EA200970837A1 - ЗАМЕЩЁННЫЕ ФЕНОКСИТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ α-РЕЦЕПТОРА ЭСТРОГЕНА - Google Patents

ЗАМЕЩЁННЫЕ ФЕНОКСИТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ α-РЕЦЕПТОРА ЭСТРОГЕНА

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Publication number
EA200970837A1
EA200970837A1 EA200970837A EA200970837A EA200970837A1 EA 200970837 A1 EA200970837 A1 EA 200970837A1 EA 200970837 A EA200970837 A EA 200970837A EA 200970837 A EA200970837 A EA 200970837A EA 200970837 A1 EA200970837 A1 EA 200970837A1
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Eurasian Patent Office
Prior art keywords
arthritis
cartilage
disease
chronic
diseases
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Application number
EA200970837A
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English (en)
Inventor
Майкл Гаул
Александер Ким
Лили Ли Сирл
Рэймонд Патч
Дионисиос Рентзеперис
Гочжан Сюй
Сичжэнь Чжу
Original Assignee
Янссен Фармацевтика Н.В.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39535719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200970837(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200970837A1 publication Critical patent/EA200970837A1/ru

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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07—ORGANIC CHEMISTRY
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I)способам получения этих соединений, композиций, промежуточных соединений и их производных для лечения состояния, включая, но не ограничиваясь этим, анкилозирующий спондилит, атеросклероз, артрит (такой как ревматоидный артрит, инфекционный артрит, детский артрит, псориатический артрит, реактивный артрит), заболевания, связанные с костями (включая заболевания, связанные с костеобразованием), рак молочной железы (включая заболевания, не отвечающие на антиэстрогенную терапию), сердечно-сосудистые расстройства, заболевания, связанные с хрящами (такие как повреждения/потеря хрящей, дегенерация хряща и заболевания, связанные с образованием хрящей), хондродисплазию, хондросаркому, хроническую травму спины, хронический бронхит, хроническое воспалительное заболевание дыхательных путей, хроническое обструктивное заболевание легких, диабет, расстройства энергетического гомеостаза, подагру, псевдоподагру, расстройства липидного обмена, метаболический синдром, множественную миелому, ожирение, остеоартрит, несовершенный остеогенез, остеолитический костный метастаз, остеомаляцию, остеопороз, болезнь Педжета, заболевание периодонта, ревматическую полимиалгию, синдром Рейтера, «туннельный синдром», гипергликемию, повышенный уровень глюкозы в крови и резистентность к инсулину.
EA200970837A 2007-03-07 2008-03-06 ЗАМЕЩЁННЫЕ ФЕНОКСИТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ α-РЕЦЕПТОРА ЭСТРОГЕНА EA200970837A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89345307P 2007-03-07 2007-03-07
PCT/US2008/056004 WO2008109727A1 (en) 2007-03-07 2008-03-06 Substituted phenoxy thiazolidinediones as estrogen related receptor-alpha modulators

Publications (1)

Publication Number Publication Date
EA200970837A1 true EA200970837A1 (ru) 2010-04-30

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EA200970837A EA200970837A1 (ru) 2007-03-07 2008-03-06 ЗАМЕЩЁННЫЕ ФЕНОКСИТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ α-РЕЦЕПТОРА ЭСТРОГЕНА

Country Status (21)

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US (2) US7846953B2 (ru)
EP (1) EP2129668A1 (ru)
JP (1) JP2010520306A (ru)
KR (1) KR20090127410A (ru)
CN (1) CN101679322A (ru)
AR (1) AR065655A1 (ru)
AU (1) AU2008222745A1 (ru)
BR (1) BRPI0808445A2 (ru)
CA (1) CA2679944A1 (ru)
CL (1) CL2008000670A1 (ru)
CO (1) CO6231008A2 (ru)
EA (1) EA200970837A1 (ru)
EC (1) ECSP099614A (ru)
IL (1) IL200757A0 (ru)
MX (1) MX2009009517A (ru)
NI (1) NI200900163A (ru)
NZ (1) NZ579372A (ru)
SV (1) SV2009003367A (ru)
TW (1) TW200902508A (ru)
UA (1) UA98485C2 (ru)
WO (1) WO2008109727A1 (ru)

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