NO20072418L - Arylsulfonylmetyl- eller arylsufonamidsubstituerte aromatiske forbindelser egnet for behandling av lidelser som reagerer pa modulering av dopamin D3-reseptoren - Google Patents

Arylsulfonylmetyl- eller arylsufonamidsubstituerte aromatiske forbindelser egnet for behandling av lidelser som reagerer pa modulering av dopamin D3-reseptoren

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Publication number
NO20072418L
NO20072418L NO20072418A NO20072418A NO20072418L NO 20072418 L NO20072418 L NO 20072418L NO 20072418 A NO20072418 A NO 20072418A NO 20072418 A NO20072418 A NO 20072418A NO 20072418 L NO20072418 L NO 20072418L
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Norway
Prior art keywords
fluorinated
alkyl
treatment
dopamine
cycloalkyl
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NO20072418A
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English (en)
Inventor
Liliane Unger
Karla Drescher
Andreas Haupt
Sean C Turner
Wilfried Braje
Roland Grandel
Christophe Henry
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Abbott Gmbh & Co Kg
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Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of NO20072418L publication Critical patent/NO20072418L/no

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    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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  • Pyridine Compounds (AREA)
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Abstract

Foreliggende oppfinnelse vedrører aromatiske forbindelser med formel I hvori Ar er fenyl eller et aromatisk 5- eller 6-leddet C-bundet heteroaromatisk radikal, hvori Ar kan bære 1 radikal R* og hvori Ar også kan bære 1 eller 2 radikaler R*'; XerNellerCH; Y er O, S, -CH=N-, -CH=CH- eller -N=CH-; A er CH2, O eller S; E er CR^R^ eller NR^ r' er Ci-C4-alkyl, C3-C4-cykloalkyl, C3-C4-cykloalkylmetyl, C3-C4-alkenyl, fluorert Ci-C4-alkyl, fluorert C3-C4-cykloalkyl, fluorert C3-C4-cykloalkylmetyl, fluorert C3-C4-alkenyl, fiormyl eller Ci-C3-alkylkarbonyl; R'' er H, C2-C4-alkyl, C3-C4-cykloalkyl, C3-C4-alkenyl, fluorert Ci-C4-alkyl, fluorert C3-C4-cykloalkyl, eller r'* og R^ er sammen (CH2)n med n som er 2 eller 3, eller R'* og R^* er sammen (CH2)n med n som er 2 eller 3; R^ og R^' er uavhengig av hverandre H, CH3, CH2F, CHF2 eller CF3; R^erH eller Cl-C4-alkyl; R^, R^ er uavhengig av hverandre valgt fra H, Ci-C2-alkyl og fluorert Ci-C2-alkyl; og de fysiologisk akseptable syreaddisjonssalter derav. Oppfinnelsen vedrører også anvendelsen av en fiorbindelse med fiormel I eller et fiarmasøytisk akseptabelt salt derav fior fremstilling av en fiarmasøytisk sammensetning fior behandlingen av en medisinsk lidelse mottakelig fior behandling med en dopamin D3-reseptorligand.
NO20072418A 2004-10-14 2007-05-11 Arylsulfonylmetyl- eller arylsufonamidsubstituerte aromatiske forbindelser egnet for behandling av lidelser som reagerer pa modulering av dopamin D3-reseptoren NO20072418L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61877604P 2004-10-14 2004-10-14
US71194205P 2005-08-26 2005-08-26
PCT/EP2005/011091 WO2006040178A1 (en) 2004-10-14 2005-10-14 Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to madulation of the dopamine d3 receptor

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US (1) US8969552B2 (no)
EP (2) EP2439203B1 (no)
JP (1) JP5193602B2 (no)
KR (2) KR20130028988A (no)
CN (2) CN103073460B (no)
AU (1) AU2005293694B2 (no)
BR (1) BRPI0516115A (no)
CA (1) CA2583779C (no)
CR (2) CR9057A (no)
EC (1) ECSP077394A (no)
ES (2) ES2436178T3 (no)
HK (1) HK1114834A1 (no)
IL (2) IL182429A (no)
MA (1) MA28952B1 (no)
MX (1) MX2007004356A (no)
NO (1) NO20072418L (no)
NZ (2) NZ589649A (no)
RU (1) RU2442781C2 (no)
TW (1) TWI361806B (no)
WO (1) WO2006040178A1 (no)
ZA (1) ZA200703060B (no)

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TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
TW201319049A (zh) * 2011-08-05 2013-05-16 Abbott Gmbh & Co Kg 胺基□唍、胺基硫□唍及胺基－１，２，３，４－四氫喹啉衍生物，包含彼等之醫藥組合物及彼等於治療之用途
CN103130685A (zh) * 2011-12-01 2013-06-05 上海药明康德新药开发有限公司 一种(2,2-二甲基-5-氧-环己基)-氨基甲酸苄酯的制备方法
CN106715395B (zh) * 2014-07-30 2020-05-12 豪夫迈·罗氏有限公司 作为taar调节剂的6-氨基-5，6，7，8-四氢萘-2-基或3-氨基色满-7-基衍生物
EP3535244A1 (en) 2016-11-02 2019-09-11 Abbvie Deutschland GmbH & Co. KG Spiro-compounds as s1p modulators

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AU2005293694A1 (en) 2006-04-20
ES2529720T3 (es) 2015-02-25
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IL182429A0 (en) 2007-07-24
CA2583779A1 (en) 2006-04-20
MA28952B1 (fr) 2007-10-01
MX2007004356A (es) 2007-07-17
ES2436178T3 (es) 2013-12-27
RU2007117802A (ru) 2008-11-20
NZ589649A (en) 2012-04-27
EP1812416B1 (en) 2013-08-21
CN103073460A (zh) 2013-05-01
WO2006040178A9 (en) 2007-04-19
CN103073460B (zh) 2015-09-09
CN101068801B (zh) 2012-11-14
EP1812416A1 (en) 2007-08-01
TWI361806B (en) 2012-04-11
IL225745A (en) 2015-10-29
EP2439203A1 (en) 2012-04-11
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JP5193602B2 (ja) 2013-05-08
IL182429A (en) 2013-08-29
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US20090012074A1 (en) 2009-01-08
US8969552B2 (en) 2015-03-03
AU2005293694B2 (en) 2011-12-01
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JP2008516914A (ja) 2008-05-22
CR9057A (es) 2008-03-18
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WO2006040178A1 (en) 2006-04-20
ECSP077394A (es) 2007-05-30
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CA2583779C (en) 2013-12-10
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