AR065657A1 - DERIVADOS DE 4-OXO-TIAZOL, COMPOSICIoN FARMACÉUTICA, MÉTODO DE PREPARACIoN DE LA MISMA Y SU USO EN LA FABRICACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MODULADAS POR EL RECEPTOR ALFA RELACIONADOS CON ESTRoGENOS. - Google Patents
DERIVADOS DE 4-OXO-TIAZOL, COMPOSICIoN FARMACÉUTICA, MÉTODO DE PREPARACIoN DE LA MISMA Y SU USO EN LA FABRICACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MODULADAS POR EL RECEPTOR ALFA RELACIONADOS CON ESTRoGENOS.Info
- Publication number
- AR065657A1 AR065657A1 ARP080100964A ARP080100964A AR065657A1 AR 065657 A1 AR065657 A1 AR 065657A1 AR P080100964 A ARP080100964 A AR P080100964A AR P080100964 A ARP080100964 A AR P080100964A AR 065657 A1 AR065657 A1 AR 065657A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- arthritis
- halo
- alkyl
- cartilage
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Compuestos derivados de 4-oxo-tiazol, composiciones farmacéuticas y método para su preparacion y su uso en medicamentos para tratar una afeccion incluyendo sin carácter limitativo espondilitis anquilosante, ateroesclerosis, artritis (tales como artritis reumatoide, artritis infecciosa, artritis de la ninez, artritis psoriásica, artritis reactiva), enfermedades relacionadas con los huesos (incluyendo aquellas relacionadas con la formacion de los huesos), cáncer de mama (incluyendo aquellos que no responden a la terapia anti-estrogénica) trastornos /cardiovasculares, enfermedades relacionadas con los cartílagos (tales como lesion/pérdida de cartílagos, degeneracion de cartílagos, y aquellas relacionadas con la formacion de cartílagos), condrodisplasia, condrosarcoma, lesion cronica de espalda, bronquitis cronica, enfermedad cronica inflamatoria de las vías aéreas, enfermedad pulmonar obstructiva cronica, diabetes, trastornos de homeostasis de energía, gota, pseudogota, trastornos de los lípidos, síndrome metabolico, mieloma multiple, obesidad, osteoartritis, osteogénesis imperfecta, metástasis osea osteolítica, osteomalacia, osteoporosis, enfermedad de Paget, enfermedad periodontal, polimialgia reumática, síndrome de Reiter, lesion por estrés reiterado, hiperglucemia, nivel elevado de glucosa en sangre, y resistencia a la insulina. Reivindicacion 1: Un compuesto de formula (1) en el cual X es S u O; R1 es halo, alquilo C1-4 sustituido en forma opcional, alcoxi C1-4 sustituido en forma opcional, o hidroxilo; R2 se selecciona de alquilo C1-3 sustituido por halo, ciano, halo, -C(O)NH2, y -C(O)O-alquilo C1-4, o en forma alternativa R2 está unido junto a R3 para formar un arilo fusionado al anillo fenilo al cual R2 y R3 se muestran unidos; R3 es H, o en forma alternativa R3 está unido junto a R2 para formar un arilo fusionado al anillo fenilo al cual R3 y R2 se muestran unidos; R4 es halo, ciano, alquilo C1-3 sustituido por halo, -CsCH, -C(O)O-alquilo C1-4, -C(O)NH2 o -S(O2)-alquilo C1-4; y R5 y R6 se seleccionan en forma independiente de H, alquilo C1-4 sustituido en forma opcional, heteroarilo sustituido en forma opcional, y heterociclilo sustituido en forma opcional, o en forma alternativa R5 y R6 están ligados junto con el átomo N al cual están unidos para formar un heterociclilo que contiene N sustituido en forma opcional; y o un isomero optico, enantiomero, diasteromero, cis-trans isomero, racemato, profármaco o sales aceptables desde el punto de vista farmacéutico de los anteriores.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89346407P | 2007-03-07 | 2007-03-07 |
Publications (1)
Publication Number | Publication Date |
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AR065657A1 true AR065657A1 (es) | 2009-06-24 |
Family
ID=39530136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100964A AR065657A1 (es) | 2007-03-07 | 2008-03-07 | DERIVADOS DE 4-OXO-TIAZOL, COMPOSICIoN FARMACÉUTICA, MÉTODO DE PREPARACIoN DE LA MISMA Y SU USO EN LA FABRICACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MODULADAS POR EL RECEPTOR ALFA RELACIONADOS CON ESTRoGENOS. |
Country Status (17)
Country | Link |
---|---|
US (1) | US8580832B2 (es) |
EP (1) | EP2134698A1 (es) |
JP (1) | JP2010520308A (es) |
KR (1) | KR20090128454A (es) |
CN (1) | CN101679327A (es) |
AR (1) | AR065657A1 (es) |
AU (1) | AU2008222755B2 (es) |
BR (1) | BRPI0808776A2 (es) |
CA (1) | CA2680212A1 (es) |
CL (1) | CL2008000667A1 (es) |
EA (1) | EA016887B1 (es) |
IL (1) | IL200759A0 (es) |
MX (1) | MX2009009520A (es) |
NZ (1) | NZ579417A (es) |
TW (1) | TW200902506A (es) |
UA (1) | UA98484C2 (es) |
WO (1) | WO2008109737A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온 |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
TW200927731A (en) | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
ES2637794T3 (es) | 2007-11-14 | 2017-10-17 | Janssen Pharmaceuticals, Inc. | Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2 |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
BRPI0920354A2 (pt) | 2008-10-16 | 2017-06-27 | Addex Pharmaceuticals Sa | derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
RS53075B (en) | 2009-05-12 | 2014-04-30 | Janssen Pharmaceuticals Inc. | 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
US20130040951A9 (en) * | 2009-08-04 | 2013-02-14 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for cancer |
US8187871B2 (en) * | 2009-08-11 | 2012-05-29 | Janssen Pharmaceutica N.V. | Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond |
WO2011019558A1 (en) * | 2009-08-11 | 2011-02-17 | Janssen Pharmaceutica Nv | Methods to measure dissociation rates for ligands that form reversible covalent bonds |
JP2013514385A (ja) | 2009-12-18 | 2013-04-25 | ヤンセン ファーマシューティカ エヌ.ベー. | エストロゲン関連受容体αモジュレーターとしての置換アミノチアゾロンインダゾール |
WO2011103130A1 (en) | 2010-02-17 | 2011-08-25 | Janssen Pharmaceutica Nv | Aminothiazolones as estrogen related receptor-alpha modulators |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
US8772277B2 (en) | 2011-08-04 | 2014-07-08 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
WO2013146435A1 (ja) | 2012-03-26 | 2013-10-03 | 日本ケミファ株式会社 | 骨・軟部に発生する巨細胞性腫瘍または軟骨肉腫の予防または治療剤 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR20220000993A (ko) | 2013-09-25 | 2022-01-04 | 닛뽕 케미파 가부시키가이샤 | 골·연부에 발생하는 거세포성 종양, 연골육종 또는 골육종의 예방, 치료 또는 전이 예방을 위한 약제, 동맥색전술용 국소 주입제 및 인공골 |
DK3431106T3 (da) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
BR112021019256A2 (pt) | 2019-03-28 | 2021-12-14 | Escient Pharmaceuticals Inc | Moduladores de receptor x4 de proteína g relacionado a mas e produtos e métodos relacionados |
CA3144891A1 (en) * | 2019-07-04 | 2021-01-07 | Lead Pharma Holding B.V. | Estrogen-related receptor alpha (err.alpha.) modulators |
CN112538038B (zh) * | 2019-09-20 | 2022-05-20 | 暨南大学 | 2-吲哚酮类ERRα反向激动剂及其药物组合物和应用 |
KR20220066822A (ko) | 2020-11-16 | 2022-05-24 | 경북대학교 산학협력단 | 골 질환 예방 또는 치료용 조성물 |
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JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
EP1398029A1 (en) | 2002-09-10 | 2004-03-17 | LION Bioscience AG | NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives |
US20080313061A1 (en) | 2004-06-30 | 2008-12-18 | Paysetter Pte Ltd | System and Method for Facilitating Transfer of Physical Money and/or Credit |
EP1781271A1 (en) * | 2004-07-14 | 2007-05-09 | Janssen Pharmaceutica N.V. | Arylidenes for the treatment of estrogen related receptor-alpha mediated diseases |
US7977489B2 (en) * | 2004-10-22 | 2011-07-12 | Exelixis, Inc. | Benzylthiazolone inhibitors of estrogen-related receptors (ERR) |
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2008
- 2008-03-06 CN CN200880015410A patent/CN101679327A/zh active Pending
- 2008-03-06 NZ NZ579417A patent/NZ579417A/en not_active IP Right Cessation
- 2008-03-06 US US12/043,311 patent/US8580832B2/en active Active
- 2008-03-06 EA EA200970839A patent/EA016887B1/ru not_active IP Right Cessation
- 2008-03-06 TW TW097107931A patent/TW200902506A/zh unknown
- 2008-03-06 AU AU2008222755A patent/AU2008222755B2/en not_active Expired - Fee Related
- 2008-03-06 UA UAA200910122A patent/UA98484C2/ru unknown
- 2008-03-06 JP JP2009552887A patent/JP2010520308A/ja active Pending
- 2008-03-06 CL CL2008000667A patent/CL2008000667A1/es unknown
- 2008-03-06 WO PCT/US2008/056029 patent/WO2008109737A1/en active Application Filing
- 2008-03-06 KR KR1020097020836A patent/KR20090128454A/ko not_active Application Discontinuation
- 2008-03-06 BR BRPI0808776-8A patent/BRPI0808776A2/pt not_active IP Right Cessation
- 2008-03-06 MX MX2009009520A patent/MX2009009520A/es unknown
- 2008-03-06 EP EP08731528A patent/EP2134698A1/en not_active Ceased
- 2008-03-06 CA CA002680212A patent/CA2680212A1/en not_active Abandoned
- 2008-03-07 AR ARP080100964A patent/AR065657A1/es not_active Application Discontinuation
-
2009
- 2009-09-06 IL IL200759A patent/IL200759A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20090128454A (ko) | 2009-12-15 |
WO2008109737A1 (en) | 2008-09-12 |
AU2008222755B2 (en) | 2013-05-02 |
US8580832B2 (en) | 2013-11-12 |
IL200759A0 (en) | 2010-05-17 |
JP2010520308A (ja) | 2010-06-10 |
EA016887B1 (ru) | 2012-08-30 |
BRPI0808776A2 (pt) | 2014-08-19 |
CL2008000667A1 (es) | 2008-11-03 |
UA98484C2 (ru) | 2012-05-25 |
TW200902506A (en) | 2009-01-16 |
CA2680212A1 (en) | 2008-09-12 |
AU2008222755A1 (en) | 2008-09-12 |
EA200970839A1 (ru) | 2010-04-30 |
NZ579417A (en) | 2012-02-24 |
CN101679327A (zh) | 2010-03-24 |
EP2134698A1 (en) | 2009-12-23 |
MX2009009520A (es) | 2009-11-18 |
US20080221179A1 (en) | 2008-09-11 |
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