CA2818174A1 - Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions - Google Patents
Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions Download PDFInfo
- Publication number
- CA2818174A1 CA2818174A1 CA2818174A CA2818174A CA2818174A1 CA 2818174 A1 CA2818174 A1 CA 2818174A1 CA 2818174 A CA2818174 A CA 2818174A CA 2818174 A CA2818174 A CA 2818174A CA 2818174 A1 CA2818174 A1 CA 2818174A1
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- Prior art keywords
- mir
- hsa
- mirna
- level
- heart failure
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Classifications
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- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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Applications Claiming Priority (7)
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| US42345610P | 2010-12-15 | 2010-12-15 | |
| US61/423,456 | 2010-12-15 | ||
| US201161495220P | 2011-06-09 | 2011-06-09 | |
| US61/495,220 | 2011-06-09 | ||
| US201161538585P | 2011-09-23 | 2011-09-23 | |
| US61/538,585 | 2011-09-23 | ||
| PCT/US2011/065120 WO2012083004A2 (en) | 2010-12-15 | 2011-12-15 | Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions |
Publications (1)
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| CA2818174A1 true CA2818174A1 (en) | 2012-06-21 |
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| CA2818174A Abandoned CA2818174A1 (en) | 2010-12-15 | 2011-12-15 | Blood-borne mirnas as surrogate markers of drug efficacy for cardiac conditions |
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| US (1) | US20140024700A1 (enExample) |
| EP (1) | EP2652146A2 (enExample) |
| JP (1) | JP2014507123A (enExample) |
| CN (1) | CN103370424A (enExample) |
| AU (1) | AU2011343719A1 (enExample) |
| CA (1) | CA2818174A1 (enExample) |
| WO (1) | WO2012083004A2 (enExample) |
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| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| WO2014083081A1 (en) * | 2012-11-27 | 2014-06-05 | Centre de Recherche Public de la Santé | Compositions and methods for evaluating heart failure |
| CN103290116B (zh) * | 2013-05-16 | 2016-09-07 | 南京市妇幼保健院 | 一种与胎儿先天性心脏病相关的母体血清/血浆miRNA标志物及其应用 |
| US20160251720A1 (en) * | 2013-11-01 | 2016-09-01 | The Trustees Of Columbia University In The City New York | MicroRNA PROFILES IN HEART FAILURE: METHODS AND SYSTEMS FOR DETECTION AND USE |
| CN103667459A (zh) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | 微小核苷酸在高血压诊断和制备降血压药物中的应用 |
| CN104740648B (zh) | 2013-12-27 | 2020-02-14 | 江苏命码生物科技有限公司 | miRNA-214抑制剂在抑制调节性T细胞中的应用 |
| CN104031987B (zh) * | 2014-05-12 | 2016-08-31 | 贵州省人民医院 | miRNA在心肌纤维化疾病治疗中的应用 |
| WO2015175831A1 (en) | 2014-05-14 | 2015-11-19 | Ohio State Innovation Foundation | Mirna biomarkers for monitoring bone marrow reconstitution |
| EP3034623A1 (en) * | 2014-12-18 | 2016-06-22 | Centro de Investigación Biomédica en Red (CIBER) | Method for predicting response to continuous positive air pressure treatment |
| EP3292213A1 (en) * | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Biomarkers for the detection of aspirin insensitivity |
| WO2016182511A1 (en) * | 2015-05-08 | 2016-11-17 | Agency For Science, Technology And Research | Method for diagnosis and prognosis of chronic heart failure |
| CN105999302A (zh) * | 2016-06-13 | 2016-10-12 | 上海市东方医院 | 一种miRNA-21a抑制剂及在制备延缓心肌梗死的药物中的用途 |
| CN107557464B (zh) * | 2016-07-02 | 2021-06-04 | 上海市公共卫生临床中心 | 用于干扰素治疗慢性乙型肝炎早期病毒学反应的预测模型及检测试剂盒 |
| CN106399473B (zh) * | 2016-08-23 | 2019-12-06 | 南京大学 | 检测和评价力量训练效果的miRNA标志物或其组合及其应用 |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| CN106729757A (zh) * | 2017-03-08 | 2017-05-31 | 复旦大学附属中山医院 | miR‑378抑制心肌肥厚和心肌纤维化并诊断心力衰竭的用途 |
| CN107858419A (zh) * | 2017-11-10 | 2018-03-30 | 青岛大学 | miRNA的应用、应用其的产品及检测方法 |
| CN107881173A (zh) * | 2017-11-16 | 2018-04-06 | 上海市东方医院 | 一种miRNA‑21小分子及其用途 |
| CN108004316A (zh) * | 2018-01-09 | 2018-05-08 | 青岛大学 | 用于预测急性心肌梗死风险的试剂盒 |
| CN108866177B (zh) * | 2018-05-31 | 2021-05-28 | 李继承 | hsa-miRNA-423-5p和hsa-miRNA-423-5p抑制剂的用途 |
| CN110055322A (zh) * | 2019-05-12 | 2019-07-26 | 青岛大学 | 用于急性心肌梗死诊断的循环miRNA标志物及其应用 |
| JP7445997B2 (ja) * | 2020-06-08 | 2024-03-08 | 国立大学法人東海国立大学機構 | マイクロrnaの慢性期心機能改善治療への利用 |
| CN112410414B (zh) * | 2020-10-09 | 2022-07-08 | 嘉兴市妇幼保健院 | 孕妇血清外泌体miRNA标志物在制备胎儿先心病早期诊断产品中的应用及试剂盒 |
| CN113943792A (zh) * | 2021-11-02 | 2022-01-18 | 石河子大学 | 检测miRNA表达量的试剂在制备诊断或预后哈萨克族高血压的试剂或试剂盒中的应用 |
| CN116726038A (zh) * | 2022-03-04 | 2023-09-12 | 南京大学 | 来源于棕榈炭的microRNA或其组合在制备止血药物中的应用 |
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| WO2008042231A2 (en) * | 2006-09-29 | 2008-04-10 | Children's Medical Center Corporation | Compositions and methods for evaluating and treating heart failure |
| US20090105174A1 (en) * | 2007-04-20 | 2009-04-23 | Amgen Inc. | Nucleic acids hybridizable to micro rna and precursors thereof |
| KR20100049079A (ko) * | 2007-07-18 | 2010-05-11 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 인간의 정상 심장과 기능부진 심장에서 마이크로 rna의 차등 발현 |
| WO2009157204A1 (ja) * | 2008-06-27 | 2009-12-30 | 学校法人 慶應義塾 | バイオマーカーとしてのマイクロrnaを用いた婦人科がんの診断・治療選択 |
| MX2011008190A (es) * | 2009-02-04 | 2011-10-06 | Univ Texas | Direccionamiento dual de mir-208 y mir-499 en el tratamiento de trastornos cardiacos. |
| WO2010130351A1 (en) * | 2009-05-15 | 2010-11-18 | Bayer Schering Pharma Ag | Micrornas as biomarkers and therapeutic targets for heart failure |
| CN101643791A (zh) * | 2009-09-04 | 2010-02-10 | 哈尔滨医科大学 | microRNA-328及其反义核苷酸在诊断、防治心脏疾病中的用途 |
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- 2011-12-15 WO PCT/US2011/065120 patent/WO2012083004A2/en not_active Ceased
- 2011-12-15 JP JP2013544771A patent/JP2014507123A/ja active Pending
- 2011-12-15 US US13/994,622 patent/US20140024700A1/en not_active Abandoned
- 2011-12-15 CA CA2818174A patent/CA2818174A1/en not_active Abandoned
- 2011-12-15 CN CN2011800675783A patent/CN103370424A/zh active Pending
- 2011-12-15 AU AU2011343719A patent/AU2011343719A1/en not_active Abandoned
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| US20140024700A1 (en) | 2014-01-23 |
| JP2014507123A (ja) | 2014-03-27 |
| CN103370424A (zh) | 2013-10-23 |
| WO2012083004A3 (en) | 2012-11-29 |
| AU2011343719A1 (en) | 2013-04-11 |
| WO2012083004A2 (en) | 2012-06-21 |
| EP2652146A2 (en) | 2013-10-23 |
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