DK3277725T3 - Konstante tungkædeområder med reduceret binding til FC-gammareceptorer - Google Patents
Konstante tungkædeområder med reduceret binding til FC-gammareceptorer Download PDFInfo
- Publication number
- DK3277725T3 DK3277725T3 DK16757988.7T DK16757988T DK3277725T3 DK 3277725 T3 DK3277725 T3 DK 3277725T3 DK 16757988 T DK16757988 T DK 16757988T DK 3277725 T3 DK3277725 T3 DK 3277725T3
- Authority
- DK
- Denmark
- Prior art keywords
- heavy chain
- reduced binding
- constant heavy
- chain regions
- gamma receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562140350P | 2015-03-30 | 2015-03-30 | |
PCT/US2016/025051 WO2016161010A2 (en) | 2015-03-30 | 2016-03-30 | Heavy chain constant regions with reduced binding to fc gamma receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3277725T3 true DK3277725T3 (da) | 2021-01-11 |
Family
ID=56842995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16757988.7T DK3277725T3 (da) | 2015-03-30 | 2016-03-30 | Konstante tungkædeområder med reduceret binding til FC-gammareceptorer |
Country Status (10)
Country | Link |
---|---|
US (3) | US10556952B2 (da) |
EP (1) | EP3277725B1 (da) |
JP (1) | JP6773679B2 (da) |
AU (1) | AU2016242866B2 (da) |
CA (1) | CA2981312C (da) |
DK (1) | DK3277725T3 (da) |
ES (1) | ES2846748T3 (da) |
HK (1) | HK1250039A1 (da) |
PL (1) | PL3277725T3 (da) |
WO (1) | WO2016161010A2 (da) |
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EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
KR20210054528A (ko) | 2018-08-31 | 2021-05-13 | 리제너론 파아마슈티컬스, 인크. | Cd3/c20 이중특이적 항체에 대한 사이토카인 방출 증후군을 경감시키는 투약 전략 |
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2016
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- 2016-03-30 CA CA2981312A patent/CA2981312C/en active Active
- 2016-03-30 ES ES16757988T patent/ES2846748T3/es active Active
- 2016-03-30 JP JP2017551033A patent/JP6773679B2/ja active Active
- 2016-03-30 DK DK16757988.7T patent/DK3277725T3/da active
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- 2016-03-30 WO PCT/US2016/025051 patent/WO2016161010A2/en active Application Filing
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US20230287117A1 (en) | 2023-09-14 |
US10556952B2 (en) | 2020-02-11 |
EP3277725B1 (en) | 2020-11-25 |
US20180282411A1 (en) | 2018-10-04 |
US11518807B2 (en) | 2022-12-06 |
CA2981312C (en) | 2023-09-26 |
ES2846748T3 (es) | 2021-07-29 |
JP2018512420A (ja) | 2018-05-17 |
US20200109203A1 (en) | 2020-04-09 |
JP6773679B2 (ja) | 2020-10-21 |
WO2016161010A2 (en) | 2016-10-06 |
PL3277725T3 (pl) | 2021-06-14 |
EP3277725A2 (en) | 2018-02-07 |
WO2016161010A3 (en) | 2016-11-10 |
CA2981312A1 (en) | 2016-10-06 |
HK1250039A1 (zh) | 2018-11-23 |
AU2016242866B2 (en) | 2021-06-03 |
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