CO6311010A2 - Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9 - Google Patents

Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9

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Publication number
CO6311010A2
CO6311010A2 CO10027142A CO10027142A CO6311010A2 CO 6311010 A2 CO6311010 A2 CO 6311010A2 CO 10027142 A CO10027142 A CO 10027142A CO 10027142 A CO10027142 A CO 10027142A CO 6311010 A2 CO6311010 A2 CO 6311010A2
Authority
CO
Colombia
Prior art keywords
cdmab
cells
avoid
surface expression
mediation
Prior art date
Application number
CO10027142A
Other languages
English (en)
Inventor
David S F Young
Helen P Findlay
Lisa M Cechetto
Alison L Ferry
Susan E Hahn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6311010A2 publication Critical patent/CO6311010A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3015—Breast
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    • C07K—PEPTIDES
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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Abstract

La invención se refiere a la clasificación, diagnóstico y tratamiento de enfermedades cancerosas (tanto tumores primarios como metástasis tumorales), particularmente a la mediación de citotoxicidad de células tumorales que evidencian expresión superficial de CD9, y más particularmente al uso de anticuerpos modificadores de enfermedades cancerosas (CDMAB) , opcionalmente en combinación con uno o más CDMAB/agentes quimioterapéuticos, como un medio para iniciar la respuesta citotóxica. La invención se refiere además a ensayos de unión, los cuales utilizan el CDMAB de la presente invención. Los anticuerpos anticáncer pueden ser conjugados a toxinas, enzimas, compuestos radioactivos, citocinas, interferones, porciones objetivo o reporteras y células hematógenas.
CO10027142A 2007-08-17 2010-03-08 Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9 CO6311010A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96516507P 2007-08-17 2007-08-17
US2658408P 2008-02-06 2008-02-06
US12401908P 2008-04-11 2008-04-11

Publications (1)

Publication Number Publication Date
CO6311010A2 true CO6311010A2 (es) 2011-08-22

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CO10027142A CO6311010A2 (es) 2007-08-17 2010-03-08 Mediacion de citotoxicidad de celulas que evidencian la expresion superficial de cd9

Country Status (12)

Country Link
US (1) US20090068182A1 (es)
EP (1) EP2190880A1 (es)
KR (1) KR20100043077A (es)
CN (1) CN101784566A (es)
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WO2011004899A1 (en) * 2009-07-06 2011-01-13 Takeda Pharmaceutical Company Limited Cancerous disease modifying antibodies
RU2607014C2 (ru) 2011-03-29 2017-01-10 Рош Гликарт Аг Fc варианты антитела
AR092027A1 (es) 2012-07-13 2015-03-18 Roche Glycart Ag Anticuerpos biespecificos anti-vegf/anti-ang-2 y su utilizacion en el tratamiento de enfermedades vasculares oculares
EA201891299A1 (ru) 2016-01-08 2019-01-31 Аимм Терапьютикс Б.В. Терапевтические антитела к cd9
US20230151109A1 (en) * 2020-02-13 2023-05-18 UCB Biopharma SRL Bispecific antibodies against cd9
US20230096030A1 (en) * 2020-02-13 2023-03-30 UCB Biopharma SRL Bispecific antibodies against cd9 and cd7
EP4103608A1 (en) * 2020-02-13 2022-12-21 UCB Biopharma SRL Bispecific antibodies against cd9 and cd137

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