AU2008296022B2 - MicroRNA signatures in human ovarian cancer - Google Patents

MicroRNA signatures in human ovarian cancer Download PDF

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Publication number
AU2008296022B2
AU2008296022B2 AU2008296022A AU2008296022A AU2008296022B2 AU 2008296022 B2 AU2008296022 B2 AU 2008296022B2 AU 2008296022 A AU2008296022 A AU 2008296022A AU 2008296022 A AU2008296022 A AU 2008296022A AU 2008296022 B2 AU2008296022 B2 AU 2008296022B2
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mir
expression
ovarian cancer
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mirs
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AU2008296022A1 (en
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Carlo M. Croce
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Ohio State University Research Foundation
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Ohio State University Research Foundation
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Priority to AU2015202920A priority patent/AU2015202920B2/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008296022A 2007-09-06 2008-09-08 MicroRNA signatures in human ovarian cancer Ceased AU2008296022B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2014202073A AU2014202073B2 (en) 2007-09-06 2014-04-14 MicroRNA signatures in human ovarian cancer
AU2015202920A AU2015202920B2 (en) 2007-09-06 2015-05-29 MicroRNA signatures in human ovarian cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96766307P 2007-09-06 2007-09-06
US60/967,663 2007-09-06
PCT/US2008/075565 WO2009033140A1 (en) 2007-09-06 2008-09-08 Microrna signatures in human ovarian cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014202073A Division AU2014202073B2 (en) 2007-09-06 2014-04-14 MicroRNA signatures in human ovarian cancer

Publications (2)

Publication Number Publication Date
AU2008296022A1 AU2008296022A1 (en) 2009-03-12
AU2008296022B2 true AU2008296022B2 (en) 2014-01-23

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AU2008296022A Ceased AU2008296022B2 (en) 2007-09-06 2008-09-08 MicroRNA signatures in human ovarian cancer

Country Status (7)

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US (2) US20100249213A1 (enExample)
EP (4) EP2183393B1 (enExample)
JP (3) JP5401460B2 (enExample)
CN (1) CN101939446B (enExample)
AU (1) AU2008296022B2 (enExample)
CA (1) CA2698771A1 (enExample)
WO (1) WO2009033140A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5489459B2 (ja) 2005-08-01 2014-05-14 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物
CA2621441C (en) 2005-09-12 2014-05-20 The Ohio State University Research Foundation Compositions and methods for the diagnosis and therapy of bcl2-associated cancers
ES2531052T3 (es) 2006-01-05 2015-03-10 Univ Ohio State Res Found Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama
ES2554531T3 (es) 2006-01-05 2015-12-21 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
CN101384273B (zh) 2006-01-05 2013-07-10 俄亥俄州立大学研究基金会 胰腺内分泌和腺泡肿瘤中的微小rna表达异常
ES2446362T3 (es) 2006-03-20 2014-03-07 The Ohio State University Research Foundation Huellas de microARN durante megacariocipoyesis humana
EP2436786B1 (en) 2006-07-13 2014-04-16 The Ohio State University Research Foundation MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma.
ATE534752T1 (de) 2006-09-19 2011-12-15 Univ Ohio State Res Found Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll)
WO2008054828A2 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
US8034560B2 (en) 2007-01-31 2011-10-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
WO2012070037A2 (en) * 2010-11-22 2012-05-31 Rosetta Genomics Ltd. Methods and materials for classification of tissue of origin of tumor samples
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
ES2537349T3 (es) 2007-06-08 2015-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para determinar un subtipo de carcinoma hepatocelular
JP5480132B2 (ja) 2007-06-15 2014-04-23 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Drosha媒介性のマイクロrnaプロセッシングを標的するための癌原性all−1融合タンパク質
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
AU2008288806B2 (en) 2007-08-22 2014-11-27 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias
EP2201112A4 (en) 2007-10-26 2011-02-02 Univ Ohio State Res Found METHOD FOR IDENTIFYING FHIT INTERACTION AND USE
EP2307028B1 (en) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
CN102575289A (zh) * 2009-06-25 2012-07-11 耶鲁大学 在处的单核苷酸多态性和癌症风险
CN102725420A (zh) 2009-08-31 2012-10-10 阿尔塞多生物技术有限公司 用于染色体重排相关肿瘤的诊断、预后和治疗的基于微小rna的方法和组合物
DK2475372T4 (da) * 2009-09-10 2020-11-30 Velin Pharma As Fremgangsmåde til fremstilling af micro-RNA og dets terapeutiske anvendelse
WO2011057304A2 (en) * 2009-11-09 2011-05-12 Yale University Microrna signatures differentiating uterine and ovarian papillary serous tumors
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
CN102080086B (zh) * 2009-12-01 2012-12-26 中国科学院上海药物研究所 人miR-133a反义核酸及其应用
EP2354246A1 (en) * 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
US10758619B2 (en) 2010-11-15 2020-09-01 The Ohio State University Controlled release mucoadhesive systems
US8883757B2 (en) 2011-01-03 2014-11-11 Rosetta Genomics Ltd. Compositions and methods for treatment of ovarian cancer
SG189505A1 (en) * 2011-01-13 2013-05-31 Ind Tech Res Inst Biomarkers for recurrence prediction of colorectal cancer
WO2012122239A1 (en) 2011-03-07 2012-09-13 The Ohio State University MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER
CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
WO2012145743A1 (en) * 2011-04-22 2012-10-26 University Of Houston Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy
HK1197273A1 (en) * 2011-10-14 2015-01-09 The Ohio State University Methods and materials related to ovarian cancer
JP2015501843A (ja) 2011-12-13 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション miR−21およびmiR−29a、エキソソーム阻害、およびがん転移に関する方法および組成物
CN104685065B (zh) 2012-01-20 2017-02-22 俄亥俄州立大学 浸润性和预后的乳腺癌生物标志物标签
WO2013148151A1 (en) * 2012-03-29 2013-10-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer
US20140274780A1 (en) * 2013-03-15 2014-09-18 PSertain Technologies Methods of improving survival in cancer
CN103343160B (zh) * 2013-05-03 2014-12-10 中国人民解放军南京军区南京总医院 microRNA-30家族的新用途
CN103243163A (zh) * 2013-05-09 2013-08-14 江苏省中医院 miR-27a的新用途
KR101508580B1 (ko) 2013-05-14 2015-04-07 연세대학교 산학협력단 재발성 난소암의 예측 또는 진단 방법
WO2014193309A1 (en) * 2013-05-30 2014-12-04 Agency For Science, Technology And Research Method For Determining Cancer Prognosis
WO2014210341A2 (en) * 2013-06-27 2014-12-31 Institute For Systems Biology Products and methods relating to micro rnas and cancer
CN103952465A (zh) * 2013-12-10 2014-07-30 长沙赢润生物技术有限公司 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法
CN104975019B (zh) * 2014-04-01 2019-07-12 上海翔琼生物技术有限公司 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用
US12188092B2 (en) * 2015-03-09 2025-01-07 Agency For Science, Technology And Research Method of determining the risk of developing breast cancer by detecting the expression levels of microRNAs (miRNAs)
CN105177173A (zh) * 2015-11-02 2015-12-23 崔长友 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11214839B2 (en) 2017-01-09 2022-01-04 Dana-Farber Cancer Institute, Inc. Circulating microRNA signatures for ovarian cancer
KR102736612B1 (ko) 2017-04-28 2024-12-03 국립연구개발법인 고쿠리츠간켄큐센터 난소 종양의 검출을 위한 키트, 디바이스, 및 방법
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
CN108992457A (zh) * 2018-01-15 2018-12-14 广东省实验动物监测所 miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用
CN108103199B (zh) * 2018-02-13 2021-08-10 朱伟 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用
CN112154217B (zh) * 2018-03-13 2025-03-07 贝勒研究院 用于治疗、诊断和预测卵巢癌的方法和组合物
CN109337978B (zh) * 2018-07-03 2023-12-01 华中科技大学同济医学院附属同济医院 miRNA在制备高级浆液性上皮性卵巢癌化疗耐药性评价试剂盒中的应用
JP2022523366A (ja) * 2019-02-21 2022-04-22 ウニベルジテート ハイデルベルク 癌の診断及び予後に関するバイオマーカーパネル
EP3968960A1 (en) * 2019-05-13 2022-03-23 Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Nanovesicles and its use for nucleic acid delivery
EP3976058A4 (en) * 2019-06-03 2023-07-19 Carmel-Haifa University Economic Corporation Ltd. TREATMENT OF HEAD AND NECK CANCER IN HUMAN
CN110564854B (zh) * 2019-09-09 2023-09-29 晶准生物医药集团有限公司 基于miRNA检测的试剂盒及其在癌症早期筛查中的应用
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
CN114854756B (zh) * 2022-05-31 2023-08-29 华南农业大学 miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105360A1 (en) * 2004-02-09 2006-05-18 Croce Carlo M Diagnosis and treatment of cancers with microRNA located in or near cancer associated chromosomal features
US20070161004A1 (en) * 2004-05-28 2007-07-12 David Brown Methods and compositions involving microRNA

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US257618A (en) * 1882-05-09 Eighths to
US176025A (en) * 1876-04-11 Improvement in check-hooks
US192111A (en) * 1877-06-19 Improvement in crimping-forms for boot-uppers
US189557A (en) * 1877-04-17 Improvement in stoves
US152112A (en) * 1874-06-16 Improvement in patterns and core-bars for casting pipes
US99034A (en) * 1870-01-18 El wood tush
US212727A (en) * 1879-02-25 Improvement in carpet-sweepers
US22934A (en) * 1859-02-15 Improvement in instruments for threading needles
US186589A (en) * 1877-01-23 Improvement in ice-machines
US24780A (en) * 1859-07-12 Improvement in sewing-machines
US188959A (en) * 1877-03-27 Improvement in brushes
US26796A (en) * 1860-01-10 Improvement in cultivators
US178502A (en) * 1876-06-13 Improvement in saw-mandrels
US192235A (en) * 1877-06-19 ceaig
US19286A (en) * 1858-02-09 boyers
US227533A (en) * 1880-05-11 Shutter-worker
US178105A (en) * 1876-05-30 Improvement in baking-pans
US105340A (en) * 1870-07-12 Improvement in fur collars
US65840A (en) * 1867-06-18 Improved medical compound
US123533A (en) * 1872-02-06 Improvement in combined latches and locks for sliding doors
US188924A (en) * 1877-03-27 Improvement in unloading grain-vessels
US75511A (en) * 1868-03-17 Jeamtm atkins
US92974A (en) * 1869-07-27 William h
US254473A (en) * 1882-03-07 Rope-clamp
US176723A (en) * 1876-04-25 Improvement in fenders for life-boats
US270484A (en) * 1883-01-09 Territobt
US175827A (en) * 1876-04-11 Improvement in air-gas machines
US163430A (en) * 1875-05-18 Improvement in gages for shaping wagon-axles
US165659A (en) * 1875-07-20 Improvement in registering board-rules
US61424A (en) * 1867-01-22 James l
US78834A (en) * 1868-06-09 William sanderson
US171667A (en) * 1876-01-04 Improvement in milk and cheese pans
US26951A (en) * 1860-01-24 John e
US163435A (en) * 1875-05-18 Improvement in paper boxes
US23594A (en) * 1859-04-12 Improvement in steam-engines
US192114A (en) * 1877-06-19 Improvement in casting brass and other metals
US253780A (en) * 1882-02-14 Apparatus for utilizing the waste products of combustion in furnaces
US176766A (en) * 1876-05-02 Improvement in fruit-jars
US65844A (en) * 1867-06-18 Improvement in preserving fruit
US123912A (en) * 1872-02-20 Improvement in devices for opening or closing umbrellas
US74797A (en) * 1868-02-25 Improvement in oheese-boxes
US116726A (en) * 1871-07-04 Improvement in punching-machines
US213292A (en) * 1879-03-18 Improvement in safety-plugs
US112630A (en) * 1871-03-14 Improvement in sleighs
US48681A (en) * 1865-07-11 Mkebagskf
US99196A (en) * 1870-01-25 Improved holdback for carriages
US256650A (en) * 1882-04-18 davis
US173319A (en) * 1876-02-08 Improvement in scroll-sawing machines
US123933A (en) * 1872-02-20 Improvement in plate-printing machinery
US123482A (en) * 1872-02-06 Improvement in railroad switches
US161004A (en) * 1875-03-23 Improvement in water-closets
US137410A (en) * 1873-04-01 Improvement in saw-sets
US54849A (en) * 1866-05-22 Improvement in trunk-locks
US99619A (en) * 1870-02-08 Improvement in neckties
US292616A (en) * 1884-01-29 Vapor-burner
US127895A (en) * 1872-06-11 Improvement in washing-machines
US203544A (en) * 1878-05-14 Improvement in treatment of flour
US19890A (en) * 1858-04-06 Gkate fob steam-engines
US105360A (en) * 1870-07-12 Improvement in faucets
US163434A (en) * 1875-05-18 Improvement in mills for grating cocoa-nuts
US192102A (en) * 1877-06-19 Improvement in paper folder and cutter
US292878A (en) * 1884-02-05 Weighing attachment for baby-carriages
US256072A (en) * 1882-04-04 Francis taggaet
US86331A (en) * 1869-01-26 Improved medical compound
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5015568A (en) * 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) * 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
ATE120497T1 (de) 1988-05-09 1995-04-15 Univ Temple Verfahren zur voraussage der wirksamkeit einer antineoplastichen behandlung bei einzelnen patienten.
US5198338A (en) * 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US6040140A (en) * 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
WO1993012136A1 (en) * 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
US5633135A (en) * 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
DE69332642T2 (de) * 1992-10-29 2003-10-02 Thomas Jefferson University, Philadelphia Methoden zur detektion von mikrometastasen bei prostata-krebs
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US7175995B1 (en) * 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US6242212B1 (en) * 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998035707A1 (en) * 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
AU5128999A (en) * 1998-07-24 2000-02-14 Yeda Research And Development Co. Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
PT1309726E (pt) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
US7060811B2 (en) * 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
US20020173478A1 (en) 2000-11-14 2002-11-21 The Trustees Of The University Of Pennsylvania Post-transcriptional gene silencing by RNAi in mammalian cells
EP2428569B1 (en) * 2001-09-28 2018-05-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Microrna molecules
AU2003241325A1 (en) * 2002-04-29 2003-11-17 Thomas Jefferson University Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression
WO2003102214A2 (en) 2002-05-31 2003-12-11 The Regents Of The University Of California Method for efficient rna interference in mammalian cells
EP1530418A4 (en) * 2002-05-31 2005-10-12 Univ Leland Stanford Junior METHOD FOR IDENTIFYING AND INSULATING STEM CELLS AND CANCER STAMPS
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
CA2504605C (en) * 2002-11-13 2016-01-19 Thomas Jefferson University Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
WO2005047505A2 (en) * 2003-08-07 2005-05-26 Whitehead Institute For Biomedical Research Methods and products for expression of micro rnas
US7799518B2 (en) * 2003-10-07 2010-09-21 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US20050186589A1 (en) * 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
EP1784501B1 (en) * 2004-05-14 2015-11-18 Rosetta Genomics Ltd VIRAL AND VIRUS ASSOCIATED MicroRNAS AND USES THEREOF
US7642348B2 (en) * 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
ES2503765T3 (es) * 2004-11-12 2014-10-07 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
WO2006133022A2 (en) 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070092882A1 (en) * 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US7390792B2 (en) * 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
ES2531052T3 (es) * 2006-01-05 2015-03-10 Univ Ohio State Res Found Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama
CN101384273B (zh) * 2006-01-05 2013-07-10 俄亥俄州立大学研究基金会 胰腺内分泌和腺泡肿瘤中的微小rna表达异常
US7955848B2 (en) * 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
WO2007127190A2 (en) * 2006-04-24 2007-11-08 The Ohio State University Research Foundation Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice
AU2007299748A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
AU2008220438A1 (en) * 2007-02-27 2008-09-04 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
US8097427B2 (en) * 2007-03-16 2012-01-17 Covalx Ag Direct mass spectrometric analysis of drug candidates targeting protein complexes
WO2009015357A1 (en) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105360A1 (en) * 2004-02-09 2006-05-18 Croce Carlo M Diagnosis and treatment of cancers with microRNA located in or near cancer associated chromosomal features
US20070161004A1 (en) * 2004-05-28 2007-07-12 David Brown Methods and compositions involving microRNA

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG, L. et al., Proceedings of the National Academy of Sciences of the United States of America, 2006, Vol. 103, No. 24, Pages 9136-9141. *

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