EP0975969A4 - Methodes de tri de composes au moyen de cellules encapsulees - Google Patents

Methodes de tri de composes au moyen de cellules encapsulees

Info

Publication number
EP0975969A4
EP0975969A4 EP98911863A EP98911863A EP0975969A4 EP 0975969 A4 EP0975969 A4 EP 0975969A4 EP 98911863 A EP98911863 A EP 98911863A EP 98911863 A EP98911863 A EP 98911863A EP 0975969 A4 EP0975969 A4 EP 0975969A4
Authority
EP
European Patent Office
Prior art keywords
methods
screening compounds
encapsulated cells
encapsulated
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98911863A
Other languages
German (de)
English (en)
Other versions
EP0975969A1 (fr
Inventor
Nicole M Nasby
Todd C Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromaxome Corp
Original Assignee
Chromaxome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromaxome Corp filed Critical Chromaxome Corp
Publication of EP0975969A1 publication Critical patent/EP0975969A1/fr
Publication of EP0975969A4 publication Critical patent/EP0975969A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98911863A 1997-03-18 1998-03-18 Methodes de tri de composes au moyen de cellules encapsulees Withdrawn EP0975969A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4088897P 1997-03-18 1997-03-18
US40888P 1997-03-18
US7104698P 1998-01-13 1998-01-13
US71046P 1998-01-13
PCT/US1998/005462 WO1998041869A1 (fr) 1997-03-18 1998-03-18 Methodes de tri de composes au moyen de cellules encapsulees

Publications (2)

Publication Number Publication Date
EP0975969A1 EP0975969A1 (fr) 2000-02-02
EP0975969A4 true EP0975969A4 (fr) 2002-07-31

Family

ID=26717558

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98911863A Withdrawn EP0975969A4 (fr) 1997-03-18 1998-03-18 Methodes de tri de composes au moyen de cellules encapsulees

Country Status (4)

Country Link
EP (1) EP0975969A4 (fr)
AU (1) AU6571598A (fr)
CA (1) CA2284066A1 (fr)
WO (1) WO1998041869A1 (fr)

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US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
CA2584453A1 (fr) 1997-07-07 1999-01-21 Medical Research Council Une methode pour augmenter la concentration d'acides nucleiques
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
IT1318605B1 (it) * 2000-06-30 2003-08-27 Uni Degli Studi Di Modena E Re Procedimoento per il dosaggio di tossine dsp del gruppo delledinophysitossine e delle yessottossine.
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
DE60239386D1 (de) 2001-01-25 2011-04-21 Evolva Ltd Zellbibliothek
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
FR2842747B1 (fr) * 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules
AU2004254552B2 (en) 2003-01-29 2008-04-24 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP1641809B2 (fr) 2003-07-05 2018-10-03 The Johns Hopkins University Procédé et compositions de détection et d'énumeration de variations génétiques
US7459294B2 (en) 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP2363205A3 (fr) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Dispositifs Microfluidiques Et Leurs Procédés D'utilisation Dans La Formation Et Le Contrôle De Nanoréacteurs
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (fr) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8759020B2 (en) 2008-07-02 2014-06-24 The University Of Wyoming Methods for natural product optimization
WO2010009365A1 (fr) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Bibliothèque de gouttelettes
EP3415235A1 (fr) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation de gouttelettes microfluidiques
EP2486409A1 (fr) 2009-10-09 2012-08-15 Universite De Strasbourg Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations
WO2011079176A2 (fr) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (fr) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Analyse numérique d'analytes
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
JP2014508516A (ja) * 2011-01-28 2014-04-10 アミリス， インコーポレイテッド ゲルに封入されたマイクロコロニーのスクリーニング
WO2012109600A2 (fr) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Procédés de formation de gouttelettes mélangées
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2527256B1 (es) * 2013-06-20 2015-11-10 Biomedal S.L. Determinación rapida de susceptibilidad a compuestos antimicrobianos
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (fr) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Procédé de détection de rétrovirus latent
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CA3114692A1 (fr) 2018-10-08 2020-04-16 Amberstone Biosciences, Inc. Dosages compartimentes de produits biologiques bispecifiques et multispecifiques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (fr) * 1988-04-22 1989-11-16 Microdrop, Inc. Procede de formation et d'utilisation de microgouttelettes
WO1994028119A1 (fr) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Nouveau procede et nouvel appareil
WO1996034112A1 (fr) * 1995-04-24 1996-10-31 Chromaxome Corp. Procedes de generation et de criblage de nouvelles voies metaboliques

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
CA1196862A (fr) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulement de cellules et de tissus vivants
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
EP0280155B1 (fr) * 1987-02-25 1992-05-20 Hoechst Aktiengesellschaft Microencapsulation de substances biologiquement actives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (fr) * 1988-04-22 1989-11-16 Microdrop, Inc. Procede de formation et d'utilisation de microgouttelettes
WO1994028119A1 (fr) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Nouveau procede et nouvel appareil
WO1996034112A1 (fr) * 1995-04-24 1996-10-31 Chromaxome Corp. Procedes de generation et de criblage de nouvelles voies metaboliques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MC DANIEL R. ET AL.: "Engineered biosynthesis of novel polyketides.", SCIENCE, vol. 262, 3 December 1993 (1993-12-03), pages 1546 - 1550, XP000910221 *
RYAN C. ET AL.: "Rapid assay for mycobacterial growth and antibiotic susceptibility using gel microdrop encapsulation.", J. CLIN. MICROBIOL., vol. 33, no. 7, July 1995 (1995-07-01), pages 1720 - 1726, XP002190454 *
See also references of WO9841869A1 *

Also Published As

Publication number Publication date
AU6571598A (en) 1998-10-12
WO1998041869A1 (fr) 1998-09-24
EP0975969A1 (fr) 2000-02-02
CA2284066A1 (fr) 1998-09-24

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