JP2014507123A5 - - Google Patents
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- JP2014507123A5 JP2014507123A5 JP2013544771A JP2013544771A JP2014507123A5 JP 2014507123 A5 JP2014507123 A5 JP 2014507123A5 JP 2013544771 A JP2013544771 A JP 2013544771A JP 2013544771 A JP2013544771 A JP 2013544771A JP 2014507123 A5 JP2014507123 A5 JP 2014507123A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- hsa
- mirna
- kit
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108091070501 miRNA Proteins 0.000 claims 18
- 239000002679 microRNA Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 13
- 239000000074 antisense oligonucleotide Substances 0.000 claims 7
- 238000012230 antisense oligonucleotides Methods 0.000 claims 7
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- -1 hsa-miR-106b Proteins 0.000 claims 4
- 208000020446 Cardiac disease Diseases 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 239000013068 control sample Substances 0.000 claims 3
- 208000019622 heart disease Diseases 0.000 claims 3
- 108091071651 miR-208 stem-loop Proteins 0.000 claims 3
- 108091084446 miR-208a stem-loop Proteins 0.000 claims 3
- 108091062547 miR-208a-1 stem-loop Proteins 0.000 claims 3
- 108091055375 miR-208a-2 stem-loop Proteins 0.000 claims 3
- 108091047268 miR-208b stem-loop Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 108091069016 Homo sapiens miR-122 stem-loop Proteins 0.000 claims 2
- 108091069004 Homo sapiens miR-125a stem-loop Proteins 0.000 claims 2
- 108091069085 Homo sapiens miR-126 stem-loop Proteins 0.000 claims 2
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 2
- 108091069002 Homo sapiens miR-145 stem-loop Proteins 0.000 claims 2
- 108091069088 Homo sapiens miR-150 stem-loop Proteins 0.000 claims 2
- 108091068960 Homo sapiens miR-195 stem-loop Proteins 0.000 claims 2
- 108091067484 Homo sapiens miR-199b stem-loop Proteins 0.000 claims 2
- 108091067470 Homo sapiens miR-204 stem-loop Proteins 0.000 claims 2
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 claims 2
- 108091067468 Homo sapiens miR-210 stem-loop Proteins 0.000 claims 2
- 108091067580 Homo sapiens miR-214 stem-loop Proteins 0.000 claims 2
- 108091070494 Homo sapiens miR-22 stem-loop Proteins 0.000 claims 2
- 108091069527 Homo sapiens miR-223 stem-loop Proteins 0.000 claims 2
- 108091032109 Homo sapiens miR-423 stem-loop Proteins 0.000 claims 2
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 claims 2
- 108091008065 MIR21 Proteins 0.000 claims 2
- 108091007780 MiR-122 Proteins 0.000 claims 2
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 210000005003 heart tissue Anatomy 0.000 claims 2
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 2
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 2
- 108091034121 miR-92a stem-loop Proteins 0.000 claims 2
- 108091041519 miR-92a-3 stem-loop Proteins 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000010606 normalization Methods 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108091070499 Caenorhabditis elegans lin-4 stem-loop Proteins 0.000 claims 1
- 108091070487 Caenorhabditis elegans miR-2 stem-loop Proteins 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 108091068992 Homo sapiens miR-143 stem-loop Proteins 0.000 claims 1
- 108091068954 Homo sapiens miR-185 stem-loop Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 108091027766 Mir-143 Proteins 0.000 claims 1
- 108091062140 Mir-223 Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 1
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 1
- 108091037787 miR-19b stem-loop Proteins 0.000 claims 1
- 108091039792 miR-20b stem-loop Proteins 0.000 claims 1
- 108091055878 miR-20b-1 stem-loop Proteins 0.000 claims 1
- 108091027746 miR-20b-2 stem-loop Proteins 0.000 claims 1
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 1
- 108091037240 miR-423 stem-loop Proteins 0.000 claims 1
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42345610P | 2010-12-15 | 2010-12-15 | |
| US61/423,456 | 2010-12-15 | ||
| US201161495220P | 2011-06-09 | 2011-06-09 | |
| US61/495,220 | 2011-06-09 | ||
| US201161538585P | 2011-09-23 | 2011-09-23 | |
| US61/538,585 | 2011-09-23 | ||
| PCT/US2011/065120 WO2012083004A2 (en) | 2010-12-15 | 2011-12-15 | Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507123A JP2014507123A (ja) | 2014-03-27 |
| JP2014507123A5 true JP2014507123A5 (enExample) | 2015-02-05 |
Family
ID=45444747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544771A Pending JP2014507123A (ja) | 2010-12-15 | 2011-12-15 | 心臓病状に対する薬効のサロゲートマーカーとしての血中ｍｉＲＮＡ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140024700A1 (enExample) |
| EP (1) | EP2652146A2 (enExample) |
| JP (1) | JP2014507123A (enExample) |
| CN (1) | CN103370424A (enExample) |
| AU (1) | AU2011343719A1 (enExample) |
| CA (1) | CA2818174A1 (enExample) |
| WO (1) | WO2012083004A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| EP2925884B1 (en) * | 2012-11-27 | 2018-01-31 | Luxembourg Institute of Health | Compositions and methods for evaluating heart failure |
| CN103290116B (zh) * | 2013-05-16 | 2016-09-07 | 南京市妇幼保健院 | 一种与胎儿先天性心脏病相关的母体血清/血浆miRNA标志物及其应用 |
| US20160251720A1 (en) * | 2013-11-01 | 2016-09-01 | The Trustees Of Columbia University In The City New York | MicroRNA PROFILES IN HEART FAILURE: METHODS AND SYSTEMS FOR DETECTION AND USE |
| CN103667459A (zh) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | 微小核苷酸在高血压诊断和制备降血压药物中的应用 |
| CN104740648B (zh) | 2013-12-27 | 2020-02-14 | 江苏命码生物科技有限公司 | miRNA-214抑制剂在抑制调节性T细胞中的应用 |
| CN104031987B (zh) * | 2014-05-12 | 2016-08-31 | 贵州省人民医院 | miRNA在心肌纤维化疾病治疗中的应用 |
| US10131952B2 (en) | 2014-05-14 | 2018-11-20 | Ohio State Innovation Foundation | MIRNA biomarkers for monitoring bone marrow reconstitution |
| EP3034623A1 (en) * | 2014-12-18 | 2016-06-22 | Centro de Investigación Biomédica en Red (CIBER) | Method for predicting response to continuous positive air pressure treatment |
| EP3292213A1 (en) * | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Biomarkers for the detection of aspirin insensitivity |
| CN113186271B (zh) * | 2015-05-08 | 2025-06-17 | 新加坡科技研究局 | 用于慢性心力衰竭的诊断和预后的方法 |
| CN105999302A (zh) * | 2016-06-13 | 2016-10-12 | 上海市东方医院 | 一种miRNA-21a抑制剂及在制备延缓心肌梗死的药物中的用途 |
| CN107557464B (zh) * | 2016-07-02 | 2021-06-04 | 上海市公共卫生临床中心 | 用于干扰素治疗慢性乙型肝炎早期病毒学反应的预测模型及检测试剂盒 |
| CN106399473B (zh) * | 2016-08-23 | 2019-12-06 | 南京大学 | 检测和评价力量训练效果的miRNA标志物或其组合及其应用 |
| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| CN106729757A (zh) * | 2017-03-08 | 2017-05-31 | 复旦大学附属中山医院 | miR‑378抑制心肌肥厚和心肌纤维化并诊断心力衰竭的用途 |
| CN107858419A (zh) * | 2017-11-10 | 2018-03-30 | 青岛大学 | miRNA的应用、应用其的产品及检测方法 |
| CN107881173A (zh) * | 2017-11-16 | 2018-04-06 | 上海市东方医院 | 一种miRNA‑21小分子及其用途 |
| CN108004316A (zh) * | 2018-01-09 | 2018-05-08 | 青岛大学 | 用于预测急性心肌梗死风险的试剂盒 |
| CN108866177B (zh) * | 2018-05-31 | 2021-05-28 | 李继承 | hsa-miRNA-423-5p和hsa-miRNA-423-5p抑制剂的用途 |
| CN110055322A (zh) * | 2019-05-12 | 2019-07-26 | 青岛大学 | 用于急性心肌梗死诊断的循环miRNA标志物及其应用 |
| WO2021250969A1 (ja) * | 2020-06-08 | 2021-12-16 | 国立大学法人東海国立大学機構 | マイクロｒｎａの慢性期心機能改善治療への利用 |
| CN112410414B (zh) * | 2020-10-09 | 2022-07-08 | 嘉兴市妇幼保健院 | 孕妇血清外泌体miRNA标志物在制备胎儿先心病早期诊断产品中的应用及试剂盒 |
| CN113943792A (zh) * | 2021-11-02 | 2022-01-18 | 石河子大学 | 检测miRNA表达量的试剂在制备诊断或预后哈萨克族高血压的试剂或试剂盒中的应用 |
| CN116726038A (zh) * | 2022-03-04 | 2023-09-12 | 南京大学 | 来源于棕榈炭的microRNA或其组合在制备止血药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090306181A1 (en) * | 2006-09-29 | 2009-12-10 | Children's Medical Center Corporation | Compositions and methods for evaluating and treating heart failure |
| US20090105174A1 (en) * | 2007-04-20 | 2009-04-23 | Amgen Inc. | Nucleic acids hybridizable to micro rna and precursors thereof |
| CN101802227B (zh) * | 2007-07-18 | 2014-12-10 | 科罗拉多大学董事会法人团体 | 非衰竭与衰竭的人心脏中微小rna的差异表达 |
| JP2010154843A (ja) * | 2008-06-27 | 2010-07-15 | Keio Gijuku | バイオマーカーとしてのマイクロｒｎａを用いた婦人科がんの診断・治療選択 |
| KR20110128838A (ko) * | 2009-02-04 | 2011-11-30 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 심장 질환 치료에서 ｍｉｒ－208 및 ｍｉｒ－499의 이중 표적화 |
| WO2010130351A1 (en) * | 2009-05-15 | 2010-11-18 | Bayer Schering Pharma Ag | Micrornas as biomarkers and therapeutic targets for heart failure |
| CN101643791A (zh) * | 2009-09-04 | 2010-02-10 | 哈尔滨医科大学 | microRNA-328及其反义核苷酸在诊断、防治心脏疾病中的用途 |
-
2011
- 2011-12-15 EP EP11804873.5A patent/EP2652146A2/en not_active Withdrawn
- 2011-12-15 WO PCT/US2011/065120 patent/WO2012083004A2/en not_active Ceased
- 2011-12-15 CN CN2011800675783A patent/CN103370424A/zh active Pending
- 2011-12-15 AU AU2011343719A patent/AU2011343719A1/en not_active Abandoned
- 2011-12-15 CA CA2818174A patent/CA2818174A1/en not_active Abandoned
- 2011-12-15 US US13/994,622 patent/US20140024700A1/en not_active Abandoned
- 2011-12-15 JP JP2013544771A patent/JP2014507123A/ja active Pending
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