MX2009001534A - Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. - Google Patents
Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva.Info
- Publication number
- MX2009001534A MX2009001534A MX2009001534A MX2009001534A MX2009001534A MX 2009001534 A MX2009001534 A MX 2009001534A MX 2009001534 A MX2009001534 A MX 2009001534A MX 2009001534 A MX2009001534 A MX 2009001534A MX 2009001534 A MX2009001534 A MX 2009001534A
- Authority
- MX
- Mexico
- Prior art keywords
- fenoterol
- analogues
- heart failure
- congestive heart
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Esta descripción se refiere al descubrimiento de análogos de (R,R)- y (R,S)-fenoterol que son altamente efectivos en la unión de receptores ß2-adrenérgicos; se proveen estructuras químicas ilustrativas para estos análogos; también se proveen composiciones farmacéuticas que incluyen el (R,R)-fenoterol y análogos de fenoterol descritos, y métodos de uso de dichos compuestos y composiciones para el tratamiento de trastornos cardiacos tales como insuficiencia cardiaca congestiva y trastornos pulmonares tales como asma o enfermedad pulmonar obstructiva crónica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83716106P | 2006-08-10 | 2006-08-10 | |
US92782507P | 2007-05-03 | 2007-05-03 | |
PCT/US2007/075731 WO2008022038A1 (en) | 2006-08-10 | 2007-08-10 | Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009001534A true MX2009001534A (es) | 2009-04-08 |
Family
ID=38917814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009001534A MX2009001534A (es) | 2006-08-10 | 2007-08-10 | Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. |
Country Status (11)
Country | Link |
---|---|
US (6) | US20100168245A1 (es) |
EP (1) | EP2064174B1 (es) |
JP (2) | JP5302194B2 (es) |
KR (1) | KR101378067B1 (es) |
CN (1) | CN103739503A (es) |
AU (1) | AU2007286051B2 (es) |
BR (1) | BRPI0716495A2 (es) |
CA (1) | CA2660707C (es) |
IL (1) | IL196965A (es) |
MX (1) | MX2009001534A (es) |
WO (1) | WO2008022038A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2660707C (en) | 2006-08-10 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
PE20091156A1 (es) * | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
CN101531602B (zh) * | 2008-03-10 | 2014-08-27 | 北京德众万全医药科技有限公司 | 一种hplc法分析分离酒石酸福莫特罗中间体的方法 |
MX2012010364A (es) * | 2010-03-08 | 2013-02-26 | Univ Tennessee Res Foundation | Antagonistas de los receptores beta-adrenérgicos y usos de los mismos. |
EP2544676B1 (en) | 2010-03-10 | 2018-09-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
JO3192B1 (ar) * | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
JP6130495B2 (ja) | 2012-05-25 | 2017-05-17 | アメリカ合衆国 | カンナビノイド受容体活性関連障害及び疾患を調節する方法 |
US9784726B2 (en) | 2013-01-08 | 2017-10-10 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
WO2017059268A1 (en) * | 2015-10-01 | 2017-04-06 | Mitchell Woods Pharmaceuticals, Inc. | Methods of reducing chemoresistance and treating cancer |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
KR101987841B1 (ko) | 2019-03-13 | 2019-06-11 | 김도현 | 완구총 |
CN110376313B (zh) * | 2019-08-20 | 2022-06-07 | 广州健康元呼吸药物工程技术有限公司 | 一种检测富马酸福莫特罗或其相关制剂中杂质的方法 |
EP4146183A1 (en) * | 2020-05-05 | 2023-03-15 | Irving W. Wainer | Method for treating symptoms of viral infections |
GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL296701A (es) * | ||||
AT235270B (de) | 1962-08-18 | 1964-08-25 | Chemie Linz Ag | Verfahren zur Herstellung von N-substituierten Phenyläthanolaminderivaten und deren Salzen |
NL125650C (es) | 1962-11-30 | 1900-01-01 | ||
SE354279B (es) * | 1969-06-13 | 1973-03-05 | Draco Ab | |
DE1962497C3 (de) * | 1969-12-12 | 1979-09-20 | C.H. Boehringer Sohn, 6507 Ingelheim | Naphthylalkyl- a -hydroxyphenäthyl-amine, ihre Herstellung und diese enthaltende Arzneimittel |
CH564509A5 (es) * | 1969-12-12 | 1975-07-31 | Boehringer Sohn Ingelheim | |
DE2010883A1 (de) * | 1970-03-07 | 1971-09-23 | Troponwerke Dinklage & Co, 5000 Köln-Mülheim | Pharmakologisch wirksame Aminoalkohole und Verfahren zu ihrer Darstellung |
AT308139B (de) | 1970-07-27 | 1973-06-25 | Degussa | Verfahren zur Herstellung von neuen basisch substituierten Alkyltheophyllinen, ihren Isomeren und Säureadditionssalzen |
IT1044214B (it) * | 1971-04-22 | 1980-03-20 | Zambeletti Spa L | 2 idrossi 2 feniletilamine so stituite dotate di proprieta vasoattive e processo per la loro preparazione |
JPS532194A (en) | 1976-06-25 | 1978-01-10 | Sekisui Jushi Kk | Packing method by plastic band |
JP2611073B2 (ja) * | 1990-07-26 | 1997-05-21 | モンサント カンパニー | 新規ポリアミンの製造方法 |
GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
US6299863B1 (en) * | 1992-04-03 | 2001-10-09 | Sepracor Inc. | Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy |
US6866839B2 (en) * | 1991-04-05 | 2005-03-15 | Sepracor Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
US5795564A (en) | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
WO1998001099A2 (en) | 1996-07-05 | 1998-01-15 | E.C. Pesterfield Assoc., Inc. | Method of treating retinal ischemia and glaucoma |
US6015837A (en) * | 1996-08-29 | 2000-01-18 | New York Medical College | Method for treating scoliosis with β2-adrenoceptor agonists |
WO1999016430A1 (en) | 1997-09-30 | 1999-04-08 | E.C. Pesterfield Associates, Inc. | Galenic forms of r-or rr-isomers of adrenergic beta-2 agonists |
ZA994264B (en) * | 1998-07-01 | 2000-01-25 | Warner Lambert Co | Stereoisomers with high affinity for adrenergic receptors. |
AU6167599A (en) | 1998-09-30 | 2000-04-17 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of a beta2 adrenergic receptor agonist in the treatment of cardiovascular disease |
ATE381537T1 (de) * | 2001-03-22 | 2008-01-15 | Glaxo Group Ltd | Formanilid-derivative als beta2-adrenorezeptor- agonisten |
US6747043B2 (en) * | 2002-05-28 | 2004-06-08 | Theravance, Inc. | Alkoxy aryl β2 adrenergic receptor agonists |
US20050107417A1 (en) * | 2003-07-28 | 2005-05-19 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising a novel anticholinergic and a betamimetic |
AU2004285961A1 (en) | 2003-11-03 | 2005-05-12 | Myogen, Inc. | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
CA2560538A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
EP1781331A1 (en) | 2004-08-09 | 2007-05-09 | Université Catholique de Louvain | Use of agonists and antagonists of beta-adrenoceptors for treating arterial diseases |
MX2007008459A (es) * | 2005-01-11 | 2007-07-25 | Glaxo Group Ltd | Sales de cinamato de un agonista beta-2 adrenergico. |
CA2660707C (en) * | 2006-08-10 | 2014-07-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
-
2007
- 2007-08-10 CA CA2660707A patent/CA2660707C/en active Active
- 2007-08-10 CN CN201310705914.3A patent/CN103739503A/zh active Pending
- 2007-08-10 US US12/376,945 patent/US20100168245A1/en not_active Abandoned
- 2007-08-10 JP JP2009524015A patent/JP5302194B2/ja active Active
- 2007-08-10 KR KR1020097002634A patent/KR101378067B1/ko active IP Right Grant
- 2007-08-10 AU AU2007286051A patent/AU2007286051B2/en active Active
- 2007-08-10 WO PCT/US2007/075731 patent/WO2008022038A1/en active Application Filing
- 2007-08-10 BR BRPI0716495-5A2A patent/BRPI0716495A2/pt not_active IP Right Cessation
- 2007-08-10 MX MX2009001534A patent/MX2009001534A/es active IP Right Grant
- 2007-08-10 EP EP07813996.1A patent/EP2064174B1/en active Active
-
2009
- 2009-02-09 IL IL196965A patent/IL196965A/en active IP Right Grant
-
2011
- 2011-12-21 US US13/333,866 patent/US8703826B2/en active Active
-
2013
- 2013-06-20 JP JP2013129406A patent/JP2013224316A/ja active Pending
-
2014
- 2014-03-06 US US14/199,208 patent/US9522871B2/en active Active
-
2016
- 2016-11-09 US US15/347,354 patent/US9908841B2/en active Active
-
2018
- 2018-01-18 US US15/874,747 patent/US10308591B2/en active Active
-
2019
- 2019-04-22 US US16/390,982 patent/US10562843B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9522871B2 (en) | 2016-12-20 |
IL196965A (en) | 2015-10-29 |
JP5302194B2 (ja) | 2013-10-02 |
US20170081276A1 (en) | 2017-03-23 |
JP2010500381A (ja) | 2010-01-07 |
EP2064174B1 (en) | 2016-10-26 |
KR101378067B1 (ko) | 2014-04-10 |
AU2007286051B2 (en) | 2013-01-10 |
WO2008022038A1 (en) | 2008-02-21 |
US10308591B2 (en) | 2019-06-04 |
US9908841B2 (en) | 2018-03-06 |
US8703826B2 (en) | 2014-04-22 |
JP2013224316A (ja) | 2013-10-31 |
KR20090051171A (ko) | 2009-05-21 |
IL196965A0 (en) | 2009-11-18 |
US20140187645A1 (en) | 2014-07-03 |
US20160009636A9 (en) | 2016-01-14 |
US20190248732A1 (en) | 2019-08-15 |
US20120157543A1 (en) | 2012-06-21 |
US10562843B2 (en) | 2020-02-18 |
CN103739503A (zh) | 2014-04-23 |
US20100168245A1 (en) | 2010-07-01 |
EP2064174A1 (en) | 2009-06-03 |
US20180141894A1 (en) | 2018-05-24 |
CA2660707C (en) | 2014-07-08 |
CA2660707A1 (en) | 2008-02-21 |
BRPI0716495A2 (pt) | 2014-03-04 |
AU2007286051A1 (en) | 2008-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009001534A (es) | Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. | |
WO2010037059A3 (en) | Heteroaryl antagonists of prostaglandin d2 receptors | |
WO2009108720A3 (en) | Antagonists of prostaglandin d2 receptors | |
HK1146485A1 (es) | ||
WO2010003127A3 (en) | Antagonists of prostaglandin d2 receptors | |
WO2009102893A3 (en) | Cyclic diaryl ether compounds as antagonists of prostaglandin d2 receptors | |
WO2011044506A3 (en) | Sulphone compounds for use in the treatment of obesity | |
WO2010042652A3 (en) | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors | |
WO2009145989A3 (en) | Aminoalkylphenyl antagonists of prostaglandin d2 receptors | |
WO2010057118A3 (en) | Heterocyclic antagonists of prostaglandin d2 receptors | |
CL2007002099A1 (es) | Compuestos derivados de 3h-espiro(1-benzofuran-2,4'-piperidina); proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento de enfermedades respiratorias, tales como epoc y asma. | |
WO2006037024A3 (en) | Salts of decitabine | |
WO2007076085A3 (en) | Fused pyrimidones and thiopyrimidones, and uses thereof | |
EA201001253A1 (ru) | N,n-дизамещенные аминоалкилбифенилы в качестве антагонистов рецепторов простагландина d | |
WO2009025785A3 (en) | Cb2 receptor ligands for the treatment of pain | |
JO2686B1 (en) | Vehicles | |
MY142036A (en) | New quaternized quinuclidine esters | |
MY150702A (en) | Substituted 4-phenyltetrahydroisoquinonelines, method of producing them, their use as medicament, and also medicament containing them | |
WO2010094720A3 (en) | Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists | |
WO2007146957A3 (en) | Ror1 as a therapeutic target for lung cancer | |
TW200720236A (en) | Organic compounds | |
WO2007082068A3 (en) | Methods and compositions for treating asthma in human and non human primates | |
WO2008001195A3 (en) | Novel processes for the preparation of dpp iv inhibitors | |
JO2645B1 (en) | Vehicles | |
MX2009008527A (es) | Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |