EA201890785A1 - Оптимизированные биспецифические анти-cd3 антитела и их применение - Google Patents
Оптимизированные биспецифические анти-cd3 антитела и их применениеInfo
- Publication number
- EA201890785A1 EA201890785A1 EA201890785A EA201890785A EA201890785A1 EA 201890785 A1 EA201890785 A1 EA 201890785A1 EA 201890785 A EA201890785 A EA 201890785A EA 201890785 A EA201890785 A EA 201890785A EA 201890785 A1 EA201890785 A1 EA 201890785A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- antigen binding
- human
- cells
- induce
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Данное изобретение относится к антителам, которые связываются с CD3 со слабой или недетектируемой аффинностью связывания и способам их применения. Согласно некоторым вариантам осуществления антитела по изобретению связывают CD3 человека с низкой аффинностью и индуцируют пролиферацию Т-клеток человека и, следовательно, индуцируют опосредованный Т-клетками лизис опухолевых клеток с высокой эффективностью. В соответствии с некоторыми вариантами осуществления данное изобретение предлагает биспецифические антигенсвязывающие молекулу, содержащие первый антигенсвязывающий домен, который специфически связывает CD3 человека со слабой или недетектируемой аффинностью связывания в анализе in vitro, и вторую антигенсвязывающую молекулу, которая специфически связывает опухолеассоциированный антиген человека. В некоторых вариантах осуществления биспецифические антигенсвязывающие молекулы по данному изобретению способны ингибировать рост опухолей, экспрессирующих целевой антиген, такой как PSMA. Антитела и биспецифические антигенсвязывающие молекулы по изобретению пригодны для лечения заболеваний и расстройств, в которых повышенный или индуцированный целевой иммунный ответ является желательным и/или терапевтически полезным. Например, антитела по изобретению пригодны для лечения различных видов рака или других заболеваний, в которых иммунотерапия, то есть иммуномодуляция эффекторных клеток, является оправданной.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222605P | 2015-09-23 | 2015-09-23 | |
| PCT/US2016/053525 WO2017053856A1 (en) | 2015-09-23 | 2016-09-23 | Optimized anti-cd3 bispecific antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201890785A1 true EA201890785A1 (ru) | 2018-10-31 |
Family
ID=57130447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890785A EA201890785A1 (ru) | 2015-09-23 | 2016-09-23 | Оптимизированные биспецифические анти-cd3 антитела и их применение |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20180355038A1 (ru) |
| EP (1) | EP3353212B1 (ru) |
| JP (3) | JP7023231B2 (ru) |
| KR (1) | KR20180050412A (ru) |
| CN (1) | CN108290951B (ru) |
| AU (1) | AU2016325630B2 (ru) |
| BR (1) | BR112018005445A2 (ru) |
| CA (1) | CA2999385A1 (ru) |
| CY (1) | CY1124944T1 (ru) |
| DK (1) | DK3353212T3 (ru) |
| EA (1) | EA201890785A1 (ru) |
| ES (1) | ES2901133T3 (ru) |
| HK (1) | HK1258304A1 (ru) |
| HR (1) | HRP20220133T8 (ru) |
| HU (1) | HUE057683T2 (ru) |
| IL (1) | IL258036B (ru) |
| LT (1) | LT3353212T (ru) |
| MA (1) | MA42935B1 (ru) |
| MD (1) | MD3353212T2 (ru) |
| MX (1) | MX2018003403A (ru) |
| MY (1) | MY195059A (ru) |
| PL (1) | PL3353212T3 (ru) |
| PT (1) | PT3353212T (ru) |
| RS (1) | RS62859B1 (ru) |
| SI (1) | SI3353212T1 (ru) |
| TW (2) | TWI783914B (ru) |
| WO (1) | WO2017053856A1 (ru) |
| ZA (1) | ZA201801673B (ru) |
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2016
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