JP2014527807A5 - - Google Patents
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- Publication number
- JP2014527807A5 JP2014527807A5 JP2014529090A JP2014529090A JP2014527807A5 JP 2014527807 A5 JP2014527807 A5 JP 2014527807A5 JP 2014529090 A JP2014529090 A JP 2014529090A JP 2014529090 A JP2014529090 A JP 2014529090A JP 2014527807 A5 JP2014527807 A5 JP 2014527807A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- osteosarcoma
- therapeutic agent
- mir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 239000002679 microRNA Substances 0.000 claims 14
- 108700011259 MicroRNAs Proteins 0.000 claims 13
- 201000008968 osteosarcoma Diseases 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 230000000692 anti-sense effect Effects 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108091064399 miR-10b stem-loop Proteins 0.000 claims 4
- 108091079012 miR-133a Proteins 0.000 claims 4
- 108091024038 miR-133a stem-loop Proteins 0.000 claims 4
- 238000011319 anticancer therapy Methods 0.000 claims 3
- 108091028606 miR-1 stem-loop Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000011394 anticancer treatment Methods 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161531942P | 2011-09-07 | 2011-09-07 | |
| US61/531,942 | 2011-09-07 | ||
| US201261696981P | 2012-09-05 | 2012-09-05 | |
| US61/696,981 | 2012-09-05 | ||
| PCT/IB2012/002626 WO2013034989A2 (en) | 2011-09-07 | 2012-09-07 | Microrna-based methods and assays for osteosarcoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527807A JP2014527807A (ja) | 2014-10-23 |
| JP2014527807A5 true JP2014527807A5 (enExample) | 2015-09-24 |
| JP6153932B2 JP6153932B2 (ja) | 2017-06-28 |
Family
ID=47832670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529090A Active JP6153932B2 (ja) | 2011-09-07 | 2012-09-07 | 骨肉腫のためのマイクロｒｎａに基づく方法およびアッセイ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9322016B2 (enExample) |
| EP (1) | EP2753692B1 (enExample) |
| JP (1) | JP6153932B2 (enExample) |
| ES (1) | ES2727334T3 (enExample) |
| WO (1) | WO2013034989A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10905708B2 (en) | 2011-09-07 | 2021-02-02 | 3-D Matrix, Ltd. | MicroRNA-based methods and assays for osteocarcinoma |
| US11260072B2 (en) | 2011-09-07 | 2022-03-01 | 3-D Matrix, Ltd. | MicroRNA-based methods and assays for osteocarcinoma |
| US9315809B2 (en) * | 2012-08-29 | 2016-04-19 | City Of Hope | Differentially expressed microRNA molecules for the treatment and diagnosis of cancer |
| CN105535995B (zh) * | 2016-01-07 | 2018-12-07 | 赣南医学院第一附属医院 | 一种骨肉瘤诊疗制剂及其应用 |
| KR101823605B1 (ko) | 2016-12-02 | 2018-03-14 | 엘지전자 주식회사 | 태양 전지 및 이를 포함하는 태양 전지 패널 |
| KR102588627B1 (ko) * | 2017-03-08 | 2023-10-16 | 김성진 | Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법 |
| MX389585B (es) * | 2017-05-08 | 2025-03-20 | Unilever Ip Holdings B V | Prevencion y/o tratamiento de una enfermedad inflamatoria de la piel |
| US20220096517A1 (en) * | 2018-11-13 | 2022-03-31 | Regulus Therapeutics Inc. | MicroRNA Compounds and Methods for Modulating MIR-10B Activity |
| JP7607330B2 (ja) * | 2021-04-30 | 2024-12-27 | 国立大学法人金沢大学 | 骨腫瘍の予後診断方法又は予後診断補助方法 |
| CN113549691B (zh) * | 2021-06-15 | 2023-03-31 | 上海长征医院 | 用于骨肉瘤分型和评估骨肉瘤预后的基因及其应用 |
| CN113684279A (zh) * | 2021-10-11 | 2021-11-23 | 核工业总医院 | 一种诊断骨肉瘤的引物组、试剂盒及检测方法 |
| CN116179552A (zh) * | 2023-03-28 | 2023-05-30 | 广东明珠生物技术有限公司 | 抑制人FAM86B1基因表达的siRNA及FAM86B1低表达的细胞系 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295604B1 (en) * | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| US20090005336A1 (en) | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| US20110021609A1 (en) * | 2008-02-28 | 2011-01-27 | The Ohio State University Research Foundation | MicroRNA Signatures Associated with Cytogenetics and Prognosis in Acute Myeloid Leukemia (AML) and Uses Thereof |
| AU2009283906A1 (en) * | 2008-08-19 | 2010-02-25 | Maine Institute For Human Genetics And Health | Micro RNA and Neurofibromatosis Type 1 in diagnosis and therapy |
| WO2010136846A1 (en) | 2009-05-25 | 2010-12-02 | Carola Ponzetto | Differentiation therapy for sarcomas |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| US8889649B2 (en) * | 2010-11-12 | 2014-11-18 | National University Corporation Ehime University | Composition containing antisense oligonucleotide to micro RNA |
-
2012
- 2012-09-07 WO PCT/IB2012/002626 patent/WO2013034989A2/en not_active Ceased
- 2012-09-07 EP EP12829323.0A patent/EP2753692B1/en active Active
- 2012-09-07 ES ES12829323T patent/ES2727334T3/es active Active
- 2012-09-07 US US14/240,178 patent/US9322016B2/en active Active
- 2012-09-07 JP JP2014529090A patent/JP6153932B2/ja active Active
-
2016
- 2016-04-12 US US15/096,480 patent/US20160355809A1/en not_active Abandoned
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