DE60239386D1 - Zellbibliothek - Google Patents
ZellbibliothekInfo
- Publication number
- DE60239386D1 DE60239386D1 DE60239386T DE60239386T DE60239386D1 DE 60239386 D1 DE60239386 D1 DE 60239386D1 DE 60239386 T DE60239386 T DE 60239386T DE 60239386 T DE60239386 T DE 60239386T DE 60239386 D1 DE60239386 D1 DE 60239386D1
- Authority
- DE
- Germany
- Prior art keywords
- novel
- libraries
- host cells
- cell library
- discovery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100128 | 2001-01-25 | ||
DKPA200100679 | 2001-05-01 | ||
US30086301P | 2001-06-27 | 2001-06-27 | |
PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60239386D1 true DE60239386D1 (de) | 2011-04-21 |
Family
ID=43646216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60239386T Expired - Lifetime DE60239386D1 (de) | 2001-01-25 | 2002-01-25 | Zellbibliothek |
Country Status (9)
Country | Link |
---|---|
US (2) | US7838287B2 (de) |
EP (1) | EP1356037B1 (de) |
JP (2) | JP2004525624A (de) |
AT (1) | ATE501251T1 (de) |
AU (1) | AU2002227883A1 (de) |
CA (1) | CA2474172C (de) |
DE (1) | DE60239386D1 (de) |
DK (1) | DK1356037T3 (de) |
WO (1) | WO2002059297A2 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
DE60324385D1 (de) * | 2002-01-25 | 2008-12-11 | Evolva Ag | Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren |
ES2368733T3 (es) | 2002-07-18 | 2011-11-21 | Merus B.V. | Producción recombinante de mezclas de anticuerpos. |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
US20060252156A1 (en) * | 2002-08-01 | 2006-11-09 | Evolva Ltd. C/O Dr. Iur. Martin Eisenring | Methods of mixing large numbers of heterologous genes |
CA2527694C (en) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
EP1737971B1 (de) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Gemische bindender proteine |
AU2006227165B2 (en) | 2005-03-18 | 2011-11-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
SG177564A1 (en) | 2009-07-06 | 2012-02-28 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
EP2571991A1 (de) | 2010-05-20 | 2013-03-27 | Evolva SA | Verfahren zur herstellung von isoprenoidverbindungen in hefe |
NZ708078A (en) | 2010-06-02 | 2017-01-27 | Evolva Nutrition Inc | Recombinant production of steviol glycosides |
WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
EP2734208B1 (de) | 2011-07-19 | 2017-03-01 | Wave Life Sciences Ltd. | Verfahren zur synthese von funktionalisierten nukleinsäuren |
CA3128532A1 (en) | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
MX360109B (es) | 2012-04-20 | 2018-10-23 | Merus Nv | Metodos y medios para la produccion de moleculas de tipo ig. |
US10829772B2 (en) | 2012-06-22 | 2020-11-10 | Monsanto Technology Llc | Unique modular vector design |
KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
EP2872485B1 (de) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
WO2014010718A1 (ja) | 2012-07-13 | 2014-01-16 | 株式会社新日本科学 | キラル核酸アジュバント |
WO2014066374A1 (en) * | 2012-10-22 | 2014-05-01 | Refactored Materials, Inc. | Cellular reprogramming for product optimization |
CA3171770A1 (en) | 2013-02-06 | 2014-08-14 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
EP3046585B1 (de) | 2013-09-17 | 2021-08-25 | Bolt Threads, Inc. | Verfahren und zusammensetzungen zur synthetisierung verbesserter seidenfasern |
US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
AU2015207773B2 (en) | 2014-01-16 | 2021-06-17 | Wave Life Sciences Ltd. | Chiral design |
BR112017002783A2 (pt) | 2014-08-11 | 2017-12-19 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
MY191735A (en) | 2014-09-09 | 2022-07-13 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
EP4148137A1 (de) | 2015-01-30 | 2023-03-15 | Evolva SA | Herstellung von steviolglycosiden in rekombinanten wirten |
CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
WO2017025362A1 (en) | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
KR20190046993A (ko) | 2016-09-14 | 2019-05-07 | 볼트 쓰레즈, 인크. | 긴 균일한 재조합 단백질 섬유 |
CN110100006A (zh) | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
WO2024075756A1 (ja) * | 2022-10-05 | 2024-04-11 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
JP7212982B1 (ja) * | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341116C (en) | 1983-02-22 | 2000-10-17 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis or foreign protein |
DE68920319D1 (de) | 1988-04-22 | 1995-02-09 | Massachusetts Inst Technology | Verfahren zum formen und zum gebrauch von mikrotröpchen. |
EP0481008B1 (de) | 1989-07-07 | 1997-11-12 | Unilever Plc | Verfahren zur herstellung eines proteins mittels eines durch mehrfachkopieintegrierung eines expressionsvektors transformierten pilzes |
US5316922A (en) | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
ATE397066T1 (de) | 1993-10-27 | 2008-06-15 | Univ Columbia | Methode zur bildung einer subtrahierten cdna bank und ihre verwendung |
US6268140B1 (en) | 1994-02-03 | 2001-07-31 | Neugenesis | Combinatorial metabolic libraries |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
CA2219136A1 (en) | 1995-04-24 | 1996-10-31 | Chromaxome Corp. | Methods for generating and screening novel metabolic pathways |
US6030779A (en) | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
US6004788A (en) | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US20010041333A1 (en) | 1997-06-16 | 2001-11-15 | Short Jay M. | High throughput screening for a bioactivity or biomolecule |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
GB9603803D0 (en) * | 1996-02-22 | 1996-04-24 | Zeneca Ltd | Production of proteins, plasmids coding therefor and organisms containing such plasmids |
US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
AU2887897A (en) | 1996-05-21 | 1997-12-09 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
US5763239A (en) | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
US6294325B1 (en) * | 1996-07-05 | 2001-09-25 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of thermostable multi genes and proteins and uses thereof |
JP2000515011A (ja) | 1996-07-09 | 2000-11-14 | アメリカ合衆国 | 形質転換関連組換えクローニング |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
CA2276064C (en) | 1997-01-17 | 2013-12-17 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
CA2282658C (en) | 1997-02-27 | 2003-02-25 | Cellomics, Inc. | A system for cell-based screening |
EP0975969A4 (de) | 1997-03-18 | 2002-07-31 | Chromaxome Corp | Screening-methode für verbindungen mit hilfe eingekapselter zellen |
WO1998054339A1 (en) | 1997-05-27 | 1998-12-03 | Hanil Synthetic Fiber Co., Ltd. | PROCESS FOR PREPARING RECOMBINANT PROTEINS USING HIGHLY EFFICIENT EXPRESSION VECTOR FROM $i(SACCHAROMYCES CEREVISIAE) |
GB9727512D0 (en) | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
WO1999045154A1 (en) | 1998-03-04 | 1999-09-10 | Diversa Corporation | Production and use of normalized dna libraries |
AU5217599A (en) | 1998-07-27 | 2000-02-21 | Genotypes, Inc. | Automatic eukaryotic artificial chromosome vector |
DE69931497T2 (de) | 1998-08-07 | 2007-05-03 | Cellay LLC, Cambridge | Gel mikrotropfen für die genetische analyse |
AU5696899A (en) | 1998-08-31 | 2000-03-21 | Maxygen, Inc. | Transformation, selection, and screening of sequence-shuffled polynucleotides for development and optimization of plant phenotypes |
EP1114320A2 (de) | 1998-09-18 | 2001-07-11 | Cellomics, Inc. | Ein system für zellbasierte reihenuntersuchungen |
AU3879300A (en) | 1999-03-09 | 2000-09-28 | Diversa Corporation | End selection in directed evolution |
JP2004500019A (ja) | 1999-03-26 | 2004-01-08 | ディベルサ コーポレーション | 定方向進化におけるエキソヌクレアーゼ仲介核酸再集合 |
GB9908814D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
AU7646000A (en) | 1999-11-05 | 2001-05-14 | Novozymes A/S | Methods to screen microorganisms or gene libraries for products secreted from a cell |
WO2001073000A2 (en) | 2000-03-24 | 2001-10-04 | Maxygen, Inc. | Methods for modulating cellular and organismal phenotypes |
AU2002226307A1 (en) | 2001-01-25 | 2002-08-06 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
ATE375394T1 (de) | 2001-01-25 | 2007-10-15 | Evolva Ltd | Concatemere unterschiedlich exprimierter multipler gene |
DK1364005T3 (da) | 2001-01-25 | 2009-02-02 | Evolva Ltd | En metode til udvikling af en celle der har en önsket fænotype og udviklede celler |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
DE60324385D1 (de) | 2002-01-25 | 2008-12-11 | Evolva Ag | Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren |
ATE386810T1 (de) | 2002-06-14 | 2008-03-15 | Dyax Corp | Rekombination von nukleinsäurebibliotheksmitgliedern |
US20030235823A1 (en) | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
US20060252156A1 (en) | 2002-08-01 | 2006-11-09 | Evolva Ltd. C/O Dr. Iur. Martin Eisenring | Methods of mixing large numbers of heterologous genes |
-
2002
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en active Application Filing
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 EP EP02709979A patent/EP1356037B1/de not_active Expired - Lifetime
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040241672A1 (en) | 2004-12-02 |
EP1356037A2 (de) | 2003-10-29 |
WO2002059297A8 (en) | 2004-04-15 |
AU2002227883A1 (en) | 2002-08-06 |
ATE501251T1 (de) | 2011-03-15 |
WO2002059297A2 (en) | 2002-08-01 |
US7838287B2 (en) | 2010-11-23 |
JP4965625B2 (ja) | 2012-07-04 |
US20120094870A1 (en) | 2012-04-19 |
JP2010043108A (ja) | 2010-02-25 |
DK1356037T3 (da) | 2011-06-27 |
WO2002059297A3 (en) | 2003-04-10 |
EP1356037B1 (de) | 2011-03-09 |
JP2004525624A (ja) | 2004-08-26 |
CA2474172A1 (en) | 2002-08-01 |
CA2474172C (en) | 2012-07-10 |
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Legal Events
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R081 | Change of applicant/patentee |
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