EA200970839A1 - ЗАМЕЩЁННЫЕ ФЕНОКСИ АМИНОТИАЗОЛОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ РОДСТВЕННОГО ЭСТРОГЕНОВОМУ РЕЦЕПТОРУ РЕЦЕПТОРА-α - Google Patents
ЗАМЕЩЁННЫЕ ФЕНОКСИ АМИНОТИАЗОЛОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ РОДСТВЕННОГО ЭСТРОГЕНОВОМУ РЕЦЕПТОРУ РЕЦЕПТОРА-αInfo
- Publication number
- EA200970839A1 EA200970839A1 EA200970839A EA200970839A EA200970839A1 EA 200970839 A1 EA200970839 A1 EA 200970839A1 EA 200970839 A EA200970839 A EA 200970839A EA 200970839 A EA200970839 A EA 200970839A EA 200970839 A1 EA200970839 A1 EA 200970839A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- arthritis
- cartilage
- disease
- chronic
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Настоящее изобретение относится к соединениям формулы (I)способам получения этих соединений, их композициям, промежуточным соединениям и производным для лечения состояний, включающих, но не ограниченных ими, анкилозирующий спондилит, артериосклероз, артрит (такой как ревматоидный артрит, инфекционный артрит, детский артрит, псориатический артрит, реактивный артрит), связанные с костями заболевания (включая заболевания, связанные с остеогенезом), рак молочной железы (включая виды, нечувствительные к антиэстрогеновой терапии), сердечно-сосудистые нарушения, связанное с хрящом заболевание (такое как повреждение/потеря хряща, дегенерация хряща, и таковые, связанные с формированием хряща), хондродисплазию, хондросаркому, хроническое повреждение спины, хронический бронхит, хроническое воспалительное заболевание дыхательных путей, хроническое обструктивное заболевание легких, диабет, нарушения гомеостаза энергии, подагру, псевдоподагру, липидные нарушения, метаболический синдром, множественную миелому, ожирение, остеоартрит, несовершенный остеогенез, остеолитический костный метастаз, остеомаляцию, остеопороз, болезнь Педжета, периодонтальное заболевание, ревматическую полимиалгию, синдром Рейтера, туннельный синдром, гипергликемию, повышенный уровень глюкозы в крови и резистентность к инсулину.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89346407P | 2007-03-07 | 2007-03-07 | |
PCT/US2008/056029 WO2008109737A1 (en) | 2007-03-07 | 2008-03-06 | Substituted phenoxy aminothiazolones as estrogen related receptor-alpha modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970839A1 true EA200970839A1 (ru) | 2010-04-30 |
EA016887B1 EA016887B1 (ru) | 2012-08-30 |
Family
ID=39530136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970839A EA016887B1 (ru) | 2007-03-07 | 2008-03-06 | ЗАМЕЩЁННЫЕ ФЕНОКСИАМИНОТИАЗОЛОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ РОДСТВЕННОГО ЭСТРОГЕНОВОМУ РЕЦЕПТОРУ РЕЦЕПТОРА-α |
Country Status (17)
Country | Link |
---|---|
US (1) | US8580832B2 (ru) |
EP (1) | EP2134698A1 (ru) |
JP (1) | JP2010520308A (ru) |
KR (1) | KR20090128454A (ru) |
CN (1) | CN101679327A (ru) |
AR (1) | AR065657A1 (ru) |
AU (1) | AU2008222755B2 (ru) |
BR (1) | BRPI0808776A2 (ru) |
CA (1) | CA2680212A1 (ru) |
CL (1) | CL2008000667A1 (ru) |
EA (1) | EA016887B1 (ru) |
IL (1) | IL200759A0 (ru) |
MX (1) | MX2009009520A (ru) |
NZ (1) | NZ579417A (ru) |
TW (1) | TW200902506A (ru) |
UA (1) | UA98484C2 (ru) |
WO (1) | WO2008109737A1 (ru) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CA2697399C (en) | 2007-09-14 | 2016-01-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
MX2010002537A (es) | 2007-09-14 | 2010-08-10 | Ortho Mcneil Janssen Pharm | 4-fenil-1h-piridin-2-onas 1,3-disubstituidas. |
NZ584145A (en) | 2007-09-14 | 2012-03-30 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones |
EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体の調節因子としての3−アザビシクロ[3.1.0]ヘキシル誘導体 |
MX2011003691A (es) | 2008-10-16 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico. |
ES2401691T3 (es) | 2008-11-28 | 2013-04-23 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato |
CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
NZ596053A (en) | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
US20130040951A9 (en) * | 2009-08-04 | 2013-02-14 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for cancer |
WO2011019558A1 (en) * | 2009-08-11 | 2011-02-17 | Janssen Pharmaceutica Nv | Methods to measure dissociation rates for ligands that form reversible covalent bonds |
US8187871B2 (en) * | 2009-08-11 | 2012-05-29 | Janssen Pharmaceutica N.V. | Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond |
CA2784753A1 (en) * | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | Substituted aminothiazolone indazoles as estrogen related receptor-.alpha. modulators |
US8426604B2 (en) | 2010-02-17 | 2013-04-23 | Janssen Pharmaceutica Nv | Aminothiazolones as estrogen related receptor-alpha modulators |
CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
WO2012062750A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
WO2013018929A1 (en) | 2011-08-04 | 2013-02-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
NZ700872A (en) | 2012-03-26 | 2016-09-30 | Nippon Chemiphar Co | Prophylactic or therapeutic agent for giant cell tumors occurring in bone and soft tissue or for chondrosarcoma |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
JP6527822B2 (ja) | 2013-09-25 | 2019-06-05 | 日本ケミファ株式会社 | 骨・軟部に発生する巨細胞性腫瘍、軟骨肉腫または骨肉腫の予防、治療または転移の予防のための薬剤、動脈塞栓術用局所注入剤、および、人工骨 |
KR20220049612A (ko) | 2014-01-21 | 2022-04-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
ES2748633T3 (es) | 2014-01-21 | 2020-03-17 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
CN113939288A (zh) * | 2019-03-28 | 2022-01-14 | 伊赛恩特制药公司 | Mas相关g蛋白受体x4的调节剂及相关产物和方法 |
CA3144891A1 (en) * | 2019-07-04 | 2021-01-07 | Lead Pharma Holding B.V. | Estrogen-related receptor alpha (err.alpha.) modulators |
CN112538038B (zh) * | 2019-09-20 | 2022-05-20 | 暨南大学 | 2-吲哚酮类ERRα反向激动剂及其药物组合物和应用 |
KR20220066822A (ko) | 2020-11-16 | 2022-05-24 | 경북대학교 산학협력단 | 골 질환 예방 또는 치료용 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5037842A (en) | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
JP2001072592A (ja) * | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
JP2003530437A (ja) * | 2000-04-13 | 2003-10-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | Aβ42低下物質 |
DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
EP1398029A1 (en) | 2002-09-10 | 2004-03-17 | LION Bioscience AG | NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives |
WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
MX2007000606A (es) * | 2004-07-14 | 2007-06-25 | Johnson & Johnson | Arilidenos para el tratamiento de enfermedades mediadas por receptor alfa relacionado con estrogeno. |
JP4931824B2 (ja) * | 2004-10-22 | 2012-05-16 | エグゼリクシス, インコーポレイテッド | 薬学的組成物 |
-
2008
- 2008-03-06 US US12/043,311 patent/US8580832B2/en active Active
- 2008-03-06 WO PCT/US2008/056029 patent/WO2008109737A1/en active Application Filing
- 2008-03-06 CN CN200880015410A patent/CN101679327A/zh active Pending
- 2008-03-06 EP EP08731528A patent/EP2134698A1/en not_active Ceased
- 2008-03-06 BR BRPI0808776-8A patent/BRPI0808776A2/pt not_active IP Right Cessation
- 2008-03-06 AU AU2008222755A patent/AU2008222755B2/en not_active Expired - Fee Related
- 2008-03-06 JP JP2009552887A patent/JP2010520308A/ja active Pending
- 2008-03-06 TW TW097107931A patent/TW200902506A/zh unknown
- 2008-03-06 EA EA200970839A patent/EA016887B1/ru not_active IP Right Cessation
- 2008-03-06 NZ NZ579417A patent/NZ579417A/en not_active IP Right Cessation
- 2008-03-06 KR KR1020097020836A patent/KR20090128454A/ko not_active Application Discontinuation
- 2008-03-06 CA CA002680212A patent/CA2680212A1/en not_active Abandoned
- 2008-03-06 MX MX2009009520A patent/MX2009009520A/es unknown
- 2008-03-06 UA UAA200910122A patent/UA98484C2/ru unknown
- 2008-03-06 CL CL2008000667A patent/CL2008000667A1/es unknown
- 2008-03-07 AR ARP080100964A patent/AR065657A1/es not_active Application Discontinuation
-
2009
- 2009-09-06 IL IL200759A patent/IL200759A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200902506A (en) | 2009-01-16 |
EA016887B1 (ru) | 2012-08-30 |
NZ579417A (en) | 2012-02-24 |
MX2009009520A (es) | 2009-11-18 |
AU2008222755B2 (en) | 2013-05-02 |
AR065657A1 (es) | 2009-06-24 |
US8580832B2 (en) | 2013-11-12 |
JP2010520308A (ja) | 2010-06-10 |
EP2134698A1 (en) | 2009-12-23 |
BRPI0808776A2 (pt) | 2014-08-19 |
UA98484C2 (ru) | 2012-05-25 |
IL200759A0 (en) | 2010-05-17 |
CN101679327A (zh) | 2010-03-24 |
WO2008109737A1 (en) | 2008-09-12 |
CL2008000667A1 (es) | 2008-11-03 |
KR20090128454A (ko) | 2009-12-15 |
CA2680212A1 (en) | 2008-09-12 |
US20080221179A1 (en) | 2008-09-11 |
AU2008222755A1 (en) | 2008-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200970839A1 (ru) | ЗАМЕЩЁННЫЕ ФЕНОКСИ АМИНОТИАЗОЛОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ РОДСТВЕННОГО ЭСТРОГЕНОВОМУ РЕЦЕПТОРУ РЕЦЕПТОРА-α | |
EA200970837A1 (ru) | ЗАМЕЩЁННЫЕ ФЕНОКСИТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ α-РЕЦЕПТОРА ЭСТРОГЕНА | |
EA200970838A1 (ru) | ЗАМЕЩЕННЫЕ ФЕНОКСИПРОИЗВОДНЫЕ N-АЛКИЛИРОВАННЫЕ ТИАЗОЛИДИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ ЭСТРОГЕН-РОДСТВЕННЫХ РЕЦЕПТОРОВ α | |
TW201144303A (en) | Aminothiazolones as estrogen related receptor-α modulators | |
AR081221A1 (es) | Anticuerpos anti gdf8 humano | |
JP2010520308A5 (ru) | ||
JP2010520306A5 (ru) | ||
JP2018535967A5 (ru) | ||
MX2012009528A (es) | Aminotiazolonas como moduladores de receptores alfa relacionados con el estrógeno. | |
MX2009001534A (es) | Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. | |
MX2021001752A (es) | Compuestos de pirrolo-dipiridina. | |
WO2010141249A3 (en) | Generation, characterization and uses thereof of anti-notch3 antibodies | |
CY1117453T1 (el) | Νεες ενωσεις τροποποιησης toy fxr (nr1h4) | |
TN2010000125A1 (en) | Substituted biphenyl gpr40 modulators | |
BRPI0508791A (pt) | composto, composição farmacêutica, uso do composto, método para elevar o hdl em um indivìduo, método para o tratamento de diabetes do tipo 2, resistência à insulina diminuìda ou redução da pressão do sangue em um indivìduo, método para diminuir o ldlc em um indivìduo, método para deslocar o tamanho de partìcula de ldl denso pequeno a ldl normal em um indivìduo, método para o tratamento de doenças ateroscleróticas incluindo doença vascular, doença das coronárias do coração, doença cerebrovascular e doença de vaso periférico em um indivìduo, método para o tratamento de doenças inflamatórias, incluindo a artrite reumatoide, a asma, a osteodistrofia e doença autoimune em um individuo, metodo de tratamento de uma doença ou condição medida por hppar-delta, método de modulação de uma função de receptor ativada por proliferador de peroxisoma (ppar), e método de tratamento de uma doença ou uma condição | |
JP2010535206A5 (ru) | ||
EA200200921A1 (ru) | Полуамиды малоновой кислоты и их производные в качестве лигандов тиреоидных рецепторов | |
JP2009506167A5 (ru) | ||
CY1118044T1 (el) | Παρασκευασμα συνδυασμου με ανταγωνιστη και κορτικοστεροειδες | |
JP2016525130A5 (ru) | ||
EA201990479A1 (ru) | Сульфонамиды в качестве агонистов gpr40 и gpr120 | |
JP2012054542A5 (ja) | トリアゾール誘導体および複素環化合物 | |
EA201171074A1 (ru) | Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y | |
SI2197841T1 (sl) | Spojine, ki vsebujejo gvanidin, uporabne kot antagonisti muskarinskih receptorjev | |
JP2014132900A5 (ru) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |