BRPI0516115A - compostos arilsulfonilmetil ou arilsulfonamida aromáticos substituìdos adequados para tratar distúrbios que respondem à modulação do receptor de dopamina d3 - Google Patents

compostos arilsulfonilmetil ou arilsulfonamida aromáticos substituìdos adequados para tratar distúrbios que respondem à modulação do receptor de dopamina d3

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Publication number
BRPI0516115A
BRPI0516115A BRPI0516115-0A BRPI0516115A BRPI0516115A BR PI0516115 A BRPI0516115 A BR PI0516115A BR PI0516115 A BRPI0516115 A BR PI0516115A BR PI0516115 A BRPI0516115 A BR PI0516115A
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Brazil
Prior art keywords
fluorinated
alkyl
dopamine
cycloalkyl
alkenyl
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BRPI0516115-0A
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English (en)
Inventor
Andreas Haupt
Liliane Unger
Sean C Turner
Wilfried Braje
Roland Grandel
Christophe Henry
Karla Drescher
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Abbott Gmbh & Co Kg
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Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of BRPI0516115A publication Critical patent/BRPI0516115A/pt

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    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

COMPOSTOS ARILSULFONILMETIL OU ARILSULFONAMIDA AROMáTICOS SUBSTITUìDOS ADEQUADOS PARA TRATAR DISTúRBIOS QUE RESPONDEM à MODULAçãO DO RECEPTOR DE DOPAMINA D~ 3~. A presente invenção se refere a compostos aromáticos de fórmula (I), em que Ar é fenil ou um radical heteroaromático ligado a C de 5 ou 6 membros, em que Ar pode carregar 1 radical R¬ a¬ e em que Ar pode também carregar 1 ou 2 radicais R<sym>; X é N ou CH; Y é O, S, -CH=N-, -CH=CH- ou - N=CH-; A é CH~ 2~, O ou S; E é CR¬ 6¬R¬ 7¬ ou NR¬ 3¬; R¬ 1¬ é alquil C~ 1~-C~ 4~, cicloalquil C~ 3~-C~ 4~, cicloalquilmetil C~ 3~-C~ 4~, alquenil C~ 3~-C~ 4~, alquil C~ 1~-C~ 4~ fluorado, cicloalquil C~ 3~-C~ 4~ fluorado, cicloalquilmetil C~ 3~C~ 4~ fluorado, alquenil C~ 3~-C~ 4~ fluorado, formil ou alquilcarbonil C~ 2~-C~ 3; R¬ 1[¬ é H, alquil C~ 2~-C~ 4~, cicloalquil C~ 3~-C~ 4~, alquenil C~ 3~-C~ 4~, alquil C~ 1~-C~ 4~ fluorado, cicloalquil C~ 3~-C~ 4 fluorado, ou R¬ 1[¬ e R¬ 2¬ juntos são (CH~ 2~) ~ n~ com n sendo 2 ou 3, ou R¬ 1[¬ e R¬ 2[¬ juntos são (CH~ 2~) ~ n~ com n sendo 2 ou 3; R¬ 2¬ e R¬2[¬ são, independentemente um do outro, H, CH~ 3~, CH~ 2~F, CHF~ 2~ ou CF~ 3~; R¬ 3¬ é H ou alquil C~ 1~-C~ 4~; R¬ 6¬, R¬ 7¬, independentemente um do outro, são selecionados de H, alquil C~ 1~-C~ 2~ e alquil C~ 1~-C~ 2~ fluorado; e os seus sais de adição de ácido fisiologicamente tolerados. A invenção também se refere ao uso de um composto de fórmula I ou um sal seu farmaceuticamente aceitável para preparar uma composição farmacêutica para o tratamento de um distúrbio médico suscetível ao tratamento com um ligante do receptor de dopamina D3.
BRPI0516115-0A 2004-10-14 2005-10-14 compostos arilsulfonilmetil ou arilsulfonamida aromáticos substituìdos adequados para tratar distúrbios que respondem à modulação do receptor de dopamina d3 BRPI0516115A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61877604P 2004-10-14 2004-10-14
US71194205P 2005-08-26 2005-08-26
PCT/EP2005/011091 WO2006040178A1 (en) 2004-10-14 2005-10-14 Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to madulation of the dopamine d3 receptor

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BRPI0516115A true BRPI0516115A (pt) 2008-08-26

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US (1) US8969552B2 (pt)
EP (2) EP2439203B1 (pt)
JP (1) JP5193602B2 (pt)
KR (2) KR20130028988A (pt)
CN (2) CN103073460B (pt)
AU (1) AU2005293694B2 (pt)
BR (1) BRPI0516115A (pt)
CA (1) CA2583779C (pt)
CR (2) CR9057A (pt)
EC (1) ECSP077394A (pt)
ES (2) ES2436178T3 (pt)
HK (1) HK1114834A1 (pt)
IL (2) IL182429A (pt)
MA (1) MA28952B1 (pt)
MX (1) MX2007004356A (pt)
NO (1) NO20072418L (pt)
NZ (2) NZ589649A (pt)
RU (1) RU2442781C2 (pt)
TW (1) TWI361806B (pt)
WO (1) WO2006040178A1 (pt)
ZA (1) ZA200703060B (pt)

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TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
TW201319049A (zh) * 2011-08-05 2013-05-16 Abbott Gmbh & Co Kg 胺基□唍、胺基硫□唍及胺基－１，２，３，４－四氫喹啉衍生物，包含彼等之醫藥組合物及彼等於治療之用途
CN103130685A (zh) * 2011-12-01 2013-06-05 上海药明康德新药开发有限公司 一种(2,2-二甲基-5-氧-环己基)-氨基甲酸苄酯的制备方法
CN106715395B (zh) * 2014-07-30 2020-05-12 豪夫迈·罗氏有限公司 作为taar调节剂的6-氨基-5，6，7，8-四氢萘-2-基或3-氨基色满-7-基衍生物
EP3535244A1 (en) 2016-11-02 2019-09-11 Abbvie Deutschland GmbH & Co. KG Spiro-compounds as s1p modulators

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AU2005293694A1 (en) 2006-04-20
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IL182429A0 (en) 2007-07-24
CA2583779A1 (en) 2006-04-20
MA28952B1 (fr) 2007-10-01
MX2007004356A (es) 2007-07-17
ES2436178T3 (es) 2013-12-27
RU2007117802A (ru) 2008-11-20
NZ589649A (en) 2012-04-27
EP1812416B1 (en) 2013-08-21
CN103073460A (zh) 2013-05-01
WO2006040178A9 (en) 2007-04-19
CN103073460B (zh) 2015-09-09
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CN101068801B (zh) 2012-11-14
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US20090012074A1 (en) 2009-01-08
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NZ555124A (en) 2010-12-24
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