CL2011002839A1 - Compuestos derivados de 1,2,4-triazolo[4,3-a]piridina, moduladores alostéricos positivos de receptores mglur2; composición farmacéutica y su proceso de preparacion; combinación farmaceutica; y su uso en el tratamiento o prevencion de un trastorno del sistema nervioso central tal como ansiedad y esquizofrenia, entre otros. - Google Patents

Compuestos derivados de 1,2,4-triazolo[4,3-a]piridina, moduladores alostéricos positivos de receptores mglur2; composición farmacéutica y su proceso de preparacion; combinación farmaceutica; y su uso en el tratamiento o prevencion de un trastorno del sistema nervioso central tal como ansiedad y esquizofrenia, entre otros.

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Publication number
CL2011002839A1
CL2011002839A1 CL2011002839A CL2011002839A CL2011002839A1 CL 2011002839 A1 CL2011002839 A1 CL 2011002839A1 CL 2011002839 A CL2011002839 A CL 2011002839A CL 2011002839 A CL2011002839 A CL 2011002839A CL 2011002839 A1 CL2011002839 A1 CL 2011002839A1
Authority
CL
Chile
Prior art keywords
prevention
treatment
triazolo
pyridine
compounds
Prior art date
Application number
CL2011002839A
Other languages
English (en)
Inventor
Gregor James Macdonald
José Maria Cid-Núnez
Lucas Olivares Ana Isabel De
Andrés Avelino Trabanco-Suarez
Original Assignee
Janssen Pharmaceuticasl Inc
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticasl Inc, Addex Pharmaceuticals Sa filed Critical Janssen Pharmaceuticasl Inc
Publication of CL2011002839A1 publication Critical patent/CL2011002839A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLO[4,3-A]PIRIDINA DE FÓRMULA (1) DONDE TODOS LOS RADICALES SON SEGÚN LO DEFINIDO EN LAS REIVINDICACIONES. LOS COMPUESTOS DE ACUERDO CON LA INVENCIÓN SON MODULADORES ALOSTÉRICOS POSITIVOS DEL SUBTIPO 2 RECEPTOR DE GLUTAMATO METABOTRÓPICO ("MGLUR2"). LOS CUALES SON ÚTILES PARA EL TRATAMIENTO O PREVENCIÓN DE TRASTORNOS NEUROLÓGICOS Y PSIQUIÁTRICOS CON LA DISFUNCIÓN DE GLUTAMATO Y ENFERMEDADES EN LAS CUALES EL SUBTIPO MGLUR2 DE RECEPTORES<br /> METABOTRÓPICOS ESTA INVOLUCRADO. LA INVENCIÓN SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ESE TIPO DE COMPUESTOS. A PROCESOS PARA PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES. Y AL USO DE ESE TIPO DE COMPUESTOS PARA LA PREVENCIÓN O TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS Y PSIQUIÁTRICOS Y ENFERMEDADES EN LAS CUALES MGLUR2 ESTA INVOLUCRADO.
CL2011002839A 2009-05-12 2011-11-11 Compuestos derivados de 1,2,4-triazolo[4,3-a]piridina, moduladores alostéricos positivos de receptores mglur2; composición farmacéutica y su proceso de preparacion; combinación farmaceutica; y su uso en el tratamiento o prevencion de un trastorno del sistema nervioso central tal como ansiedad y esquizofrenia, entre otros. CL2011002839A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09160064 2009-05-12

Publications (1)

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CL2011002839A1 true CL2011002839A1 (es) 2012-04-09

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CL2011002839A CL2011002839A1 (es) 2009-05-12 2011-11-11 Compuestos derivados de 1,2,4-triazolo[4,3-a]piridina, moduladores alostéricos positivos de receptores mglur2; composición farmacéutica y su proceso de preparacion; combinación farmaceutica; y su uso en el tratamiento o prevencion de un trastorno del sistema nervioso central tal como ansiedad y esquizofrenia, entre otros.

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US (2) US8716480B2 (es)
EP (1) EP2430021B1 (es)
JP (1) JP5707391B2 (es)
KR (1) KR20120039532A (es)
CN (1) CN102439009B (es)
AR (1) AR076860A1 (es)
AU (1) AU2010246608B2 (es)
CA (1) CA2760084C (es)
CL (1) CL2011002839A1 (es)
EA (1) EA020556B1 (es)
ES (1) ES2428401T3 (es)
HK (1) HK1166784A1 (es)
IL (1) IL215911A (es)
MX (1) MX2011011963A (es)
MY (1) MY153913A (es)
NZ (1) NZ595945A (es)
SG (1) SG175931A1 (es)
TW (1) TW201100415A (es)
WO (1) WO2010130423A1 (es)
ZA (1) ZA201107833B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
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