CN116585399A - 植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途 - Google Patents
植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途 Download PDFInfo
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- CN116585399A CN116585399A CN202310720393.2A CN202310720393A CN116585399A CN 116585399 A CN116585399 A CN 116585399A CN 202310720393 A CN202310720393 A CN 202310720393A CN 116585399 A CN116585399 A CN 116585399A
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Abstract
本发明提供植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障提升TGM1、KRT、AQP3、FLG、鞘磷脂磷酸二酯酶、GBA、及HAS基因表达的组合物的用途。其中,植物萃取物为0.125mg/mL的普洱茶萃取物与0.125mg/mL的菠菜萃取物的组合,或0.125mg/mL的四季春茶萃取物与0.125mg/mL的菠菜萃取物的组合。相较于单一成分的萃取物,本发明的萃取物组合能够有效提升TGM1、KRT、AQP3、FLG、鞘磷脂磷酸二酯酶、GBA、及HAS等皮肤相关基因的表达。
Description
本申请为申请人根据申请日为2018年04月03日的母案申请(申请号:201880021296.1,发明名称:植物萃取物在制备用于提升TGM1、KRT、AQP3、FLG、GBA、及HAS基因表达的组合物中的用途)所提出的分案申请。
相关申请的交叉引用
本申请主张在2017年04月03日在美国提交的中国专利申请号No.62/480,860、以及在2017年05月08日在美国提交的中国专利申请号No.62/503,185的优先权,其全部内容通过引用包含于此。
技术领域
本发明涉及一种含有植物萃取物的组合物,尤其涉及一种用以提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的含有植物萃取物的组合物的用途。
背景技术
表皮层为皮肤的最外层,由外往内依序为角质层、颗粒层、有棘层及基底层,表皮层主要由基底层中未分化的圆柱型角质细胞持续向上进行分化形成,此过程称为角质化。角质细胞内含水量高,随着细胞向上代谢分化,角质细胞形状会逐渐变成扁平状,且细胞核及细胞器开始退化萎缩,并在角质层形成不具细胞核与细胞器的死细胞。表皮层的主要功能为使皮肤保水,并形成皮肤屏障以抵御各种外来伤害,其中表皮层最外层由弱酸性的皮脂膜以及如砖墙结构的角质层所构成,此屏障能锁住皮肤的水分和油脂、抵抗皮肤表面病菌入侵,及对抗外界异物及紫外光等伤害,对人体有非常重要的保护作用。
表皮层中的角质层,其角质细胞虽然为死细胞,但其主要成分为角蛋白(keratin),角蛋白能吸收水分使皮肤保持湿润,角质细胞也会分泌如玻尿酸等物质作为细胞间质,以维持表皮层皮肤屏障的结构完整,以防止皮肤水分散失及形成完整防护。当皮肤接触过冷或过热的环境以及照射紫外光等刺激,会导致角质细胞无法维持正常的代谢循环,并使得皮肤表皮层屏障受损,而让皮肤变得粗糙、干燥脱屑、脆弱易受刺激、敏感泛红且会使皮肤保水能力下降,因此角质层的健康对于皮肤保湿以及抵御外来伤害着实非常重要。
综合上面所述,为了改善因角质细胞受损导致皮肤变得脆弱、易敏,以及皮肤保水能力下降的问题,开发一种能有效维持角质细胞排列、维持角质层结构完整以及使角质细胞分泌更多保湿因子,以提升皮肤屏障以及保湿功能的组合物,着实有其必要性。
然而,目前用于该用途的成分或药物有限,若为某种植物萃取物,其必须施予相当高的剂量,在使用成本上以及效果上有其局限,因此,若能施予多种萃取物的少量组分,即可产生单一成分的高剂量效果时,对于前述功效的运用,不但可大幅提升,也同时降低了使用成本。
发明内容
缘此,本发明的一目的在提供一种植物萃取物用于制备提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途,其中植物萃取物为0.125mg/mL的普洱茶萃取物与0.125mg/mL的菠菜萃取物的组合,或0.125mg/mL的四季春茶萃取物与0.125mg/mL的菠菜萃取物的组合,且四季春茶萃取物是将四季春茶茶叶以水于50℃~100℃萃取0.5~3小时所得。
在一些实施例中,前述四季春茶萃取物的制备过程中,水与四季春茶茶叶的液固比为5~20:1~5。
在一些实施例中,前述四季春茶萃取物的萃取温度为75℃~95℃。
在一些实施例中,组合物具有提升转谷氨酰胺酶1(Transglutaminase 1,TGM1)基因、角蛋白(Keratin,KRT)基因、水通道蛋白3(Aquaporin 3,AQP3)基因、聚角蛋白微丝(Filaggrin,FLG)基因、葡萄糖脑苷酯酶(Glucocerebrosidase,GBA)基因、及玻尿酸合成酶(Hyaluronan synthase,HAS)基因表达的能力。
在本发明的一实施例中,其中该角蛋白基因包含角蛋白1(Keratin1,KRT1)基因、角蛋白10(Keratin10,KRT10)基因及角蛋白14(Keratin14,KRT14)基因;该玻尿酸合成酶基因包含玻尿酸合成酶2(Hyaluronan synthase 2,HAS2)基因及玻尿酸合成酶3(Hyaluronansynthase 3,HAS3)基因。
在本发明的一实施例中,所述组合物更具有促进皮肤保湿的功效。
在本发明的一实施例中,所述组合物进一步包含医药上可接受的载体,且该组合物为粉末、颗粒、液体、胶状或膏状的剂型,又所述组合物被制备成医药品或食品产品的形式。
附图说明
图1为本发明的各植物萃取组合物的保湿分数。
具体实施方式
以下将配合附图进一步说明本发明的实施方式,下述所列举的实施例用以阐明本发明的发明特点及应用,而非以限定本发明的范围,对于本领域技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,因此本发明的保护范围应当以本申请权利要求书的内容为准。
实施例1植物萃取物的制备
实施例1-1本发明四季春茶萃取物的制备方法
四季春茶(Four Seasons Spring tea)萃取物的制备方法如下:首先,将四季春茶茶叶(leaves of Four Seasons Spring tea plant)洗净并进行干燥,再用粉碎机将四季春茶茶叶进行粗碎,接着以水为溶剂对四季春茶茶叶的粗碎物进行萃取,该溶剂与四季春茶茶叶粗碎物以液固比5~20:1~5均匀混合,萃取温度为50℃~100℃,优选为75℃~95℃,萃取时间约为0.5~3小时,得到四季春茶的粗萃取物,将该粗萃取物冷却至室温后,经由400目的滤网过滤以移除残余固体物,再进一步于45℃~70℃进行减压浓缩而获得浓缩产物,即为本发明的四季春茶萃取物。
实施例1-2本发明菠菜萃取物的制备方法
菠菜萃取物通过对菠菜(Spinacia oleracea)进行萃取而获得,本实施例中使用的菠菜萃取物可购自弘祥农产加工厂。
实施例1-3本发明蓝莓萃取物的制备方法
蓝莓萃取物通过对北美蓝莓(Vaccinium Cyanococcus)果实进行萃取而获得,本实施例中使用的蓝莓萃取物可购自元弘草本科研有限公司。
实施例1-4本发明普洱茶萃取物的制备方法
普洱茶(Puerh tea)萃取物通过对普洱茶茶叶(post-fermented leaves ofCamellia sinensis)进行萃取而获得,本实施例中使用的普洱茶萃取物可购自南京泽朗生物科技有限公司。
实施例2本发明植物萃取组合物提升TGM1、KRT1、KRT10、KRT14、APQ3及FLG基因表达的效果
本发明以人类初代皮肤角质细胞(human primary epidermal keratinocytes,HPEK)进行TGM1、KRT1、KRT10、KRT14、APQ3及FLG的基因分析。该人类初代皮肤角质细胞购自CELLnTEC公司(瑞士)编号HPEK-50,将该细胞在无血清的角质细胞培养液(keratinocyte-SFM)(Gibco公司,编号为#10724-011,美国)中培养。
首先,将1.5×105个人类初代皮肤角质细胞种植于含2mL的上述培养液的6孔培养板中,将人类初代角质细胞分成十组各别加入:(1)0.125mg/mL的普洱茶萃取物、(2)0.125mg/mL的菠菜萃取物、(3)0.125mg/mL的四季春茶萃取物、(4)0.125mg/mL的以1:1比例混合的普洱茶萃取物与菠菜萃取物的组合物、(5)0.125mg/mL的以1:1比例混合的四季春茶萃取物与菠菜萃取物的组合物、(6)0.25mg/mL的普洱茶萃取物、(7)0.25mg/mL的蓝莓萃取物、(8)0.25mg/mL的四季春茶萃取物、(9)0.25mg/mL的以1:1比例混合的普洱茶萃取物与蓝莓萃取物的组合物、(10)0.25mg/mL的以1:1比例混合的四季春茶萃取物与蓝莓萃取物的组合物,并以没有加入任何萃取物的组别为空白对照组。加入植物萃取物后置于37℃培养箱,使角质细胞形成受植物萃取物刺激后的角质细胞,于第6小时与24小时更换培养液,培养液为角质细胞培养液及植物萃取液。接着,将角质细胞加入裂解液(lysis buffer)收集成管后,使用RNA萃取试剂试剂盒(购自Geneaid公司,中国台湾,Lot No.FC24015-G)分别收集两组角质细胞内的RNA,接着利用III反转录酶(购自Invitrogene公司,美国,编号18080-051)以2000ng的萃取RNA为模板并以引物产生mRNA反转录的相应cDNA产物,接着利用ABI StepOnePlusTM Real-Time PCR system(Thermo Fisher Scientific公司,美国)以及KAPA/>FAST qPCR Kits(购自Sigma公司,美国,编号38220000000)将六组反转录后产物分别以表1的组合引物进行定量实时反转录聚合酶链式反应(quantitativereal-time reverse transcription polymerase chain reaction)试验,定量TGM1基因、KRT1基因、KRT10基因、KRT14基因、APQ3基因、FLG基因、GBA基因、HAS2基因及HAS3基因的mRNA表达量,条件为95℃反应1秒,60℃反应20秒,总共40个循环,其中定量数值取自阈值循环数(Ct),而目标基因的mRNA相对量推导自方程式2-△Ct,其中△Ct=Ct目标基因-CtACTB(β-肌动蛋白,beta-actin),接着以SCORE法来定量该十组中个别基因表达量的分数,再将各基因的表达分数求和作为该组的保湿分数,其中SCORE法是利用ACTB基因及基准基因(空白对照组中相应的个别基因)的循环阈值来计算。
表1定量实时反转录聚合酶连锁反应的组合引物
本发明的各植物萃取组合物的保湿分数如表2及图1所示,保湿分数越高代表保湿能力越高。先前研究指出转谷氨酰胺酶(Transglutaminase1,TGM)会使角质化细胞的细胞膜与结构蛋白间形成强力键结,并能增加表皮层的强度与稳定性;角蛋白(Keratin,KRT)会形成角蛋白微丝,而聚角蛋白微丝(Filaggrin,FLG)会帮助角蛋白微丝组装成坚固的网络,为皮肤提供强度和弹性;水通道蛋白(Aquaporin,AQP)则会增加角质细胞内水的通透性,以提高角质细胞的含水量;玻尿酸合成酶(Hyaluronan synthase,HAS)会促进角质细胞分泌玻尿酸的能力,并使皮肤角质层结构完整且提升皮肤屏障功能,能使皮肤保水力提升;而葡萄糖脑苷酯酶(Glucocerebrosidase,GBA)则与维持角质结构完整有关。单独以0.125mg/mL普洱茶萃取物、四季春茶萃取物、及菠菜萃取物处理角质细胞所获得的保湿分数分别为2.16、4.2、及2.04;然而以0.125mg/mL的1:1比例混合的普洱茶萃取物与菠菜萃取物的组合物、及四季春茶萃取物与菠菜萃取物的组合物则分别为7.2及10.2;单独以0.25mg/mL普洱茶萃取物、四季春茶萃取物、及蓝莓萃取物处理角质细胞所获得的保湿分数分别为3.5、3.8、及4.7;然而以0.25mg/mL的1:1比例混合的普洱茶萃取物与蓝莓萃取物的组合物、及四季春茶萃取物与蓝莓萃取物的组合物则分别为7.4及6.6,由以上结果可知普洱茶萃取物与蓝莓萃取物的组合物、普洱茶萃取物与菠菜萃取物的组合物、四季春茶萃取物与蓝莓萃取物的组合物、及四季春茶萃取物与菠菜萃取物的组合物对于提升皮肤保湿基因表达的效果相当显著,皆较单独普洱茶萃取物、四季春茶萃取物、菠菜萃取物及蓝莓萃取物更为有效地提升TGM1、KRT1、KRT10、KRT14、APQ3及FLG基因的表达,并能更有效的维持皮肤角质细胞排列,使皮肤角质层结构完整,也能有效地提升皮肤屏障功能以及使皮肤形成更多保湿因子。
表2各组萃取物的保湿分数
综上所述,本发明的普洱茶萃取物与蓝莓萃取物的组合物、普洱茶萃取物与菠菜萃取物的组合物、四季春茶萃取物与蓝莓萃取物的组合物、或四季春茶萃取物与菠菜萃取物的组合物能够产生超乎预期的相乘效果,使皮肤保湿基因的表达较单纯普洱茶萃取物或四季春茶萃取物显著增加,并能更有效地维持皮肤角质细胞排列,使皮肤角质层结构完整,并提升皮肤屏障功能以及使皮肤形成更多保湿因子。
因此,本发明的用于提升转谷氨酰胺酶1基因、角蛋白基因、水通道蛋白3基因、聚角蛋白微丝基因、葡萄糖脑苷酯酶基因、及玻尿酸合成酶基因表达的含有植物萃取物的组合物的用途,也可进一步添加于食品、保健食品、膳食补充品或饮品中,且也可将本发明的植物萃取物的组合物用于制备医药组合物,该医药组合物也可进一步加入所属技术领域所熟知的载体或其他辅剂,该医药组合物的剂型,可为但不限于溶液、胶囊、或锭剂。
Claims (10)
1.一种植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途,其特征在于,所述植物萃取物为0.125mg/mL的普洱茶萃取物与0.125mg/mL的菠菜萃取物的组合,或0.125mg/mL的四季春茶萃取物与0.125mg/mL的菠菜萃取物的组合,所述四季春茶萃取物是将四季春茶茶叶以水于50℃~100℃萃取0.5~3小时所得。
2.如权利要求1所述的用途,其中所述水与所述四季春茶茶叶的液固比为5~20:1~5。
3.如权利要求1所述的用途,其中所述四季春茶萃取物的萃取温度为75℃~95℃。
4.如权利要求1所述的用途,其中所述组合物具有提升转谷氨酰胺酶1(Transglutaminase 1,TGM1)基因、角蛋白(Keratin,KRT)基因、水通道蛋白3(Aquaporin3,AQP3)基因、聚角蛋白微丝(Filaggrin,FLG)基因、葡萄糖脑苷酯酶(Glucocerebrosidase,GBA)基因、及玻尿酸合成酶(Hyaluronan synthase,HAS)基因表达的能力。
5.如权利要求4所述的用途,其中所述角蛋白(KRT)基因包含角蛋白1(Keratin1,KRT1)基因、角蛋白10(Keratin10,KRT10)基因及角蛋白14(Keratin14,KRT14)基因。
6.如权利要求4所述的用途,其中所述玻尿酸合成酶(HAS)基因包含玻尿酸合成酶2(Hyaluronan synthase 2,HAS2)基因及玻尿酸合成酶3(Hyaluronan synthase 3,HAS3)基因。
7.如权利要求1所述的用途,其中所述组合物更具有促进皮肤保湿的能力。
8.如权利要求1所述的用途,其中所述组合物进一步包含医药上可接受的载体。
9.如权利要求1所述的用途,其中所述组合物为粉末、颗粒、液体、胶状或膏状的剂型。
10.如权利要求1所述的用途,其中所述组合物被制备成医药品或食品产品的形式。
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TWI671081B (zh) * | 2017-04-03 | 2019-09-11 | 大江生醫股份有限公司 | 用以提升轉谷氨醯胺酶1基因、角蛋白基因、水通道蛋白3基因、聚角蛋白微絲基因、葡萄糖腦苷酯酶基因、及玻尿酸合成酶基因表現之含有植物萃取物之組成物的用途 |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103957904A (zh) * | 2011-11-23 | 2014-07-30 | 株式会社爱茉莉太平洋 | 含有茶氨酸衍生物的皮肤外用剂组合物 |
Family Cites Families (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5433965A (en) * | 1993-02-16 | 1995-07-18 | The Procter & Gamble Company | Beverage compositions and sweetening compositions which contain juice derived from botanical subfamily Cucurbitaceae |
CN1173991A (zh) * | 1996-08-15 | 1998-02-25 | 夏慧田 | 一种功能型饮品及其制作方法 |
JP4220687B2 (ja) * | 1997-05-07 | 2009-02-04 | 豊也 加藤 | テストステロン5α−リダクターゼ阻害剤 |
AU1135701A (en) * | 1999-10-14 | 2001-04-23 | Schroeder, Fritz H. | Compositions with anti-prostate cancer activity |
JP2001200238A (ja) * | 2000-01-19 | 2001-07-24 | Pokka Corp | 紫外線吸収剤及びそれを含有した皮膚外用剤 |
AU2003248775A1 (en) * | 2002-08-01 | 2004-02-23 | Gene Cloning, Inc. | Oligonucleotides for treating proliferative disorders |
TW200500013A (en) * | 2003-06-27 | 2005-01-01 | zhen-sheng Li | Method for producing GABA tea |
US7320797B2 (en) * | 2003-08-29 | 2008-01-22 | Bioderm Research | Antiaging cosmetic delivery systems |
JP4439900B2 (ja) * | 2003-12-18 | 2010-03-24 | アサヒビール株式会社 | 滋養強壮アルコールドリンク |
CN1569123A (zh) * | 2004-04-30 | 2005-01-26 | 成进学 | 用蛇、蜂、宏、微量元素强化中药方剂的内服功能性药剂及其生产工艺 |
CN1631268A (zh) * | 2004-12-14 | 2005-06-29 | 孙伟 | 绿色保健黄山贡菊花饮料 |
PL1843778T3 (pl) * | 2005-02-03 | 2010-06-30 | Dsm Ip Assets Bv | Kompozycje zawierające galusan epigalokatechiny i hydrolizat białkowy |
KR100728055B1 (ko) * | 2005-02-24 | 2007-06-13 | (주)바이오뉴트리젠 | 비만증 및 고지혈증 예방용 식품 |
CA2546464A1 (en) * | 2005-05-04 | 2006-11-04 | Richard Wachsberg | Sequential application of oral and topical formulations for treating wrinkles and other damage to skin |
CN100366176C (zh) * | 2005-07-10 | 2008-02-06 | 蓝金义 | 一种扁豆保健茶 |
JP2007119373A (ja) * | 2005-10-26 | 2007-05-17 | Arkray Inc | メイラード反応生成物分解剤およびそれを用いた飲食品 |
CN101312660B (zh) * | 2005-11-23 | 2013-07-17 | 可口可乐公司 | 供体重管理之高效甜味剂以及经彼甜化的组成物 |
AT503219B1 (de) * | 2006-02-03 | 2008-07-15 | Annerl Brigitte | Kombinationspräparat auf basis von antioxidanzien zur verbesserung der samenqualität |
WO2007091151A2 (en) * | 2006-02-06 | 2007-08-16 | Indus Biotech Private Limited | A synergistic pharmaceutical and/or neutraceutical flavanoid composition for management of diabetes mellitus |
KR101252553B1 (ko) * | 2006-04-28 | 2013-04-08 | (주)아모레퍼시픽 | 식물 추출물을 함유하는 화장료 조성물 |
KR100853838B1 (ko) * | 2006-05-18 | 2008-08-22 | 전현철 | 새콤달콤한 콜라겐 감귤(柑橘) 비타 침출 녹차 조성물 및 그 제조방법 |
ITBA20060049A1 (it) * | 2006-08-02 | 2008-02-03 | Pierre S R L | Integratore alimentare a base di licopene biologico e procedimento per l'ottenimento del licopene biologico. |
CN101120792A (zh) * | 2006-08-09 | 2008-02-13 | 黄商丽铃 | 含抗氧化成份物质的饮食品制造方法 |
FR2906143B1 (fr) * | 2006-09-21 | 2010-01-22 | Etienne Pierre Dominiq Soudant | Procede de traitement binaire cosmetique, pharmaceutique et dermatologique permettant de synchroniser ou de resynchroniser la peau et l'organisme entier |
TW200816926A (en) | 2006-10-02 | 2008-04-16 | Animal Technology Inst Taiwan | A black tea extract and uses thereof |
US20080138393A1 (en) * | 2006-12-11 | 2008-06-12 | Access To Business Group International Llc | Water soluble extract of spinach for prevention and repair of DNA damage |
CN100560123C (zh) * | 2007-01-30 | 2009-11-18 | 中国人民解放军第三○二医院 | 一种治疗脂肪肝的中药提取物、胶囊剂及制备方法 |
EP2129371B1 (en) * | 2007-03-19 | 2021-05-05 | ATM Metabolics LLLP | Composition for treating diabetes and metabolic disorders with quercetin, myrcetin and chlorogenic acid |
JP2008280310A (ja) * | 2007-04-11 | 2008-11-20 | Oriza Yuka Kk | テストステロン生成及び代謝促進剤 |
TW200841826A (en) | 2007-04-20 | 2008-11-01 | Bion Tech Inc | Composition comprising five kinds of process fruit/vegetable |
EP1982604A1 (de) | 2007-04-20 | 2008-10-22 | Naturheilzentrum Allgäu | Nahrungsergänzungsmittel zum Ausgleich von Nährstoffmangel |
US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
CN101317615B (zh) | 2007-06-08 | 2011-05-25 | 上海中医药大学 | 一种银棘茶饮料及其制备方法 |
US20090092687A1 (en) * | 2007-10-03 | 2009-04-09 | Stein Daniel S | Prhormone composition and method of use thereof |
CN101868243A (zh) * | 2007-11-21 | 2010-10-20 | 客乐谐制药株式会社 | 芳香酶抑制剂 |
WO2009084275A1 (ja) * | 2007-12-28 | 2009-07-09 | Unitika Ltd. | 経口投与組成物 |
BRPI0909185A2 (pt) * | 2008-03-20 | 2015-08-25 | Virun Inc | Derivado de vitamina e e seus usos |
CN101254206A (zh) | 2008-04-03 | 2008-09-03 | 上海麟翔生物技术有限公司 | 可改善性功能障碍的组合物 |
CN101589808A (zh) * | 2008-05-26 | 2009-12-02 | 萨哈春食品供应有限公司 | 含姜黄素提取物的饮料制剂 |
CN101623038A (zh) * | 2008-07-08 | 2010-01-13 | 刘泳宏 | 一种天然五色降脂减肥茶饮料及制作方法 |
CN101474304A (zh) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | 用于降低血糖与血脂的药物组合物 |
DE202009002126U1 (de) * | 2009-02-13 | 2009-04-16 | Orthomol Pharmazeutische Vertriebs Gmbh | Spurenelement enthaltende Zusammensetzung |
US8357382B1 (en) * | 2009-04-02 | 2013-01-22 | Hilt Bethany L | Cosmetic formulations |
KR20120023787A (ko) * | 2009-05-22 | 2012-03-13 | 가부시키가이샤 에리나 | 대사증후군의 예방제 및/또는 치료제 |
KR20100129938A (ko) * | 2009-06-02 | 2010-12-10 | 전태자 | 질환 치료용 미생물 발효 조성물 |
CN102018069B (zh) * | 2009-09-23 | 2013-08-07 | 吉林天士力矿泉饮品有限公司 | 一种蓝莓普洱茶饮料及其制备方法 |
JP2011132150A (ja) * | 2009-12-22 | 2011-07-07 | Kirin Holdings Co Ltd | 濃縮赤ワインエキスを有効成分とする抗うつ剤 |
KR101372037B1 (ko) * | 2010-04-06 | 2014-03-10 | (주)아모레퍼시픽 | 근육 타입 변화를 촉진하는 조성물 |
CN101816360A (zh) | 2010-05-12 | 2010-09-01 | 吉林农业大学 | 人参枸杞速溶茶 |
CN101843298B (zh) * | 2010-06-03 | 2011-08-17 | 湖南省五季风生物科技有限责任公司 | 一种饲料添加剂植物复合提取物及其制备方法与应用 |
US9028890B2 (en) | 2010-06-25 | 2015-05-12 | Horphag Research (Ip) Pre Ltd. | Composition for improving sexual wellness |
CN101984837B (zh) * | 2010-10-29 | 2012-12-26 | 华南农业大学 | 一种柑桔乌龙茶及其加工方法 |
CN102258196B (zh) * | 2010-12-24 | 2013-03-06 | 天津天狮生物发展有限公司 | 一种具有抗氧化功能的保健食品 |
CN102125586B (zh) * | 2011-01-14 | 2013-04-24 | 开曼富丽华德生物医药科技有限公司 | 治疗和预防心脑血管疾病的药物组合物 |
CN102132872B (zh) * | 2011-03-04 | 2012-08-22 | 浙江农林大学 | 一种保健食品及其用途 |
CN102091006B (zh) | 2011-03-28 | 2012-01-25 | 云南龙润茶业集团有限公司 | 一种茶提取物洗面奶及其制备方法 |
CN102204701B (zh) * | 2011-04-20 | 2012-10-10 | 沈阳麦金利食品制造有限公司 | 一种防辐射植物发酵饮料及制造方法 |
CN102273529B (zh) | 2011-07-24 | 2012-11-21 | 马伟光 | 一种蓝莓养生茶及其制备方法 |
CN102250741B (zh) * | 2011-07-25 | 2012-07-18 | 陈俊杰 | 蓝莓sod红酒及其制备方法 |
CN102258638B (zh) * | 2011-08-17 | 2012-10-03 | 深圳华博生物科技发展有限公司 | 一种抗衰老的植物提取组合物及其制备方法和应用 |
KR20130032625A (ko) * | 2011-09-23 | 2013-04-02 | 주식회사 장원 | 발효차 혼합 조성물 |
CN102552562A (zh) * | 2011-10-20 | 2012-07-11 | 宁波海逸生物科技有限公司 | 一种增强免疫力、延缓衰老功能的保健药物配方 |
CN102423374B (zh) * | 2011-11-23 | 2013-08-07 | 桂林莱茵生物科技股份有限公司 | 一种具有减肥作用的药物组合物 |
CN102406592B (zh) * | 2011-11-28 | 2013-05-08 | 广东轻工职业技术学院 | 一种具有美白护肤功能的中药提取物组合物及其应用 |
KR102142311B1 (ko) * | 2011-12-16 | 2020-08-10 | (주)아모레퍼시픽 | 텐저레틴을 함유하는 피부 외용제 조성물 |
KR20130088912A (ko) * | 2012-01-31 | 2013-08-09 | (주)아모레퍼시픽 | 텐저레틴 및 egcg를 함유하는 피부 외용제 조성물 |
CN102524782A (zh) * | 2012-02-07 | 2012-07-04 | 葛志奎 | 一种百病益饿食医食疗配方及其制备方法 |
CN102578645A (zh) * | 2012-02-14 | 2012-07-18 | 陕西理工学院 | 一种柑橘红茶复合果汁茶饮料的制造方法 |
CN102613572A (zh) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | 黄芪复合提神醒脑制剂及其制备方法 |
CN102669344A (zh) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | 一种食品延缓衰老茶冲剂 |
US20130344215A1 (en) * | 2012-06-26 | 2013-12-26 | Yl Holdings, Inc. | Weight loss beverage |
KR101908346B1 (ko) * | 2012-06-29 | 2018-10-17 | (주)아모레퍼시픽 | 차수를 포함하는 피부 노화 방지용 조성물 |
CN102763885B (zh) * | 2012-08-09 | 2013-12-04 | 颐和美林(天津)生物科技有限公司 | 一种含白藜芦醇的固体饮料的制备方法 |
CN102783542A (zh) * | 2012-08-10 | 2012-11-21 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓袋泡红茶 |
CN102754725B (zh) * | 2012-08-10 | 2013-08-14 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓红茶 |
CN103653085A (zh) * | 2012-09-22 | 2014-03-26 | 青岛道合生物科技有限公司 | 一种滋阴补肾药膳猪骨汤 |
US9962364B2 (en) * | 2012-12-26 | 2018-05-08 | A-Z Ltd. | Wound healing accelerator |
KR101451872B1 (ko) * | 2013-02-15 | 2014-10-16 | 한국 한의학 연구원 | 알파-스피나스테롤을 유효성분으로 포함하는 안드로겐-관련 질환, 질병 또는 상태 예방 또는 치료용 약제학적 조성물 |
CN103405363B (zh) * | 2013-07-29 | 2015-09-30 | 惠州市博美化妆品有限公司 | 一种防晒修复组合物 |
CN103519267A (zh) * | 2013-09-27 | 2014-01-22 | 安徽省林锦记食品工业有限公司 | 一种蜂蜜醋保健饮料及其制作方法 |
CN104543983A (zh) * | 2013-10-15 | 2015-04-29 | 泰运生技有限公司 | 保健食品组合物 |
CN103549061A (zh) * | 2013-10-31 | 2014-02-05 | 合肥康龄养生科技有限公司 | 一种蓝莓普洱凉茶饮料的制备方法 |
CN104623670A (zh) * | 2013-11-06 | 2015-05-20 | 高松 | 一种含西红花素的组合物及其应用 |
KR102176766B1 (ko) * | 2013-11-06 | 2020-11-10 | 목포대학교 산학협력단 | 차나무 잎 아임계수 추출물을 유효성분으로 포함하는 화장료 조성물 |
CN103609769B (zh) * | 2013-11-23 | 2015-04-08 | 青岛农业大学 | 蓝莓香型绿茶和蓝莓红茶的制备方法 |
CN103735687B (zh) * | 2013-12-30 | 2016-06-29 | 北京康比特体育科技股份有限公司 | 一种减肥组合物及其制备方法 |
CN103876020A (zh) * | 2014-02-21 | 2014-06-25 | 张静 | 一种葡萄红茶养生粥 |
CN103999901B (zh) * | 2014-04-23 | 2015-12-09 | 柳培健 | 一种紫苏黑糖玉米酥 |
TW201540294A (zh) | 2014-04-25 | 2015-11-01 | Caliway Biomedical Co Ltd | 用於抑制脂肪細胞、降低體脂肪、減少體重或促進脂肪代謝之植物萃取組成物及其醫藥組合物與用途 |
CA2946612C (en) * | 2014-05-30 | 2022-06-21 | Shaklee Corporation | Chardonnay grape seed extract |
CN104027762A (zh) * | 2014-05-30 | 2014-09-10 | 陆宇 | 一种具有醒酒解酒功效的感冒药及其制备方法 |
CN104109609A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 糯米酒荞麦果汁饮料及其制备方法 |
CN104106691A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 椰果荞麦茶饮料及其制备方法 |
CN104127594A (zh) * | 2014-08-14 | 2014-11-05 | 孙战强 | 应用于糖尿病预防与控制的植物提取组合物 |
CN105454784A (zh) * | 2014-09-03 | 2016-04-06 | 张陈 | 舒缓神经的保健品 |
CN105494827A (zh) * | 2014-10-15 | 2016-04-20 | 王萍 | 一种养生红酒巧克力 |
CN105878087A (zh) * | 2014-10-16 | 2016-08-24 | 王萍 | 一种天然有机植物婴幼儿沐浴露 |
CN104274439A (zh) * | 2014-10-21 | 2015-01-14 | 河南牧翔动物药业有限公司 | 原花青素在制备治疗畜禽生殖相关疾病药物的应用 |
CN104365753A (zh) * | 2014-10-28 | 2015-02-25 | 五河童师傅食品有限公司 | 一种花香美酒润肤糕及其制备方法 |
CN105616243A (zh) * | 2014-10-31 | 2016-06-01 | 郁丁丁 | 一种泥状面膜精华液 |
CN104397565A (zh) * | 2014-11-19 | 2015-03-11 | 凤阳嘉禾农业科技有限公司 | 一种美容养颜薏仁面粉 |
WO2016115765A1 (zh) * | 2015-01-24 | 2016-07-28 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN105851308A (zh) * | 2015-01-24 | 2016-08-17 | 苏志力 | 一种保健茶 |
CN104782698A (zh) * | 2015-03-27 | 2015-07-22 | 张青杰 | 一种五行植物粉(青色)食品配方及其制备工艺 |
CN104783288A (zh) * | 2015-04-30 | 2015-07-22 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN104800146A (zh) * | 2015-05-13 | 2015-07-29 | 朱敏 | 一种美白淡斑面膜液、制造方法及美白淡斑面膜 |
CN104920692A (zh) * | 2015-06-26 | 2015-09-23 | 王魁兴 | 一种益气补精保健茶 |
CN105146656A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 左旋肉碱与植物提取物的饮品组合物及其制备方法和应用 |
CN105146655A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 含有茶树花的饮品组合物及其制备方法和应用 |
CN105194102A (zh) * | 2015-10-30 | 2015-12-30 | 中国科学院昆明植物研究所 | 大叶茶提取物及其制备方法和在化妆品中的应用 |
CN105248820B (zh) * | 2015-11-13 | 2019-07-05 | 福建奥正投资发展有限公司 | 辣木叶与红糖的组合物及其制备方法和应用 |
CN105341939A (zh) * | 2015-11-17 | 2016-02-24 | 界首市菁华科技信息咨询服务有限公司 | 一种含有毛蛋提取物的预防老年心血管疾病的速溶粉 |
CN105248732A (zh) * | 2015-11-20 | 2016-01-20 | 刘书元 | 一种蛋黄果奶茶 |
CN105360528A (zh) * | 2015-11-23 | 2016-03-02 | 刘韶娜 | 一种固体咖啡 |
CN105285211A (zh) * | 2015-11-23 | 2016-02-03 | 刘韶娜 | 一种果蔬奶茶冲剂 |
CN105412354A (zh) * | 2015-12-01 | 2016-03-23 | 苟春虎 | 黑枸杞护眼棒棒糖 |
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KR102161179B1 (ko) * | 2015-12-29 | 2020-09-29 | 연세대학교 원주산학협력단 | 홍차줄기 추출물을 함유하는 항산화성 조성물 |
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CN105851316A (zh) * | 2016-04-21 | 2016-08-17 | 华南农业大学 | 柑橘乌龙茶及其制备方法 |
CN105995696A (zh) * | 2016-05-20 | 2016-10-12 | 安徽省华之慧生态农业发展有限公司 | 一种富含膳食纤维的益生元夹心蔬菜纸及其制备方法 |
CN105941728A (zh) * | 2016-05-24 | 2016-09-21 | 安徽源和堂药业股份有限公司 | 一种橘子皮泡腾茶饮颗粒 |
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CN106085749A (zh) * | 2016-06-18 | 2016-11-09 | 吴金珠 | 一种带有减肥功能的保健饮料 |
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CN106070466A (zh) * | 2016-07-28 | 2016-11-09 | 合肥吴复和食品有限公司 | 一种消脂瘦身山药陈皮糕 |
CN106265415A (zh) | 2016-08-11 | 2017-01-04 | 胡安平 | 一种具有保湿和晒后修护功能的护肤组合物及其应用 |
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CN106418546A (zh) * | 2016-09-22 | 2017-02-22 | 上海承煌实业有限公司 | 一种蓝莓叶黄素 |
KR20160126932A (ko) * | 2016-10-12 | 2016-11-02 | 우상호 | 기능성 워터리스 세정제 조성물 및 이를 포함하는 워터리스 세정제 |
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CN106509235A (zh) * | 2016-12-06 | 2017-03-22 | 广西职业技术学院 | 蜜香橘红茶的制作方法 |
TWI671081B (zh) * | 2017-04-03 | 2019-09-11 | 大江生醫股份有限公司 | 用以提升轉谷氨醯胺酶1基因、角蛋白基因、水通道蛋白3基因、聚角蛋白微絲基因、葡萄糖腦苷酯酶基因、及玻尿酸合成酶基因表現之含有植物萃取物之組成物的用途 |
CN109706018A (zh) * | 2017-10-23 | 2019-05-03 | 谢玮 | 一种红酒泡腾片及其制备方法 |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103957904A (zh) * | 2011-11-23 | 2014-07-30 | 株式会社爱茉莉太平洋 | 含有茶氨酸衍生物的皮肤外用剂组合物 |
Non-Patent Citations (3)
Title |
---|
武谦虎编著: "《美容食物一本通》", vol. 1, 30 September 2013, 中国医药科技出版社, pages: 45 * |
许晴: "冬季皮肤干燥缓解", 《湖南农机》, 31 December 2011 (2011-12-31), pages 35 * |
齐继成: "植物多酚的开发应用前景", 《中国医药技术与市场》, vol. 7, no. 4, 15 July 2007 (2007-07-15), pages 31 - 34 * |
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