BRPI0516529A - compostos de 6-amino(aza)indano apropriados para o tratamento de distúrbios que respondem à modulação do receptor de dopamina d3 - Google Patents

compostos de 6-amino(aza)indano apropriados para o tratamento de distúrbios que respondem à modulação do receptor de dopamina d3

Info

Publication number
BRPI0516529A
BRPI0516529A BRPI0516529-6A BRPI0516529A BRPI0516529A BR PI0516529 A BRPI0516529 A BR PI0516529A BR PI0516529 A BRPI0516529 A BR PI0516529A BR PI0516529 A BRPI0516529 A BR PI0516529A
Authority
BR
Brazil
Prior art keywords
aza
amino
treatment
fluoridated
alkyl
Prior art date
Application number
BRPI0516529-6A
Other languages
English (en)
Inventor
Karla Drescher
Andreas Haupt
Liliane Unger
Sean C Turner
Wilfried Braje
Rolan Grandel
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of BRPI0516529A publication Critical patent/BRPI0516529A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPOSTOS DE 6-AMINO (AZA) INDANO APROPRIADOS PARA O TRATAMENTO DE DISTúRBIOS QUE RESPONDEM à MODULAçãO DO RECEPTOR DE DOPAMINA D~ 3~. A presente invenção relaciona-se ao composto de 6-amino (aza) indano de fórmula (I) onde Ar é fenila ou um radical heteroaromático aromático de 5- ou 6- membros C-ligados, onde Ar pode carregar 1 radical R¬ a¬ e onde Ar pode também carregar I ou 2 radicais R¬ b¬ ; X são N ou CH; E é CR¬ 6¬R¬ 7¬ ou NR¬ 3¬; R¬ 1¬ é alquila C~ 1~-C~ 4~, cicloalquila C~ 3~-C~ 4~, cicloalquilmetila C~ 3~-C~ 4~, alquenila C~ 3~-C~ 4~, alquila C~ 1~-C~ 4~ fluoretada, cicloalquil C~ 3~-C~ 4~ fluoretada, cicloalquilmetila C~ 3~-C~ 4~ fluoretada, alquenila C~ 3~-C~ 4~ fluoretada, formila ou alquilcarbonila C~ 1~-C~ 3~; R¬ 1a¬ é H ou R¬ 1a¬ e R¬ 2¬ ou R¬ 1a¬ juntos são (CH~ 2~)~ n~ com n sendo 1, 2, 3 ou 4; R¬ 2¬ e R¬ 2a¬ , cada um, são independentemente H, CH~ 3~, CH~ 2~F, CHF~ 2~ ou CF~ 3~; R¬ 3¬ é H ou alquila C~ 1~-C~ 4~; e os sais de adição ácida fisiologicamente tolerados destes compostos. A invenção relaciona-se também às composições farmacêuticas que compreendem pelo menos um composto de fórmula (I) ou de um sal farmaceuticamente aceitável disso e a um método para tratar um distúrbio médico suscetível ao tratamento com um ligante do receptor de dopamina D~ 3~, o referido método compreendendo administrar uma quantidade eficaz de pelo menos um composto de fórmula (I) ou um sal farmaceuticamente aceitável disso.
BRPI0516529-6A 2004-10-14 2005-10-14 compostos de 6-amino(aza)indano apropriados para o tratamento de distúrbios que respondem à modulação do receptor de dopamina d3 BRPI0516529A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61874304P 2004-10-14 2004-10-14
PCT/EP2005/011090 WO2006040177A1 (en) 2004-10-14 2005-10-14 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 recptor

Publications (1)

Publication Number Publication Date
BRPI0516529A true BRPI0516529A (pt) 2008-09-09

Family

ID=35482313

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516529-6A BRPI0516529A (pt) 2004-10-14 2005-10-14 compostos de 6-amino(aza)indano apropriados para o tratamento de distúrbios que respondem à modulação do receptor de dopamina d3

Country Status (14)

Country Link
US (1) US7759397B2 (pt)
EP (2) EP2311801A1 (pt)
JP (1) JP5193601B2 (pt)
KR (1) KR101300046B1 (pt)
CN (1) CN101039900B (pt)
AU (1) AU2005293693B2 (pt)
BR (1) BRPI0516529A (pt)
CA (1) CA2583967C (pt)
IL (1) IL182430A (pt)
MX (1) MX2007004355A (pt)
NZ (1) NZ555121A (pt)
TW (1) TWI382013B (pt)
WO (1) WO2006040177A1 (pt)
ZA (1) ZA200703059B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP3057958B1 (en) 2013-10-17 2019-05-01 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
AU2014336153A1 (en) 2013-10-17 2016-04-28 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2703688B1 (fr) 1993-04-09 1995-05-19 Rhone Poulenc Chimie Réactif de désallylation, procédé de désallylation utilisant ledit réactif.
US5708018A (en) * 1993-08-06 1998-01-13 Pharmacia & Upjohn Company 2-aminoindans as selective dopamine D3 ligands
CA2208600A1 (en) * 1995-02-01 1996-08-08 Pharmacia & Upjohn Company 2-aminoindans as selective dopamine d3 ligands
EP0909299B1 (en) 1996-05-30 2003-02-19 Baker Hughes Incorporated Control of naphthenic acid corrosion with thiophosphorus compounds
WO1997045403A1 (en) 1996-05-31 1997-12-04 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands
DE19922443A1 (de) 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals

Also Published As

Publication number Publication date
TWI382013B (zh) 2013-01-11
AU2005293693B2 (en) 2011-11-17
IL182430A0 (en) 2007-07-24
TW200628437A (en) 2006-08-16
EP1807392A1 (en) 2007-07-18
CN101039900A (zh) 2007-09-19
JP5193601B2 (ja) 2013-05-08
CN101039900B (zh) 2012-03-21
AU2005293693A2 (en) 2006-04-20
NZ555121A (en) 2011-01-28
KR101300046B1 (ko) 2013-08-30
US7759397B2 (en) 2010-07-20
KR20070069203A (ko) 2007-07-02
IL182430A (en) 2011-10-31
AU2005293693A1 (en) 2006-04-20
JP2008516913A (ja) 2008-05-22
CA2583967C (en) 2013-07-23
EP2311801A1 (en) 2011-04-20
CA2583967A1 (en) 2006-04-20
MX2007004355A (es) 2007-07-17
WO2006040177A1 (en) 2006-04-20
ZA200703059B (en) 2008-09-25
US20080318996A1 (en) 2008-12-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]