JP2010538610A5 - - Google Patents
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- JP2010538610A5 JP2010538610A5 JP2010524221A JP2010524221A JP2010538610A5 JP 2010538610 A5 JP2010538610 A5 JP 2010538610A5 JP 2010524221 A JP2010524221 A JP 2010524221A JP 2010524221 A JP2010524221 A JP 2010524221A JP 2010538610 A5 JP2010538610 A5 JP 2010538610A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- ovarian cancer
- subject
- cell
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091070501 miRNA Proteins 0.000 claims 54
- 206010033128 Ovarian cancer Diseases 0.000 claims 32
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 32
- 210000004027 cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 23
- 230000014509 gene expression Effects 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 12
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 10
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 10
- 108091074450 miR-200c stem-loop Proteins 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 108091058688 miR-141 stem-loop Proteins 0.000 claims 9
- 108091028684 Mir-145 Proteins 0.000 claims 7
- 108091084619 miR-125b-1 stem-loop Proteins 0.000 claims 7
- 108091060382 miR-140 stem-loop Proteins 0.000 claims 7
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 108091062154 Mir-205 Proteins 0.000 claims 3
- 108091055059 miR-30c stem-loop Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091028141 MiR-203 Proteins 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 2
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 2
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 2
- 201000004228 ovarian endometrial cancer Diseases 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical group O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- 230000006429 DNA hypomethylation Effects 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000012649 demethylating agent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108091023796 miR-182 stem-loop Proteins 0.000 claims 1
- -1 miR-30-5p Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 208000030806 ovarian endometrioid adenocarcinoma Diseases 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96766307P | 2007-09-06 | 2007-09-06 | |
| US60/967,663 | 2007-09-06 | ||
| PCT/US2008/075565 WO2009033140A1 (en) | 2007-09-06 | 2008-09-08 | Microrna signatures in human ovarian cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013223103A Division JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538610A JP2010538610A (ja) | 2010-12-16 |
| JP2010538610A5 true JP2010538610A5 (enExample) | 2011-10-27 |
| JP5401460B2 JP5401460B2 (ja) | 2014-01-29 |
Family
ID=40429408
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524221A Expired - Fee Related JP5401460B2 (ja) | 2007-09-06 | 2008-09-08 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2013223103A Pending JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2015076636A Ceased JP2015130879A (ja) | 2007-09-06 | 2015-04-03 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013223103A Pending JP2014027948A (ja) | 2007-09-06 | 2013-10-28 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
| JP2015076636A Ceased JP2015130879A (ja) | 2007-09-06 | 2015-04-03 | ヒト卵巣癌中のマイクロｒｎａシグネチャー |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100249213A1 (enExample) |
| EP (4) | EP2183393B1 (enExample) |
| JP (3) | JP5401460B2 (enExample) |
| CN (1) | CN101939446B (enExample) |
| AU (1) | AU2008296022B2 (enExample) |
| CA (1) | CA2698771A1 (enExample) |
| WO (1) | WO2009033140A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| CA2621441C (en) | 2005-09-12 | 2014-05-20 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| ES2531052T3 (es) | 2006-01-05 | 2015-03-10 | Univ Ohio State Res Found | Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama |
| ES2554531T3 (es) | 2006-01-05 | 2015-12-21 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| CN101384273B (zh) | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436786B1 (en) | 2006-07-13 | 2014-04-16 | The Ohio State University Research Foundation | MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma. |
| ATE534752T1 (de) | 2006-09-19 | 2011-12-15 | Univ Ohio State Res Found | Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll) |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| WO2012070037A2 (en) * | 2010-11-22 | 2012-05-31 | Rosetta Genomics Ltd. | Methods and materials for classification of tissue of origin of tumor samples |
| US9096906B2 (en) | 2007-03-27 | 2015-08-04 | Rosetta Genomics Ltd. | Gene expression signature for classification of tissue of origin of tumor samples |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| JP5480132B2 (ja) | 2007-06-15 | 2014-04-23 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｄｒｏｓｈａ媒介性のマイクロｒｎａプロセッシングを標的するための癌原性ａｌｌ−１融合タンパク質 |
| US8367632B2 (en) | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| CN101835902B (zh) | 2007-08-03 | 2014-03-26 | 俄亥俄州立大学研究基金会 | 编码ncrna的超保守区域 |
| AU2008288806B2 (en) | 2007-08-22 | 2014-11-27 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias |
| EP2201112A4 (en) | 2007-10-26 | 2011-02-02 | Univ Ohio State Res Found | METHOD FOR IDENTIFYING FHIT INTERACTION AND USE |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| CN102575289A (zh) * | 2009-06-25 | 2012-07-11 | 耶鲁大学 | 在处的单核苷酸多态性和癌症风险 |
| CN102725420A (zh) | 2009-08-31 | 2012-10-10 | 阿尔塞多生物技术有限公司 | 用于染色体重排相关肿瘤的诊断、预后和治疗的基于微小rna的方法和组合物 |
| DK2475372T4 (da) * | 2009-09-10 | 2020-11-30 | Velin Pharma As | Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse |
| WO2011057304A2 (en) * | 2009-11-09 | 2011-05-12 | Yale University | Microrna signatures differentiating uterine and ovarian papillary serous tumors |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| EP2354246A1 (en) * | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| US10758619B2 (en) | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
| US8883757B2 (en) | 2011-01-03 | 2014-11-11 | Rosetta Genomics Ltd. | Compositions and methods for treatment of ovarian cancer |
| SG189505A1 (en) * | 2011-01-13 | 2013-05-31 | Ind Tech Res Inst | Biomarkers for recurrence prediction of colorectal cancer |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| CN102178959B (zh) * | 2011-03-15 | 2013-10-23 | 清华大学深圳研究生院 | 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用 |
| WO2012145743A1 (en) * | 2011-04-22 | 2012-10-26 | University Of Houston | Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy |
| HK1197273A1 (en) * | 2011-10-14 | 2015-01-09 | The Ohio State University | Methods and materials related to ovarian cancer |
| JP2015501843A (ja) | 2011-12-13 | 2015-01-19 | オハイオ・ステイト・イノベーション・ファウンデーション | ｍｉＲ−２１およびｍｉＲ−２９ａ、エキソソーム阻害、およびがん転移に関する方法および組成物 |
| CN104685065B (zh) | 2012-01-20 | 2017-02-22 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
| WO2013148151A1 (en) * | 2012-03-29 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer |
| US20140274780A1 (en) * | 2013-03-15 | 2014-09-18 | PSertain Technologies | Methods of improving survival in cancer |
| CN103343160B (zh) * | 2013-05-03 | 2014-12-10 | 中国人民解放军南京军区南京总医院 | microRNA-30家族的新用途 |
| CN103243163A (zh) * | 2013-05-09 | 2013-08-14 | 江苏省中医院 | miR-27a的新用途 |
| KR101508580B1 (ko) | 2013-05-14 | 2015-04-07 | 연세대학교 산학협력단 | 재발성 난소암의 예측 또는 진단 방법 |
| WO2014193309A1 (en) * | 2013-05-30 | 2014-12-04 | Agency For Science, Technology And Research | Method For Determining Cancer Prognosis |
| WO2014210341A2 (en) * | 2013-06-27 | 2014-12-31 | Institute For Systems Biology | Products and methods relating to micro rnas and cancer |
| CN103952465A (zh) * | 2013-12-10 | 2014-07-30 | 长沙赢润生物技术有限公司 | 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法 |
| CN104975019B (zh) * | 2014-04-01 | 2019-07-12 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用 |
| US12188092B2 (en) * | 2015-03-09 | 2025-01-07 | Agency For Science, Technology And Research | Method of determining the risk of developing breast cancer by detecting the expression levels of microRNAs (miRNAs) |
| CN105177173A (zh) * | 2015-11-02 | 2015-12-23 | 崔长友 | 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11214839B2 (en) | 2017-01-09 | 2022-01-04 | Dana-Farber Cancer Institute, Inc. | Circulating microRNA signatures for ovarian cancer |
| KR102736612B1 (ko) | 2017-04-28 | 2024-12-03 | 국립연구개발법인 고쿠리츠간켄큐센터 | 난소 종양의 검출을 위한 키트, 디바이스, 및 방법 |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| CN108992457A (zh) * | 2018-01-15 | 2018-12-14 | 广东省实验动物监测所 | miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用 |
| CN108103199B (zh) * | 2018-02-13 | 2021-08-10 | 朱伟 | 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用 |
| CN112154217B (zh) * | 2018-03-13 | 2025-03-07 | 贝勒研究院 | 用于治疗、诊断和预测卵巢癌的方法和组合物 |
| CN109337978B (zh) * | 2018-07-03 | 2023-12-01 | 华中科技大学同济医学院附属同济医院 | miRNA在制备高级浆液性上皮性卵巢癌化疗耐药性评价试剂盒中的应用 |
| JP2022523366A (ja) * | 2019-02-21 | 2022-04-22 | ウニベルジテート ハイデルベルク | 癌の診断及び予後に関するバイオマーカーパネル |
| EP3968960A1 (en) * | 2019-05-13 | 2022-03-23 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Nanovesicles and its use for nucleic acid delivery |
| EP3976058A4 (en) * | 2019-06-03 | 2023-07-19 | Carmel-Haifa University Economic Corporation Ltd. | TREATMENT OF HEAD AND NECK CANCER IN HUMAN |
| CN110564854B (zh) * | 2019-09-09 | 2023-09-29 | 晶准生物医药集团有限公司 | 基于miRNA检测的试剂盒及其在癌症早期筛查中的应用 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN114854756B (zh) * | 2022-05-31 | 2023-08-29 | 华南农业大学 | miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用 |
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2008
- 2008-09-08 CN CN200880112585.9A patent/CN101939446B/zh not_active Expired - Fee Related
- 2008-09-08 CA CA2698771A patent/CA2698771A1/en not_active Abandoned
- 2008-09-08 AU AU2008296022A patent/AU2008296022B2/en not_active Ceased
- 2008-09-08 WO PCT/US2008/075565 patent/WO2009033140A1/en not_active Ceased
- 2008-09-08 EP EP08799295.4A patent/EP2183393B1/en not_active Not-in-force
- 2008-09-08 US US12/676,670 patent/US20100249213A1/en not_active Abandoned
- 2008-09-08 EP EP14164377.5A patent/EP2775001B1/en not_active Not-in-force
- 2008-09-08 EP EP16156869.6A patent/EP3048177A1/en not_active Withdrawn
- 2008-09-08 JP JP2010524221A patent/JP5401460B2/ja not_active Expired - Fee Related
- 2008-09-08 EP EP16184406.3A patent/EP3138926A3/en not_active Withdrawn
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2013
- 2013-10-28 JP JP2013223103A patent/JP2014027948A/ja active Pending
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