JP4095444B2 - ペンタペプチド化合物及びそれに関する使用 - Google Patents

ペンタペプチド化合物及びそれに関する使用

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Publication number
JP4095444B2
JP4095444B2 JP2002585470A JP2002585470A JP4095444B2 JP 4095444 B2 JP4095444 B2 JP 4095444B2 JP 2002585470 A JP2002585470 A JP 2002585470A JP 2002585470 A JP2002585470 A JP 2002585470A JP 4095444 B2 JP4095444 B2 JP 4095444B2
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Japan
Prior art keywords
lower alkyl
hydrogen
compound
compounds
acid
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Expired - Lifetime
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JP2002585470A
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English (en)
Japanese (ja)
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JP2004531544A (ja
JP2004531544A5 (enExample
Inventor
ドロニナ，スヴェトラナ
センター，ピーター，ディー．
トキ，ブライアン，イー．
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シアトル ジェネティクス，インコーポレーテッド
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Priority claimed from US09/845,786 external-priority patent/US20030083263A1/en
Application filed by シアトル ジェネティクス，インコーポレーテッド filed Critical シアトル ジェネティクス，インコーポレーテッド
Publication of JP2004531544A publication Critical patent/JP2004531544A/ja
Publication of JP2004531544A5 publication Critical patent/JP2004531544A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002585470A 2001-04-30 2002-04-30 ペンタペプチド化合物及びそれに関する使用 Expired - Lifetime JP4095444B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/845,786 US20030083263A1 (en) 2001-04-30 2001-04-30 Pentapeptide compounds and uses related thereto
US10/001,191 US6884869B2 (en) 2001-04-30 2001-11-01 Pentapeptide compounds and uses related thereto
PCT/US2002/013435 WO2002088172A2 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto

Publications (3)

Publication Number Publication Date
JP2004531544A JP2004531544A (ja) 2004-10-14
JP2004531544A5 JP2004531544A5 (enExample) 2005-12-22
JP4095444B2 true JP4095444B2 (ja) 2008-06-04

Family

ID=26668695

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002585470A Expired - Lifetime JP4095444B2 (ja) 2001-04-30 2002-04-30 ペンタペプチド化合物及びそれに関する使用

Country Status (6)

Country Link
US (2) US6884869B2 (enExample)
EP (1) EP1390393A4 (enExample)
JP (1) JP4095444B2 (enExample)
AU (1) AU2002308515C1 (enExample)
CA (1) CA2445875C (enExample)
WO (1) WO2002088172A2 (enExample)

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