CA2698771A1 - Microrna signatures in human ovarian cancer - Google Patents

Microrna signatures in human ovarian cancer Download PDF

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Publication number
CA2698771A1
CA2698771A1 CA2698771A CA2698771A CA2698771A1 CA 2698771 A1 CA2698771 A1 CA 2698771A1 CA 2698771 A CA2698771 A CA 2698771A CA 2698771 A CA2698771 A CA 2698771A CA 2698771 A1 CA2698771 A1 CA 2698771A1
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mir
ovarian cancer
expression
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cell
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French (fr)
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Carlo M. Croce
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Ohio State University Research Foundation
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
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  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2698771A 2007-09-06 2008-09-08 Microrna signatures in human ovarian cancer Abandoned CA2698771A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96766307P 2007-09-06 2007-09-06
US60/967,663 2007-09-06
PCT/US2008/075565 WO2009033140A1 (en) 2007-09-06 2008-09-08 Microrna signatures in human ovarian cancer

Publications (1)

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CA2698771A1 true CA2698771A1 (en) 2009-03-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2698771A Abandoned CA2698771A1 (en) 2007-09-06 2008-09-08 Microrna signatures in human ovarian cancer

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US (2) US20100249213A1 (enExample)
EP (4) EP3048177A1 (enExample)
JP (3) JP5401460B2 (enExample)
CN (1) CN101939446B (enExample)
AU (1) AU2008296022B2 (enExample)
CA (1) CA2698771A1 (enExample)
WO (1) WO2009033140A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101341259B (zh) 2005-08-01 2011-12-21 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
AU2006291165B2 (en) 2005-09-12 2013-03-14 The Ohio State University Research Foundation Compositions and methods for the diagnosis and therapy of BCL2-associated cancers
EP2591794A1 (en) 2006-01-05 2013-05-15 The Ohio State University Research Foundation MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors
EP2514433B1 (en) 2006-01-05 2015-10-21 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer
EP2487255A3 (en) 2006-01-05 2012-10-10 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
EP2371971B1 (en) 2006-03-20 2013-11-27 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
EP2455493B1 (en) 2006-07-13 2014-01-08 The Ohio State University Research Foundation Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases
CA2663027A1 (en) 2006-09-19 2008-08-14 The Ohio State University Research Foundation Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
CN101627134B (zh) 2007-01-31 2013-11-06 俄亥俄州立大学研究基金会 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
EP2559772B1 (en) 2007-06-08 2015-04-15 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Methods for determining a hepatocellular carcinoma subtype
EP2719773A3 (en) 2007-06-15 2014-07-30 The Ohio State University Research Foundation miRNA as marker for acute lamphomic leucemia
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
US8465918B2 (en) 2007-08-03 2013-06-18 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
WO2009026487A1 (en) 2007-08-22 2009-02-26 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
CN102137927B (zh) 2007-10-26 2014-03-12 俄亥俄州立大学研究基金会 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途
WO2009152300A1 (en) 2008-06-11 2009-12-17 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
AU2010265889A1 (en) * 2009-06-25 2012-01-19 Yale University Single nucleotide polymorphisms in BRCA1 and cancer risk
JP2013502906A (ja) 2009-08-31 2013-01-31 アルケド バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 染色体再編成を伴う腫瘍の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物
US9078914B2 (en) 2009-09-10 2015-07-14 Velin-Pharma A/S Method for the preparation of micro-RNA and its therapeutic application
US20120219958A1 (en) * 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
CA2781547A1 (en) 2009-11-23 2011-05-26 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CN102080086B (zh) * 2009-12-01 2012-12-26 中国科学院上海药物研究所 人miR-133a反义核酸及其应用
EP2354246A1 (en) * 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
AU2011326032B2 (en) 2010-11-12 2016-10-06 The Ohio State University Research Foundation Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
CN103313706A (zh) 2010-11-15 2013-09-18 俄亥俄州立大学研究基金会 控制释放粘膜粘合系统
EP2643479B1 (en) * 2010-11-22 2017-09-13 Rosetta Genomics Ltd Methods and materials for classification of tissue of origin of tumor samples
WO2012093384A1 (en) * 2011-01-03 2012-07-12 Rosetta Genomics Ltd. Compositions and methods for treatment of ovarian cancer
CN103384829A (zh) * 2011-01-13 2013-11-06 财团法人工业技术研究院 预测大肠直肠癌复发的生物标记
CN103561750A (zh) 2011-03-07 2014-02-05 俄亥俄州立大学 通过microRNA-155(miR-155)诱导的增变活性使炎症与癌症关联
CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
US8765707B2 (en) 2011-04-22 2014-07-01 University Of Houston System MicroRNA-140-5p as a tumor suppressor and sensitizing agent for chemotherapy
WO2013056217A1 (en) * 2011-10-14 2013-04-18 The Ohio State University Methods and materials related to ovarian cancer
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
EP2804960A4 (en) 2012-01-20 2015-08-19 Univ Ohio State BREAST CANCER BIOMARK SIGNATURES FOR INVASIVITY AND FORECAST
WO2013148151A1 (en) * 2012-03-29 2013-10-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer
WO2014145142A2 (en) * 2013-03-15 2014-09-18 Miles Gregory Method of improving survival in cancer
CN103343160B (zh) * 2013-05-03 2014-12-10 中国人民解放军南京军区南京总医院 microRNA-30家族的新用途
CN103243163A (zh) * 2013-05-09 2013-08-14 江苏省中医院 miR-27a的新用途
KR101508580B1 (ko) 2013-05-14 2015-04-07 연세대학교 산학협력단 재발성 난소암의 예측 또는 진단 방법
WO2014193309A1 (en) * 2013-05-30 2014-12-04 Agency For Science, Technology And Research Method For Determining Cancer Prognosis
US20170218454A1 (en) * 2013-06-27 2017-08-03 Institute For Systems Biology Products and Methods Relating to Micro RNAS and Cancer
CN103952465A (zh) * 2013-12-10 2014-07-30 长沙赢润生物技术有限公司 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法
CN104975019B (zh) * 2014-04-01 2019-07-12 上海翔琼生物技术有限公司 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用
SG11201707325RA (en) * 2015-03-09 2017-10-30 Agency Science Tech & Res Method of determining the risk of developing breast cancer by detecting the expression levels of micrornas (mirnas)
CN105177173A (zh) * 2015-11-02 2015-12-23 崔长友 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
EP3565903A4 (en) * 2017-01-09 2020-12-23 Dana-Farber Cancer Institute, Inc. CIRCULATING MICRORNA SIGNATURES FOR OVARIAN CANCER
WO2018199275A1 (ja) 2017-04-28 2018-11-01 東レ株式会社 卵巣腫瘍の検出のためのキット、デバイス及び方法
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
CN108992457A (zh) * 2018-01-15 2018-12-14 广东省实验动物监测所 miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用
CN108103199B (zh) * 2018-02-13 2021-08-10 朱伟 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用
CN112154217B (zh) * 2018-03-13 2025-03-07 贝勒研究院 用于治疗、诊断和预测卵巢癌的方法和组合物
CN109337978B (zh) * 2018-07-03 2023-12-01 华中科技大学同济医学院附属同济医院 miRNA在制备高级浆液性上皮性卵巢癌化疗耐药性评价试剂盒中的应用
CA3127154A1 (en) * 2019-02-21 2020-08-27 Universitat Heidelberg Biomarker panel for diagnosis and prognosis of cancer
CA3139578A1 (en) * 2019-05-13 2020-11-19 Fundacio Hospital Universitari Vall D'hebron - Institut De Recerca Nanovesicles and its use for nucleic acid delivery
EP3976058A4 (en) * 2019-06-03 2023-07-19 Carmel-Haifa University Economic Corporation Ltd. TREATMENT OF HEAD AND NECK CANCER IN HUMAN
CN110564854B (zh) * 2019-09-09 2023-09-29 晶准生物医药集团有限公司 基于miRNA检测的试剂盒及其在癌症早期筛查中的应用
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
CN114854756B (zh) * 2022-05-31 2023-08-29 华南农业大学 miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US74797A (en) * 1868-02-25 Improvement in oheese-boxes
US173319A (en) * 1876-02-08 Improvement in scroll-sawing machines
US75511A (en) * 1868-03-17 Jeamtm atkins
US256072A (en) * 1882-04-04 Francis taggaet
US163435A (en) * 1875-05-18 Improvement in paper boxes
US176766A (en) * 1876-05-02 Improvement in fruit-jars
US24780A (en) * 1859-07-12 Improvement in sewing-machines
US105340A (en) * 1870-07-12 Improvement in fur collars
US292616A (en) * 1884-01-29 Vapor-burner
US292878A (en) * 1884-02-05 Weighing attachment for baby-carriages
US61424A (en) * 1867-01-22 James l
US178105A (en) * 1876-05-30 Improvement in baking-pans
US112630A (en) * 1871-03-14 Improvement in sleighs
US86331A (en) * 1869-01-26 Improved medical compound
US188959A (en) * 1877-03-27 Improvement in brushes
US212727A (en) * 1879-02-25 Improvement in carpet-sweepers
US105360A (en) * 1870-07-12 Improvement in faucets
US19890A (en) * 1858-04-06 Gkate fob steam-engines
US99034A (en) * 1870-01-18 El wood tush
US65844A (en) * 1867-06-18 Improvement in preserving fruit
US26796A (en) * 1860-01-10 Improvement in cultivators
US188924A (en) * 1877-03-27 Improvement in unloading grain-vessels
US192111A (en) * 1877-06-19 Improvement in crimping-forms for boot-uppers
US78834A (en) * 1868-06-09 William sanderson
US254473A (en) * 1882-03-07 Rope-clamp
US99196A (en) * 1870-01-25 Improved holdback for carriages
US137410A (en) * 1873-04-01 Improvement in saw-sets
US270484A (en) * 1883-01-09 Territobt
US48681A (en) * 1865-07-11 Mkebagskf
US26951A (en) * 1860-01-24 John e
US176723A (en) * 1876-04-25 Improvement in fenders for life-boats
US256650A (en) * 1882-04-18 davis
US186589A (en) * 1877-01-23 Improvement in ice-machines
US22934A (en) * 1859-02-15 Improvement in instruments for threading needles
US165659A (en) * 1875-07-20 Improvement in registering board-rules
US178502A (en) * 1876-06-13 Improvement in saw-mandrels
US192102A (en) * 1877-06-19 Improvement in paper folder and cutter
US99619A (en) * 1870-02-08 Improvement in neckties
US253780A (en) * 1882-02-14 Apparatus for utilizing the waste products of combustion in furnaces
US192235A (en) * 1877-06-19 ceaig
US152112A (en) * 1874-06-16 Improvement in patterns and core-bars for casting pipes
US23594A (en) * 1859-04-12 Improvement in steam-engines
US192114A (en) * 1877-06-19 Improvement in casting brass and other metals
US116726A (en) * 1871-07-04 Improvement in punching-machines
US19286A (en) * 1858-02-09 boyers
US161004A (en) * 1875-03-23 Improvement in water-closets
US176025A (en) * 1876-04-11 Improvement in check-hooks
US227533A (en) * 1880-05-11 Shutter-worker
US123482A (en) * 1872-02-06 Improvement in railroad switches
US163430A (en) * 1875-05-18 Improvement in gages for shaping wagon-axles
US54849A (en) * 1866-05-22 Improvement in trunk-locks
US171667A (en) * 1876-01-04 Improvement in milk and cheese pans
US65840A (en) * 1867-06-18 Improved medical compound
US92974A (en) * 1869-07-27 William h
US123533A (en) * 1872-02-06 Improvement in combined latches and locks for sliding doors
US123933A (en) * 1872-02-20 Improvement in plate-printing machinery
US123912A (en) * 1872-02-20 Improvement in devices for opening or closing umbrellas
US163434A (en) * 1875-05-18 Improvement in mills for grating cocoa-nuts
US213292A (en) * 1879-03-18 Improvement in safety-plugs
US127895A (en) * 1872-06-11 Improvement in washing-machines
US175827A (en) * 1876-04-11 Improvement in air-gas machines
US189557A (en) * 1877-04-17 Improvement in stoves
US203544A (en) * 1878-05-14 Improvement in treatment of flour
US257618A (en) * 1882-05-09 Eighths to
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5015568A (en) * 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) * 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
EP0341904B1 (en) 1988-05-09 1995-03-29 Temple University of the Commonwealth System of Higher Education Method for predicting the effectiveness of antineoplastic therapy in individual patients
US5198338A (en) * 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
WO1993012136A1 (en) * 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
US5633135A (en) * 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
US6040140A (en) * 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
JPH08502889A (ja) * 1992-10-29 1996-04-02 トーマス・ジェファーソン・ユニバーシティ 前立腺癌の微小転移を検出する方法
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US7175995B1 (en) * 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US6242212B1 (en) * 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998035707A1 (en) * 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
AU5128999A (en) * 1998-07-24 2000-02-14 Yeda Research And Development Co. Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Rna 간섭의 rna 서열 특이적인 매개체
US7060811B2 (en) * 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
US20020173478A1 (en) 2000-11-14 2002-11-21 The Trustees Of The University Of Pennsylvania Post-transcriptional gene silencing by RNAi in mammalian cells
EP2385123B1 (en) * 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Microrna molecules
WO2003092370A1 (en) * 2002-04-29 2003-11-13 Thomas Jefferson University Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression
US7217568B2 (en) * 2002-05-31 2007-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying and isolating stem cells and cancer stem cells
EP1537227B1 (en) 2002-05-31 2010-02-17 The Regents Of The University Of California Method for efficient rna interference in mammalian cells
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
AU2003291433B2 (en) * 2002-11-13 2008-05-22 Thomas Jefferson University Compositions and methods for cancer diagnosis and therapy
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
WO2005047505A2 (en) * 2003-08-07 2005-05-26 Whitehead Institute For Biomedical Research Methods and products for expression of micro rnas
CN1964986A (zh) * 2003-10-07 2007-05-16 千年药品公司 用于鉴定、评价、预防和治疗卵巢癌的核酸分子和蛋白质
US20050186589A1 (en) * 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
EP1713938A2 (en) * 2004-02-09 2006-10-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
EP1784501B1 (en) * 2004-05-14 2015-11-18 Rosetta Genomics Ltd VIRAL AND VIRUS ASSOCIATED MicroRNAS AND USES THEREOF
EP2290074B1 (en) * 2004-05-28 2014-12-17 Asuragen, Inc. Methods and compositions involving microRNA
US7642348B2 (en) * 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
CA2850323A1 (en) * 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
WO2006133022A2 (en) 2005-06-03 2006-12-14 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070092882A1 (en) * 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US7390792B2 (en) * 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
EP2487255A3 (en) * 2006-01-05 2012-10-10 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
EP2591794A1 (en) * 2006-01-05 2013-05-15 The Ohio State University Research Foundation MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors
US7955848B2 (en) * 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
CA2650026C (en) * 2006-04-24 2013-01-22 The Ohio State University Research Foundation Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
ATE553196T1 (de) * 2007-02-27 2012-04-15 Rosetta Genomics Ltd Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod
US8097427B2 (en) * 2007-03-16 2012-01-17 Covalx Ag Direct mass spectrometric analysis of drug candidates targeting protein complexes
AU2008279016B2 (en) * 2007-07-25 2013-08-22 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker

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