SG10202109108UA - Chimeric antigen receptors (cars), compositions and methods thereof - Google Patents

Chimeric antigen receptors (cars), compositions and methods thereof

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Publication number
SG10202109108UA
SG10202109108UA SG10202109108UA SG10202109108UA SG10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA
Authority
SG
Singapore
Prior art keywords
cars
compositions
methods
chimeric antigen
antigen receptors
Prior art date
Application number
SG10202109108UA
Inventor
Yupo Ma
Kevin Pinz
Xun Jiang
Masayuki Wada
Kevin Chen
Original Assignee
Icell Gene Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/538,620 external-priority patent/US11820819B2/en
Application filed by Icell Gene Therapeutics Llc filed Critical Icell Gene Therapeutics Llc
Publication of SG10202109108UA publication Critical patent/SG10202109108UA/en

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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
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CN115947869B (en) * 2022-11-28 2023-12-12 广州佰芮慷生物科技有限公司 Chimeric antigen receptor targeting human cytomegalovirus, CAR-NK cell and application
CN115838439B (en) * 2022-12-06 2023-10-31 上海恩凯细胞技术有限公司 Preparation method and application of chimeric transition receptor gene modified NK cells
CN116949099B (en) * 2023-07-12 2024-04-02 山东大学第二医院 Parallel chimeric antigen receptor T cell targeting CD38 and CS1 antigens and preparation method and application thereof
CN117143194B (en) * 2023-11-01 2024-02-06 北京大学第一医院 Anti-platelet aggregation polypeptide, preparation method and application thereof
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