WO2004044141A2 - Conjugated oligomeric compounds and their use in gene modulation - Google Patents

Conjugated oligomeric compounds and their use in gene modulation Download PDF

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Publication number
WO2004044141A2
WO2004044141A2 PCT/US2003/035088 US0335088W WO2004044141A2 WO 2004044141 A2 WO2004044141 A2 WO 2004044141A2 US 0335088 W US0335088 W US 0335088W WO 2004044141 A2 WO2004044141 A2 WO 2004044141A2
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WO
WIPO (PCT)
Prior art keywords
composition
oligomeric compound
conjugate moiety
comprises
oligomeric
Prior art date
Application number
PCT/US2003/035088
Other languages
French (fr)
Other versions
WO2004044141A8 (en
WO2004044141A3 (en
Inventor
Muthiah Manoharan
Brenda Baker
Ann Eldrup
Balkrishen Bhat
Richard H. Griffey
Eric E. Swayze
Stanley T. Crooke
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US42376002P priority Critical
Priority to US60/423,760 priority
Priority to US61624103A priority
Priority to US10/616,241 priority
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Publication of WO2004044141A2 publication Critical patent/WO2004044141A2/en
Publication of WO2004044141A8 publication Critical patent/WO2004044141A8/en
Publication of WO2004044141A3 publication Critical patent/WO2004044141A3/en

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