EP0975969A4 - Screening-methode für verbindungen mit hilfe eingekapselter zellen - Google Patents

Screening-methode für verbindungen mit hilfe eingekapselter zellen

Info

Publication number
EP0975969A4
EP0975969A4 EP98911863A EP98911863A EP0975969A4 EP 0975969 A4 EP0975969 A4 EP 0975969A4 EP 98911863 A EP98911863 A EP 98911863A EP 98911863 A EP98911863 A EP 98911863A EP 0975969 A4 EP0975969 A4 EP 0975969A4
Authority
EP
European Patent Office
Prior art keywords
methods
screening compounds
encapsulated cells
encapsulated
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98911863A
Other languages
English (en)
French (fr)
Other versions
EP0975969A1 (de
Inventor
Nicole M Nasby
Todd C Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromaxome Corp
Original Assignee
Chromaxome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromaxome Corp filed Critical Chromaxome Corp
Publication of EP0975969A1 publication Critical patent/EP0975969A1/de
Publication of EP0975969A4 publication Critical patent/EP0975969A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98911863A 1997-03-18 1998-03-18 Screening-methode für verbindungen mit hilfe eingekapselter zellen Withdrawn EP0975969A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4088897P 1997-03-18 1997-03-18
US40888P 1997-03-18
US7104698P 1998-01-13 1998-01-13
US71046P 1998-01-13
PCT/US1998/005462 WO1998041869A1 (en) 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells

Publications (2)

Publication Number Publication Date
EP0975969A1 EP0975969A1 (de) 2000-02-02
EP0975969A4 true EP0975969A4 (de) 2002-07-31

Family

ID=26717558

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98911863A Withdrawn EP0975969A4 (de) 1997-03-18 1998-03-18 Screening-methode für verbindungen mit hilfe eingekapselter zellen

Country Status (4)

Country Link
EP (1) EP0975969A4 (de)
AU (1) AU6571598A (de)
CA (1) CA2284066A1 (de)
WO (1) WO1998041869A1 (de)

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US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
EP1801214B1 (de) 1997-07-07 2010-11-10 Medical Research Council In-vitro-Sortierverfahren
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
IT1318605B1 (it) * 2000-06-30 2003-08-27 Uni Degli Studi Di Modena E Re Procedimoento per il dosaggio di tossine dsp del gruppo delledinophysitossine e delle yessottossine.
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
WO2002059297A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S A library of a collection of cells
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
FR2842747B1 (fr) * 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules
EP2159285B1 (de) 2003-01-29 2012-09-26 454 Life Sciences Corporation Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
JP5183063B2 (ja) 2003-07-05 2013-04-17 ザ ジョンズ ホプキンス ユニバーシティ 遺伝的変異の検出および列挙のための方法ならびに組成物
US7459294B2 (en) 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP3913375A1 (de) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und steuerung von nanoreaktoren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2481815B1 (de) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8759020B2 (en) * 2008-07-02 2014-06-24 The University Of Wyoming Methods for natural product optimization
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2622103B2 (de) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwichassays in tröpfchen
EP2668284B1 (de) * 2011-01-28 2014-10-15 Amyris, Inc. Screening von in einem gel verkapselten mikrokolonien
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP3709018A1 (de) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2527256B1 (es) * 2013-06-20 2015-11-10 Biomedal S.L. Determinación rapida de susceptibilidad a compuestos antimicrobianos
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
JP7257508B2 (ja) * 2018-10-08 2023-04-13 アンバーストーン・バイオサイエンシーズ・インコーポレイテッド 二重特異性および多重特異性生物学的物質の区画化されたアッセイ

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
DE3871176D1 (de) * 1987-02-25 1992-06-25 Hoechst Ag Mikroenkapsulierung von biologisch aktivem material.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MC DANIEL R. ET AL.: "Engineered biosynthesis of novel polyketides.", SCIENCE, vol. 262, 3 December 1993 (1993-12-03), pages 1546 - 1550, XP000910221 *
RYAN C. ET AL.: "Rapid assay for mycobacterial growth and antibiotic susceptibility using gel microdrop encapsulation.", J. CLIN. MICROBIOL., vol. 33, no. 7, July 1995 (1995-07-01), pages 1720 - 1726, XP002190454 *
See also references of WO9841869A1 *

Also Published As

Publication number Publication date
EP0975969A1 (de) 2000-02-02
WO1998041869A1 (en) 1998-09-24
AU6571598A (en) 1998-10-12
CA2284066A1 (en) 1998-09-24

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