BR0310099A - método para tratar dislipidemia ou uma doença associada com a dislipidemia - Google Patents
método para tratar dislipidemia ou uma doença associada com a dislipidemiaInfo
- Publication number
- BR0310099A BR0310099A BRPI0310099-5A BR0310099A BR0310099A BR 0310099 A BR0310099 A BR 0310099A BR 0310099 A BR0310099 A BR 0310099A BR 0310099 A BR0310099 A BR 0310099A
- Authority
- BR
- Brazil
- Prior art keywords
- dyslipidemia
- treating
- disease associated
- apolipoprotein
- effect
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6917—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a lipoprotein vesicle, e.g. HDL or LDL proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO PARA TRATAR DISLIPIDEMIA OU UMA DOENçA ASSOCIADA COM A DISLIPIDEMIA". A invenção fornece métodos de tratar ou prevenir uma condição ou distúrbio associados com a dislipidemia com composições que compreendem complexos de apolipoproteína-esfingomielina. Os métodos da invenção permitem a redução, em 4 a 20 vezes, da quantidade de apolipoproteína requerida para a administração terapêutica para efetuar um efeito melhorativo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38151202P | 2002-05-17 | 2002-05-17 | |
PCT/US2003/015467 WO2003096983A2 (en) | 2002-05-17 | 2003-05-16 | Method of treating dyslipidemic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0310099A true BR0310099A (pt) | 2007-03-20 |
Family
ID=29550136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0310099-5A BR0310099A (pt) | 2002-05-17 | 2003-05-16 | método para tratar dislipidemia ou uma doença associada com a dislipidemia |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040067873A1 (pt) |
EP (1) | EP1511508A4 (pt) |
JP (1) | JP2006507223A (pt) |
AU (1) | AU2003239489A1 (pt) |
BR (1) | BR0310099A (pt) |
CA (1) | CA2486127C (pt) |
MX (1) | MXPA04011312A (pt) |
WO (1) | WO2003096983A2 (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004020316D1 (de) * | 2003-01-20 | 2009-05-14 | Tno | Die verwendung von sphingolipiden zur senkung der cholesterin- und triglyzeridspiegel im plasma. |
NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
EP1576894A1 (en) * | 2004-03-16 | 2005-09-21 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | The use of sphingolipids in the treatment and prevention of type 2 diabetes mellitus, insulin resistance and Metabolic Syndrome |
DE602005026785D1 (de) * | 2004-03-16 | 2011-04-21 | Tno | Verwendung von sphingolipiden bei der behandlung und vorbeugung von typ-2-diabetes mellitus, insulinresistenz und metabolismussyndrom |
AU2005310341A1 (en) | 2004-11-30 | 2006-06-08 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
US8206750B2 (en) * | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
BRPI0614966A2 (pt) * | 2005-08-26 | 2016-09-13 | Cerenis Therapeutics Holding S A | vetor de expressão, bactéria de ácido lático, apolipoproteína isenta de endotoxina, e, método de produção de uma apolipoproteína isenta de endotoxina |
GB0606212D0 (en) * | 2006-03-28 | 2006-05-10 | Karobio Ab | Pharmaceutical compositions |
EP2537526A1 (en) * | 2006-06-01 | 2012-12-26 | Institut de Cardiologie de Montréal | Method and compound for the treatment of valvular stenosis |
ATE540681T1 (de) * | 2006-06-26 | 2012-01-15 | Amgen Inc | Verfahren zur behandlung von atherosklerose |
US8541236B2 (en) * | 2006-12-08 | 2013-09-24 | University Of Washington | Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls |
US7985728B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US7985727B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Apo A-I mimetic peptides and methods of treatment |
US8044021B2 (en) | 2007-09-20 | 2011-10-25 | Abbott Cardiovascular Systems Inc. | Sustained release of apo A-I mimetic peptides and methods of treatment |
US9173890B2 (en) * | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US8101565B2 (en) | 2007-09-20 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US8241861B1 (en) | 2008-07-08 | 2012-08-14 | Insilicos, Llc | Methods and compositions for diagnosis or prognosis of cardiovascular disease |
CA2982157A1 (en) | 2009-02-16 | 2010-08-19 | Cerenis Therapeutics Holding Sa | Apolipoprotein a-i mimics |
WO2010131718A1 (ja) * | 2009-05-13 | 2010-11-18 | 丸大食品株式会社 | 鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び/又は抗高脂血症剤 |
US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
CN103118683B (zh) * | 2010-06-30 | 2015-08-19 | 杰特有限公司 | 重建高密度脂蛋白制剂及其生产方法 |
CA2807448A1 (en) * | 2010-08-30 | 2012-03-08 | F. Hoffmann-La Roche Ag | Tetranectin-apolipoprotein a-i, lipid particles containing it and its use |
SI2767546T1 (sl) | 2011-02-07 | 2019-03-29 | Cerenis Therapeutics Holding Sa | Lipoproteinski kompleksi in izdelava ter uporaba le-teh |
WO2012162392A1 (en) | 2011-05-23 | 2012-11-29 | Timothy Hla | Endothelium protective materials and methods of use |
KR20140054115A (ko) * | 2011-08-25 | 2014-05-08 | 에프. 호프만-라 로슈 아게 | 단축 테트라넥틴-아포지단백질 a-i 융합 단백질, 그를 함유하는 지질 입자 및 그의 용도 |
KR20190084334A (ko) * | 2011-12-21 | 2019-07-16 | 시에스엘 리미티드 | 아포지질단백질 제형을 위한 용량 용법 |
US9610324B2 (en) | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
US9125943B2 (en) | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
KR20170003611A (ko) | 2014-05-02 | 2017-01-09 | 세레니스 쎄라퓨틱스 홀딩 에스에이 | Hdl 요법 마커 |
US20160074473A1 (en) | 2014-07-31 | 2016-03-17 | Kinemed, Inc. | Effect of phospholipid composition of reconstituted hdl on its cholesterol efflux and anti-inflammatory properties |
KR20180027532A (ko) | 2015-07-10 | 2018-03-14 | 펩티노보 바이오파마, 엘엘씨 | 소수성 약물의 효능 개선용 제형 |
SG11201903945XA (en) * | 2016-11-10 | 2019-05-30 | Csl Ltd | Reconstituted high density lipoprotein treatment of myocardial infarction |
WO2019030575A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding | APOMÈRES |
US20190048049A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding Sa | Cargomers |
WO2021209823A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein- based complexes |
CN116322646A (zh) | 2020-10-01 | 2023-06-23 | 阿比奥尼克斯制药公司 | 用于治疗眼病的包含基于脂质结合蛋白的复合物的组合物 |
EP4322746A1 (en) | 2021-04-15 | 2024-02-21 | Abionyx Pharma SA | Use of lipid binding protein-based complexes in organ preservation solutions |
WO2023196804A1 (en) * | 2022-04-04 | 2023-10-12 | Phyto Tech Corp. | Use of apolipoprotein a-v as an oral ingestible protein for nutraceutical or pharmaceutical applications |
WO2023194798A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
WO2023194797A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
WO2023237927A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
WO2023237935A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
WO2024150064A1 (en) | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61152632A (ja) * | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
JPH07507554A (ja) | 1992-06-12 | 1995-08-24 | エヌ・ブイ・イノゲネテイクス・エス・エイ | 新規ペプチドおよびタンパク質,それらの調製方法,ならびにコレステロール受容体としてのそれらの使用 |
US5674855A (en) | 1992-08-12 | 1997-10-07 | The Rogosin Institute | Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions |
SE9203753D0 (sv) | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
FR2723741A1 (fr) | 1994-08-16 | 1996-02-23 | Fournier Sca Lab | Peptides inhibiteurs de la proteine de transfert des esters de cholesterol et leur utilisation en therapeutique |
US6258596B1 (en) * | 1995-05-22 | 2001-07-10 | Aventis Pharmaceuticals Products Inc. | Variants of apolipoprotein A-I |
FR2734568B1 (fr) | 1995-05-22 | 1997-06-20 | Rhone Poulenc Rorer Sa | Nouveaux variants de l'apolipoproteine |
NZ331980A (en) | 1996-03-29 | 2000-09-29 | Helmut Hauser | Amphipathic peptides with alpha helices as cholesterol and other lipid uptake inhibitors |
GB9609702D0 (en) | 1996-05-09 | 1996-07-10 | Royal Free Hosp School Med | Anticoagulant peptides |
US6046166A (en) * | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6004925A (en) * | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6037323A (en) * | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6267377B1 (en) * | 1999-11-12 | 2001-07-31 | Herman W. Griggs | Astronomy-based card game |
US6514523B1 (en) * | 2000-02-14 | 2003-02-04 | Ottawa Heart Institute Research Corporation | Carrier particles for drug delivery and process for preparation |
US7208288B2 (en) | 2000-10-13 | 2007-04-24 | Broderick Joseph P | Methods for enhancing the lysis of coagulated blood with apolipoprotein E2 phenotype |
WO2003097696A1 (en) | 2002-05-17 | 2003-11-27 | Esperion Therapeutics, Inc. | Methods and copositions for the treatment of ischemic reperfusion |
PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
-
2003
- 2003-05-16 US US10/440,213 patent/US20040067873A1/en not_active Abandoned
- 2003-05-16 WO PCT/US2003/015467 patent/WO2003096983A2/en active Search and Examination
- 2003-05-16 BR BRPI0310099-5A patent/BR0310099A/pt not_active IP Right Cessation
- 2003-05-16 CA CA2486127A patent/CA2486127C/en not_active Expired - Fee Related
- 2003-05-16 EP EP03734054A patent/EP1511508A4/en not_active Withdrawn
- 2003-05-16 MX MXPA04011312A patent/MXPA04011312A/es not_active Application Discontinuation
- 2003-05-16 AU AU2003239489A patent/AU2003239489A1/en not_active Abandoned
- 2003-05-16 JP JP2004504982A patent/JP2006507223A/ja not_active Withdrawn
-
2007
- 2007-08-22 US US11/843,223 patent/US7994120B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20080269111A1 (en) | 2008-10-30 |
EP1511508A2 (en) | 2005-03-09 |
WO2003096983A3 (en) | 2005-01-13 |
AU2003239489A8 (en) | 2003-12-02 |
WO2003096983A2 (en) | 2003-11-27 |
EP1511508A4 (en) | 2009-07-08 |
JP2006507223A (ja) | 2006-03-02 |
CA2486127A1 (en) | 2003-11-27 |
US20040067873A1 (en) | 2004-04-08 |
MXPA04011312A (es) | 2005-02-14 |
CA2486127C (en) | 2014-03-11 |
AU2003239489A1 (en) | 2003-12-02 |
US7994120B2 (en) | 2011-08-09 |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |