EP0975969A4 - Methods for screening compounds using encapsulated cells - Google Patents

Methods for screening compounds using encapsulated cells

Info

Publication number
EP0975969A4
EP0975969A4 EP98911863A EP98911863A EP0975969A4 EP 0975969 A4 EP0975969 A4 EP 0975969A4 EP 98911863 A EP98911863 A EP 98911863A EP 98911863 A EP98911863 A EP 98911863A EP 0975969 A4 EP0975969 A4 EP 0975969A4
Authority
EP
European Patent Office
Prior art keywords
methods
screening compounds
encapsulated cells
encapsulated
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98911863A
Other languages
German (de)
French (fr)
Other versions
EP0975969A1 (en
Inventor
Nicole M Nasby
Todd C Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chromaxome Corp
Original Assignee
Chromaxome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromaxome Corp filed Critical Chromaxome Corp
Publication of EP0975969A1 publication Critical patent/EP0975969A1/en
Publication of EP0975969A4 publication Critical patent/EP0975969A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98911863A 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells Withdrawn EP0975969A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4088897P 1997-03-18 1997-03-18
US40888P 1997-03-18
US7104698P 1998-01-13 1998-01-13
US71046P 1998-01-13
PCT/US1998/005462 WO1998041869A1 (en) 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells

Publications (2)

Publication Number Publication Date
EP0975969A1 EP0975969A1 (en) 2000-02-02
EP0975969A4 true EP0975969A4 (en) 2002-07-31

Family

ID=26717558

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98911863A Withdrawn EP0975969A4 (en) 1997-03-18 1998-03-18 Methods for screening compounds using encapsulated cells

Country Status (4)

Country Link
EP (1) EP0975969A4 (en)
AU (1) AU6571598A (en)
CA (1) CA2284066A1 (en)
WO (1) WO1998041869A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
DE69838521T2 (en) 1997-07-07 2008-05-21 Medical Research Council Method for increasing the concentration of nucleic acid molecules
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
IT1318605B1 (en) * 2000-06-30 2003-08-27 Uni Degli Studi Di Modena E Re PROCESS FOR THE DOSAGE OF TOXINS DSP OF THE DYNOPHYSITOSSINE GROUP AND YESSOTTOSSINS.
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
DK1356037T3 (en) 2001-01-25 2011-06-27 Evolva Ltd Library with a collection of cells
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
FR2842747B1 (en) * 2002-07-23 2004-10-15 Commissariat Energie Atomique METHOD AND DEVICE FOR SCREENING MOLECULES IN CELLS
DE602004036672C5 (en) 2003-01-29 2012-11-29 454 Life Sciences Corporation Nucleic acid amplification based on bead emulsion
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US7459294B2 (en) 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2009536313A (en) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド Microfluidic devices and methods for use in nanoreactor formation and control
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8759020B2 (en) 2008-07-02 2014-06-24 The University Of Wyoming Methods for natural product optimization
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012103516A1 (en) * 2011-01-28 2012-08-02 Amyris, Inc. Gel-encapsulated microcolony screening
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2527256B1 (en) * 2013-06-20 2015-11-10 Biomedal S.L. QUICK DETERMINATION OF SUSCEPTIBILITY TO COMPOUNDS ANTIMICROBIALS
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2020076730A1 (en) * 2018-10-08 2020-04-16 Amberstone Biosciences, Inc. Compartmentalized assays of bispecific and multispecific biologics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
US4399219A (en) * 1981-01-29 1983-08-16 Massachusetts Institute Of Technology Process for isolating microbiologically active material
SE441009B (en) * 1982-03-08 1985-09-02 Kjell Nilsson WAY TO IMMOBILIZE LIVING BIOMATERIAL IN PEARLY POLYMERS
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4801529A (en) * 1985-06-18 1989-01-31 Brandeis University Methods for isolating mutant microoganisms using microcapsules coated with indicator material
EP0280155B1 (en) * 1987-02-25 1992-05-20 Hoechst Aktiengesellschaft Microencapsulation of biologically active material

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2159171A (en) * 1984-05-24 1985-11-27 Damon Biotech Inc Process for screening or selecting cells
WO1989010786A2 (en) * 1988-04-22 1989-11-16 Microdrop, Inc. Process for forming and using microdroplets
WO1994028119A1 (en) * 1993-05-21 1994-12-08 Smithkline Beecham P.L.C. Novel process and apparatus
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MC DANIEL R. ET AL.: "Engineered biosynthesis of novel polyketides.", SCIENCE, vol. 262, 3 December 1993 (1993-12-03), pages 1546 - 1550, XP000910221 *
RYAN C. ET AL.: "Rapid assay for mycobacterial growth and antibiotic susceptibility using gel microdrop encapsulation.", J. CLIN. MICROBIOL., vol. 33, no. 7, July 1995 (1995-07-01), pages 1720 - 1726, XP002190454 *
See also references of WO9841869A1 *

Also Published As

Publication number Publication date
AU6571598A (en) 1998-10-12
EP0975969A1 (en) 2000-02-02
CA2284066A1 (en) 1998-09-24
WO1998041869A1 (en) 1998-09-24

Similar Documents

Publication Publication Date Title
EP0975969A4 (en) Methods for screening compounds using encapsulated cells
EP1009855A4 (en) Method for separating cells
GB9824544D0 (en) Screening system
AU5312198A (en) Screening method
GB0009358D0 (en) Compound screening method
SG70655A1 (en) New spirocyclic compounds
GB9707996D0 (en) Screening
EP1010094A4 (en) Compound screening system
GB9826890D0 (en) Method for screening compounds
GB9701245D0 (en) Method of screening compounds
IL137371A0 (en) Gene expression methods for screening compounds
GB0009363D0 (en) Compound screening method
GB2359626B (en) Compound screening method
GB9820988D0 (en) Screening method
GB0028736D0 (en) Separator for enclosed cell
GB9724480D0 (en) Screening process
IL120802A (en) Process for encapsulating laygon
AU7462798A (en) Concrete cover frames for anode nets
GB9711214D0 (en) Screening method
TW491273U (en) Improved structure for lid
TW346996U (en) Improved structure for frame
TW342695U (en) Improved structure for show frame
LT97051A (en) Hopper frame
TW345886U (en) Improved structure for table-chair
TW342644U (en) Improved structure for belt-head

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19991007

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20020619

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7G 01N 33/549 A, 7G 01N 33/50 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20031108