SI3353212T1 - Optimizirana bispecifična protitelesa proti-CD3 in njihove uporabe - Google Patents
Optimizirana bispecifična protitelesa proti-CD3 in njihove uporabeInfo
- Publication number
- SI3353212T1 SI3353212T1 SI201631414T SI201631414T SI3353212T1 SI 3353212 T1 SI3353212 T1 SI 3353212T1 SI 201631414 T SI201631414 T SI 201631414T SI 201631414 T SI201631414 T SI 201631414T SI 3353212 T1 SI3353212 T1 SI 3353212T1
- Authority
- SI
- Slovenia
- Prior art keywords
- bispecific antibodies
- optimized anti
- optimized
- bispecific
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222605P | 2015-09-23 | 2015-09-23 | |
| PCT/US2016/053525 WO2017053856A1 (en) | 2015-09-23 | 2016-09-23 | Optimized anti-cd3 bispecific antibodies and uses thereof |
| EP16781236.1A EP3353212B1 (en) | 2015-09-23 | 2016-09-23 | Optimized anti-cd3 bispecific antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3353212T1 true SI3353212T1 (sl) | 2022-01-31 |
Family
ID=57130447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201631414T SI3353212T1 (sl) | 2015-09-23 | 2016-09-23 | Optimizirana bispecifična protitelesa proti-CD3 in njihove uporabe |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20180355038A1 (sl) |
| EP (1) | EP3353212B1 (sl) |
| JP (3) | JP7023231B2 (sl) |
| KR (1) | KR20180050412A (sl) |
| CN (1) | CN108290951B (sl) |
| AU (1) | AU2016325630B2 (sl) |
| BR (1) | BR112018005445A2 (sl) |
| CA (1) | CA2999385A1 (sl) |
| CY (1) | CY1124944T1 (sl) |
| DK (1) | DK3353212T3 (sl) |
| EA (1) | EA201890785A1 (sl) |
| ES (1) | ES2901133T3 (sl) |
| HK (1) | HK1258304A1 (sl) |
| HR (1) | HRP20220133T8 (sl) |
| HU (1) | HUE057683T2 (sl) |
| IL (1) | IL258036B (sl) |
| LT (1) | LT3353212T (sl) |
| MA (1) | MA42935B1 (sl) |
| MD (1) | MD3353212T2 (sl) |
| MX (1) | MX2018003403A (sl) |
| MY (1) | MY195059A (sl) |
| PL (1) | PL3353212T3 (sl) |
| PT (1) | PT3353212T (sl) |
| RS (1) | RS62859B1 (sl) |
| SI (1) | SI3353212T1 (sl) |
| TW (2) | TWI783914B (sl) |
| WO (1) | WO2017053856A1 (sl) |
| ZA (1) | ZA201801673B (sl) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PL3221359T3 (pl) | 2014-11-17 | 2020-11-16 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia nowotworów przy użyciu dwuswoistego przeciwciała CD3XCD20 |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| AU2016267691B2 (en) * | 2015-05-28 | 2022-06-16 | Genentech, Inc. | Cell-based assay for detecting anti-CD3 homodimers |
| TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| US11530277B2 (en) | 2016-04-20 | 2022-12-20 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| AR109451A1 (es) | 2016-04-20 | 2018-12-12 | Regeneron Pharma | Composiciones y métodos para preparar anticuerpos basados en el uso de loci mejoradores de expresión |
| BR112019005670A2 (pt) | 2016-09-23 | 2019-06-04 | Regeneron Pharma | anticorpos anti-muc16 (mucina 16) |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| TWI789399B (zh) * | 2017-06-22 | 2023-01-11 | 財團法人生物技術開發中心 | 不對稱異二聚fc-scfv融合抗globo h及抗cd3雙特異性抗體及其於癌症治療上之用途 |
| EA201990784A1 (ru) * | 2017-09-14 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Анти-muc16 (mucin16) антитела |
| KR20200058525A (ko) * | 2017-09-29 | 2020-05-27 | 리제너론 파아마슈티컬스, 인크. | 스타필로코커스 표적 항원 및 보체 성분에 결합하는 이특이적 항원-결합 분자 및 이의 용도 |
| WO2019133761A1 (en) * | 2017-12-27 | 2019-07-04 | Teneobio, Inc. | Cd3-delta/epsilon heterodimer specific antibodies |
| AU2019290198A1 (en) | 2018-06-21 | 2021-01-14 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-PSMA x anti-CD28 antibodies and uses thereof |
| TW202005985A (zh) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗ＣＤ３ｘＭＵＣ１６抗體及抗ＰＤ－１抗體治療癌症的方法 |
| JOP20200343A1 (ar) | 2018-07-02 | 2020-12-31 | Xencor Inc | بروتين ربط مولد ضد مضاد لـ steap1 |
| KR20210034032A (ko) | 2018-07-19 | 2021-03-29 | 리제너론 파아마슈티컬스, 인크. | 이중특이적 항-BCMA x 항-CD3 항체 및 이의 용도 |
| KR20210049863A (ko) | 2018-08-23 | 2021-05-06 | 리제너론 파아마슈티컬스, 인크. | 항-Fc 엡실론-R1 알파 (FCERIA) 항체, FCERIA 및 CD3에 결합하는 이중특이적 항원-결합 분자 및 이들의 용도 |
| AU2019331024A1 (en) | 2018-08-31 | 2021-03-18 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for CD3/C20 bispecific antibodies |
| EP3864049A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
| TW202028246A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | B7h3單域抗體及其治療性組合物 |
| JP2022504822A (ja) | 2018-10-11 | 2022-01-13 | インヒブルクス インコーポレイテッド | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
| WO2020076992A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | 5t4 single domain antibodies and therapeutic compositions thereof |
| CA3121842A1 (en) * | 2018-12-04 | 2020-03-19 | Novartis Ag | Binding molecules against cd3 and uses thereof |
| CA3121565A1 (en) * | 2018-12-07 | 2020-06-11 | Jiangsu Hengrui Medicine Co., Ltd. | Cd3 antibody and pharmaceutical use thereof |
| SG11202105948TA (en) | 2018-12-19 | 2021-07-29 | Regeneron Pharma | Bispecific anti-muc16 x anti-cd28 antibodies and uses thereof |
| AU2019405747A1 (en) | 2018-12-19 | 2021-06-17 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-CD28 x anti-CD22 antibodies and uses thereof |
| CA3134335A1 (en) | 2019-03-22 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | Egfr x cd28 multispecific antibodies |
| AU2020296181A1 (en) * | 2019-06-21 | 2021-12-16 | Regeneron Pharmaceuticals, Inc. | Use of bispecific antigen-binding molecules that bind PSMA and CD3 in combination with 4-1BB co-stimulation |
| WO2021006199A1 (ja) | 2019-07-05 | 2021-01-14 | 小野薬品工業株式会社 | Ｐｄ－１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| BR112022002012A2 (pt) | 2019-08-15 | 2022-06-07 | Regeneron Pharma | Moléculas multispecíficas de ligação a antígeno para células-alvo e usos das mesma |
| CN110551222B (zh) * | 2019-08-27 | 2023-06-06 | 重庆市畜牧科学院 | 一种新型双功能抗体及其用途 |
| EP4069373A1 (en) | 2019-12-06 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Methods of treating multiple myeloma with bispecific anti-bcma x anti-cd3 antibodies |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| EP4214233A1 (en) | 2020-09-16 | 2023-07-26 | Amgen Inc. | Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer |
| CN116963774A (zh) | 2021-01-28 | 2023-10-27 | 瑞泽恩制药公司 | 用于治疗细胞因子释放综合征的组合物和方法 |
| IL308257A (en) | 2021-05-05 | 2024-01-01 | Immatics Biotechnologies Gmbh | Antigen binding proteins that uniquely bind PRAME |
| WO2023097219A2 (en) * | 2021-11-24 | 2023-06-01 | Adimab, Llc | Anti-idiotype antibodies |
| TW202346337A (zh) | 2022-03-29 | 2023-12-01 | 美商恩格姆生物製藥公司 | Ilt3及cd3結合劑以及其使用方法 |
| US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| CN114685675B (zh) * | 2022-04-27 | 2023-02-03 | 深圳市汉科生物工程有限公司 | 双特异性抗体及其在治疗癌症中的用途 |
| WO2024012513A1 (en) * | 2022-07-13 | 2024-01-18 | Hansoh Bio Llc | Antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
| WO2024081180A1 (en) | 2022-10-10 | 2024-04-18 | Regeneron Pharmaceuticals, Inc. | Methods for reducing alloantibody levels in subjects in need of solid organ transplantation |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
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| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| CA2461631A1 (en) * | 2001-09-28 | 2003-04-03 | Elusys Therapeutics, Inc. | Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| SI1629011T1 (sl) | 2003-05-31 | 2010-05-31 | Micromet Ag | Humane molekule za vezavo anti hu cd |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| JP2012508022A (ja) * | 2008-11-06 | 2012-04-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 減少した免疫原性を有する操作された抗体および作製方法 |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2011056997A1 (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
| ES2603559T5 (es) | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Cadena ligera común de ratón |
| PL3339323T3 (pl) * | 2010-08-12 | 2020-05-18 | Eli Lilly And Company | Przeciwciała przeciwko peptydowi N3pGlu amyloidu beta i ich zastosowania |
| CN107586340B (zh) * | 2011-08-23 | 2022-01-21 | 罗切格利卡特公司 | 对t细胞活化性抗原和肿瘤抗原特异性的双特异性抗体及使用方法 |
| WO2013157105A1 (ja) * | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| WO2013184761A1 (en) * | 2012-06-05 | 2013-12-12 | Regeneron Pharmaceuticals, Inc. | Methods for making fully human bispecific antibodies using a common light chain |
| JOP20200236A1 (ar) * | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| SI2900694T1 (sl) * | 2012-09-27 | 2018-12-31 | Merus N.V. | Bispecifična IGG protitelesa kot vključitelji T-celic |
| EP2904016B1 (en) * | 2012-10-08 | 2018-11-14 | Roche Glycart AG | Fc-free antibodies comprising two fab-fragments and methods of use |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| JP6510532B2 (ja) * | 2013-12-20 | 2019-05-08 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性ｈｅｒ２抗体及び使用方法 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
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2016
- 2016-09-23 MX MX2018003403A patent/MX2018003403A/es unknown
- 2016-09-23 CN CN201680068487.4A patent/CN108290951B/zh active Active
- 2016-09-23 JP JP2018534519A patent/JP7023231B2/ja active Active
- 2016-09-23 SI SI201631414T patent/SI3353212T1/sl unknown
- 2016-09-23 LT LTEPPCT/US2016/053525T patent/LT3353212T/lt unknown
- 2016-09-23 DK DK16781236.1T patent/DK3353212T3/da active
- 2016-09-23 AU AU2016325630A patent/AU2016325630B2/en active Active
- 2016-09-23 WO PCT/US2016/053525 patent/WO2017053856A1/en active Application Filing
- 2016-09-23 TW TW105130880A patent/TWI783914B/zh active
- 2016-09-23 HR HRP20220133TT patent/HRP20220133T8/hr unknown
- 2016-09-23 EA EA201890785A patent/EA201890785A1/ru unknown
- 2016-09-23 EP EP16781236.1A patent/EP3353212B1/en active Active
- 2016-09-23 MD MDE20180740T patent/MD3353212T2/ro unknown
- 2016-09-23 HU HUE16781236A patent/HUE057683T2/hu unknown
- 2016-09-23 PL PL16781236T patent/PL3353212T3/pl unknown
- 2016-09-23 MY MYPI2018700990A patent/MY195059A/en unknown
- 2016-09-23 PT PT167812361T patent/PT3353212T/pt unknown
- 2016-09-23 ES ES16781236T patent/ES2901133T3/es active Active
- 2016-09-23 IL IL258036A patent/IL258036B/en unknown
- 2016-09-23 KR KR1020187011246A patent/KR20180050412A/ko not_active Application Discontinuation
- 2016-09-23 TW TW111122347A patent/TWI784917B/zh active
- 2016-09-23 RS RS20220089A patent/RS62859B1/sr unknown
- 2016-09-23 MA MA42935A patent/MA42935B1/fr unknown
- 2016-09-23 BR BR112018005445A patent/BR112018005445A2/pt active Search and Examination
- 2016-09-23 CA CA2999385A patent/CA2999385A1/en active Pending
- 2016-09-23 US US15/780,504 patent/US20180355038A1/en not_active Abandoned
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2018
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2019
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2021
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2022
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2023
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