DK2691417T3 - Antistof fc-varianter - Google Patents

Antistof fc-varianter Download PDF

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Publication number
DK2691417T3
DK2691417T3 DK12710732.4T DK12710732T DK2691417T3 DK 2691417 T3 DK2691417 T3 DK 2691417T3 DK 12710732 T DK12710732 T DK 12710732T DK 2691417 T3 DK2691417 T3 DK 2691417T3
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DK
Denmark
Prior art keywords
antibody
ser
val
thr
pro
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DK12710732.4T
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English (en)
Inventor
Manfred Kubbies
Tilman Schlothauer
Ekkehard Moessner
Monika Baehner
Stefan Jenewein
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Roche Glycart Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45888223&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2691417(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
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Publication of DK2691417T3 publication Critical patent/DK2691417T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Claims (8)

1. Antistof eller et Fc-fusionsprotein omfattende en Fc-variant afen vild-type human IgGl Fc-region, hvor Fc-varianten af den vild-type humane IgGl Fc-region indeholder aminosyresubstitutionerne P329G, L234A og L235A, hvor resterne er nummereret i henhold til EU Kabat index.
2. Antistoffet eller Fc-fusionsprotein ifølge krav 1, hvor den vild-type humane IgGl-region inducerer en ADCC og hvor ADCC induceret af antistof eller Fc-fusionsprotein omfattende IgGl-Fc-varianten reduceres til 0-20% af ADCC induceret af antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region.
3. Antistoffet eller Fc-fusionsprotein ifølge kravene 1 eller 2, hvor antistoffet eller Fc-fusionsprotein omfattende Fc-varianten, udviser en reduceret eller fjernet affinitet for en Fc-receptor der er ansvarlig for en effektorfunktion sammenlignet med antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region.
4. Antistoffet eller Fc-fusionsprotein ifølge et hvilket som helst af kravene 1-3, hvor antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region inducerer thrombocytaggregation og hvor thrombocytaggregationen induceret af antistoffet eller Fc-fusionsprotein omfattende IgGl-Fc-varianten reduceres sammenlignet med thrombocytaggregationen induceret af antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region.
5. Antistoffet eller Fc-fusionsprotein ifølge et hvilket som helst af kravene 1-4, hvor antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region inducerer CDC og hvor CDC induceret af antistoffet eller Fc-fusions-protein omfattende IgGl-Fc-varianten er stærkt reduceret sammenlignet med CDC induceret af antistoffet eller Fc-fusionsprotein omfattende den vild-type humane IgGl Fc-region.
6. Antistoffet ifølge et hvilket som helst af kravene 1-5, hvor antistoffet er et anti-CD9-antistof, der er kendetegnet ved at vild-type Fc-regionen omfatter som tung kæde variabel-region SEQ ID NO:9 og som variabel let kæde-region SEQ ID NO:8.
7. Antistoffet eller Fc-fusionsprotein ifølge et hvilket som helst af kravene 1-6 til anvendelse som medikament.
8. Antistoffet eller Fc-fusionsprotein ifølge et hvilket som helst af kravene 1-6, til anvendelse i en fremgangsmåde til behandling af en sygdom hos et individ hvor det er favorabelt at en effektorfunktion af antistoffet eller Fc-fusionsprotein er stærkt reduceret sammenlignet med effektorfunktionen induceret af antistoffet eller Fc-fusionsprotein omfattende en vild-type human IgG Fc-region, fremgangsmåden omfatter administration af antistoffet eller Fc-fusionsprotein ifølge et hvilket som helst af kravene 1-6 til individet.
DK12710732.4T 2011-03-29 2012-03-27 Antistof fc-varianter DK2691417T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11160251 2011-03-29
PCT/EP2012/055393 WO2012130831A1 (en) 2011-03-29 2012-03-27 Antibody fc variants

Publications (1)

Publication Number Publication Date
DK2691417T3 true DK2691417T3 (da) 2018-11-19

Family

ID=45888223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12710732.4T DK2691417T3 (da) 2011-03-29 2012-03-27 Antistof fc-varianter

Country Status (26)

Country Link
US (5) US8969526B2 (da)
EP (2) EP3590965A1 (da)
JP (1) JP5926791B2 (da)
KR (2) KR101614195B1 (da)
CN (2) CN105949313B (da)
AR (1) AR085741A1 (da)
AU (1) AU2012234335B2 (da)
BR (1) BR112013024574B1 (da)
CA (1) CA2828289C (da)
DK (1) DK2691417T3 (da)
ES (1) ES2692268T3 (da)
HK (1) HK1193109A1 (da)
HR (1) HRP20181690T1 (da)
HU (1) HUE041335T2 (da)
IL (1) IL228002B (da)
LT (1) LT2691417T (da)
MX (2) MX354359B (da)
MY (1) MY163539A (da)
PL (1) PL2691417T3 (da)
PT (1) PT2691417T (da)
RS (1) RS57895B1 (da)
RU (1) RU2607014C2 (da)
SG (2) SG193554A1 (da)
SI (1) SI2691417T1 (da)
TR (1) TR201815420T4 (da)
WO (1) WO2012130831A1 (da)

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