JP2010504102A5 - - Google Patents
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- JP2010504102A5 JP2010504102A5 JP2009529373A JP2009529373A JP2010504102A5 JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5 JP 2009529373 A JP2009529373 A JP 2009529373A JP 2009529373 A JP2009529373 A JP 2009529373A JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5
- Authority
- JP
- Japan
- Prior art keywords
- hsa
- mir
- mirna
- expression
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 63
- 230000014509 gene expression Effects 0.000 claims description 42
- 239000000523 sample Substances 0.000 claims description 31
- 108091070501 miRNA Proteins 0.000 claims description 25
- 239000002679 microRNA Substances 0.000 claims description 24
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 15
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 14
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 14
- 201000002528 pancreatic cancer Diseases 0.000 claims description 14
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 14
- 238000009396 hybridization Methods 0.000 claims description 11
- 230000003321 amplification Effects 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 9
- 206010033645 Pancreatitis Diseases 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 239000011324 bead Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
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- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 210000001819 pancreatic juice Anatomy 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- -1 hsa-let-7f Proteins 0.000 claims 4
- 108091067465 Homo sapiens miR-217 stem-loop Proteins 0.000 claims 3
- 108091070365 Homo sapiens miR-30a stem-loop Proteins 0.000 claims 2
- 108091065436 Homo sapiens miR-30e stem-loop Proteins 0.000 claims 2
- 108091070514 Homo sapiens let-7b stem-loop Proteins 0.000 claims 1
- 108091070511 Homo sapiens let-7c stem-loop Proteins 0.000 claims 1
- 108091070512 Homo sapiens let-7d stem-loop Proteins 0.000 claims 1
- 108091069046 Homo sapiens let-7g stem-loop Proteins 0.000 claims 1
- 108091069047 Homo sapiens let-7i stem-loop Proteins 0.000 claims 1
- 108091068853 Homo sapiens miR-100 stem-loop Proteins 0.000 claims 1
- 108091068928 Homo sapiens miR-107 stem-loop Proteins 0.000 claims 1
- 108091069094 Homo sapiens miR-134 stem-loop Proteins 0.000 claims 1
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 1
- 108091068991 Homo sapiens miR-141 stem-loop Proteins 0.000 claims 1
- 108091068992 Homo sapiens miR-143 stem-loop Proteins 0.000 claims 1
- 108091069002 Homo sapiens miR-145 stem-loop Proteins 0.000 claims 1
- 108091069088 Homo sapiens miR-150 stem-loop Proteins 0.000 claims 1
- 108091068955 Homo sapiens miR-154 stem-loop Proteins 0.000 claims 1
- 108091065981 Homo sapiens miR-155 stem-loop Proteins 0.000 claims 1
- 108091067627 Homo sapiens miR-182 stem-loop Proteins 0.000 claims 1
- 108091068956 Homo sapiens miR-186 stem-loop Proteins 0.000 claims 1
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 claims 1
- 108091067468 Homo sapiens miR-210 stem-loop Proteins 0.000 claims 1
- 108091067580 Homo sapiens miR-214 stem-loop Proteins 0.000 claims 1
- 108091067572 Homo sapiens miR-221 stem-loop Proteins 0.000 claims 1
- 108091067573 Homo sapiens miR-222 stem-loop Proteins 0.000 claims 1
- 108091069527 Homo sapiens miR-223 stem-loop Proteins 0.000 claims 1
- 108091069517 Homo sapiens miR-224 stem-loop Proteins 0.000 claims 1
- 108091070395 Homo sapiens miR-31 stem-loop Proteins 0.000 claims 1
- 108091066896 Homo sapiens miR-331 stem-loop Proteins 0.000 claims 1
- 108091066985 Homo sapiens miR-335 stem-loop Proteins 0.000 claims 1
- 108091067535 Homo sapiens miR-375 stem-loop Proteins 0.000 claims 1
- 108091067243 Homo sapiens miR-377 stem-loop Proteins 0.000 claims 1
- 108091067552 Homo sapiens miR-379 stem-loop Proteins 0.000 claims 1
- 108091032930 Homo sapiens miR-429 stem-loop Proteins 0.000 claims 1
- 108091032542 Homo sapiens miR-452 stem-loop Proteins 0.000 claims 1
- 108091092307 Homo sapiens miR-494 stem-loop Proteins 0.000 claims 1
- 108091092303 Homo sapiens miR-497 stem-loop Proteins 0.000 claims 1
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 claims 1
- 108091070375 Homo sapiens miR-95 stem-loop Proteins 0.000 claims 1
- 108091070376 Homo sapiens miR-96 stem-loop Proteins 0.000 claims 1
- 108091007773 MIR100 Proteins 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091007772 MIRLET7C Proteins 0.000 claims 1
- 108091028141 MiR-203 Proteins 0.000 claims 1
- 108091062154 Mir-205 Proteins 0.000 claims 1
- 108091064378 miR-196b stem-loop Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 208000000668 Chronic Pancreatitis Diseases 0.000 description 11
- 206010033649 Pancreatitis chronic Diseases 0.000 description 11
- 210000004923 pancreatic tissue Anatomy 0.000 description 11
- 108091054189 miR-196a stem-loop Proteins 0.000 description 10
- 230000001575 pathological effect Effects 0.000 description 10
- 108091035328 miR-217 stem-loop Proteins 0.000 description 8
- 108091039135 miR-217-1 stem-loop Proteins 0.000 description 8
- 108091029206 miR-217-2 stem-loop Proteins 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 238000003762 quantitative reverse transcription PCR Methods 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 210000000496 pancreas Anatomy 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 3
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 101710124239 Poly(A) polymerase Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 108091092825 miR-24 stem-loop Proteins 0.000 description 2
- 108091032978 miR-24-3 stem-loop Proteins 0.000 description 2
- 108091064025 miR-24-4 stem-loop Proteins 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000000513 principal component analysis Methods 0.000 description 2
- 108020005075 5S Ribosomal RNA Proteins 0.000 description 1
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 description 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 108010008699 Mucin-4 Proteins 0.000 description 1
- 102000007270 Mucin-4 Human genes 0.000 description 1
- 208000016222 Pancreatic disease Diseases 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 description 1
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 238000003253 miRNA assay Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000985 reactive dye Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82617306P | 2006-09-19 | 2006-09-19 | |
| US60/826,173 | 2006-09-19 | ||
| PCT/US2007/078936 WO2008036765A2 (en) | 2006-09-19 | 2007-09-19 | Micrornas differentially expressed in pancreatic diseases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504102A JP2010504102A (ja) | 2010-02-12 |
| JP2010504102A5 true JP2010504102A5 (enExample) | 2011-11-24 |
| JP5520605B2 JP5520605B2 (ja) | 2014-06-11 |
Family
ID=38947406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529373A Active JP5520605B2 (ja) | 2006-09-19 | 2007-09-19 | 膵臓疾患で差次的に発現されるマイクロｒｎａおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090131348A1 (enExample) |
| EP (2) | EP2487240B1 (enExample) |
| JP (1) | JP5520605B2 (enExample) |
| AU (1) | AU2007299828C1 (enExample) |
| CA (1) | CA2664383C (enExample) |
| IL (1) | IL197690A0 (enExample) |
| WO (1) | WO2008036765A2 (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2290068A3 (en) | 2004-05-28 | 2012-01-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
| ES2503765T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| JP5489459B2 (ja) * | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| CA2621441C (en) * | 2005-09-12 | 2014-05-20 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| CA2624531A1 (en) * | 2005-10-05 | 2007-04-19 | Carlo M. Croce | Wwox gene, vectors containing the same, and uses in treatment of cancer |
| ES2531052T3 (es) | 2006-01-05 | 2015-03-10 | Univ Ohio State Res Found | Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama |
| ES2554531T3 (es) | 2006-01-05 | 2015-12-21 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| CN101384273B (zh) | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436786B1 (en) | 2006-07-13 | 2014-04-16 | The Ohio State University Research Foundation | MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma. |
| ATE534752T1 (de) | 2006-09-19 | 2011-12-15 | Univ Ohio State Res Found | Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll) |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| US8034560B2 (en) * | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| CN104195226B (zh) * | 2007-04-30 | 2017-01-11 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US8415096B2 (en) | 2007-05-23 | 2013-04-09 | University Of South Florida | Micro-RNAs modulating immunity and inflammation |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| ES2537349T3 (es) * | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| JP5480132B2 (ja) * | 2007-06-15 | 2014-04-23 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｄｒｏｓｈａ媒介性のマイクロｒｎａプロセッシングを標的するための癌原性ａｌｌ−１融合タンパク質 |
| US8367632B2 (en) * | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| CN101835902B (zh) | 2007-08-03 | 2014-03-26 | 俄亥俄州立大学研究基金会 | 编码ncrna的超保守区域 |
| AU2008288806B2 (en) * | 2007-08-22 | 2014-11-27 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias |
| EP2212440A4 (en) * | 2007-10-11 | 2011-04-06 | Univ Ohio State Res Found | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES |
| EP2201112A4 (en) | 2007-10-26 | 2011-02-02 | Univ Ohio State Res Found | METHOD FOR IDENTIFYING FHIT INTERACTION AND USE |
| WO2009058893A2 (en) * | 2007-10-29 | 2009-05-07 | University Of Southern California | Preventing hyaluronan-mediated tumorigenetic mechanisms using intronic rnas |
| CA2707157A1 (en) * | 2007-11-30 | 2009-06-04 | The Ohio State University Research Foundation | Microrna expression profiling and targeting in peripheral blood in lung cancer |
| EP2254668A4 (en) * | 2008-02-28 | 2012-08-15 | Univ Ohio State Res Found | MICROARN SIGNATURES ASSOCIATED WITH HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND USES THEREOF |
| ES2600165T3 (es) * | 2008-02-28 | 2017-02-07 | The Ohio State University Research Foundation | Antagonistas de miR-32 para aumentar la respuesta del cáncer de próstata a la apoptosis |
| EP2281903B1 (en) * | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| WO2009143379A2 (en) * | 2008-05-21 | 2009-11-26 | Fred Hutchinson Cancer Research Center | Use of extracellular rna to measure disease |
| WO2009147658A2 (en) * | 2008-06-02 | 2009-12-10 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| KR101043433B1 (ko) * | 2008-07-18 | 2011-06-22 | 국립암센터 | 마이크로ｒｎａ분자를 포함하는 항암 조성물 |
| WO2010033822A2 (en) * | 2008-09-19 | 2010-03-25 | Immune Disease Institute, Inc | Therapeutic and diagnostic strategies |
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| CN101475984A (zh) | 2008-12-15 | 2009-07-08 | 江苏命码生物科技有限公司 | 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒 |
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| EP2471950B1 (en) * | 2009-08-24 | 2015-04-01 | National University Corporation Kanazawa University | Detection of digestive system cancer by means of gene expression profiling |
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| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| WO2011075873A1 (zh) * | 2009-12-24 | 2011-06-30 | 北京命码生科科技有限公司 | 胰腺癌标记物及其检测方法、试剂盒和生物芯片 |
| CA2789404C (en) * | 2010-02-26 | 2020-03-24 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets |
| US9320756B2 (en) | 2010-05-07 | 2016-04-26 | Centre National De La Recherche Scientifique | UCP1 (thermogenin)—inducing agents for use in the treatment of a disorder of the energy homeostasis |
| EP2603592A2 (en) * | 2010-08-13 | 2013-06-19 | The University Court of the University of Glasgow | Therapeutic uses of microvesicles and related micrornas |
| EP3075396A1 (en) | 2010-10-17 | 2016-10-05 | Yeda Research and Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| US10758619B2 (en) | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
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| WO2015073531A1 (en) * | 2013-11-13 | 2015-05-21 | The Texas A & M University System | Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells |
| JP6611411B2 (ja) * | 2013-12-05 | 2019-11-27 | 東レ株式会社 | 膵臓がんの検出キット及び検出方法 |
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2007
- 2007-09-19 WO PCT/US2007/078936 patent/WO2008036765A2/en not_active Ceased
- 2007-09-19 JP JP2009529373A patent/JP5520605B2/ja active Active
- 2007-09-19 EP EP12159733.0A patent/EP2487240B1/en not_active Not-in-force
- 2007-09-19 AU AU2007299828A patent/AU2007299828C1/en not_active Ceased
- 2007-09-19 EP EP07842816A patent/EP2115138A2/en not_active Withdrawn
- 2007-09-19 CA CA2664383A patent/CA2664383C/en not_active Expired - Fee Related
- 2007-09-19 US US11/857,948 patent/US20090131348A1/en not_active Abandoned
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2009
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2018
- 2018-03-12 US US15/917,935 patent/US20190330623A1/en not_active Abandoned
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