KR20250172722A - 키랄 디자인 - Google Patents

키랄 디자인

Info

Publication number
KR20250172722A
KR20250172722A KR1020257039389A KR20257039389A KR20250172722A KR 20250172722 A KR20250172722 A KR 20250172722A KR 1020257039389 A KR1020257039389 A KR 1020257039389A KR 20257039389 A KR20257039389 A KR 20257039389A KR 20250172722 A KR20250172722 A KR 20250172722A
Authority
KR
South Korea
Prior art keywords
oligonucleotide
linkages
internucleotide linkages
chiral
chirally controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257039389A
Other languages
English (en)
Korean (ko)
Inventor
미나 미나
데이비드 찰스 도넬 버틀러
나오키 이와모토
네나드 스브르지카파
그레고리 엘 버딘
이반 즐라테프
Original Assignee
웨이브 라이프 사이언시스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 웨이브 라이프 사이언시스 리미티드 filed Critical 웨이브 라이프 사이언시스 리미티드
Publication of KR20250172722A publication Critical patent/KR20250172722A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Window Of Vehicle (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
KR1020257039389A 2014-01-16 2015-01-16 키랄 디자인 Pending KR20250172722A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461928405P 2014-01-16 2014-01-16
US61/928,405 2014-01-16
US201462063359P 2014-10-13 2014-10-13
US62/063,359 2014-10-13
KR1020247037406A KR20240164968A (ko) 2014-01-16 2015-01-16 키랄 디자인
PCT/IB2015/000395 WO2015107425A2 (en) 2014-01-16 2015-01-16 Chiral design

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020247037406A Division KR20240164968A (ko) 2014-01-16 2015-01-16 키랄 디자인

Publications (1)

Publication Number Publication Date
KR20250172722A true KR20250172722A (ko) 2025-12-09

Family

ID=53039535

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020257039389A Pending KR20250172722A (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020247037406A Ceased KR20240164968A (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020167022289A Active KR102423317B1 (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020237036550A Ceased KR20230152178A (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020227024673A Abandoned KR20220106232A (ko) 2014-01-16 2015-01-16 키랄 디자인

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020247037406A Ceased KR20240164968A (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020167022289A Active KR102423317B1 (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020237036550A Ceased KR20230152178A (ko) 2014-01-16 2015-01-16 키랄 디자인
KR1020227024673A Abandoned KR20220106232A (ko) 2014-01-16 2015-01-16 키랄 디자인

Country Status (19)

Country Link
US (4) US10160969B2 (enExample)
EP (2) EP3094728B1 (enExample)
JP (5) JP6382344B2 (enExample)
KR (5) KR20250172722A (enExample)
CN (2) CN113278617A (enExample)
AU (3) AU2015207773B2 (enExample)
BR (1) BR112016016400A2 (enExample)
CA (1) CA2936712A1 (enExample)
CL (1) CL2016001814A1 (enExample)
DK (1) DK3094728T3 (enExample)
ES (1) ES2917473T3 (enExample)
IL (1) IL246703A0 (enExample)
MX (1) MX2016009290A (enExample)
MY (1) MY193116A (enExample)
PL (1) PL3094728T3 (enExample)
PT (1) PT3094728T (enExample)
RU (1) RU2016133035A (enExample)
SG (2) SG10201912897UA (enExample)
WO (1) WO2015107425A2 (enExample)

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