JP5707391B2 - ７−アリール−１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 - Google Patents

７−アリール−１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 Download PDF

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JP5707391B2
JP5707391B2 JP2012510159A JP2012510159A JP5707391B2 JP 5707391 B2 JP5707391 B2 JP 5707391B2 JP 2012510159 A JP2012510159 A JP 2012510159A JP 2012510159 A JP2012510159 A JP 2012510159A JP 5707391 B2 JP5707391 B2 JP 5707391B2
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halo
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chloro
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JP2012526736A5 (enExample
JP2012526736A (ja
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ホセ， マリア シドゥ−ヌネズ，
ホセ， マリア シドゥ−ヌネズ，
ルーカス オリヴァレス， アナ， イザベル デ
ルーカス オリヴァレス， アナ， イザベル デ
アンドレ， アヴェリノ トラバンコ−スアレス，
アンドレ， アヴェリノ トラバンコ−スアレス，
グレゴール， ジェームス マクドナルド，
グレゴール， ジェームス マクドナルド，
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ジャンセン ファーマシューティカルズ， インコーポレイテッド
ジャンセン ファーマシューティカルズ， インコーポレイテッド
アデックス ファーマ エス エー
アデックス ファーマ エス エー
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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JP2012510159A 2009-05-12 2010-05-11 ７−アリール−１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 Expired - Fee Related JP5707391B2 (ja)

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EP09160064 2009-05-12
EP09160064.3 2009-05-12
PCT/EP2010/002909 WO2010130423A1 (en) 2009-05-12 2010-05-11 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

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JP2012526736A JP2012526736A (ja) 2012-11-01
JP2012526736A5 JP2012526736A5 (enExample) 2015-01-08
JP5707391B2 true JP5707391B2 (ja) 2015-04-30

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US (2) US8716480B2 (enExample)
EP (1) EP2430021B1 (enExample)
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KR (1) KR20120039532A (enExample)
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CN102439009B (zh) 2014-11-12
EA020556B1 (ru) 2014-12-30
AU2010246608A1 (en) 2011-11-17
EP2430021B1 (en) 2013-08-28
WO2010130423A1 (en) 2010-11-18
US20120184528A1 (en) 2012-07-19
SG175931A1 (en) 2011-12-29
US8716480B2 (en) 2014-05-06
HK1166784A1 (en) 2012-11-09
EA201190302A1 (ru) 2012-06-29
NZ595945A (en) 2013-03-28

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