JP2010504102A5 - - Google Patents
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- JP2010504102A5 JP2010504102A5 JP2009529373A JP2009529373A JP2010504102A5 JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5 JP 2009529373 A JP2009529373 A JP 2009529373A JP 2009529373 A JP2009529373 A JP 2009529373A JP 2010504102 A5 JP2010504102 A5 JP 2010504102A5
- Authority
- JP
- Japan
- Prior art keywords
- hsa
- mir
- mirna
- expression
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 63
- 230000014509 gene expression Effects 0.000 claims description 42
- 239000000523 sample Substances 0.000 claims description 31
- 108091070501 miRNA Proteins 0.000 claims description 25
- 239000002679 microRNA Substances 0.000 claims description 24
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 15
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 14
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 14
- 201000002528 pancreatic cancer Diseases 0.000 claims description 14
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 14
- 238000009396 hybridization Methods 0.000 claims description 11
- 230000003321 amplification Effects 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 9
- 206010033645 Pancreatitis Diseases 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 3
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- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 210000001819 pancreatic juice Anatomy 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- -1 hsa-let-7f Proteins 0.000 claims 4
- 108091067465 Homo sapiens miR-217 stem-loop Proteins 0.000 claims 3
- 108091070365 Homo sapiens miR-30a stem-loop Proteins 0.000 claims 2
- 108091065436 Homo sapiens miR-30e stem-loop Proteins 0.000 claims 2
- 108091070514 Homo sapiens let-7b stem-loop Proteins 0.000 claims 1
- 108091070511 Homo sapiens let-7c stem-loop Proteins 0.000 claims 1
- 108091070512 Homo sapiens let-7d stem-loop Proteins 0.000 claims 1
- 108091069046 Homo sapiens let-7g stem-loop Proteins 0.000 claims 1
- 108091069047 Homo sapiens let-7i stem-loop Proteins 0.000 claims 1
- 108091068853 Homo sapiens miR-100 stem-loop Proteins 0.000 claims 1
- 108091068928 Homo sapiens miR-107 stem-loop Proteins 0.000 claims 1
- 108091069094 Homo sapiens miR-134 stem-loop Proteins 0.000 claims 1
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 1
- 108091068991 Homo sapiens miR-141 stem-loop Proteins 0.000 claims 1
- 108091068992 Homo sapiens miR-143 stem-loop Proteins 0.000 claims 1
- 108091069002 Homo sapiens miR-145 stem-loop Proteins 0.000 claims 1
- 108091069088 Homo sapiens miR-150 stem-loop Proteins 0.000 claims 1
- 108091068955 Homo sapiens miR-154 stem-loop Proteins 0.000 claims 1
- 108091065981 Homo sapiens miR-155 stem-loop Proteins 0.000 claims 1
- 108091067627 Homo sapiens miR-182 stem-loop Proteins 0.000 claims 1
- 108091068956 Homo sapiens miR-186 stem-loop Proteins 0.000 claims 1
- 108091070493 Homo sapiens miR-21 stem-loop Proteins 0.000 claims 1
- 108091067468 Homo sapiens miR-210 stem-loop Proteins 0.000 claims 1
- 108091067580 Homo sapiens miR-214 stem-loop Proteins 0.000 claims 1
- 108091067572 Homo sapiens miR-221 stem-loop Proteins 0.000 claims 1
- 108091067573 Homo sapiens miR-222 stem-loop Proteins 0.000 claims 1
- 108091069527 Homo sapiens miR-223 stem-loop Proteins 0.000 claims 1
- 108091069517 Homo sapiens miR-224 stem-loop Proteins 0.000 claims 1
- 108091070395 Homo sapiens miR-31 stem-loop Proteins 0.000 claims 1
- 108091066896 Homo sapiens miR-331 stem-loop Proteins 0.000 claims 1
- 108091066985 Homo sapiens miR-335 stem-loop Proteins 0.000 claims 1
- 108091067535 Homo sapiens miR-375 stem-loop Proteins 0.000 claims 1
- 108091067243 Homo sapiens miR-377 stem-loop Proteins 0.000 claims 1
- 108091067552 Homo sapiens miR-379 stem-loop Proteins 0.000 claims 1
- 108091032930 Homo sapiens miR-429 stem-loop Proteins 0.000 claims 1
- 108091032542 Homo sapiens miR-452 stem-loop Proteins 0.000 claims 1
- 108091092307 Homo sapiens miR-494 stem-loop Proteins 0.000 claims 1
- 108091092303 Homo sapiens miR-497 stem-loop Proteins 0.000 claims 1
- 108091070377 Homo sapiens miR-93 stem-loop Proteins 0.000 claims 1
- 108091070375 Homo sapiens miR-95 stem-loop Proteins 0.000 claims 1
- 108091070376 Homo sapiens miR-96 stem-loop Proteins 0.000 claims 1
- 108091007773 MIR100 Proteins 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091007772 MIRLET7C Proteins 0.000 claims 1
- 108091028141 MiR-203 Proteins 0.000 claims 1
- 108091062154 Mir-205 Proteins 0.000 claims 1
- 108091064378 miR-196b stem-loop Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 208000000668 Chronic Pancreatitis Diseases 0.000 description 11
- 206010033649 Pancreatitis chronic Diseases 0.000 description 11
- 210000004923 pancreatic tissue Anatomy 0.000 description 11
- 108091054189 miR-196a stem-loop Proteins 0.000 description 10
- 230000001575 pathological effect Effects 0.000 description 10
- 108091035328 miR-217 stem-loop Proteins 0.000 description 8
- 108091039135 miR-217-1 stem-loop Proteins 0.000 description 8
- 108091029206 miR-217-2 stem-loop Proteins 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 238000003762 quantitative reverse transcription PCR Methods 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 210000000496 pancreas Anatomy 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 3
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 101710124239 Poly(A) polymerase Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 108091092825 miR-24 stem-loop Proteins 0.000 description 2
- 108091032978 miR-24-3 stem-loop Proteins 0.000 description 2
- 108091064025 miR-24-4 stem-loop Proteins 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000000513 principal component analysis Methods 0.000 description 2
- 108020005075 5S Ribosomal RNA Proteins 0.000 description 1
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 description 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 108010008699 Mucin-4 Proteins 0.000 description 1
- 102000007270 Mucin-4 Human genes 0.000 description 1
- 208000016222 Pancreatic disease Diseases 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 description 1
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 238000003253 miRNA assay Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000985 reactive dye Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82617306P | 2006-09-19 | 2006-09-19 | |
| US60/826,173 | 2006-09-19 | ||
| PCT/US2007/078936 WO2008036765A2 (en) | 2006-09-19 | 2007-09-19 | Micrornas differentially expressed in pancreatic diseases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504102A JP2010504102A (ja) | 2010-02-12 |
| JP2010504102A5 true JP2010504102A5 (enExample) | 2011-11-24 |
| JP5520605B2 JP5520605B2 (ja) | 2014-06-11 |
Family
ID=38947406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529373A Active JP5520605B2 (ja) | 2006-09-19 | 2007-09-19 | 膵臓疾患で差次的に発現されるマイクロｒｎａおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090131348A1 (enExample) |
| EP (2) | EP2487240B1 (enExample) |
| JP (1) | JP5520605B2 (enExample) |
| AU (1) | AU2007299828C1 (enExample) |
| CA (1) | CA2664383C (enExample) |
| IL (1) | IL197690A0 (enExample) |
| WO (1) | WO2008036765A2 (enExample) |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2471924A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| WO2007016548A2 (en) * | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| US8481505B2 (en) * | 2005-09-12 | 2013-07-09 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of BCL2-associated cancers |
| CA2624531A1 (en) * | 2005-10-05 | 2007-04-19 | Carlo M. Croce | Wwox gene, vectors containing the same, and uses in treatment of cancer |
| EP2484782B1 (en) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| AU2007205234B2 (en) | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| ES2425387T3 (es) | 2006-07-13 | 2013-10-15 | The Ohio State University Research Foundation | Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| JP2010516291A (ja) * | 2007-01-31 | 2010-05-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性白血病（ａｍｌ）の診断、予後及び治療のためのマイクロｒｎａに基づく方法及び組成物 |
| CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US8415096B2 (en) | 2007-05-23 | 2013-04-09 | University Of South Florida | Micro-RNAs modulating immunity and inflammation |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| US8465917B2 (en) * | 2007-06-08 | 2013-06-18 | The Ohio State University Research Foundation | Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| EP2173911B1 (en) * | 2007-07-31 | 2014-06-18 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| EP2653561B1 (en) * | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) * | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| EP2212440A4 (en) * | 2007-10-11 | 2011-04-06 | Univ Ohio State Res Found | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES |
| WO2009055773A2 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| WO2009058893A2 (en) * | 2007-10-29 | 2009-05-07 | University Of Southern California | Preventing hyaluronan-mediated tumorigenetic mechanisms using intronic rnas |
| EP2225396A4 (en) * | 2007-11-30 | 2011-03-02 | Univ Ohio State Res Found | PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER |
| US20110054009A1 (en) * | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders |
| JP2011517932A (ja) * | 2008-02-28 | 2011-06-23 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | ヒト慢性リンパ球性白血病（ｃｃｌ）と関連するマイクロｒｎａシグネチャーおよびその使用 |
| EP2281903B1 (en) | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| US20110160290A1 (en) * | 2008-05-21 | 2011-06-30 | Muneesh Tewari | Use of extracellular rna to measure disease |
| EP2294218A2 (en) * | 2008-06-02 | 2011-03-16 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
| WO2009152300A1 (en) | 2008-06-11 | 2009-12-17 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| KR101043433B1 (ko) * | 2008-07-18 | 2011-06-22 | 국립암센터 | 마이크로ｒｎａ분자를 포함하는 항암 조성물 |
| WO2010033818A2 (en) | 2008-09-19 | 2010-03-25 | Immune Disease Institute, Inc. | Mirna targets |
| EP2191834A1 (en) * | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| CN101475984A (zh) | 2008-12-15 | 2009-07-08 | 江苏命码生物科技有限公司 | 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒 |
| EP2634266B1 (en) * | 2009-05-22 | 2015-10-14 | Asuragen, INC. | miRNA biomarkers of prostate disease |
| US8932990B2 (en) * | 2009-08-24 | 2015-01-13 | National University Corporation Kanazawa University | Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling |
| JPWO2011024918A1 (ja) * | 2009-08-26 | 2013-01-31 | 国立大学法人大阪大学 | 血管新生抑制剤及び血管新生抑制方法 |
| EP2775300A3 (en) * | 2009-08-28 | 2015-04-01 | Asuragen, INC. | miRNA Biomarkers of Lung Disease |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| EP2518158B1 (en) * | 2009-12-24 | 2016-09-14 | Micromedmark Biotech Co., Ltd | Pancreatic cancer markers and detecting methods |
| WO2011106104A2 (en) * | 2010-02-26 | 2011-09-01 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets |
| EP3181692A1 (en) * | 2010-05-07 | 2017-06-21 | Centre National De La Recherche Scientifique | Ucp1 (thermogenin) - inducing agents for use in the treatment of a disorder of the energy homeostasis |
| EP2603592A2 (en) * | 2010-08-13 | 2013-06-19 | The University Court of the University of Glasgow | Therapeutic uses of microvesicles and related micrornas |
| EP2627766B1 (en) | 2010-10-17 | 2016-05-25 | Yeda Research and Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| JP6155194B2 (ja) | 2010-11-17 | 2017-06-28 | インターペース ダイアグノスティックス リミテッド ライアビリティ カンパニー | 良性甲状腺新生物と悪性甲状腺新生物を区別するためのバイオマーカーとしてのｍｉＲＮＡ |
| US8895509B2 (en) | 2010-11-23 | 2014-11-25 | Georgia Tech Research Corporation | MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells |
| WO2012083969A2 (en) | 2010-12-22 | 2012-06-28 | Herlev Hospital | Microrna for diagnosis of pancreatic cancer |
| JP2014509852A (ja) | 2011-03-07 | 2014-04-24 | ジ・オハイオ・ステート・ユニバーシティ | マイクロＲＮＡ−１５５（ｍｉＲ−１５５）により誘導される変異誘発活性は炎症および癌を結び付ける |
| JP6211511B2 (ja) * | 2011-04-18 | 2017-10-11 | ディアミール, エルエルシーDiamir, Llc | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
| WO2012174470A1 (en) * | 2011-06-16 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of pyruvate carboxylase expression |
| US9644241B2 (en) * | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| EP2756102B1 (en) * | 2011-09-13 | 2019-04-24 | Commonwealth Scientific and Industrial Research Organisation | Detection of viral infection |
| CA2852066A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| WO2013063519A1 (en) * | 2011-10-26 | 2013-05-02 | Asuragen, Inc. | Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts |
| CN102358901A (zh) * | 2011-11-11 | 2012-02-22 | 天津托普泰克生物科技有限公司 | Has-miR-520e的抗肿瘤用途 |
| EP2790735A4 (en) | 2011-12-13 | 2015-12-09 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS RELATING TO MIR-21 AND MIR-29A, EXOSOME INHIBITION, AND CANCER METASTASIS |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| WO2014093924A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| EP3434774A1 (en) | 2013-01-17 | 2019-01-30 | ModernaTX, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| EP2948769B1 (en) * | 2013-01-22 | 2019-05-08 | Neoproteomics AB | Platelet biomarkers in cancer diagnosis |
| KR101501562B1 (ko) * | 2013-04-05 | 2015-03-11 | 연세대학교 산학협력단 | 췌장암 진단 마커를 검출하는 방법 |
| US20150141342A1 (en) * | 2013-06-11 | 2015-05-21 | Indiana University Research And Technology Corp. | BLOOD BORNE miRNA SIGNATURE FOR THE ACCURATE DIAGNOSIS OF PANCREATIC DUCTAL ADENOCARCINOMA |
| KR101520545B1 (ko) | 2013-09-06 | 2015-05-15 | 가천대학교 산학협력단 | 근육염증 진단용 조성물 및 그의 용도 |
| WO2015073531A1 (en) * | 2013-11-13 | 2015-05-21 | The Texas A & M University System | Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells |
| JP6611411B2 (ja) * | 2013-12-05 | 2019-11-27 | 東レ株式会社 | 膵臓がんの検出キット及び検出方法 |
| JP6797017B2 (ja) * | 2014-05-30 | 2020-12-09 | 東レ株式会社 | 膵臓がんの検出キット又はデバイス及び検出方法 |
| EP3461904A1 (en) | 2014-11-10 | 2019-04-03 | ModernaTX, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
| GB201501930D0 (en) | 2015-02-05 | 2015-03-25 | Univ London Queen Mary | Biomarkers for pancreatic cancer |
| WO2017047800A1 (ja) * | 2015-09-16 | 2017-03-23 | 国立大学法人東北大学 | 核酸分子 |
| GB201517028D0 (en) * | 2015-09-25 | 2015-11-11 | Univ London Queen Mary | Novel biomarkers for pancreatic cancer |
| AU2016377398B2 (en) * | 2015-12-23 | 2022-10-13 | Repluca Pty Ltd | Nucleic acid oligomers and uses therefor |
| EP3405579A1 (en) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| PL3458083T3 (pl) | 2016-05-18 | 2023-03-13 | Modernatx, Inc. | Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania |
| EP3468537A1 (en) | 2016-06-14 | 2019-04-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| US11427838B2 (en) | 2016-06-29 | 2022-08-30 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders |
| WO2018002762A1 (en) | 2016-06-29 | 2018-01-04 | Crispr Therapeutics Ag | Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders |
| CA3029119A1 (en) | 2016-06-29 | 2018-01-04 | Crispr Therapeutics Ag | Materials and methods for treatment of friedreich ataxia and other related disorders |
| EP3481857B1 (en) | 2016-07-06 | 2026-02-11 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| EP4650364A3 (en) | 2016-07-06 | 2026-01-21 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| CA3042015A1 (en) | 2016-10-26 | 2018-05-03 | Modernatx, Inc. | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| EP3538067A1 (en) | 2016-11-08 | 2019-09-18 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| MX2019009070A (es) | 2017-02-01 | 2019-10-30 | Modernatx Inc | Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion. |
| WO2018154418A1 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| WO2018154462A2 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders |
| AU2018224387B2 (en) | 2017-02-22 | 2024-08-08 | Crispr Therapeutics Ag | Compositions and methods for gene editing |
| WO2018154439A1 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders |
| EP3585899A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Materials and methods for treatment of primary hyperoxaluria type 1 (ph1) and other alanine-glyoxylate aminotransferase (agxt) gene related conditions or disorders |
| CA3058406A1 (en) * | 2017-03-30 | 2018-10-04 | The Board Of Trustees Of The University Of Illinois | Method and kit for diagnosing early stage pancreatic cancer |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| EP3645737A4 (en) * | 2017-06-29 | 2021-03-24 | The University of Sydney | CELL-FREE MICRORNA SIGNATURES OF BETA CELL DEATH OF PANCREATIC ISLAND CELLS |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| EP3714055A1 (en) | 2017-11-21 | 2020-09-30 | CRISPR Therapeutics AG | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| US20190314291A1 (en) | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| JP7500536B2 (ja) | 2018-03-23 | 2024-06-17 | アデノサイト リミテッド | 強化された細胞病理学的細胞採取のための細胞および／または組織片の剥離を誘導する方法 |
| US20210163928A1 (en) | 2018-04-11 | 2021-06-03 | Modernatx, Inc. | Messenger rna comprising functional rna elements |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US20210220471A1 (en) * | 2018-07-13 | 2021-07-22 | Memorial Sloan Kettering Cancer Center | Methods of using pharmacologic inhibitors of type 2 cytokine signaling to treat or prevent pancreatic cancer |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| CN113939282A (zh) | 2019-01-31 | 2022-01-14 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| BR112021017744A2 (pt) | 2019-03-08 | 2021-11-16 | Obsidian Therapeutics Inc | Composições e métodos de cd40l para regulação ajustável |
| EP3987027A1 (en) | 2019-06-24 | 2022-04-27 | ModernaTX, Inc. | Endonuclease-resistant messenger rna and uses thereof |
| MA56517A (fr) | 2019-06-24 | 2022-04-27 | Modernatx Inc | Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| US20230285297A1 (en) | 2020-01-31 | 2023-09-14 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| CN111172285A (zh) * | 2020-02-26 | 2020-05-19 | 江南大学附属医院 | 用于胰腺癌早期诊断和/或预后监测的miRNA组及其应用 |
| ES2856232B2 (es) * | 2020-03-25 | 2023-11-24 | Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre | Biomarcadores para predecir la respuesta de un sujeto a una terapia con bcg, metodos y usos basados en los mismos |
| US11965162B2 (en) * | 2020-04-16 | 2024-04-23 | The Johns Hopkins University | MicroRNA and inhibitors thereof and methods of treatment |
| JP2023535225A (ja) | 2020-07-24 | 2023-08-16 | ストランド セラピューティクス インコーポレイテッド | 改変ヌクレオチドを含む脂質ナノ粒子 |
| TW202220637A (zh) | 2020-08-06 | 2022-06-01 | 美商現代公司 | 製備脂質奈米顆粒之方法 |
| KR20230129479A (ko) | 2021-01-08 | 2023-09-08 | 스트랜드 세러퓨틱스 인코포레이티드 | 발현 구성체 및 이의 용도 |
| WO2022170133A1 (en) * | 2021-02-04 | 2022-08-11 | The Cleveland Clinic Foundation | Micro rna liver cancer markers and uses thereof |
| CA3171589A1 (en) | 2021-05-03 | 2022-11-03 | Moritz THRAN | Improved nucleic acid sequence for cell type specific expression |
| WO2023009861A2 (en) * | 2021-07-29 | 2023-02-02 | The Trustees Of Indiana University | Materials and methods for treating or preventing pancreatitis |
| KR102978534B1 (ko) * | 2022-02-23 | 2026-06-15 | 연세대학교 산학협력단 | 췌장암 진단을 위한 세포외 소포체 유래 miRNA 유전자 바이오마커 및 이의 용도 |
| WO2023166425A1 (en) | 2022-03-01 | 2023-09-07 | Crispr Therapeutics Ag | Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions |
| AU2023262576A1 (en) | 2022-04-26 | 2024-10-10 | Strand Therapeutics Inc. | Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof |
| WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
| US20250375391A1 (en) | 2022-07-29 | 2025-12-11 | Modernatx, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and relates uses |
| WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
| CN121079317A (zh) | 2023-04-28 | 2025-12-05 | 深圳深信生物科技有限公司 | 经修饰的递送载体及其应用 |
| WO2024259373A1 (en) | 2023-06-14 | 2024-12-19 | Modernatx, Inc. | Compounds and compositions for delivery of therapeutic agents |
| WO2025160381A1 (en) | 2024-01-26 | 2025-07-31 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2025166202A1 (en) | 2024-01-31 | 2025-08-07 | Modernatx, Inc. | Lipid nanoparticle compositions comprising sialic acid derivatives and the uses thereof |
| CN122180503A (zh) | 2024-04-30 | 2026-06-09 | 深圳深信生物科技有限公司 | 脂质纳米颗粒及其应用 |
Family Cites Families (214)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1529202A (en) | 1976-02-20 | 1978-10-18 | Ciba Geigy Ag | Spectral sensitising dyes |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| US5221619A (en) | 1977-11-08 | 1993-06-22 | Genentech, Inc. | Method and means for microbial polypeptide expression |
| US5583013A (en) | 1977-11-08 | 1996-12-10 | Genentech, Inc. | Method and means for microbial polypeptide expression |
| JPS55116259A (en) | 1979-03-01 | 1980-09-06 | Fuji Photo Film Co Ltd | Microimmunoassay method |
| DE3170135D1 (en) | 1980-09-02 | 1985-05-30 | Fuji Photo Film Co Ltd | Method for immunochemical measurement of trace components |
| JPS5745460A (en) | 1980-09-02 | 1982-03-15 | Fuji Photo Film Co Ltd | Inspection sheet for measuring trace component and inspecting method using said sheet |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US4682195A (en) | 1985-09-30 | 1987-07-21 | General Electric Company | Insulated gate device with configured emitter contact pad |
| US4959463A (en) | 1985-10-15 | 1990-09-25 | Genentech, Inc. | Intermediates |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| EP0266032A1 (en) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US4816571A (en) | 1987-06-04 | 1989-03-28 | Applied Biosystems, Inc. | Chemical capping by phosphitylation during oligonucleotide synthesis |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5602244A (en) | 1988-05-26 | 1997-02-11 | Competitive Technologies, Inc. | Polynucleotide phosphorodithioate compounds |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5708154A (en) | 1989-02-24 | 1998-01-13 | City Of Hope | RNA-DNA hybrid molecules of nucleic acid |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
| US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| WO1991006556A1 (en) | 1989-10-24 | 1991-05-16 | Gilead Sciences, Inc. | 2' modified oligonucleotides |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US5859221A (en) | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5872232A (en) | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
| US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5223618A (en) | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| JPH0874B2 (ja) | 1990-07-27 | 1996-01-10 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド |
| US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| EP0604552B1 (en) | 1991-09-18 | 1997-02-12 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| DE69233087T2 (de) | 1991-11-22 | 2003-12-24 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verfahren zur Herstellung von Polymerarrays |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| US5260191A (en) * | 1992-01-30 | 1993-11-09 | Agracetus, Inc. | Method for diagnosing tumors |
| US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
| ATE244259T1 (de) | 1992-02-12 | 2003-07-15 | Chromagen Inc | Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen |
| DE4204650C1 (enExample) | 1992-02-15 | 1993-07-08 | Hoffmeister, Helmut, Dr., 4400 Muenster, De | |
| EP1382386A3 (en) | 1992-02-19 | 2004-12-01 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
| EP0592626B1 (en) | 1992-03-11 | 2003-01-29 | Dana-Farber Cancer Institute, Inc. | METHODS TO CLONE mRNA |
| JP2775346B2 (ja) | 1992-04-03 | 1998-07-16 | アプライド バイオシステムズ，インコーポレイテッド | プローブ構成物および方法 |
| US5428148A (en) | 1992-04-24 | 1995-06-27 | Beckman Instruments, Inc. | N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis |
| US5438131A (en) | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5858988A (en) | 1993-02-24 | 1999-01-12 | Wang; Jui H. | Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use |
| US5580726A (en) | 1994-04-29 | 1996-12-03 | Geron Corporation | Method and Kit for enhanced differential display |
| WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| JPH09508800A (ja) | 1994-02-14 | 1997-09-09 | スミスクライン・ビーチャム・コーポレイション | 差次的発現遺伝子の同定法 |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5574146A (en) | 1994-08-30 | 1996-11-12 | Beckman Instruments, Inc. | Oligonucleotide synthesis with substituted aryl carboxylic acids as activators |
| US5554744A (en) | 1994-09-23 | 1996-09-10 | Hybridon, Inc. | Method for loading solid supports for nucleic acid synthesis |
| US6096314A (en) * | 1994-10-07 | 2000-08-01 | Yeda Research And Development Co. Ltd. | Peptides and pharmaceutical compositions comprising them |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| WO1997027317A1 (en) | 1996-01-23 | 1997-07-31 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| DE19518505A1 (de) | 1995-05-19 | 1996-11-21 | Max Planck Gesellschaft | Verfahren zur Genexpressionsanalyse |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5637683A (en) | 1995-07-13 | 1997-06-10 | Cornell Research Foundation, Inc. | Nucleic acid analog with amide linkage and method of making that analog |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| US5658734A (en) | 1995-10-17 | 1997-08-19 | International Business Machines Corporation | Process for synthesizing chemical compounds |
| US5705629A (en) | 1995-10-20 | 1998-01-06 | Hybridon, Inc. | Methods for H-phosphonate synthesis of mono- and oligonucleotides |
| US6418382B2 (en) * | 1995-10-24 | 2002-07-09 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US5670663A (en) | 1996-02-14 | 1997-09-23 | Regents Of The University Of California | Recovery of taxanes from conifers |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| US5886165A (en) | 1996-09-24 | 1999-03-23 | Hybridon, Inc. | Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments |
| US6218523B1 (en) * | 1997-03-07 | 2001-04-17 | Diagnostic Products Corporation | Prostate cancer-specific marker |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| NO972006D0 (no) | 1997-04-30 | 1997-04-30 | Forskningsparken I Aas As | Ny metode for diagnose av sykdommer |
| US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
| US6368799B1 (en) | 1997-06-13 | 2002-04-09 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
| JP2001521754A (ja) | 1997-10-30 | 2001-11-13 | コールド スプリング ハーバー ラボラトリー | Ｄｎａ識別のためのプローブアレイ及びプローブアレイの使用方法 |
| US6121058A (en) | 1998-01-02 | 2000-09-19 | Intel Corporation | Method for removing accumulated solder from probe card probing features |
| US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| US6576420B1 (en) * | 1998-06-23 | 2003-06-10 | Regents Of The University Of California | Method for early diagnosis of, and determination of prognosis in, cancer |
| US6730477B1 (en) * | 1998-08-04 | 2004-05-04 | Diadexus, Inc. | Method of diagnosing, monitoring and staging breast cancer |
| US6638717B2 (en) | 1999-05-19 | 2003-10-28 | Aventis Pharmaceuticals, Inc. | Microarray-based subtractive hybridzation |
| CA2377385A1 (en) * | 1999-06-03 | 2000-12-14 | Jessie L.S. Au | Methods and compositions for modulating cell proliferation and cell death |
| US6201112B1 (en) | 1999-07-22 | 2001-03-13 | Agilent Technologies Inc. | Method for 3′ end-labeling ribonucleic acids |
| US20020094546A1 (en) * | 1999-10-07 | 2002-07-18 | Shimkets Richard A. | Growth factor polypeptides and nucleic acids encoding same |
| US6435245B1 (en) * | 1999-11-18 | 2002-08-20 | Pitney Bowes Inc. | System for folding and tabbing sheets |
| JP2003515149A (ja) | 1999-11-26 | 2003-04-22 | キュラジェン コーポレイション | 核酸プローブアレイ |
| US6383749B2 (en) | 1999-12-02 | 2002-05-07 | Clontech Laboratories, Inc. | Methods of labeling nucleic acids for use in array based hybridization assays |
| US6447723B1 (en) | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
| WO2001070095A2 (en) * | 2000-03-23 | 2001-09-27 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| EP1268818A2 (en) * | 2000-03-24 | 2003-01-02 | Millennium Pharmaceuticals, Inc. | 18221, dual specificity phosphatase and uses thereof |
| US6787335B2 (en) * | 2000-03-27 | 2004-09-07 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating mammary gland cancer |
| AU2001251013A1 (en) * | 2000-03-28 | 2001-10-08 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer |
| US20020119156A1 (en) * | 2000-03-29 | 2002-08-29 | Sei-Yu Chen | Compositions and methods of diagnosing, monitoring, staging, imaging and treating lung cancer |
| US20020068307A1 (en) * | 2000-03-30 | 2002-06-06 | Jason Pluta | Compositions and methods for diagnosing, monitoring, staging, imaging and treating stomach cancer |
| US7947463B2 (en) * | 2000-05-10 | 2011-05-24 | Signe Biopharma, Inc. | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers |
| US20030009295A1 (en) * | 2001-03-14 | 2003-01-09 | Victor Markowitz | System and method for retrieving and using gene expression data from multiple sources |
| JP5078212B2 (ja) * | 2000-06-02 | 2012-11-21 | ブラッコ・スイス・ソシエテ・アノニム | 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法 |
| AU2001276371A1 (en) * | 2000-06-30 | 2002-01-14 | Epigenomics Ag | Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics |
| AU2001281136A1 (en) * | 2000-08-04 | 2002-02-18 | Board Of Regents, The University Of Texas System | Detection and diagnosis of smoking related cancers |
| AU2001292842A1 (en) * | 2000-09-19 | 2002-04-02 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
| US20030082604A1 (en) | 2000-09-27 | 2003-05-01 | Swanson Melvin J. | High density arrays |
| US7162371B1 (en) * | 2000-10-11 | 2007-01-09 | Georgia Tech Research Corporation | Differentially-expressed conifer cDNAs, and their use in improving somatic embryogenesis |
| US6617112B2 (en) | 2000-10-11 | 2003-09-09 | Monsanto Technology Llc | Methods for gene array analysis of nuclear runoff transcripts |
| GB0029360D0 (en) * | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| KR20040034582A (ko) * | 2000-12-04 | 2004-04-28 | 프리마겐 홀딩 비.브이. | 내공생체 세포소기관의 시험 및 그것에 의해 동정할 수있는 화합물 |
| US20030099976A1 (en) * | 2001-01-17 | 2003-05-29 | Tai-Jay Chang | Androgen receptor complex-associated protein |
| US20040115671A1 (en) * | 2001-01-18 | 2004-06-17 | Zlokovic Berislav V | Gene expression profiling of endothelium in alzheimer's disease |
| US7015047B2 (en) * | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
| EP1390387A4 (en) * | 2001-04-20 | 2004-12-08 | Ludwig Inst Cancer Res | TESTICLES CANCER ANTIGENS |
| EP1399460A4 (en) * | 2001-04-27 | 2005-04-13 | Sunnybrook & Women S College H | GENESIS ASSOCIATED WITH BREAST CANCER AND THEIR USE |
| AUPR480901A0 (en) * | 2001-05-04 | 2001-05-31 | Genomics Research Partners Pty Ltd | Diagnostic method for assessing a condition of a performance animal |
| WO2002099568A2 (en) * | 2001-06-01 | 2002-12-12 | Prosanos Corporation | Information processing method for disease stratification and assessment of disease progressing |
| US20040086504A1 (en) * | 2001-06-21 | 2004-05-06 | Deepak Sampath | Cyr61 as a target for treatment and diagnosis of breast cancer |
| WO2003001335A2 (en) * | 2001-06-22 | 2003-01-03 | Gene Logic, Inc. | Platform for management and mining of genomic data |
| US7297480B2 (en) * | 2001-06-28 | 2007-11-20 | Dermtech International | Method for detection of melanoma |
| JP4572276B2 (ja) * | 2001-06-29 | 2010-11-04 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | Ｔ細胞調節遺伝子およびその使用方法 |
| US20030143571A1 (en) | 2001-08-08 | 2003-07-31 | North Carolina State University | Infectious disease microarray |
| WO2003020898A2 (en) | 2001-08-30 | 2003-03-13 | Spectral Genomics, Inc. | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
| AU2002339865A1 (en) * | 2001-09-05 | 2003-03-18 | The Children's Hospital Of Philadelphia | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors |
| US20040241696A1 (en) | 2001-09-06 | 2004-12-02 | Peinado Miguel A | Genetic analysis of biological samples in arrayed expanded representations of their nucleic acids |
| EP1425090A2 (en) | 2001-09-07 | 2004-06-09 | Corning Incorporated | MICROCOLUMN−PLATFORM BASED ARRAY FOR HIGH−THROUGHPUT ANALYSIS |
| IL159422A0 (en) * | 2001-09-20 | 2004-06-01 | Cornell Res Foundation Inc | Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate-specific membrane antigen |
| WO2003029485A2 (en) | 2001-10-02 | 2003-04-10 | Azign Bioscience A/S | Specific differential display arrays |
| CA2463725A1 (en) | 2001-10-12 | 2003-11-06 | Spectral Genomics, Inc. | Compilations of nucleic acids and arrays and methods of using them |
| WO2003040410A1 (en) | 2001-11-02 | 2003-05-15 | Nimblegen Systems, Inc. | Detection of hybridization oligonucleotide microarray through covalently labeling microarray probe |
| EP1451579A4 (en) * | 2001-11-19 | 2005-12-28 | Protometrix Inc | METHOD OF USING NON-ANTIBODY PROTEIN FOR DETECTING AND MEASURING AN ANALYTE |
| WO2003053586A1 (en) | 2001-12-19 | 2003-07-03 | Affymetrix, Inc. | Array plates and method for constructing array plates |
| EP1465997A4 (en) * | 2001-12-27 | 2006-05-24 | Agy Therapeutics Inc | USE OF BIOMOLECULAR OBJECTIVES IN THE TREATMENT AND VISUALIZATION OF TUMORS |
| AU2003212878A1 (en) * | 2002-01-30 | 2003-09-02 | Epigenomics Ag | Identification of cell differentiation states based on methylation patterns |
| CA2474530A1 (en) | 2002-02-07 | 2003-08-14 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Diagnostic microarray and method of use thereof |
| US20030232356A1 (en) | 2002-02-08 | 2003-12-18 | Dooley Thomas P. | Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays |
| US20060088831A1 (en) | 2002-03-07 | 2006-04-27 | University Of Utah Research Foundation | Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis |
| JP2005521420A (ja) * | 2002-04-03 | 2005-07-21 | エージーワイ セラピューティクス インコーポレイティッド | 脳腫瘍の処置及び可視化における生体分子標的の使用法 |
| US20070025997A1 (en) * | 2002-04-03 | 2007-02-01 | Usha Nagavarapu | Use of biomolecular targets in the treatment and visualization of brain tumors |
| EP1502098B1 (en) | 2002-05-03 | 2008-09-17 | ViaLogy, LLC | Method for characterizing microarray output data |
| CA2524569C (en) * | 2002-05-03 | 2013-10-22 | Duke University | A method of regulating gene expression |
| KR20050037991A (ko) * | 2002-05-20 | 2005-04-25 | 노드롭 그루만 코포레이션 | 자동 오염원 생물학적 병원체 검출시스템 |
| ATE513923T1 (de) | 2002-05-24 | 2011-07-15 | Roche Nimblegen Inc | Mikroarrays und verfahren zur durchführung einer hybridisierungsreaktion für mehrere proben auf einem einzigen mikroarray |
| AUPS261402A0 (en) | 2002-05-28 | 2002-06-20 | Compusign Pty Ltd | Array monitoring |
| US20030228579A1 (en) * | 2002-06-05 | 2003-12-11 | Uri Alon | Ordering genes by analysis of expression kinetics |
| US20040029128A1 (en) * | 2002-08-08 | 2004-02-12 | Epigenomics, Inc. | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| US20040029121A1 (en) * | 2002-08-08 | 2004-02-12 | Susan Cottrell | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| AU2003268105B2 (en) * | 2002-08-16 | 2011-11-03 | John Wayne Cancer Institute | Molecular lymphatic mapping of sentinel lymph nodes |
| WO2004025556A2 (en) * | 2002-09-12 | 2004-03-25 | Baylor College Of Medecine | System and method for image segmentation |
| AU2003267583A1 (en) | 2002-09-19 | 2004-04-08 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
| WO2004041212A2 (en) * | 2002-11-01 | 2004-05-21 | Todd Charlton Sacktor | Apkc isoforms in nervous system disorders and cancer |
| EP1418241A1 (en) * | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Method for quantifying a ratio between at least two nucleic acid sequences |
| WO2004062487A2 (en) * | 2003-01-13 | 2004-07-29 | Emory University | Methods of detecting gene expression in normal and cancerous cells |
| DE602004012531T2 (de) * | 2003-01-16 | 2009-04-16 | North Carolina State University | Verarmung an endogenen primordialen keimzellen in vogelspezies |
| US20040224337A1 (en) * | 2003-03-04 | 2004-11-11 | Erik Foehr | Use of biomolecular targets in the treatment and visualization of tumors |
| WO2004083816A2 (en) * | 2003-03-14 | 2004-09-30 | John Wayne Cancer Institute | Loss of heterozygosity of the dna markers in the 12q22-23 region |
| US7718364B2 (en) * | 2003-03-25 | 2010-05-18 | John Wayne Cancer Institute | DNA markers for management of cancer |
| US20040229211A1 (en) * | 2003-05-13 | 2004-11-18 | Yeung Wah Hin Alex | Sensitive diagnostic testing methodology using multiplex real time PCR with one dye (MOD) and its use as in severe acute respiratory syndrome (SARS) |
| WO2004105573A2 (en) * | 2003-05-21 | 2004-12-09 | The Wistar Institute Of Anatomy And Biology | Method of diagnosis of cancer based on gene expression profiles in cells |
| US20060183128A1 (en) * | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| AU2004291656A1 (en) * | 2003-11-10 | 2005-06-02 | Noxxon Pharma Ag | Nucleic acids specifically binding bioactive ghrelin |
| US20050130172A1 (en) * | 2003-12-16 | 2005-06-16 | Bayer Corporation | Identification and verification of methylation marker sequences |
| US20050130170A1 (en) * | 2003-12-16 | 2005-06-16 | Jeanne Harvey | Identification and verification of methylation marker sequences |
| EP1713938A2 (en) * | 2004-02-09 | 2006-10-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| US7402389B2 (en) * | 2004-02-24 | 2008-07-22 | The Translational Genomics Research Institute (Tgen) | Compositions and methods for prognosis of cancers |
| US20060195266A1 (en) * | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
| CA2561073C (en) * | 2004-03-27 | 2014-01-14 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Composition and method for cancer treatment |
| EP2471924A1 (en) * | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| US20060134661A1 (en) * | 2004-10-12 | 2006-06-22 | Richard Essner | Treatment of cancer and compositions |
| WO2006060653A2 (en) * | 2004-11-30 | 2006-06-08 | Veridex Llc | Lung cancer prognostics |
| US20060154275A1 (en) * | 2004-12-02 | 2006-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Regulated genes in cervical cancer |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| US7495073B2 (en) * | 2005-03-24 | 2009-02-24 | Asia Hepato Gene Company | Short isoform of Annexin A10 at chromosome 4q, termed Annexin 10s (ANXA10s) and methods of use |
| GB0601102D0 (en) * | 2006-01-19 | 2006-03-01 | Nuclea Biomarkers Llc | Kinase Peptides And Antibodies |
| WO2006128245A1 (en) * | 2005-06-03 | 2006-12-07 | Southern Adelaide Health Service-Flinders Medical Centre | Targeting cells with altered microrna expression |
| IL177006A0 (en) * | 2005-08-02 | 2006-12-10 | Veridex Llc | Predicting bone relapse of breast cancer |
| US20070041934A1 (en) * | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
| AU2007205234B2 (en) * | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2522748A1 (en) * | 2006-03-02 | 2012-11-14 | The Ohio State University | MicroRNA expression profile associated with pancreatic cancer |
| CA2655355C (en) * | 2006-06-16 | 2014-05-06 | Taisho Pharmaceutical Co., Ltd. | Use of rpn2 gene expression inhibitor |
| ES2425387T3 (es) * | 2006-07-13 | 2013-10-15 | The Ohio State University Research Foundation | Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre |
| CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
-
2007
- 2007-09-19 CA CA2664383A patent/CA2664383C/en not_active Expired - Fee Related
- 2007-09-19 EP EP12159733.0A patent/EP2487240B1/en not_active Not-in-force
- 2007-09-19 EP EP07842816A patent/EP2115138A2/en not_active Withdrawn
- 2007-09-19 AU AU2007299828A patent/AU2007299828C1/en not_active Ceased
- 2007-09-19 US US11/857,948 patent/US20090131348A1/en not_active Abandoned
- 2007-09-19 JP JP2009529373A patent/JP5520605B2/ja active Active
- 2007-09-19 WO PCT/US2007/078936 patent/WO2008036765A2/en not_active Ceased
-
2009
- 2009-03-19 IL IL197690A patent/IL197690A0/en unknown
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2018
- 2018-03-12 US US15/917,935 patent/US20190330623A1/en not_active Abandoned
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