DK2869837T3 - Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse - Google Patents
Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse Download PDFInfo
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- DK2869837T3 DK2869837T3 DK13737564.8T DK13737564T DK2869837T3 DK 2869837 T3 DK2869837 T3 DK 2869837T3 DK 13737564 T DK13737564 T DK 13737564T DK 2869837 T3 DK2869837 T3 DK 2869837T3
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- ULARYIUTHAWJMU-UHFFFAOYSA-M sodium;1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O ULARYIUTHAWJMU-UHFFFAOYSA-M 0.000 description 1
- VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
- MIDXXTLMKGZDPV-UHFFFAOYSA-M sodium;1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCN1C(=O)C=CC1=O MIDXXTLMKGZDPV-UHFFFAOYSA-M 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
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- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000002653 sulfanylmethyl group Chemical group [H]SC([H])([H])[*] 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
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- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- MODVSQKJJIBWPZ-VLLPJHQWSA-N tesetaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3CC[C@@]2(C)[C@H]2[C@@H](C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C(=CC=CN=4)F)C[C@]1(O)C3(C)C)O[C@H](O2)CN(C)C)C(=O)C1=CC=CC=C1 MODVSQKJJIBWPZ-VLLPJHQWSA-N 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
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- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 description 1
- 229930013292 trichothecene Natural products 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 108010079202 tyrosyl-alanyl-cysteine Proteins 0.000 description 1
- 108010071635 tyrosyl-prolyl-arginine Proteins 0.000 description 1
- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
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- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- XLYOFNOQVPJJNP-OUBTZVSYSA-N water-17o Chemical compound [17OH2] XLYOFNOQVPJJNP-OUBTZVSYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (11)
1. Anti-theophyllin-antistof, hvor antistoffet omfatter (a) HVR-H1 omfattende aminosyresekvensen af SEQ ID NO: 01, (b) HVR-H2 omfattende aminosyresekvensen af SEQ ID NO: 02, og (c) HVR-H3 omfattende aminosyresekvensen af SEQ ID NO: 03, (d) HVR-L1 omfattende aminosyresekvensen af SEQ ID NO: 05; (e) HVR-L2 omfattende aminosyresekvensen af SEQ ID NO: 06; og (f) HVR-L3 omfattende aminosyresekvensen af SEQ ID NO: 07, hvor antistoffet er et humaniseret antistof og omfatter ved position 71 af det tung-kæde variable domæne nummereret ifølge Kabat aminosyregruppen arginin, og omfatter ved position 46 af det let-kæde variable domæne nummereret ifølge Kabat aminosyregruppen leucin.
2. Antistoffet ifølge krav 1, omfattende (a) en VH-sekvens med mindst 95% sekvensidentitet med aminosyresekvensen af SEQ ID NO: 04; (b) en VL-sekvens med mindst 95% sekvensidentitet med aminosyresekvensen af SEQ ID NO: 08; eller (c) en VH-sekvens som i (a) og en VL-sekvens som i (b), hvor aminosyregruppen ved position 71 af det tung-kæde variable domæne nummereret ifølge Kabat er arginin og aminosyregruppen ved position 46 af det let-kæde variable domæne nummereret ifølge Kabat er leucin.
3. Antistoffet ifølge krav 1, omfattende en VH-sekvens af SEQ ID NO: 04.
4. Antistoffet ifølge krav 3, omfattende en VL-sekvens of SEQ ID NO: 08.
5. Antistof omfattende en VH-sekvens af SEQ ID NO: 04 og en VL-sekvens af SEQ ID NO: 08.
6. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et fuldlængde-IgGl-antistof eller et fuldlængde-IgG4-antistof.
7. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et monoklonalt antistof.
8. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et antistoffragment der binder theophyllin.
9. Farmaceutisk formulering omfattende antistoffet ifølge et hvilket som helst af de foregående krav og en farmaceutisk acceptabel bærer.
10. Antistoffet ifølge et hvilket som helst af kravene 1 til 8 til anvendelse som et medikament.
11. Anvendelse af antistoffet ifølge et hvilket som helst af kravene 1 til 8 i fremstillingen af et medikament.
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EP12174958 | 2012-07-04 | ||
PCT/EP2013/064090 WO2014006118A1 (en) | 2012-07-04 | 2013-07-04 | Anti-theophylline antibodies and methods of use |
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DK2869837T3 true DK2869837T3 (da) | 2016-09-26 |
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DK13737564.8T DK2869837T3 (da) | 2012-07-04 | 2013-07-04 | Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse |
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US (1) | US9925272B2 (da) |
EP (2) | EP2869837B1 (da) |
JP (2) | JP6324376B2 (da) |
KR (1) | KR20150023938A (da) |
CN (2) | CN107082810B (da) |
BR (1) | BR112014030843A2 (da) |
CA (1) | CA2872184A1 (da) |
DK (1) | DK2869837T3 (da) |
ES (1) | ES2600154T3 (da) |
HK (1) | HK1203354A1 (da) |
HU (1) | HUE029435T2 (da) |
MX (1) | MX353951B (da) |
PL (1) | PL2869837T3 (da) |
RU (2) | RU2017128512A (da) |
SI (1) | SI2869837T1 (da) |
WO (1) | WO2014006118A1 (da) |
Families Citing this family (6)
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CN104411725B (zh) | 2012-07-04 | 2018-09-28 | 弗·哈夫曼-拉罗切有限公司 | 抗生物素抗体及使用方法 |
JP6148729B2 (ja) | 2012-07-04 | 2017-06-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 共有結合している抗原−抗体結合体 |
WO2015101587A1 (en) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
CN111228509A (zh) | 2014-01-03 | 2020-06-05 | 豪夫迈·罗氏有限公司 | 双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及其作为血脑屏障穿梭物的应用 |
EP3089759B1 (en) | 2014-01-03 | 2018-12-05 | F. Hoffmann-La Roche AG | Covalently linked polypeptide toxin-antibody conjugates |
CN106687476B (zh) | 2014-06-26 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 抗brdu抗体及使用方法 |
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Publication number | Publication date |
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EP2869837A1 (en) | 2015-05-13 |
WO2014006118A1 (en) | 2014-01-09 |
CN107082810B (zh) | 2020-12-25 |
EP3138578B1 (en) | 2022-01-12 |
CN104394886B (zh) | 2017-05-24 |
CN104394886A (zh) | 2015-03-04 |
KR20150023938A (ko) | 2015-03-05 |
JP6324376B2 (ja) | 2018-05-16 |
ES2600154T3 (es) | 2017-02-07 |
SI2869837T1 (sl) | 2016-12-30 |
JP2018138561A (ja) | 2018-09-06 |
MX353951B (es) | 2018-02-07 |
MX2014014381A (es) | 2015-02-05 |
HUE029435T2 (en) | 2017-02-28 |
JP2015527983A (ja) | 2015-09-24 |
CA2872184A1 (en) | 2014-01-09 |
US20150238628A1 (en) | 2015-08-27 |
RU2015102068A (ru) | 2016-08-20 |
EP3138578A1 (en) | 2017-03-08 |
US9925272B2 (en) | 2018-03-27 |
BR112014030843A2 (pt) | 2019-10-15 |
RU2630664C2 (ru) | 2017-09-11 |
EP2869837B1 (en) | 2016-09-14 |
CN107082810A (zh) | 2017-08-22 |
RU2017128512A (ru) | 2019-02-15 |
JP6549278B2 (ja) | 2019-07-24 |
HK1203354A1 (en) | 2015-10-30 |
PL2869837T3 (pl) | 2017-03-31 |
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