JP7054622B2 - ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 - Google Patents

ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 Download PDF

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JP7054622B2
JP7054622B2 JP2017503498A JP2017503498A JP7054622B2 JP 7054622 B2 JP7054622 B2 JP 7054622B2 JP 2017503498 A JP2017503498 A JP 2017503498A JP 2017503498 A JP2017503498 A JP 2017503498A JP 7054622 B2 JP7054622 B2 JP 7054622B2
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seq
amino acid
acid sequence
bcma
cells
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JP2017527271A (ja
JP2017527271A5 (show.php
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ジェニファー・ブログドン
ユージーン・チェ
ヒルマー・エーバースバッハ
デイビッド・グラス
ヘザー・ヒュエ
カール・エイチ・ジューン
ジョアン・マニック
マイケル・シー・ミローン
レオン・マーフィー
ガブリエラ・プレサ
セレスト・リチャードソン
マルコ・ルエラ
ラシュマ・シン
ワン・ヨンチアン
チーロン・ウー
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ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K35/14—Blood; Artificial blood
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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JP2017503498A 2014-07-21 2015-07-21 ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 Active JP7054622B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014082586 2014-07-21
CNPCT/CN2014/082586 2014-07-21
CN2014090501 2014-11-06
CNPCT/CN2014/090501 2014-11-06
PCT/US2015/041378 WO2016014565A2 (en) 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor

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JP2017527271A JP2017527271A (ja) 2017-09-21
JP2017527271A5 JP2017527271A5 (show.php) 2018-08-30
JP7054622B2 true JP7054622B2 (ja) 2022-04-14

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JP2020167201A Pending JP2021019610A (ja) 2014-07-21 2020-10-01 ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置

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US (3) US10174095B2 (show.php)
EP (1) EP3172237A2 (show.php)
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KR (1) KR102612313B1 (show.php)
CN (1) CN106687483B (show.php)
AU (2) AU2015292744C1 (show.php)
BR (1) BR112017001183A2 (show.php)
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