SG11201605782UA - Chiral design - Google Patents

Chiral design

Info

Publication number
SG11201605782UA
SG11201605782UA SG11201605782UA SG11201605782UA SG11201605782UA SG 11201605782U A SG11201605782U A SG 11201605782UA SG 11201605782U A SG11201605782U A SG 11201605782UA SG 11201605782U A SG11201605782U A SG 11201605782UA SG 11201605782U A SG11201605782U A SG 11201605782UA
Authority
SG
Singapore
Prior art keywords
chiral
design
chiral design
Prior art date
Application number
SG11201605782UA
Inventor
Meena
David Butler
Naoki Iwamoto
Nenad Svrzikapa
Gregory L Verdine
Ivan Zlatev
Original Assignee
Wave Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201461928405P priority Critical
Priority to US201462063359P priority
Application filed by Wave Life Sciences Ltd filed Critical Wave Life Sciences Ltd
Priority to PCT/IB2015/000395 priority patent/WO2015107425A2/en
Publication of SG11201605782UA publication Critical patent/SG11201605782UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
SG11201605782UA 2014-01-16 2015-01-16 Chiral design SG11201605782UA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201461928405P true 2014-01-16 2014-01-16
US201462063359P true 2014-10-13 2014-10-13
PCT/IB2015/000395 WO2015107425A2 (en) 2014-01-16 2015-01-16 Chiral design

Publications (1)

Publication Number Publication Date
SG11201605782UA true SG11201605782UA (en) 2016-08-30

Family

ID=53039535

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201605782UA SG11201605782UA (en) 2014-01-16 2015-01-16 Chiral design

Country Status (12)

Country Link
US (1) US10160969B2 (en)
EP (1) EP3094728A2 (en)
JP (2) JP6382344B2 (en)
KR (1) KR20160107326A (en)
CN (1) CN106068325A (en)
AU (1) AU2015207773A1 (en)
CA (1) CA2936712A1 (en)
CL (1) CL2016001814A1 (en)
MX (1) MX2016009290A (en)
RU (1) RU2016133035A3 (en)
SG (1) SG11201605782UA (en)
WO (1) WO2015107425A2 (en)

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SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
MX342945B (en) 2009-07-06 2016-10-18 Ontorii Inc * Novel nucleic acid prodrugs and methods use thereof.
EP3248982A1 (en) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Thiosulfonate reagents for the synthesis of functionalized nucleic acids
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
KR101850319B1 (en) 2012-07-13 2018-04-20 웨이브 라이프 사이언시스 리미티드 Asymmetric auxiliary group
JP6246121B2 (en) 2012-07-13 2017-12-13 株式会社新日本科学 Chiral-nucleic acid adjuvants
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
WO2015108047A1 (en) 2014-01-15 2015-07-23 株式会社新日本科学 Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
SG11201605782UA (en) 2014-01-16 2016-08-30 Wave Life Sciences Ltd Chiral design
MX2018000796A (en) * 2015-07-22 2018-03-23 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof.
CN108137492A (en) * 2015-10-09 2018-06-08 波涛生命科学有限公司 Oligonucleotide compositions and methods thereof
KR20190025821A (en) 2016-04-29 2019-03-12 사렙타 쎄러퓨틱스, 인코퍼레이티드 Oligonucleotide analogs targeted to the human lmna
WO2017210647A1 (en) * 2016-06-03 2017-12-07 Wave Life Sciences Ltd. Oligonucleotides, compositions and methods thereof
AU2017290231A1 (en) 2016-06-30 2019-02-07 Sarepta Therapeutics, Inc. Exon skipping oligomers for muscular dystrophy
WO2019032612A1 (en) * 2017-08-08 2019-02-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof

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