MX2010001637A - Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9. - Google Patents

Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9.

Info

Publication number
MX2010001637A
MX2010001637A MX2010001637A MX2010001637A MX2010001637A MX 2010001637 A MX2010001637 A MX 2010001637A MX 2010001637 A MX2010001637 A MX 2010001637A MX 2010001637 A MX2010001637 A MX 2010001637A MX 2010001637 A MX2010001637 A MX 2010001637A
Authority
MX
Mexico
Prior art keywords
cdmab
cells
surface expression
avoid
mediation
Prior art date
Application number
MX2010001637A
Other languages
English (en)
Inventor
Susan E Hahn
Helen P Findlay
David S F Young
Lisa M Cechetto
Alison L Ferry
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority claimed from PCT/US2008/001452 external-priority patent/WO2008097508A1/en
Publication of MX2010001637A publication Critical patent/MX2010001637A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C—CHEMISTRY; METALLURGY
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Abstract

La invención se refiere a la clasificación, diagnóstico y tratamiento de enfermedades cancerosas (tanto tumores primarios como metástasis tumorales), particularmente a la mediación de citotoxicidad de células tumorales que evidencian expresión superficial de CD9, y más particularmente al uso de anticuerpos modificadores de enfermedades cancerosas (CDMAB), opcionalmente en combinación con uno o más CDMAB/agentes quimioterapéuticos, como un medio para iniciar la respuesta citotóxica. La invención se refiere además a ensayos de unión, los cuales utilizan el CDMAB de la presente invención. Los anticuerpo anticáncer pueden ser conjugados a toxinas, enzimas, compuestos radioactivos, citocinas, interferones, porciones objetivo o reporteras y células hematógenas.
MX2010001637A 2007-08-17 2008-02-02 Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9. MX2010001637A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US96516507P 2007-08-17 2007-08-17
PCT/US2008/001452 WO2008097508A1 (en) 2007-02-02 2008-02-02 Automatic belay warning system
US2658408P 2008-02-06 2008-02-06
US12401908P 2008-04-11 2008-04-11

Publications (1)

Publication Number Publication Date
MX2010001637A true MX2010001637A (es) 2010-03-15

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Application Number Title Priority Date Filing Date
MX2010001637A MX2010001637A (es) 2007-08-17 2008-02-02 Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9.

Country Status (12)

Country Link
US (1) US20090068182A1 (es)
EP (1) EP2190880A1 (es)
KR (1) KR20100043077A (es)
CN (1) CN101784566A (es)
AU (1) AU2008288639A1 (es)
BR (1) BRPI0816230A2 (es)
CA (1) CA2696027A1 (es)
CO (1) CO6311010A2 (es)
CR (1) CR11238A (es)
EC (1) ECSP109970A (es)
MX (1) MX2010001637A (es)
WO (1) WO2009023955A1 (es)

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WO2012130831A1 (en) * 2011-03-29 2012-10-04 Roche Glycart Ag Antibody fc variants
LT3495387T (lt) 2012-07-13 2021-11-25 Roche Glycart Ag Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti
SG11201805649UA (en) 2016-01-08 2018-07-30 Aimm Therapeutics Bv Therapeutic anti-cd9 antibody
WO2021160268A1 (en) * 2020-02-13 2021-08-19 UCB Biopharma SRL Bispecific antibodies against cd9
US20230096030A1 (en) * 2020-02-13 2023-03-30 UCB Biopharma SRL Bispecific antibodies against cd9 and cd7
US20230151108A1 (en) * 2020-02-13 2023-05-18 UCB Biopharma SRL Bispecific antibodies against cd9 and cd137

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US6180357B1 (en) * 1999-10-08 2001-01-30 Arius Research, Inc. Individualized patient-specific anti-cancer antibodies

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