Thomas Tuschl |
Rna-interference by single-stranded rna molecules
|
|
US20040023905A1
(en)
|
2002-07-31 |
2004-02-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of LAR expression
|
|
US20050255086A1
(en)
|
2002-08-05 |
2005-11-17 |
Davidson Beverly L |
Nucleic acid silencing of Huntington's Disease gene
|
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
|
AU2003259735A1
(en)
|
2002-08-08 |
2004-02-25 |
Sirna Therapeutics, Inc. |
Small-mer compositions and methods of use
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
|
EP1537208A1
(en)
|
2002-09-13 |
2005-06-08 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
ATE544466T1
(de)
|
2002-10-29 |
2012-02-15 |
Coley Pharm Group Inc |
Verwendung von cpg oligonukleotide zur behandlung von hepatitis c virus infektion
|
|
AU2003295389A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
AU2003291721A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US7381527B2
(en)
|
2002-11-06 |
2008-06-03 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants
|
|
CA2505801A1
(en)
|
2002-11-13 |
2004-05-27 |
Rosanne Crooke |
Antisense modulation of apolipoprotein b expression
|
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
JP2006507841A
(ja)
|
2002-11-14 |
2006-03-09 |
ダーマコン， インコーポレイテッド |
機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
|
|
ATE479752T1
(de)
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
GB0306657D0
(en)
|
2003-03-24 |
2003-04-30 |
Avecia Ltd |
Process and compounds
|
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
|
WO2004084940A1
(en)
|
2003-03-26 |
2004-10-07 |
Cytos Biotechnology Ag |
Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
|
|
ITRM20030149A1
(it)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
US20090247488A1
(en)
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
CN101410120A
(zh)
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
抗炎的膦酸酯化合物
|
|
US7429565B2
(en)
|
2003-04-25 |
2008-09-30 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
EP1617848A2
(en)
|
2003-04-25 |
2006-01-25 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate conjugates
|
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
|
WO2004096233A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates
|
|
US7045306B2
(en)
|
2003-04-28 |
2006-05-16 |
The General Hospital Corporation |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
|
|
US7214491B2
(en)
|
2003-05-07 |
2007-05-08 |
E. I. Du Pont De Nemours And Company |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
|
|
AU2004239114B2
(en)
|
2003-05-14 |
2008-03-13 |
Japan Science And Technology Agency |
Inhibition of the expression of huntingtin gene
|
|
WO2005002507A2
(en)
|
2003-06-03 |
2005-01-13 |
Isis Pharmaceuticals, Inc. |
Modulation of survivin expression
|
|
AU2004257149A1
(en)
|
2003-06-20 |
2005-01-27 |
Coley Pharmaceutical Gmbh |
Small molecule toll-like receptor (TLR) antagonists
|
|
EP2530157B1
(en)
|
2003-07-31 |
2016-09-28 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of miRNAs
|
|
JP2011088935A
(ja)
|
2003-08-08 |
2011-05-06 |
Chiralgen Ltd |
リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド３’−ホスホロアミダイト
|
|
JP2005089441A
(ja)
|
2003-08-08 |
2005-04-07 |
Toudai Tlo Ltd |
立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
WO2005019237A1
(en)
|
2003-08-21 |
2005-03-03 |
Griffith University |
Novel sulfenamides
|
|
CA2535800A1
(en)
|
2003-08-21 |
2005-03-03 |
Griffith University |
Novel sulfenamide oxides
|
|
JP2007504152A
(ja)
|
2003-08-27 |
2007-03-01 |
ビオタ， インコーポレイテッド |
治療剤としての新規三環ヌクレオシドまたはヌクレオチド
|
|
JP4731324B2
(ja)
|
2003-08-28 |
2011-07-20 |
武 今西 |
Ｎ−ｏ結合性架橋構造型新規人工核酸
|
|
JP4616175B2
(ja)
|
2003-09-02 |
2011-01-19 |
株式会社キラルジェン |
５’−ホスフィチル化モノマーおよびｈ−ホスホネートオリゴヌクレオチド誘導体の製造方法
|
|
WO2005023828A1
(ja)
|
2003-09-02 |
2005-03-17 |
Takeshi Wada |
リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
DK3342425T3
(da)
|
2003-09-09 |
2020-03-16 |
Geron Corp |
Modificerede oligonukleotider til inhibering af telomerase
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
ES2808561T3
(es)
|
2003-09-12 |
2021-03-01 |
Univ Massachusetts |
Interferencia por ARN para el tratamiento de trastornos de ganancia de función
|
|
GB0323968D0
(en)
|
2003-10-13 |
2003-11-19 |
Glaxosmithkline Biolog Sa |
Immunogenic compositions
|
|
KR101107818B1
(ko)
|
2003-10-30 |
2012-01-31 |
콜레이 파마시티컬 그룹, 인코포레이티드 |
향상된 면역자극 효능을 가진 ｃ-부류 올리고뉴클레오티드유사체
|
|
US20050239102A1
(en)
|
2003-10-31 |
2005-10-27 |
Verdine Gregory L |
Nucleic acid binding oligonucleotides
|
|
US7846436B2
(en)
|
2003-11-28 |
2010-12-07 |
Chemgenes Corporation |
Oligonucleotides and related compounds
|
|
WO2005063983A1
(en)
|
2003-12-29 |
2005-07-14 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
|
JP4945129B2
(ja)
|
2004-01-27 |
2012-06-06 |
株式会社キラルジェン |
フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
|
WO2005076744A2
(en)
|
2004-02-18 |
2005-08-25 |
Frutarom Ltd. |
Method for the preparation of peptide-oligonucleotide conjugates
|
|
JP3976742B2
(ja)
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
|
|
WO2005085272A1
(ja)
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
WO2005092909A1
(ja)
|
2004-03-25 |
2005-10-06 |
Toudai Tlo, Ltd. |
立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法
|
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
US20050267300A1
(en)
|
2004-04-05 |
2005-12-01 |
Muthiah Manoharan |
Processes and reagents for oligonucleotide synthesis and purification
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
AU2005248410B2
(en)
|
2004-05-27 |
2010-04-22 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Differential expression of molecules associated with acute stroke
|
|
US7759318B1
(en)
|
2004-05-28 |
2010-07-20 |
Isis Pharmaceuticals, Inc. |
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
|
|
EP1765416A4
(en)
|
2004-06-03 |
2010-03-24 |
Isis Pharmaceuticals Inc |
DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION
|
|
ATE498685T1
(de)
|
2004-06-28 |
2011-03-15 |
Univ Western Australia |
Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
|
|
DK2997980T3
(en)
|
2004-08-10 |
2018-03-26 |
Kastle Therapeutics Llc |
PROCEDURES FOR MODULATING LIPROPROTEIN AND CHOLESTEROL LEVELS
|
|
BRPI0514644A
(pt)
|
2004-08-26 |
2008-06-17 |
Nippon Shinyaku Co Ltd |
composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna
|
|
EP1791557A4
(en)
|
2004-09-07 |
2009-09-23 |
Archemix Corp |
MEDICAL CHEMISTRY USING APTAMERS
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
US20090203132A1
(en)
|
2004-09-09 |
2009-08-13 |
Swayze Eric E |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
EP2397563A3
(en)
|
2004-09-17 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
|
US20060089325A1
(en)
|
2004-10-13 |
2006-04-27 |
Sanjay Bhanot |
Antisense modulation of PTP1B expression
|
|
US8212012B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US9120774B2
(en)
|
2004-11-03 |
2015-09-01 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
AU2005301957B2
(en)
|
2004-11-03 |
2012-02-23 |
Department Of Health And Human Services |
Novobiocin analogues as anticancer agents
|
|
WO2010096650A1
(en)
|
2009-02-20 |
2010-08-26 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US8212011B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues
|
|
US7622451B2
(en)
|
2004-11-03 |
2009-11-24 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
KR100721928B1
(ko)
|
2004-11-05 |
2007-05-28 |
주식회사 바이오씨에스 |
ＣｐＧ 올리고데옥시뉴클레오티드를 함유하는 피부질환의치료 또는 예방용 약학적 조성물
|
|
EP1657307A1
(en)
|
2004-11-16 |
2006-05-17 |
Immunotech S.A. |
Oligonucleotides that induce the secretion of GM-CSF
|
|
JP4981681B2
(ja)
|
2004-12-09 |
2012-07-25 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法
|
|
WO2006065751A2
(en)
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
WO2006066260A2
(en)
|
2004-12-17 |
2006-06-22 |
Thiosense, Inc. |
Compositions of and methods for producing phosphorus-chiral monomers and oligomers
|
|
US20070099851A1
(en)
|
2004-12-30 |
2007-05-03 |
Linn Gregory S |
Stable analogues of ribose-1-phosphate and methods for treating diabetes and other metabolic disorders
|
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
|
JP4836145B2
(ja)
|
2005-01-28 |
2011-12-14 |
クウォン，ヒュン−ジョ |
マイコバクテリアに由来する、免疫機能刺激用、免疫疾患治療用、アトピー性皮膚炎治療用および／または正常免疫細胞保護用オリゴヌクレオチド
|
|
JP2008531018A
(ja)
|
2005-02-24 |
2008-08-14 |
コーリー ファーマシューティカル グループ，インコーポレイテッド |
免疫刺激性オリゴヌクレオチド
|
|
ATE534652T1
(de)
|
2005-04-01 |
2011-12-15 |
Univ California |
Phosphono-pent-2-en-1-yl-nukleoside und analoga
|
|
WO2006117400A2
(en)
|
2005-05-05 |
2006-11-09 |
Antisense Pharma Gmbh |
Use of low doses of oligonucleotides antisense to tgf-beta, vegf, interleukin-10, c-jun, c-fos or prostaglandin e2 genes in the treatment of tumors
|
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
|
US20060257912A1
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
|
SI2548560T1
(sl)
|
2005-06-23 |
2015-12-31 |
Isis Pharmaceuticals, Inc. |
Sestavki in postopki za moduliranje izrezovanja smn2
|
|
US20070161590A1
(en)
|
2005-06-28 |
2007-07-12 |
Medtronic, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
EP1948600B1
(en)
|
2005-07-05 |
2014-04-16 |
The President & Fellows Of Harvard College |
Liver targeted conjugates
|
|
JP4984634B2
(ja)
|
2005-07-21 |
2012-07-25 |
ソニー株式会社 |
物理情報取得方法および物理情報取得装置
|
|
EP1924252B1
(en)
|
2005-07-28 |
2011-09-07 |
ID-Fish Technology, Inc. |
Method for improving cell permeability to foreign particles
|
|
CA2620856C
(en)
|
2005-08-29 |
2017-11-28 |
Isis Pharmaceuticals, Inc. |
Methods for use in modulating mir-122a
|
|
US8501703B2
(en)
|
2005-08-30 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
|
US20070077993A1
(en)
|
2005-09-30 |
2007-04-05 |
Midgley Timothy M |
Method and apparatus for collecting user game play data and crediting users in a gaming environment
|
|
EP2982679A1
(en)
|
2005-10-12 |
2016-02-10 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
|
|
US9308252B2
(en)
|
2005-10-27 |
2016-04-12 |
Cook Biotech, Inc. |
Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
|
|
EP1942185A4
(en)
|
2005-10-28 |
2009-11-25 |
Tosoh Corp |
PROCESS FOR PREPARING CAROTINOIDY SYNTHETIZING MICROORGANISM AND METHOD FOR CAROTINOID PRODUCTION
|
|
CN101365801B
(zh)
|
2005-10-28 |
2013-03-27 |
阿尔尼拉姆医药品有限公司 |
抑制亨廷顿基因表达的组合物和方法
|
|
AU2006315632A1
(en)
|
2005-11-11 |
2007-05-24 |
Pfizer, Inc. |
Combinations and methods of using an immunomodulatory oligodeoxynucleotide
|
|
WO2007064291A1
(en)
|
2005-11-30 |
2007-06-07 |
Jyoti Chattopadhyaya |
Method and compounds for rna synthesis
|
|
JP5256043B2
(ja)
|
2005-12-02 |
2013-08-07 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
|
|
US8076303B2
(en)
*
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
|
CA2634381C
(en)
|
2005-12-21 |
2011-03-08 |
Pfizer Products Inc. |
Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
|
|
DK2161038T3
(da)
|
2006-01-26 |
2014-03-03 |
Isis Pharmaceuticals Inc |
Sammensætninger og deres anvendelser rettet mod Huntington
|
|
US7399845B2
(en)
|
2006-01-27 |
2008-07-15 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
WO2007095316A2
(en)
|
2006-02-15 |
2007-08-23 |
Coley Pharmaceutical Gmbh |
Compositions and methods for oligonucleotide formulations
|
|
JP4713514B2
(ja)
|
2006-02-20 |
2011-06-29 |
エフ．ホフマン−ラ ロシュ アーゲー |
改善された標識試薬
|
|
US8383660B2
(en)
|
2006-03-10 |
2013-02-26 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
|
US9040674B2
(en)
|
2006-03-31 |
2015-05-26 |
Applied Biosystems, Llc |
Reagents useful for synthesizing rhodamine-labeled oligonucleotides
|
|
WO2007118222A2
(en)
|
2006-04-06 |
2007-10-18 |
Ibis Biosciences, INC |
Compositions for the use in identification of fungi
|
|
JP5016666B2
(ja)
|
2006-04-20 |
2012-09-05 |
エフ．ホフマン−ラ ロシュ アーゲー |
ケモカイン受容体のジアゼパン誘導体モジュレーター
|
|
US8206923B2
(en)
|
2006-04-24 |
2012-06-26 |
Elvira Garza Gonzalez |
Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
|
|
AU2007243412A1
(en)
|
2006-04-25 |
2007-11-08 |
Immune Disease Institute Inc. |
Targeted delivery to leukocytes using non-protein carriers
|
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
WO2007131232A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to ptpr alpha
|
|
JP5731115B2
(ja)
|
2006-05-05 |
2015-06-10 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
遺伝子発現を調節するための化合物および方法
|
|
US20090012120A1
(en)
|
2006-05-10 |
2009-01-08 |
Board Of Trustees Of Michigan State University |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
PL2034015T3
(pl)
|
2006-05-31 |
2012-11-30 |
Toray Industries |
Immunostymulujący oligonukleotyd i jego zastosowanie farmaceutyczne
|
|
US8097596B2
(en)
|
2006-06-30 |
2012-01-17 |
Lakewood-Amedex, Inc. |
Compositions and methods for the treatment of muscle wasting
|
|
EP2046993A4
(en)
|
2006-07-07 |
2010-11-17 |
Univ Massachusetts |
RNA SILENCING COMPOSITIONS, AND METHODS OF TREATING HUNTINGTON CHOREA
|
|
EP2046964B1
(en)
|
2006-07-12 |
2018-07-04 |
The Regents of The University of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
|
CA2659155A1
(en)
|
2006-07-20 |
2008-01-24 |
Amgen Inc. |
Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1
|
|
GB0614947D0
(en)
|
2006-07-27 |
2006-09-06 |
Isis Innovation |
Epitope reduction therapy
|
|
CA2660052A1
(en)
|
2006-08-04 |
2008-02-07 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of jnk proteins
|
|
AT504194B1
(de)
|
2006-09-07 |
2008-07-15 |
Oesterr Rotes Kreuz |
Bakteriennachweis
|
|
US8138330B2
(en)
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
CN101517082B
(zh)
|
2006-09-27 |
2014-01-22 |
科勒制药有限责任公司 |
具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
|
|
ES2620472T5
(es)
|
2006-10-18 |
2020-07-09 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido
|
|
CN101589047A
(zh)
|
2006-10-23 |
2009-11-25 |
Irm责任有限公司 |
组织蛋白酶类抑制剂
|
|
KR20090058584A
(ko)
|
2006-10-26 |
2009-06-09 |
콜리 파마슈티칼 게엠베하 |
올리고리보뉴클레오티드 및 그의 용도
|
|
FR2908414B1
(fr)
|
2006-11-13 |
2012-01-20 |
Centre Nat Rech Scient |
Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
|
|
MX2009005252A
(es)
|
2006-11-17 |
2009-05-28 |
Abbott Lab |
Aminopirrolidinas como antagonistas del receptor de quimiocina.
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
EP2453016A1
(en)
|
2006-11-27 |
2012-05-16 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
JP2010512421A
(ja)
|
2006-12-12 |
2010-04-22 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Ｔｌｒ９の合成アゴニスト
|
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
|
US20100190837A1
(en)
|
2007-02-15 |
2010-07-29 |
Isis Pharmaceuticals, Inc. |
5'-Substituted-2-F' Modified Nucleosides and Oligomeric Compounds Prepared Therefrom
|
|
KR20090128494A
(ko)
|
2007-03-24 |
2009-12-15 |
겐자임 코포레이션 |
인간 아포리포프로틴 ｂ에 상보적인 안티센스 올리고뉴클레오타이드 투여
|
|
US7960353B2
(en)
|
2007-05-10 |
2011-06-14 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
JP5646320B2
(ja)
|
2007-05-11 |
2014-12-24 |
アダイニクス， インコーポレイテッド |
遺伝子発現と疼痛
|
|
EP2149571A4
(en)
|
2007-05-24 |
2010-09-01 |
Kyorin Seiyaku Kk |
MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
|
|
GB0710186D0
(en)
|
2007-05-29 |
2007-07-04 |
Texas Instr Denmark |
PWM loop with minimum allasing error property
|
|
WO2008150729A2
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
EP2155671B8
(en)
|
2007-06-05 |
2018-02-21 |
Integrative Research Laboratories Sweden AB |
Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
WO2008151833A2
(en)
|
2007-06-13 |
2008-12-18 |
Hochschule Mannheim |
Compounds for the modulation of huntingtin aggregation, methods and means for identifying such compounds
|
|
EP2014769B1
(en)
|
2007-06-18 |
2010-03-31 |
Commissariat à l'Energie Atomique |
Reversible siRNAa-based silencing of mutated and endogenous wild-type huntingtin gene and its application for the treatment of Huntington's disease
|
|
GB0712494D0
(en)
|
2007-06-27 |
2007-08-08 |
Isis Innovation |
Substrate reduction therapy
|
|
ATE538127T1
(de)
|
2007-07-05 |
2012-01-15 |
Isis Pharmaceuticals Inc |
6-disubstituierte bicyclische nukleinsäureanaloga
|
|
EP2357231A2
(en)
|
2007-07-09 |
2011-08-17 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory RNA (SIMRA) compounds
|
|
TWI413530B
(zh)
|
2007-07-20 |
2013-11-01 |
Kao Corp |
有機聚矽氧
|
|
WO2009015479A1
(en)
|
2007-07-31 |
2009-02-05 |
University Of Saskatchewan |
Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
|
|
WO2009017803A2
(en)
|
2007-08-02 |
2009-02-05 |
The Texas A & M University System |
Antisense microrna and uses therefor
|
|
JP2010536787A
(ja)
|
2007-08-15 |
2010-12-02 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Ｔｏｌｌ様受容体モジュレータ
|
|
JP5792955B2
(ja)
|
2007-10-01 |
2015-10-14 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
線維芽細胞増殖因子受容体４発現のアンチセンスモジュレーション
|
|
KR100886139B1
(ko)
|
2007-11-13 |
2009-02-27 |
주식회사 삼천리제약 |
올리고뉴클레오타이드의 제조방법
|
|
AR069869A1
(es)
|
2007-12-21 |
2010-02-24 |
Exelixis Inc |
Derivados de benzofuro[3,2-d]pirimidinas inhibidores de proteinquinasas,composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento del cancer.
|
|
TWI340765B
(en)
|
2007-12-26 |
2011-04-21 |
Ind Tech Res Inst |
Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof
|
|
CN101911676A
(zh)
|
2008-01-15 |
2010-12-08 |
联发科技股份有限公司 |
用以播放复数个视频信号以及复数个音频信号的多媒体处理装置及其方法以及多媒体播放系统
|
|
WO2009089659A1
(en)
|
2008-01-18 |
2009-07-23 |
Shanghai Targetdrug Co., Ltd. |
Pyrollidine-based compounds
|
|
WO2009098197A1
(en)
|
2008-02-04 |
2009-08-13 |
Biofocus Dpi B.V. |
Target sequences and methods to identify the same, useful in treatment of neurodegenerative diseases
|
|
JP2009190983A
(ja)
|
2008-02-12 |
2009-08-27 |
Tokyo Institute Of Technology |
オリゴヌクレオチド誘導体
|
|
US8426378B2
(en)
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
|
WO2009142822A2
(en)
|
2008-03-26 |
2009-11-26 |
Alnylam Pharmaceuticals, Inc. |
2-f modified rna interference agents
|
|
KR101806314B1
(ko)
|
2008-04-03 |
2017-12-07 |
스프링 뱅크 파마슈티칼스, 인크. |
바이러스 감염증을 치료하기 위한 조성물 및 방법
|
|
US8350022B2
(en)
|
2008-04-04 |
2013-01-08 |
Universitaet Hamburg |
Method for the stereoselective synthesis of phosphorus compounds
|
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
CA2726866A1
(en)
|
2008-05-09 |
2009-11-12 |
The University Of British Columbia |
Methods and compositions for the treatment of huntington's disease
|
|
US8679750B2
(en)
|
2008-05-09 |
2014-03-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington'S disease
|
|
WO2009143390A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Methods for modulating expression of rbp4
|
|
WO2009143387A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Modulation of smrt expression
|
|
WO2009143391A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc |
Methods for modulation expression of creb
|
|
WO2009148605A2
(en)
|
2008-06-04 |
2009-12-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
CN102143746A
(zh)
|
2008-07-03 |
2011-08-03 |
埃克塞利希斯股份有限公司 |
Cdk 调节剂
|
|
WO2010030849A1
(en)
|
2008-09-12 |
2010-03-18 |
University Of Louisville Research Foundation, Inc. |
Compositions and methods for treating cancer,inhibiting proliferation, and inducing cell death
|
|
US8163707B2
(en)
|
2008-09-15 |
2012-04-24 |
Enanta Pharmaceuticals, Inc. |
4′-allene-substituted nucleoside derivatives
|
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
DK2361256T3
(da)
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
|
JP2012504962A
(ja)
|
2008-10-07 |
2012-03-01 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
テロメラーゼ阻害剤およびその使用方法
|
|
KR101672563B1
(ko)
|
2008-10-22 |
2016-11-03 |
쿠아크 파마수티칼스 인코퍼레이티드 |
안질환을 치료하는 방법
|
|
JP5763539B2
(ja)
|
2008-10-24 |
2015-08-12 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
５’及び２’ビス置換ヌクレオシド及びそれから製造されるオリゴマー化合物
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
CN102282155B
(zh)
|
2008-12-02 |
2017-06-09 |
日本波涛生命科学公司 |
磷原子修饰的核酸的合成方法
|
|
EP2382227A1
(en)
|
2008-12-23 |
2011-11-02 |
Girindus America, Inc. |
Sulfurizing reagents and their use for oligonucleotides synthesis
|
|
WO2010080953A1
(en)
|
2009-01-08 |
2010-07-15 |
Isis Pharmaceuticals, Inc. |
Transgenic murine model of human lipoprotein metabolism, hypercholesterolemia and cardiovascular disease
|
|
KR20100087540A
(ko)
|
2009-01-28 |
2010-08-05 |
삼성전자주식회사 |
잉크젯 기록용 잉크 조성물
|
|
WO2010091301A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and excipients
|
|
MX2011008383A
(es)
|
2009-02-10 |
2011-09-06 |
Idera Pharmaceuticals Inc |
Agonistas basados en acido ribonucleico sintetico de receptor 7 tipo toll.
|
|
EP3424939A1
(en)
|
2009-03-02 |
2019-01-09 |
Alnylam Pharmaceuticals Inc. |
Nucleic acid chemical modifications
|
|
EP2408796B1
(en)
|
2009-03-16 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III
|
|
US8653254B2
(en)
|
2009-03-31 |
2014-02-18 |
Takeda Pharmaceutical Company Limited |
Process for producing nucleoside
|
|
US8987222B2
(en)
|
2009-04-08 |
2015-03-24 |
University Of Massachusetts |
Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
|
|
CA2759098A1
(en)
|
2009-04-14 |
2010-10-21 |
Smith Holdings, Llc |
Methods and compositions for the treatment of medical conditions involving cellular programming
|
|
US9260493B2
(en)
|
2009-05-07 |
2016-02-16 |
The Regents Of The University Of California |
Transducible delivery of nucleic acids using modified dsRNA binding domains
|
|
WO2010141471A2
(en)
|
2009-06-01 |
2010-12-09 |
The Regents Of The University Of California |
Nucleic acid delivery compositions and methods of use thereof
|
|
PT2437753T
(pt)
|
2009-06-05 |
2016-11-23 |
Infectious Disease Res Inst |
Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos
|
|
LT3305302T
(lt)
|
2009-06-17 |
2018-12-10 |
Biogen Ma Inc. |
Junginiai ir būdai smn2 splaisingo moduliavimui subjekte
|
|
JP5670097B2
(ja)
|
2009-06-19 |
2015-02-18 |
花王株式会社 |
二層分離型毛髪化粧料
|
|
EP2447273A4
(en)
|
2009-06-23 |
2013-06-19 |
Takeda Pharmaceutical |
PROCESS FOR SYNTHETIZING NUCLEIC ACID
|
|
WO2011005761A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc |
Novel nucleic acid prodrugs and methods use thereof
|
|
WO2011005764A1
(en)
|
2009-07-06 |
2011-01-13 |
Ada Technologies, Inc. |
Electrochemical device and method for long-term measurement of hypohalites
|
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
|
WO2011005942A2
(en)
|
2009-07-08 |
2011-01-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
UA107360C2
(en)
|
2009-08-05 |
2014-12-25 |
Biogen Idec Inc |
Bicyclic aryl sphingosine 1-phosphate analogs
|
|
WO2011017521A2
(en)
|
2009-08-06 |
2011-02-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US8927553B2
(en)
|
2009-08-10 |
2015-01-06 |
Daljit Singh Dhanoa |
Deuterium-enriched alkyl sulfonamides and uses thereof
|
|
RU2751847C9
(ru)
|
2009-09-11 |
2021-08-20 |
Ионис Фармасьютикалз, Инк. |
Модуляция экспрессии гентингтина
|
|
JP5878758B2
(ja)
|
2009-09-16 |
2016-03-08 |
株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ |
Ｒｎａ及びその誘導体合成のための新規保護基
|
|
WO2011038288A1
(en)
|
2009-09-25 |
2011-03-31 |
Isis Pharmaceuticals, Inc. |
Modulation of ttc39 expression to increase hdl
|
|
JP5629324B2
(ja)
|
2009-10-15 |
2014-11-19 |
ファイザー・インク |
ピロロ［２，３−ｄ］ピリミジン化合物
|
|
TWI475051B
(zh)
|
2009-11-18 |
2015-03-01 |
Kao Corp |
Organic polysiloxane
|
|
JP5809408B2
(ja)
|
2009-11-25 |
2015-11-10 |
花王株式会社 |
毛髪化粧料
|
|
EP2512246B1
(en)
|
2009-12-17 |
2015-09-30 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
US8647742B2
(en)
|
2009-12-28 |
2014-02-11 |
Achira Labs Pvt. Ltd. |
Diagnostic gel composition, method for making a diagnostic gel composition
|
|
AU2011203986C1
(en)
|
2010-01-08 |
2015-03-05 |
Ionis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
|
US8750507B2
(en)
|
2010-01-25 |
2014-06-10 |
Cisco Technology, Inc. |
Dynamic group creation for managed key servers
|
|
US9006198B2
(en)
|
2010-02-08 |
2015-04-14 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
WO2011097643A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
SI2534149T1
(sl)
|
2010-02-10 |
2015-02-27 |
Glaxosmithkline Llc Corporation Service Company |
6-amino-2-((1S)-1-metilbutil)oksi)-9-(5-(1-pipridinil)pentil)-7,9- dihidro-8H purin-8-on maleat
|
|
US8859755B2
(en)
|
2010-03-05 |
2014-10-14 |
Chiralgen, Ltd. |
Method for preparing ribonucleoside phosphorothioate
|
|
WO2011127175A1
(en)
|
2010-04-06 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cd130 (gp130) expression
|
|
WO2011127307A1
(en)
|
2010-04-07 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cetp expression
|
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
|
EP3091027B1
(en)
|
2010-04-28 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
WO2011135396A1
(en)
|
2010-04-30 |
2011-11-03 |
Cellectis |
Method for modulating double-strand break-induced homologous recombination
|
|
GB201008902D0
(en)
|
2010-05-27 |
2010-07-14 |
Imp Innovations Ltd |
Membrane enhanced polymer sythesis
|
|
ES2908978T3
(es)
|
2010-08-31 |
2022-05-04 |
Sirna Therapeutics Inc |
Nuevas entidades químicas simples y métodos para la administración de oligonucleótidos
|
|
WO2012039448A1
(ja)
|
2010-09-24 |
2012-03-29 |
株式会社キラルジェン |
不斉補助基
|
|
WO2012043633A1
(ja)
|
2010-09-30 |
2012-04-05 |
独立行政法人国立精神・神経医療研究センター |
優性変異遺伝子発現抑制剤
|
|
KR101381048B1
(ko)
|
2010-10-20 |
2014-04-14 |
씨제이제일제당 (주) |
Ｏ-포스포세린 생산 균주 및 이로부터 생산된 ｏ-포스포세린으로부터 ｌ-시스테인 또는 이의 유도체의 생산방법
|
|
DK2632472T3
(en)
|
2010-10-29 |
2018-03-19 |
Sirna Therapeutics Inc |
RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
|
|
EP2638163B1
(en)
|
2010-11-12 |
2017-05-17 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
US8822671B2
(en)
|
2010-11-30 |
2014-09-02 |
The University Of Tokyo |
2'-O-modified RNA
|
|
WO2012092367A1
(en)
|
2010-12-28 |
2012-07-05 |
University Of Rochester |
Nucleic acid binding compounds, methods of making, and use thereof
|
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
CA2827380C
(en)
|
2011-02-12 |
2020-08-25 |
University Of Iowa Research Foundation |
Therapeutic nucleic acids
|
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
FR2975600B1
(fr)
|
2011-05-24 |
2013-07-05 |
Assist Publ Hopitaux De Paris |
Agents pour le traitement de tumeurs
|
|
RU2014106024A
(ru)
|
2011-07-19 |
2015-08-27 |
Юниверсити Оф Айдахо |
Варианты осуществления зонда и способы направленного действия на нуклеиновые кислоты
|
|
EP2734208B1
(en)
*
|
2011-07-19 |
2017-03-01 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
US9752142B2
(en)
|
2011-08-11 |
2017-09-05 |
Ionis Pharmaceuticals, Inc. |
Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
|
|
US9282242B2
(en)
|
2011-08-24 |
2016-03-08 |
Htc Corporation |
Method and electric device for taking panoramic photograph
|
|
EP2751269B1
(en)
|
2011-08-29 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
US20140080896A1
(en)
|
2011-08-30 |
2014-03-20 |
The Regents Of The University Of California |
Identification of small molecules that facilitate therapeutic exon skipping
|
|
US9896729B2
(en)
|
2011-08-31 |
2018-02-20 |
The University Of Manchester |
Method for diagnosing a neurodegenerative disease
|
|
WO2013036833A1
(en)
|
2011-09-09 |
2013-03-14 |
Mayo Foundation For Medical Education And Research |
Detecting frontotemporal dementia and amyotrophic lateral sclerosis
|
|
JP6317675B2
(ja)
|
2011-11-30 |
2018-04-25 |
サレプタ セラピューティクス， インコーポレイテッド |
延長リピート病を処置するためのオリゴヌクレオチド
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン，インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
CN102675386B
(zh)
|
2011-12-24 |
2014-07-02 |
河南科技大学 |
一种龙胆苦苷分离提纯方法
|
|
WO2013134558A1
(en)
|
2012-03-07 |
2013-09-12 |
The Texas A & M University System |
Cancer treatment targeting non-coding rna overexpression
|
|
EA028928B9
(ru)
|
2012-03-13 |
2018-05-31 |
Джилид Сайэнс, Инк. |
2'-замещенные карбануклеозидные аналоги для противовирусного лечения
|
|
KR20130114435A
(ko)
|
2012-04-09 |
2013-10-17 |
삼성전자주식회사 |
다수의 전극을 갖는 생분자 검출 장치
|
|
EP3228712A1
(en)
|
2012-04-23 |
2017-10-11 |
BioMarin Technologies B.V. |
Rna modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
|
|
HK1203514A1
(en)
|
2012-05-22 |
2015-10-30 |
Idenix Pharmaceuticals Llc |
D-amino acid compounds for liver disease
|
|
US9284344B2
(en)
|
2012-05-30 |
2016-03-15 |
Hokkaido System Science Co., Ltd. |
Oligonucleotide synthesis method using highly dispersible liquid-phase support
|
|
AU2013288048A1
(en)
|
2012-07-13 |
2015-01-22 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
|
CN104661664B
(zh)
*
|
2012-07-13 |
2020-07-03 |
波涛生命科学有限公司 |
手性控制
|
|
AU2013287630B2
(en)
|
2012-07-13 |
2017-05-25 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant
|
|
EP4253395A3
(en)
|
2012-08-06 |
2023-11-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for the preparation of carbohydrate conjugated rna agents
|
|
CN104736551B
(zh)
|
2012-08-15 |
2017-07-28 |
Ionis制药公司 |
使用改进的封端方案制备寡聚化合物的方法
|
|
WO2014059356A2
(en)
|
2012-10-12 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2014062686A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating c9orf72 expression
|
|
WO2014062736A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Methods for monitoring c9orf72 expression
|
|
BR112015008399A8
(pt)
|
2012-10-15 |
2017-10-03 |
Ionis Pharmaceuticals Inc |
Composto para modular a expressão de c90rf72, seu uso, oligonucleotídeo modificado, composto de fita dupla e composição
|
|
JP2015535261A
(ja)
|
2012-10-29 |
2015-12-10 |
コクリスタル ファーマ，インコーポレイテッド |
ウイルス感染及び癌の治療のためのピリミジンヌクレオチド及びその一リン酸プロドラッグ
|
|
EP2725029A1
(en)
|
2012-10-29 |
2014-04-30 |
Laboratoire Biodim |
New antibacterial compounds and biological applications thereof
|
|
JP6358955B2
(ja)
|
2012-10-31 |
2018-07-18 |
武田薬品工業株式会社 |
新規修飾核酸
|
|
BR112015010116A2
(pt)
|
2012-11-15 |
2017-08-22 |
Roche Innovation Ct Copenhagen As |
COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB
|
|
JP6463687B2
(ja)
|
2012-11-26 |
2019-02-06 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ |
Ｆｇｆｒ３の発現の調節のための組成物及び方法
|
|
WO2014099941A1
(en)
|
2012-12-19 |
2014-06-26 |
Idenix Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
HK1215718A1
(zh)
|
2013-01-30 |
2016-09-09 |
F. Hoffmann-La Roche Ag |
Lna寡核苷酸碳水化合物缀合物
|
|
WO2014121287A2
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
AU2014219019B2
(en)
|
2013-02-22 |
2020-04-16 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (siNA) molecules containing a 2' internucleoside linkage
|
|
MX2015013628A
(es)
|
2013-03-28 |
2016-02-18 |
Syngenta Ltd |
Metodos para controlar las plagas resistentes a neonicotinoides.
|
|
US20160050930A1
(en)
|
2013-03-28 |
2016-02-25 |
Syngenta Limited |
Methods of controlling neonicotinoid resistant pests
|
|
IL296543B2
(en)
|
2013-05-01 |
2025-02-01 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating HBV and TTR expression
|
|
DK3015467T3
(da)
|
2013-05-24 |
2025-02-10 |
Ajinomoto Kk |
Morpholino-oligonukleotidfremstillingsfremgangsmåde
|
|
CN105247052A
(zh)
|
2013-05-24 |
2016-01-13 |
罗氏创新中心哥本哈根有限公司 |
B-细胞cll/淋巴瘤11a(bcl11a)的寡核苷酸调节剂及其用途
|
|
CA2916252A1
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
|
JP6255092B2
(ja)
|
2013-06-27 |
2017-12-27 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Ｐｃｓｋ９を標的とするアンチセンスオリゴマーおよびコンジュゲート
|
|
TWI772856B
(zh)
|
2013-07-19 |
2022-08-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
CN105579582A
(zh)
|
2013-07-25 |
2016-05-11 |
埃克西奎雷股份有限公司 |
用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体
|
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
CN105579442A
(zh)
|
2013-09-06 |
2016-05-11 |
先正达参股股份有限公司 |
杀虫化合物
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
|
EP3052627B1
(en)
|
2013-10-04 |
2018-08-22 |
Novartis AG |
Novel formats for organic compounds for use in rna interference
|
|
EP3055414A4
(en)
|
2013-10-11 |
2017-07-19 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
|
US20160230172A1
(en)
|
2013-10-14 |
2016-08-11 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
EP3058069B1
(en)
|
2013-10-14 |
2019-07-24 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating expression of c9orf72 antisense transcript
|
|
EP3068905A4
(en)
|
2013-11-11 |
2017-07-05 |
Sangamo BioSciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
EP3068885A1
(en)
|
2013-11-14 |
2016-09-21 |
Roche Innovation Center Copenhagen A/S |
Apob antisense conjugate compounds
|
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3095460A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
CN113278617A
(zh)
|
2014-01-16 |
2021-08-20 |
波涛生命科学有限公司 |
手性设计
|
|
US10280418B2
(en)
|
2014-03-18 |
2019-05-07 |
Univeristy Of Massachusetts |
RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
|
|
EP3137476B1
(en)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
BR122020024443B1
(pt)
|
2014-05-01 |
2022-02-22 |
Ionis Pharmaceuticals, Inc |
Composto e composição farmacêutica para modulação da expressão de angptl3
|
|
CN106413760B
(zh)
|
2014-05-08 |
2020-01-14 |
桑格摩生物科学股份有限公司 |
用于治疗亨廷顿病的方法和组合物
|
|
RU2711147C2
(ru)
|
2014-05-20 |
2020-01-15 |
Юниверсити Оф Айова Рисерч Фаундейшн |
Терапевтические соединения для лечения болезни хантингтона
|
|
US20160017327A1
(en)
|
2014-07-11 |
2016-01-21 |
The Johns Hopkins University |
Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity
|
|
CA2955250A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
SG11201700828PA
(en)
|
2014-08-07 |
2017-03-30 |
Takeda Pharmaceuticals Co |
Cationic lipid
|
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
|
WO2016037191A1
(en)
|
2014-09-05 |
2016-03-10 |
Health Research, Inc. |
Use of huntingtin-derived plasmids and peptides for active immunization as a huntington's disease (hd) therapeutic
|
|
JP2017536366A
(ja)
|
2014-11-19 |
2017-12-07 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Ｌｎａキラルホスホロチオエート
|
|
DK3234131T3
(da)
|
2014-12-16 |
2020-06-29 |
Roche Innovation Ct Copenhagen As |
Fremgangsmåde til screening af kiral toksicitet
|
|
HUE043842T2
(hu)
|
2014-12-24 |
2019-09-30 |
Uniqure Ip Bv |
RNAi-indukált huntingtin gén szuppresszió
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
EP3254104B1
(en)
|
2015-02-04 |
2021-08-25 |
Bristol-Myers Squibb Company |
Methods of selecting therapeutic molecules
|
|
US20180023081A1
(en)
|
2015-02-04 |
2018-01-25 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
EA201791805A1
(ru)
|
2015-02-10 |
2018-05-31 |
Джензим Корпорейшн |
ВАРИАНТ СРЕДСТВА ДЛЯ RNAi
|
|
EP3256587A2
(en)
|
2015-02-13 |
2017-12-20 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
WO2016138017A1
(en)
|
2015-02-23 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing antisense activity
|
|
EP4636085A3
(en)
|
2015-03-03 |
2026-01-07 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
|
WO2016145142A1
(en)
|
2015-03-10 |
2016-09-15 |
Emory University |
Nucleotide and nucleoside therapeutics compositions and uses related thereto
|
|
WO2016154096A1
(en)
|
2015-03-20 |
2016-09-29 |
Ionis Pharmaceuticals, Inc. |
Modulation of smggds expression
|
|
CA2980337A1
(en)
|
2015-04-03 |
2016-10-06 |
University Of Massachusetts |
Oligonucleotide compounds for targeting huntingtin mrna
|
|
US10851371B2
(en)
|
2015-04-10 |
2020-12-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of SMN expression
|
|
WO2016168592A2
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
EP4545544A3
(en)
|
2015-06-29 |
2025-10-08 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
|
BR112017028194B1
(pt)
|
2015-07-10 |
2023-03-14 |
Ionis Pharmaceuticals, Inc |
Composto oligomérico modulador de diaciglicerol aciltransferase 2 (dgat2), composição, e seus usos
|
|
EP3919619A1
(en)
|
2015-07-17 |
2021-12-08 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
US20180216114A1
(en)
|
2015-07-27 |
2018-08-02 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
|
HUE051998T2
(hu)
|
2015-07-31 |
2021-04-28 |
Alnylam Pharmaceuticals Inc |
Transztiretin (TTR) iRNS készítmények és eljárások azok alkalmazása TTR-asszociált betegségek kezelésére vagy megelõzésére
|
|
HK1252479A1
(zh)
|
2015-08-24 |
2019-05-24 |
Roche Innovation Center Copenhagen A/S |
Lna-g方法
|
|
CN108348541A
(zh)
|
2015-08-25 |
2018-07-31 |
阿尔尼拉姆医药品有限公司 |
用于治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物
|
|
KR102866196B1
(ko)
|
2015-09-02 |
2025-09-29 |
알닐람 파마슈티칼스 인코포레이티드 |
프로그램된 세포사 1 리간드 1 (PD-L1) iRNA 조성물 및 그의 사용 방법
|
|
EP3356447A4
(en)
|
2015-10-01 |
2019-06-12 |
Memorial Sloan-Kettering Cancer Center |
INHIBITORS OF MENACHINONE BIOSYNTHESIS
|
|
US10874686B2
(en)
|
2015-10-01 |
2020-12-29 |
Memorial Sloan-Kettering Cancer Center |
Anthranilyl-adenosinemonosulfamate analogs and uses thereof
|
|
US10577388B2
(en)
|
2015-10-02 |
2020-03-03 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugation process
|
|
WO2017062862A2
(en)
|
2015-10-09 |
2017-04-13 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
US10955407B2
(en)
|
2015-10-22 |
2021-03-23 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
|
WO2017079291A1
(en)
|
2015-11-02 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating c90rf72
|
|
HRP20210227T1
(hr)
|
2015-11-12 |
2021-03-19 |
F. Hoffmann - La Roche Ag |
Oligonukleotidi za indukciju ekspresije paternalnog gena ube3a
|
|
AU2017234150B2
(en)
|
2016-03-13 |
2021-09-16 |
Wave Life Sciences Ltd. |
Compositions and methods for phosphoramidite and oligonucleotide synthesis
|
|
RU2747822C2
(ru)
|
2016-03-14 |
2021-05-14 |
Ф. Хоффманн-Ля Рош Аг |
Олигонуклеотиды для понижения экспрессии pd-l1
|
|
US11267843B2
(en)
|
2016-03-18 |
2022-03-08 |
Roche Innovation Center Copenhagen A/S |
Stereodefining L-monomers
|
|
WO2017165489A1
(en)
|
2016-03-23 |
2017-09-28 |
Emory University |
Antiviral agents for treating zika and dengue virus infections
|
|
CA3017532A1
(en)
|
2016-04-13 |
2017-10-19 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing c9orf72 expression
|
|
US11248019B2
(en)
|
2016-04-14 |
2022-02-15 |
Hoffmann-La Roche Inc. |
Trityl-mono-GalNAc compounds and their use
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
|
WO2017194498A1
(en)
|
2016-05-12 |
2017-11-16 |
Roche Innovation Center Copenhagen A/S |
Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide
|
|
JP7083756B2
(ja)
|
2016-05-13 |
2022-06-13 |
エフ．ホフマン－ラ ロシュ アーゲー |
タンパク質系試料回収マトリックス及び装置
|
|
WO2017198775A1
(en)
|
2016-05-18 |
2017-11-23 |
Eth Zurich |
Stereoselective synthesis of phosphorothioate oligoribonucleotides
|
|
MA45188A
(fr)
|
2016-06-03 |
2019-04-10 |
Wave Life Sciences Ltd |
Oligonucléotides, compositions et méthodes associées
|
|
WO2017221883A1
(ja)
|
2016-06-20 |
2017-12-28 |
武田薬品工業株式会社 |
抗体－薬物コンジュゲート
|
|
US20190264267A1
(en)
|
2016-07-25 |
2019-08-29 |
Wave Life Sciences Ltd. |
Phasing
|
|
MA46905A
(fr)
|
2016-11-23 |
2019-10-02 |
Wave Life Sciences Ltd |
Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotides
|
|
CN120330183A
(zh)
|
2017-06-02 |
2025-07-18 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
EP3630789A4
(en)
|
2017-06-02 |
2021-06-16 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THEIR USE
|
|
CN111050806A
(zh)
|
2017-06-02 |
2020-04-21 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
JP7402696B2
(ja)
|
2017-06-21 |
2023-12-21 |
ウェイブ ライフ サイエンシズ リミテッド |
合成のための化合物、組成物、及び方法
|
|
WO2019032607A1
(en)
|
2017-08-08 |
2019-02-14 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
|
|
KR20250123934A
(ko)
|
2017-09-18 |
2025-08-18 |
웨이브 라이프 사이언시스 리미티드 |
올리고뉴클레오티드 제조 기술
|
|
US11596646B2
(en)
|
2017-10-12 |
2023-03-07 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
WO2019200185A1
(en)
|
2018-04-12 |
2019-10-17 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
US12391942B2
(en)
|
2018-05-11 |
2025-08-19 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
US20220186217A1
(en)
|
2018-12-06 |
2022-06-16 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
CA3126845A1
(en)
|
2019-02-01 |
2020-08-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
US20230089442A1
(en)
|
2019-03-20 |
2023-03-23 |
Pachamuthu Kandasamy |
Technologies useful for oligonucleotide preparation
|
|
JPWO2020196662A1
(enExample)
|
2019-03-25 |
2020-10-01 |
|
|
|
MX2021012862A
(es)
|
2019-04-25 |
2022-03-04 |
Wave Life Sciences Ltd |
Composiciones de oligonucleotidos y metodos de uso de las mismas.
|
|
MX2021012981A
(es)
|
2019-04-25 |
2022-01-18 |
Wave Life Sciences Ltd |
Composiciones de oligonucleotido y metodos de uso de las mismas.
|
|
EP3965780A4
(en)
|
2019-05-09 |
2023-10-25 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE
|
|
CN114585737A
(zh)
|
2019-10-06 |
2022-06-03 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
WO2021071788A2
(en)
|
2019-10-06 |
2021-04-15 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
AU2021230473A1
(en)
|
2020-03-01 |
2022-09-22 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
BR112022023465A2
(pt)
|
2020-05-22 |
2023-01-10 |
Wave Life Sciences Ltd |
Agente de rnai de fita dupla (dsrnai), composição de oligonucleotídeo quiralmente controlada, oligonucleotídeo de fita dupla, método para reduzir o nível e/ou a atividade de um transcrito ou uma proteína codificada pelo mesmo, e método para supressão específica quanto ao alelo de um transcrito de uma sequência de ácidos nucleicos
|
|
WO2021237223A1
(en)
|
2020-05-22 |
2021-11-25 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
WO2022046723A1
(en)
|
2020-08-24 |
2022-03-03 |
Wave Life Sciences Ltd. |
Immunoassays for detecting wild type huntingtin protein and methods of treatment employing such immunoassays
|
|
WO2022046667A1
(en)
|
2020-08-24 |
2022-03-03 |
Wave Life Sciences Ltd. |
Cells and non-human animals engineered to express adar1 and uses thereof
|
|
EP4217363A4
(en)
|
2020-09-24 |
2024-09-25 |
Mayo Foundation for Medical Education and Research |
Screening platforms
|
|
JP2023548584A
(ja)
|
2020-11-08 |
2023-11-17 |
ウェイブ ライフ サイエンシズ リミテッド |
オリゴヌクレオチド組成物及びその方法
|
|
CN116507724A
(zh)
|
2020-11-08 |
2023-07-28 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
WO2023049477A2
(en)
|
2021-09-26 |
2023-03-30 |
Wave Life Sciences Ltd. |
Compositions for editing mecp2 transcripts and methods thereof
|
|
CA3232070A1
(en)
|
2021-09-26 |
2023-03-30 |
Prashant MONIAN |
Oligonucleotide compositions and methods thereof
|
|
CA3236136A1
(en)
|
2021-10-27 |
2023-05-04 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
EP4422645A4
(en)
|
2021-10-27 |
2025-12-03 |
Wave Life Sciences Ltd |
OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE
|
|
WO2023154528A1
(en)
|
2022-02-11 |
2023-08-17 |
Wave Life Sciences Ltd. |
Stereoselective technologies for chiral compounds
|
|
KR20240168981A
(ko)
|
2022-03-02 |
2024-12-02 |
웨이브 라이프 사이언시스 리미티드 |
엑손 스키핑을 위한 올리고뉴클레오티드 조성물 및 이의 방법
|
|
IL316178A
(en)
|
2022-04-15 |
2024-12-01 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods related thereto
|
|
US20250302995A1
(en)
|
2022-05-12 |
2025-10-02 |
Chikdu Shakti Shivalila |
Oligonucleotide compositions and methods thereof
|
|
WO2024035946A1
(en)
|
2022-08-11 |
2024-02-15 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|