CN114712430A - 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 - Google Patents
一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 Download PDFInfo
- Publication number
- CN114712430A CN114712430A CN202210511635.2A CN202210511635A CN114712430A CN 114712430 A CN114712430 A CN 114712430A CN 202210511635 A CN202210511635 A CN 202210511635A CN 114712430 A CN114712430 A CN 114712430A
- Authority
- CN
- China
- Prior art keywords
- extract
- composition
- effect
- promoting
- testosterone secretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title claims abstract description 138
- 229960003604 testosterone Drugs 0.000 title claims abstract description 69
- 230000028327 secretion Effects 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 230000001737 promoting effect Effects 0.000 title claims abstract description 47
- 239000000419 plant extract Substances 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 146
- 235000009337 Spinacia oleracea Nutrition 0.000 claims abstract description 37
- 235000020095 red wine Nutrition 0.000 claims abstract description 26
- 241000207199 Citrus Species 0.000 claims abstract description 25
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 25
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 20
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 20
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 20
- 235000019216 blueberry extract Nutrition 0.000 claims abstract description 12
- 229940055416 blueberry extract Drugs 0.000 claims abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 235000013361 beverage Nutrition 0.000 claims abstract description 5
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 5
- 235000013402 health food Nutrition 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 244000300264 Spinacia oleracea Species 0.000 claims abstract description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 235000012041 food component Nutrition 0.000 claims description 3
- 239000005417 food ingredient Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 description 50
- 244000269722 Thea sinensis Species 0.000 description 43
- 241000219315 Spinacia Species 0.000 description 34
- 235000020710 ginseng extract Nutrition 0.000 description 22
- 241000533293 Sesbania emerus Species 0.000 description 21
- 235000020688 green tea extract Nutrition 0.000 description 18
- 229940094952 green tea extract Drugs 0.000 description 18
- 235000006468 Thea sinensis Nutrition 0.000 description 17
- 229940069765 bean extract Drugs 0.000 description 17
- 235000013616 tea Nutrition 0.000 description 17
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 15
- 239000011648 beta-carotene Substances 0.000 description 15
- 235000013734 beta-carotene Nutrition 0.000 description 15
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 15
- 229960002747 betacarotene Drugs 0.000 description 15
- 235000020279 black tea Nutrition 0.000 description 14
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 14
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 13
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 13
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 12
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 12
- 239000001751 lycopene Substances 0.000 description 12
- 235000012661 lycopene Nutrition 0.000 description 12
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 12
- 229960004999 lycopene Drugs 0.000 description 12
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- 235000020748 rosemary extract Nutrition 0.000 description 11
- 229940092258 rosemary extract Drugs 0.000 description 10
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 10
- 239000008513 turmeric extract Substances 0.000 description 10
- 235000009569 green tea Nutrition 0.000 description 9
- 235000020240 turmeric extract Nutrition 0.000 description 9
- 229940052016 turmeric extract Drugs 0.000 description 9
- 244000163122 Curcuma domestica Species 0.000 description 8
- 240000000851 Vaccinium corymbosum Species 0.000 description 8
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 8
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 8
- 235000021014 blueberries Nutrition 0.000 description 8
- 230000001133 acceleration Effects 0.000 description 7
- 235000003373 curcuma longa Nutrition 0.000 description 7
- 230000001965 increasing effect Effects 0.000 description 7
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 6
- 235000011430 Malus pumila Nutrition 0.000 description 6
- 235000015103 Malus silvestris Nutrition 0.000 description 6
- 241000219095 Vitis Species 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 150000008442 polyphenolic compounds Chemical class 0.000 description 6
- 235000013824 polyphenols Nutrition 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 244000020518 Carthamus tinctorius Species 0.000 description 5
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 5
- 235000003392 Curcuma domestica Nutrition 0.000 description 5
- 244000241838 Lycium barbarum Species 0.000 description 5
- 235000015459 Lycium barbarum Nutrition 0.000 description 5
- 241000219823 Medicago Species 0.000 description 5
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 5
- 235000009754 Vitis X bourquina Nutrition 0.000 description 5
- 235000012333 Vitis X labruscana Nutrition 0.000 description 5
- 235000014787 Vitis vinifera Nutrition 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 235000013976 turmeric Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 240000002234 Allium sativum Species 0.000 description 4
- 235000019224 Camellia sinensis var Qingmao Nutrition 0.000 description 4
- 240000007154 Coffea arabica Species 0.000 description 4
- 235000015468 Lycium chinense Nutrition 0.000 description 4
- 240000002624 Mespilus germanica Species 0.000 description 4
- 235000017784 Mespilus germanica Nutrition 0.000 description 4
- 235000000560 Mimusops elengi Nutrition 0.000 description 4
- 235000007837 Vangueria infausta Nutrition 0.000 description 4
- 235000011399 aloe vera Nutrition 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 235000004611 garlic Nutrition 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 235000020339 pu-erh tea Nutrition 0.000 description 4
- 230000001568 sexual effect Effects 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 240000004371 Panax ginseng Species 0.000 description 3
- 229940069521 aloe extract Drugs 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 235000020706 garlic extract Nutrition 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- 241001116389 Aloe Species 0.000 description 2
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- 239000006000 Garlic extract Substances 0.000 description 2
- 240000004658 Medicago sativa Species 0.000 description 2
- 235000010624 Medicago sativa Nutrition 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 230000037182 bone density Effects 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229940087559 grape seed Drugs 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 235000021508 Coleus Nutrition 0.000 description 1
- 244000061182 Coleus blumei Species 0.000 description 1
- 235000014375 Curcuma Nutrition 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241001106041 Lycium Species 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 241000255972 Pieris <butterfly> Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 240000002913 Trifolium pratense Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003263 anabolic agent Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 102000001307 androgen receptors Human genes 0.000 description 1
- 108010080146 androgen receptors Proteins 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 125000001409 beta-carotene group Chemical group 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 102000015694 estrogen receptors Human genes 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 210000002332 leydig cell Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000001356 masculinizing effect Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 229940119485 safflower extract Drugs 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/163—Liquid or semi-liquid tea extract preparations, e.g. gels, liquid extracts in solid capsules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
一种包含植物萃取物的组合物,包含柑橘萃取物以及选自由蓝莓萃取物、葡萄籽萃取物、菠菜萃取物及红酒萃取物所组成的群组中的任一种组份,此组合物相对于单一成分能够更有效地提升睾固酮的分泌,并可用于制造用于促进睾固酮分泌的医药组合物、或诸如一般食品、保健食品、膳食补充品或饮品的食品组合物。
Description
本申请为申请人根据母案申请(申请号:201880021757.5,发明名称:一种可促进睾固酮分泌的组合物及其用途)所提出的分案申请。
相关申请的交叉引用
本申请主张在2017年04月03日在美国提交的美国专利申请号No.62/480,860、以及在2017年05月08日在美国提交的美国专利申请号No.62/503,185的优先权,其全部内容通过引用包含于此。
技术领域
本发明涉及一种包含植物萃取物的组合物及其用途,尤其涉及一种可促进睾固酮分泌的组合物及其用途。
背景技术
睾固酮(Testosterone)是一种由类固醇衍生的激素,主要由男性的睾丸或女性的卵巢所分泌,少数由肾上腺分泌。睾固酮属于体内主要的雄激素及蛋白同化甾类,无论对于男性或女性,在健康上都有重要的影响,例如其具有增强性欲、提升肌肉质量与强度、增强免疫功能或维持骨质密度、对抗骨质疏松症等效用。
睾固酮在人类或脊椎动物体内,可转化为雌二醇,使某些雌激素受体活化,而影响软骨的成长或排卵素的分泌。此外,睾固酮也可直接以本身或以血清二氢睾固酮(Dihydrotestosterone,DHT)的形式活化雄激素受体,从而促进男性激素相关基因的表现、增加肌肉质量及力量以及骨质的密度及强度,并可刺激线性生长及骨骼成熟等;另一方面,在雄性化效应上则可促进性器官的成熟与男性第二性征的表现。
因此,若能适当提升体内睾固酮的分泌量,对于雄性特征的显现、性欲的维持,都有不错的效果,进一步还可增强肌肉的质量、骨骼的密度,对于老化也有减缓的效果。然而,目前可用于促进睾固酮分泌量增加的成分或药物有限,若为某种植物萃取物,其必须施予相当高的剂量,在使用成本上以及效果上有其局限,因此,若能施予多种萃取物的少量组份,即可产生单一成分的高剂量效果时,对于前述功效的运用,不但可大幅提升,也同时降低了使用成本。
在国人日常所常食用或饮用的植物或保健成分中,例如:葡萄籽、红茶、绿茶、红酒、柑橘、菠菜、青咖啡豆、蓝莓、普洱茶、四季春、青花菜苗、人参、枸杞、芦荟、姜黄、大蒜、红花苜蓿、迷迭香的萃取物,以及苹果多酚、β胡萝卜素或茄红素等,并未知悉其单独或组合是否具有促进睾固酮分泌的效果,若又能从复方的组合物中,找寻出可大幅提升睾固酮分泌的组份组合,对于相关用户而言将是一大福音。
发明内容
本发明目的之一在于提供一种包含植物萃取物的组合物,通过其本身,或制备成医药组合物或食品组合物,可结合多种植物其萃取物和/或其他组份的作用,而大幅促进睾固酮分泌的浓度,达到使个体在性征上的表现,以及肌肉、骨骼的生长质量上都能获得提升。
在本发明的一实施例中,上述组合物包含选自由葡萄籽萃取物与红茶萃取物、葡萄籽萃取物与绿茶萃取物、葡萄籽萃取物与柑橘萃取物、葡萄籽萃取物与菠菜萃取物、红酒萃取物与红茶萃取物、红酒萃取物与普洱茶萃取物、红酒萃取物与四季春萃取物、红酒萃取物与菠菜萃取物、红酒萃取物与青咖啡豆萃取物、红酒萃取物与蓝莓萃取物、红酒萃取物与葡萄籽萃取物、柑橘萃取物与菠菜萃取物、柑橘萃取物与青咖啡豆萃取物、柑橘萃取物与红酒萃取物、柑橘萃取物与蓝莓萃取物、柑橘萃取物与葡萄籽萃取物、青咖啡豆萃取物与蓝莓萃取物、青咖啡豆萃取物与绿茶萃取物、青咖啡豆萃取物与菠菜萃取物、青咖啡豆萃取物与普洱茶萃取物、菠菜萃取物与绿茶萃取物、菠菜萃取物与柑橘萃取物、菠菜萃取物与普洱茶萃取物、菠菜萃取物与四季春萃取物、菠菜萃取物与蓝莓萃取物、菠菜萃取物与葡萄籽萃取物、青花菜苗萃取物与茄红素、苹果多酚与姜黄萃取物、苹果多酚与青花菜苗萃取物、β胡萝卜素与姜黄萃取物、β胡萝卜素与茄红素、β胡萝卜素与青花菜苗萃取物、人参萃取物与姜黄萃取物、人参萃取物与茄红素、人参萃取物与青花菜苗萃取物、人参萃取物与β胡萝卜素、枸杞萃取物与β胡萝卜素、枸杞萃取物与人参萃取物、芦荟萃取物与红花苜蓿萃取物、迷迭香萃取物与姜黄萃取物、迷迭香萃取物与枸杞萃取物、迷迭香萃取物与大蒜萃取物、及迷迭香萃取物与红花苜蓿萃取物所组成的组中的至少任一组份组合。也就是说,本发明实施例的组成分,可为上述组中任意一组合的组合物,也可为二个组合以上所组成的组合物。
在本发明的一实施例中,其中该组份组合中组份间的比例为0.8~1.2∶1.2~0.8,优选为1∶1。
在本发明的另一实施例中,提供一种医药组合物,可将前述组成分制备成一医药组合物。
在本发明的前述实施例中,该医药组合物可包括前述组中的任一组合或二个以上组合所组成的组合物、及药学上可接受的载体。
在本发明的前述实施例中,该医药组合物的剂型可为溶液、胶囊或锭剂。
本发明的再一实施例中,提供一种食品组合物。
在本发明的前述实施例中,该食品组合物可包括前述组中任一组合或二个以上组合所组成的组合物、及食品成分,而该食品成分可为一般食品、保健食品、膳食补充品或饮品的成分。
本发明的另一实施例中,提供一种包含植物萃取物的组合物的用途,利用该组合物来促进睾固酮的分泌,而该组合物可为前述群组中任一组合或二个以上组合所组成的组合物。
在本发明的前述实施例中,该包含植物萃取物的组合物可进一步用于制造促进睾固酮分泌的医药组合物,或用于制造促进睾固酮分泌的食品、保健食品、膳食补充品或饮品。
附图说明
图1是本发明实施例中不同植物萃取物组合或与组份组合对于睾固酮分泌影响的结果比较图。
图2是本发明实施例中另一种植物萃取物组合或与组份组合对于睾固酮分泌影响的结果比较图。
具体实施方式
以下将进一步说明本发明的实施方式,下述所列举的实施例用以阐明本发明的发明特点及应用,而非以限定本发明的范围,对于本领域技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,因此本发明的保护范围应当以本申请权利要求书的内容为准。
实施例1植物萃取物的制备
实施例1-1红茶萃取物的制备
首先,将红茶茶叶(fermented leaves of Camellia sinensis)洗净及干燥,用粉碎机将红茶粗碎,之后以水为溶剂,以该溶剂与红茶粗碎物以液固比5~20∶1~5的比例混合后,在50℃~100℃下对红茶粗碎物进行萃取0.5~3小时。萃取温度优选为75℃~95℃。
经上述萃取步骤所得红茶萃取物冷却至室温后,以400目(mesh)滤网过滤以移除残余固体物。过滤后的红茶萃取物可进一步在45℃~70℃下进行减压浓缩而获得浓缩产物。
实施例1-2绿茶萃取物的制备
将绿茶茶叶(unfermented leaves of Camellia sinensis)洗净及干燥,用粉碎机将绿茶粗碎,之后以水为溶剂,以该溶剂与绿茶粗碎物以液固比5~20∶1~5的比例混合后,在50℃~100℃下对绿茶粗碎物进行萃取0.5~3小时。萃取温度优选为75℃~95℃。
经上述萃取步骤所得绿茶萃取物冷却至室温后,以400目(mesh)滤网过滤以移除残余固体物。过滤后的绿茶萃取物可进一步在45℃~70℃下进行减压浓缩而获得浓缩产物。
实施例1-3四季春萃取物的制备
将四季春茶茶叶(leaves ofFour Seasons Spring tea plant)洗净及干燥,用粉碎机将四季春茶粗碎,之后以水为溶剂,以该溶剂与四季春茶粗碎物以液固比5~20∶1~5的比例混合后,在50℃~100℃下对四季春茶粗碎物进行萃取0.5~3小时。萃取温度优选为75℃~95℃。
经上述萃取步骤所得四季春茶萃取物冷却至室温后,以400目(mesh)滤网过滤以移除残余固体物。过滤后的四季春茶萃取物可进一步在45℃~70℃下进行减压浓缩而获得浓缩产物。
实施例1-4其他植物萃取物的制备
其余萃取物系取自市售产品,包括:葡萄籽萃取物[萃取自葡萄属(Vitis spp.)植物种子,购自诚鸿生物科技有限公司]、柑橘萃取物[萃取自柑橘(Citrus reticulata)果实,购自罗顿贸易有限公司]、菠菜萃取物[萃取自菠菜(Spinaciaoleracea),购自弘祥农产加工厂]、普洱茶萃取物[萃取自普洱茶茶叶(post-fermented leaves ofCamelliasinensis),购自南京译朗生物科技有限公司]、青咖啡豆萃取物[萃取自未经烘焙的咖啡属(Coffea spp.)植物种子,购自ARJUNANATURALEXTRACTS LTD(印度)]、红酒萃取物[萃取自红葡萄酒,购自上海博优堂生物技术有限公司]、蓝莓萃取物[萃取自北美蓝莓(VacciniumCyanococcus)果实,购自元弘草本科研有限公司]、青花菜苗萃取物[萃取自青花菜(Brassica oleracea var.italica)幼苗,购自蝶理株式会社]、人参萃取物[萃取自人参(Panax ginseng)根部,购自Hunan HuachengBiotech,Inc]、枸杞萃取物[萃取自枸杞(Lyciumchinense)果实,购自湖南华康生物科技股份有限公司]、芦荟萃取物[萃取自芦荟(Aloe vera),购自元弘草本科研有限公司]、迷迭香萃取物[萃取自迷迭香(Rosmarinusofficinalis),购自佳景百草股份有限公司]、姜黄萃取物[萃取自姜黄(Curcuma longa)根茎,购自ARJUNANATURALEXTRACTS LTD]、红花苜蓿萃取物[萃取自红花苜蓿(Trifolium pretense),购自茂世兴业有限公司]、大蒜萃取物[萃取自大蒜(Alliumsativum)鳞茎,购自长沙市惠瑞生物科技有限公司]。将这些萃取物以水配制成适当浓度后备用。
实施例2组成物其他组份的制备
组合物其他组份也取自市售产品,β胡萝卜素(beta carotene)购自巨研贸易有限公司,茄红素(lycopene)购自湖南朗林生物资源股份有限公司。该些组份以水配制成适当浓度后备用。
实施例3植物萃取物或与组份的组合对睾固酮分泌影响的测试
准备老鼠Leydig细胞(以下简称TM3细胞,ATCC CRL1714),培养于细胞培养液中[Ham’s F12培养液与含有5%马血清、2.5%胎牛血清、0.5mM丙酮酸钠、15mM HEPES与1%盘尼西林/链霉素(Penicillin/streptomycin)的Dulbecco′s modified Eagle′s培养液(Gibco),以1∶1混合]。于24孔盘每孔中加入500μl细胞培养液,使每孔具有2×104个TM3细胞,并于37℃培养24小时。待细胞粘附后,移除原培养液,加入500μl新鲜的前述细胞培养液。
之后将样本分为二组,其中,A组为对照组,不加入植物萃取物或其他试验组份,B组则为试验组。试验组B中分别依照表1至表3所列的植物萃取物、组份种类,分别以0.03125mg/ml至4mg/ml的剂量,以个别萃取物/组份,或两萃取物/组份组合以1∶1的比例加入由前述实施例1或2中所制备的萃取物/组份后,于37℃下反应24小时,之后进行睾固酮分泌量状况的分析。表中所示剂量是个别萃取物、或组合萃取物中各组份的剂量。
首先取出50μl上述各组组成物反应后培养液的上清液,以睾固酮ELISA检测套组(USCN,Cat#CEA458Ge),进行睾固酮浓度的检测。之后将检测出的数值以微软Excel软件,利用学生t检定分析二样本间是否具有统计上的显着性(*表示p值<0.05;**表示p值<0.01;***表示p值<0.001)。前述睾固酮浓度变化的结果分别如表1、表2以及图1、图2所示。
表1
表2
表3
表1与表2分别是各组植物萃取物组合或植物萃取物与组份组合后,睾固酮浓度变化的列表。图1与图2则是表1与表2数值图示化的比较柱状图。请先参照表1与图1,单独葡萄籽萃取物(0.125mg/ml)对于睾固酮分泌的促进效果为205.13%,但与红茶(0.125mg/ml,单独促进效果为29.11%)或绿茶(0.125mg/ml,单独促进效果为45.15%)萃取物组合作用后,则可分别提升为291.63%与252.60%。而以0.5mg/ml浓度的葡萄籽萃取物与柑橘(0.5mg/ml,单独促进效果为97.92%)、菠菜(0.5mg/ml,单独促进效果为67.28%)结合的状况下,则可分别提升至513.44%与654.40%。由以上结果可知,葡萄籽萃取物与红茶萃取物、葡萄籽萃取物与绿茶萃取物、葡萄籽萃取物与柑橘萃取物、葡萄籽萃取物与菠菜萃取物的萃取物复方组合物,能够显着提升睾固酮的分泌。
另一方面,单独红酒萃取物(0.5mg/ml)对于睾固酮分泌的促进效果仅有117.34%,但分别与0.5mg/ml的红茶(单独促进效果为29.11%)、普洱茶(单独促进效果为78.47%)、四季春(单独促进效果为57.57%)、菠菜(单独促进效果为67.28)、青咖啡豆(单独促进效果为46.77%)、蓝莓(单独促进效果为83.72%)、葡萄籽(单独促进效果为462.78%)等萃取物组合后,可分别提升睾固酮分泌量252.08%、247.71%、251.08%、550.65%、431.90%、369.92%、369.92%、446.62%。由以上结果可知,红酒萃取物与红茶萃取物、红酒萃取物与普洱茶萃取物、红酒萃取物与四季春萃取物、红酒萃取物与菠菜萃取物、红酒萃取物与青咖啡豆萃取物、红酒萃取物与蓝莓萃取物、红酒萃取物与葡萄籽萃取物的萃取物复方组合物,对于睾固酮分泌提升的效果更为显着。
此外,单独柑橘萃取物(0.125、0.25、0.5mg/ml)对于睾固酮分泌的促进效果仅有97.92%、76.82%、78.36%,但分别与菠菜(0.5mg/ml,单独促进效果为67.28%)、青咖啡豆(0.25mg/ml,单独促进效果为72.01%)、红酒(0.5mg/ml,单独促进效果为117.34%)、蓝莓(0.125mg/ml,单独促进效果为80.62%)、葡萄籽(0.5mg/ml,单独促进效果为462.78%)等萃取物组合后,可分别提升睾固酮分泌量达426.99%、525.31%、465.76%、301.82%、513.44%。由以上结果可知,柑橘萃取物与菠菜萃取物、柑橘萃取物与青咖啡豆萃取物、柑橘萃取物与红酒萃取物、柑橘萃取物与蓝莓萃取物、柑橘萃取物与葡萄籽萃取物的萃取物复方组合物,对于睾固酮分泌提升的效果也相当显着。
同样地,单独青咖啡豆萃取物(0.25、1mg/ml)对于睾固酮分泌的促进效果仅有72.60%与35.01%,但分别与红酒(0.25mg/ml,单独促进效果为75.59%)、蓝莓(0.25mg/ml,单独促进效果为75.69%)、绿茶(1mg/ml,单独促进效果为15.39%)、柑橘(0.25mg/ml,单独促进效果为76.82%)、菠菜(1mg/ml,单独促进效果为61.58%)、普洱茶(1mg/ml,单独促进效果为54.71%)等萃取物组合后,可分别提升睾固酮分泌量431.90%、382.36%、171.07%、525.31%、345.70%、169.75%。由以上结果可知,青咖啡豆萃取物与蓝莓萃取物、青咖啡豆萃取物与绿茶萃取物、青咖啡豆萃取物与菠菜萃取物、青咖啡豆萃取物与普洱茶萃取物的萃取物复方组合物,对于睾固酮分泌提升的效果也相当好。
再进一步,单独菠菜萃取物(0.25、0.5、1mg/ml)对于睾固酮分泌的促进效果分别为98.45%、67.28%与61.58%,但分别与绿茶(0.5mg/ml,单独促进效果为21.33%)、柑橘(0.5mg/ml,单独促进效果为78.36%)、普洱茶(0.5mg/ml,单独促进效果为78.4%)、四季春(0.5mg/ml,单独促进效果为57.57%)、青咖啡豆(1mg/ml,单独促进效果为35.01%)、红酒(0.25mg/ml,单独促进效果为75.59%)、蓝莓(0.5mg/ml,单独促进效果为83.72%)、葡萄籽(0.5mg/ml,单独促进效果为462.78%)等萃取物组合后,可分别提升睾固酮分泌量162.33%、426.99%、463.94%、279.38%、345.70%、550.65%、349.28%、654.40%。由以上结果可知,菠菜萃取物与绿茶萃取物、菠菜萃取物与柑橘萃取物、菠菜萃取物与普洱茶萃取物、菠菜萃取物与四季春萃取物、菠菜萃取物与蓝莓萃取物、菠菜萃取物与葡萄籽萃取物的萃取物复方组合物,同样对于睾固酮分泌提升有相当好的效果。
请继续参照表2与图2,单独青花菜苗萃取物(0.25mg/ml)对于睾固酮分泌的促进效果仅92.26%,但与茄红素(0.25mg/ml,单独促进效果为104.02%)组合后,可提升睾固酮分泌量258.51%。单独苹果多酚(0.03125mg/ml)对于睾固酮分泌的促进效果仅91.89%,但分别与姜黄(0.03125mg/ml,单独促进效果为111.89%)、青花菜苗(0.25mg/ml,单独促进效果为92.26%)等萃取物组合后,可分别提升睾固酮分泌量258.91%、291.25%。由以上结果可知,青花菜苗萃取物与茄红素、苹果多酚与姜黄萃取物、苹果多酚与青花菜苗萃取物的萃取物复方组合物,对于睾固酮分泌提升有相当好的效果。
另一方面,单独β胡萝卜素(0.03125、0.125、0.25mg/ml)对于睾固酮分泌的促进效果仅有66.21%、103.79%、111.42%,但分别与姜黄(0.03125mg/ml,单独促进效果为111.89%)、茄红素(0.125mg/ml,单独促进效果为99.94%)、青花菜苗(0.25mg/ml,单独促进效果为104.02%)等萃取物或组份组合后,可分别提升睾固酮分泌量215.27%、227.98%、240.61%。由以上结果可知,β胡萝卜素与姜黄萃取物、β胡萝卜素与茄红素、β胡萝卜素与青花菜苗萃取物的萃取物复方组合物的萃取物复方组合物,对于睾固酮分泌提升有不错的效果。
单独人参萃取物(0.03125、0.25mg/ml)对于睾固酮分泌的促进效果仅有114.78%、116.9%,但分别与姜黄(0.03125mg/ml,单独促进效果为111.89%)、茄红素(0.25mg/ml,单独促进效果为104.02%)、青花菜苗(单独促进效果为92.26%)、β胡萝卜素(0.25mg/ml,单独促进效果为111.42%)等萃取物或组份组合后,可分别提升睾固酮分泌量297.97%、322.37%、343.29%、270.67%。同样的,单独枸杞萃取物(0.25mg/ml)对于睾固酮分泌的促进效果仅有121.85%,但分别与β胡萝卜素(0.25mg/ml,单独促进效果为111.42%)、人参萃取物(0.25mg/ml,单独促进效果为116.9%)等萃取物或组份组合后,可分别提升睾固酮分泌量257.52%、269.71%。由以上结果可知,人参萃取物与姜黄萃取物、人参萃取物与茄红素、人参萃取物与青花菜苗萃取物、人参萃取物与β胡萝卜素、枸杞萃取物与β胡萝卜素、枸杞萃取物与人参萃取物的萃取物复方组合物,对于睾固酮分泌提升也有不错的效果。
单独芦荟萃取物(0.25mg/ml)对于睾固酮分泌的促进效果仅有108.8%,但与红花苜蓿萃取物(0.25mg/ml,单独促进效果为89.32%)组合后,可提升睾固酮分泌量278.95%。最后,单独迷迭香萃取物(0.03125、0.25mg/ml)对于睾固酮分泌的促进效果仅有106.84%与48.43%,但分别与姜黄(0.03125mg/ml,单独促进效果为111.89%)、枸杞(0.25mg/ml,单独促进效果为121.85%)、大蒜(0.25mg/ml,单独促进效果为128.88%)、红花苜蓿(0.25mg/ml,单独促进效果为89.32%)等萃取物或组份组合后,可分别提升睾固酮分泌量263.63%、186.73%、186.70%、156.70%。由以上结果可知,芦荟萃取物与红花苜蓿萃取物、迷迭香萃取物与姜黄萃取物、迷迭香萃取物与枸杞萃取物、迷迭香萃取物与大蒜萃取物,以及迷迭香萃取物与红花苜蓿萃取物的萃取物复方组合物,对于睾固酮分泌提升也有不错的效果。
通过上述试验可知,本发明实施例的具促进睾固酮分泌功能的组合物,在两种萃取物或萃取物与组份结合的情况下,皆可产生超乎预期的相乘促进效果,使睾固酮的分泌显着增加。因此,可利用该些组合物制备相关的医药或食品组合物,使施用者或食用者在性征或肌肉、骨骼的质量上获得改善。
此外,本发明实施方式的具促进睾固酮分泌功能的组合物,也可进一步添加于食品、保健食品、膳食补充品或饮品中。将本发明实施方式的具促进睾固酮分泌功能的组合物制备为医药组合物时,该医药组合物也可进一步加入所属技术领域所熟知的载体或其他辅剂。医药组合物的剂型,可为但不限于溶液、胶囊、或锭剂。
Claims (7)
1.一种植物萃取物的组合物,其特征在于,包含柑橘萃取物以及选自蓝莓萃取物、葡萄籽萃取物、菠菜萃取物及红酒萃取物所组成的群组中的任一种组份。
2.如权利要求1所述的组合物,其特征在于,其中所述柑橘萃取物与选到的所述组份间的比例为0.8~1.2∶1.2~0.8。
3.如权利要求2所述的组合物,其特征在于,其中所述柑橘萃取物与选到的所述组份间的比例为1∶1。
4.如权利要求1所述的组合物,其特征在于,更包括:药学上可接受的载体,且所述的组合物是医药组合物。
5.如权利要求4所述的组合物,其特征在于,所述组合物的剂型为溶液、胶囊或锭剂。
6.如权利要求1所述的组合物,其特征在于,更包括:食品成分,所述食品成分为一般食品、保健食品、膳食补充品或饮品的成分,且所述的组合物是食品组合物。
7.一种如权利要求1所述的组合物是用于制造促进睾固酮分泌的医药组合物的用途。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762480860P | 2017-04-03 | 2017-04-03 | |
US62/480,860 | 2017-04-03 | ||
US201762503185P | 2017-05-08 | 2017-05-08 | |
US62/503,185 | 2017-05-08 | ||
PCT/CN2018/081709 WO2018184523A1 (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
CN201880021757.5A CN110494150B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880021757.5A Division CN110494150B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114712430A true CN114712430A (zh) | 2022-07-08 |
Family
ID=63712329
Family Applications (17)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210511419.8A Active CN114652776B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880019596.6A Active CN110430888B (zh) | 2017-04-03 | 2018-04-03 | 一种促进胶原蛋白增生的植物萃取物组合物 |
CN202210511849.XA Active CN114832037B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN202111031378.4A Pending CN113769007A (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
CN202210511635.2A Pending CN114712430A (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN202210511675.7A Active CN114652781B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880021296.1A Pending CN110573171A (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备用于提升tgm1、krt、aqp3、flg、gba、及has基因表达的组合物中的用途 |
CN202210511769.4A Active CN114832024B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880021268.XA Pending CN110461347A (zh) | 2017-04-03 | 2018-04-03 | 一种减少紫外线损伤的植物萃取物组合物 |
CN202210511634.8A Active CN114652780B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
CN201880021757.5A Active CN110494150B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
CN202310720393.2A Pending CN116585399A (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途 |
CN201880021260.3A Pending CN110461348A (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
CN202210511639.0A Pending CN114712412A (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN202210508157.XA Pending CN114712476A (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880019606.6A Active CN110621329B (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备保护心血管的组合物中的用途 |
CN201880021297.6A Active CN110545833B (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210511419.8A Active CN114652776B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880019596.6A Active CN110430888B (zh) | 2017-04-03 | 2018-04-03 | 一种促进胶原蛋白增生的植物萃取物组合物 |
CN202210511849.XA Active CN114832037B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN202111031378.4A Pending CN113769007A (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
Family Applications After (12)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210511675.7A Active CN114652781B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880021296.1A Pending CN110573171A (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备用于提升tgm1、krt、aqp3、flg、gba、及has基因表达的组合物中的用途 |
CN202210511769.4A Active CN114832024B (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880021268.XA Pending CN110461347A (zh) | 2017-04-03 | 2018-04-03 | 一种减少紫外线损伤的植物萃取物组合物 |
CN202210511634.8A Active CN114652780B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
CN201880021757.5A Active CN110494150B (zh) | 2017-04-03 | 2018-04-03 | 一种可促进睾固酮分泌的组合物及其用途 |
CN202310720393.2A Pending CN116585399A (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备用于提高皮肤强度和弹性、表皮层稳定性及皮肤屏障的组合物的用途 |
CN201880021260.3A Pending CN110461348A (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
CN202210511639.0A Pending CN114712412A (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN202210508157.XA Pending CN114712476A (zh) | 2017-04-03 | 2018-04-03 | 一种包含植物萃取物的组合物及其促进睾固酮分泌的用途 |
CN201880019606.6A Active CN110621329B (zh) | 2017-04-03 | 2018-04-03 | 植物萃取物在制备保护心血管的组合物中的用途 |
CN201880021297.6A Active CN110545833B (zh) | 2017-04-03 | 2018-04-03 | 包含植物萃取物的组合物及其用途 |
Country Status (6)
Country | Link |
---|---|
US (7) | US20200368307A1 (zh) |
EP (4) | EP3607961B1 (zh) |
CN (17) | CN114652776B (zh) |
ES (1) | ES2924075T3 (zh) |
TW (8) | TWI736754B (zh) |
WO (7) | WO2018184527A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI736754B (zh) * | 2017-04-03 | 2021-08-21 | 大江生醫股份有限公司 | 含有植物萃取物之組成物其於促進膠原蛋白增生之用途 |
US11065295B1 (en) * | 2020-02-05 | 2021-07-20 | DailyColors Health Inc. | Compositions and methods for nutritional supplements |
CN115697087B (zh) * | 2020-06-22 | 2024-08-23 | 株式会社日本药业 | 睾酮分泌促进剂 |
CN113101247B (zh) * | 2021-04-19 | 2022-09-23 | 广东丸美生物技术股份有限公司 | 一种蓝莓花青素防晒组合物、防晒泥膏及其制备方法 |
WO2023149769A1 (ko) * | 2022-02-07 | 2023-08-10 | 전동욱 | 자외선에 의한 피부 손상 예방, 개선 또는 치료를 위한 조성물 및 이를 이용한 피부보호 방법 |
KR102593843B1 (ko) * | 2022-02-07 | 2023-10-27 | 전동욱 | 자외선에 의한 피부 손상 예방, 개선 또는 치료를 위한 조성물 및 이를 이용한 피부보호 방법 |
CN114767651B (zh) * | 2022-03-07 | 2023-06-02 | 石家庄华加药用胶囊有限公司 | 一种高韧性硬质植物空心胶囊及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008280310A (ja) * | 2007-04-11 | 2008-11-20 | Oriza Yuka Kk | テストステロン生成及び代謝促進剤 |
CN103999901A (zh) * | 2014-04-23 | 2014-08-27 | 柳培健 | 一种紫苏黑糖玉米酥 |
CN106418546A (zh) * | 2016-09-22 | 2017-02-22 | 上海承煌实业有限公司 | 一种蓝莓叶黄素 |
Family Cites Families (134)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5433965A (en) * | 1993-02-16 | 1995-07-18 | The Procter & Gamble Company | Beverage compositions and sweetening compositions which contain juice derived from botanical subfamily Cucurbitaceae |
CN1173991A (zh) | 1996-08-15 | 1998-02-25 | 夏慧田 | 一种功能型饮品及其制作方法 |
JP4220687B2 (ja) * | 1997-05-07 | 2009-02-04 | 豊也 加藤 | テストステロン5α−リダクターゼ阻害剤 |
AU1135701A (en) * | 1999-10-14 | 2001-04-23 | Schroeder, Fritz H. | Compositions with anti-prostate cancer activity |
JP2001200238A (ja) * | 2000-01-19 | 2001-07-24 | Pokka Corp | 紫外線吸収剤及びそれを含有した皮膚外用剤 |
WO2004012654A2 (en) * | 2002-08-01 | 2004-02-12 | Gene Cloning, Inc. | Oligonucleotides for treating proliferative disorders |
TW200500013A (en) * | 2003-06-27 | 2005-01-01 | zhen-sheng Li | Method for producing GABA tea |
US7320797B2 (en) | 2003-08-29 | 2008-01-22 | Bioderm Research | Antiaging cosmetic delivery systems |
JP4439900B2 (ja) * | 2003-12-18 | 2010-03-24 | アサヒビール株式会社 | 滋養強壮アルコールドリンク |
CN1569123A (zh) * | 2004-04-30 | 2005-01-26 | 成进学 | 用蛇、蜂、宏、微量元素强化中药方剂的内服功能性药剂及其生产工艺 |
CN1631268A (zh) * | 2004-12-14 | 2005-06-29 | 孙伟 | 绿色保健黄山贡菊花饮料 |
EP1843778B1 (en) * | 2005-02-03 | 2009-12-23 | DSM IP Assets B.V. | Compositions comprising epigallocatechin gallate and protein hydrolysate |
KR100728055B1 (ko) * | 2005-02-24 | 2007-06-13 | (주)바이오뉴트리젠 | 비만증 및 고지혈증 예방용 식품 |
CA2546464A1 (en) * | 2005-05-04 | 2006-11-04 | Richard Wachsberg | Sequential application of oral and topical formulations for treating wrinkles and other damage to skin |
CN100366176C (zh) * | 2005-07-10 | 2008-02-06 | 蓝金义 | 一种扁豆保健茶 |
JP2007119373A (ja) * | 2005-10-26 | 2007-05-17 | Arkray Inc | メイラード反応生成物分解剤およびそれを用いた飲食品 |
CN101312660B (zh) * | 2005-11-23 | 2013-07-17 | 可口可乐公司 | 供体重管理之高效甜味剂以及经彼甜化的组成物 |
AT503219B1 (de) * | 2006-02-03 | 2008-07-15 | Annerl Brigitte | Kombinationspräparat auf basis von antioxidanzien zur verbesserung der samenqualität |
WO2007091151A2 (en) * | 2006-02-06 | 2007-08-16 | Indus Biotech Private Limited | A synergistic pharmaceutical and/or neutraceutical flavanoid composition for management of diabetes mellitus |
KR101252553B1 (ko) * | 2006-04-28 | 2013-04-08 | (주)아모레퍼시픽 | 식물 추출물을 함유하는 화장료 조성물 |
KR100853838B1 (ko) * | 2006-05-18 | 2008-08-22 | 전현철 | 새콤달콤한 콜라겐 감귤(柑橘) 비타 침출 녹차 조성물 및 그 제조방법 |
ITBA20060049A1 (it) * | 2006-08-02 | 2008-02-03 | Pierre S R L | Integratore alimentare a base di licopene biologico e procedimento per l'ottenimento del licopene biologico. |
CN101120792A (zh) * | 2006-08-09 | 2008-02-13 | 黄商丽铃 | 含抗氧化成份物质的饮食品制造方法 |
FR2906143B1 (fr) * | 2006-09-21 | 2010-01-22 | Etienne Pierre Dominiq Soudant | Procede de traitement binaire cosmetique, pharmaceutique et dermatologique permettant de synchroniser ou de resynchroniser la peau et l'organisme entier |
TW200816926A (en) | 2006-10-02 | 2008-04-16 | Animal Technology Inst Taiwan | A black tea extract and uses thereof |
US20080138393A1 (en) * | 2006-12-11 | 2008-06-12 | Access To Business Group International Llc | Water soluble extract of spinach for prevention and repair of DNA damage |
CN100560123C (zh) * | 2007-01-30 | 2009-11-18 | 中国人民解放军第三○二医院 | 一种治疗脂肪肝的中药提取物、胶囊剂及制备方法 |
MX2009009996A (es) * | 2007-03-19 | 2010-01-20 | Atm Metabolics Lllp | Composicion y metodo para tratar diabetes y trastornos metabolicos. |
EP1982604A1 (de) * | 2007-04-20 | 2008-10-22 | Naturheilzentrum Allgäu | Nahrungsergänzungsmittel zum Ausgleich von Nährstoffmangel |
TW200841826A (en) * | 2007-04-20 | 2008-11-01 | Bion Tech Inc | Composition comprising five kinds of process fruit/vegetable |
US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
CN101317615B (zh) * | 2007-06-08 | 2011-05-25 | 上海中医药大学 | 一种银棘茶饮料及其制备方法 |
US20090092687A1 (en) * | 2007-10-03 | 2009-04-09 | Stein Daniel S | Prhormone composition and method of use thereof |
US20100255127A1 (en) * | 2007-11-21 | 2010-10-07 | Kracie Pharma, Ltd. | Aromatase inhibitor |
EP2226071B1 (en) * | 2007-12-28 | 2016-04-13 | Daicel Corporation | Composition for oral administration |
US8765661B2 (en) * | 2008-03-20 | 2014-07-01 | Virun, Inc. | Compositions containing non-polar compounds |
CN101254206A (zh) | 2008-04-03 | 2008-09-03 | 上海麟翔生物技术有限公司 | 可改善性功能障碍的组合物 |
CN101589808A (zh) * | 2008-05-26 | 2009-12-02 | 萨哈春食品供应有限公司 | 含姜黄素提取物的饮料制剂 |
CN101623038A (zh) * | 2008-07-08 | 2010-01-13 | 刘泳宏 | 一种天然五色降脂减肥茶饮料及制作方法 |
CN101474304A (zh) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | 用于降低血糖与血脂的药物组合物 |
DE202009002126U1 (de) * | 2009-02-13 | 2009-04-16 | Orthomol Pharmazeutische Vertriebs Gmbh | Spurenelement enthaltende Zusammensetzung |
US8357382B1 (en) * | 2009-04-02 | 2013-01-22 | Hilt Bethany L | Cosmetic formulations |
JPWO2010134373A1 (ja) * | 2009-05-22 | 2012-11-08 | 株式会社エリナ | メタボリックシンドロームの予防剤及び/又は治療剤 |
KR20100129938A (ko) * | 2009-06-02 | 2010-12-10 | 전태자 | 질환 치료용 미생물 발효 조성물 |
CN102018069B (zh) * | 2009-09-23 | 2013-08-07 | 吉林天士力矿泉饮品有限公司 | 一种蓝莓普洱茶饮料及其制备方法 |
JP2011132150A (ja) * | 2009-12-22 | 2011-07-07 | Kirin Holdings Co Ltd | 濃縮赤ワインエキスを有効成分とする抗うつ剤 |
KR101372037B1 (ko) * | 2010-04-06 | 2014-03-10 | (주)아모레퍼시픽 | 근육 타입 변화를 촉진하는 조성물 |
CN101816360A (zh) | 2010-05-12 | 2010-09-01 | 吉林农业大学 | 人参枸杞速溶茶 |
CN101843298B (zh) * | 2010-06-03 | 2011-08-17 | 湖南省五季风生物科技有限责任公司 | 一种饲料添加剂植物复合提取物及其制备方法与应用 |
CA2803360C (en) | 2010-06-25 | 2020-03-24 | Horphag Research (Ip) Pre Ltd | Composition for improving sexual wellness |
CN101984837B (zh) * | 2010-10-29 | 2012-12-26 | 华南农业大学 | 一种柑桔乌龙茶及其加工方法 |
CN102258196B (zh) * | 2010-12-24 | 2013-03-06 | 天津天狮生物发展有限公司 | 一种具有抗氧化功能的保健食品 |
CN102125586B (zh) * | 2011-01-14 | 2013-04-24 | 开曼富丽华德生物医药科技有限公司 | 治疗和预防心脑血管疾病的药物组合物 |
CN102132872B (zh) | 2011-03-04 | 2012-08-22 | 浙江农林大学 | 一种保健食品及其用途 |
CN102091006B (zh) | 2011-03-28 | 2012-01-25 | 云南龙润茶业集团有限公司 | 一种茶提取物洗面奶及其制备方法 |
CN102204701B (zh) * | 2011-04-20 | 2012-10-10 | 沈阳麦金利食品制造有限公司 | 一种防辐射植物发酵饮料及制造方法 |
CN102273529B (zh) | 2011-07-24 | 2012-11-21 | 马伟光 | 一种蓝莓养生茶及其制备方法 |
CN102250741B (zh) * | 2011-07-25 | 2012-07-18 | 陈俊杰 | 蓝莓sod红酒及其制备方法 |
CN102258638B (zh) * | 2011-08-17 | 2012-10-03 | 深圳华博生物科技发展有限公司 | 一种抗衰老的植物提取组合物及其制备方法和应用 |
KR20130032625A (ko) * | 2011-09-23 | 2013-04-02 | 주식회사 장원 | 발효차 혼합 조성물 |
CN102552562A (zh) * | 2011-10-20 | 2012-07-11 | 宁波海逸生物科技有限公司 | 一种增强免疫力、延缓衰老功能的保健药物配方 |
CN102423374B (zh) * | 2011-11-23 | 2013-08-07 | 桂林莱茵生物科技股份有限公司 | 一种具有减肥作用的药物组合物 |
KR101956155B1 (ko) * | 2011-11-23 | 2019-06-25 | (주)아모레퍼시픽 | 데아닌 유도체를 함유하는 피부 외용제 조성물 |
CN102406592B (zh) * | 2011-11-28 | 2013-05-08 | 广东轻工职业技术学院 | 一种具有美白护肤功能的中药提取物组合物及其应用 |
KR102142311B1 (ko) * | 2011-12-16 | 2020-08-10 | (주)아모레퍼시픽 | 텐저레틴을 함유하는 피부 외용제 조성물 |
KR20130088912A (ko) * | 2012-01-31 | 2013-08-09 | (주)아모레퍼시픽 | 텐저레틴 및 egcg를 함유하는 피부 외용제 조성물 |
CN102524782A (zh) * | 2012-02-07 | 2012-07-04 | 葛志奎 | 一种百病益饿食医食疗配方及其制备方法 |
CN102578645A (zh) | 2012-02-14 | 2012-07-18 | 陕西理工学院 | 一种柑橘红茶复合果汁茶饮料的制造方法 |
CN102613572A (zh) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | 黄芪复合提神醒脑制剂及其制备方法 |
CN102669344A (zh) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | 一种食品延缓衰老茶冲剂 |
US20130344215A1 (en) * | 2012-06-26 | 2013-12-26 | Yl Holdings, Inc. | Weight loss beverage |
KR101908346B1 (ko) * | 2012-06-29 | 2018-10-17 | (주)아모레퍼시픽 | 차수를 포함하는 피부 노화 방지용 조성물 |
CN102763885B (zh) * | 2012-08-09 | 2013-12-04 | 颐和美林(天津)生物科技有限公司 | 一种含白藜芦醇的固体饮料的制备方法 |
CN102783542A (zh) * | 2012-08-10 | 2012-11-21 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓袋泡红茶 |
CN102754725B (zh) * | 2012-08-10 | 2013-08-14 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓红茶 |
CN103653085A (zh) * | 2012-09-22 | 2014-03-26 | 青岛道合生物科技有限公司 | 一种滋阴补肾药膳猪骨汤 |
AU2013367193A1 (en) * | 2012-12-26 | 2015-07-16 | A-Z Ltd. | Wound healing accelerator |
KR101451872B1 (ko) * | 2013-02-15 | 2014-10-16 | 한국 한의학 연구원 | 알파-스피나스테롤을 유효성분으로 포함하는 안드로겐-관련 질환, 질병 또는 상태 예방 또는 치료용 약제학적 조성물 |
CN103405363B (zh) * | 2013-07-29 | 2015-09-30 | 惠州市博美化妆品有限公司 | 一种防晒修复组合物 |
CN103519267A (zh) * | 2013-09-27 | 2014-01-22 | 安徽省林锦记食品工业有限公司 | 一种蜂蜜醋保健饮料及其制作方法 |
CN104543983A (zh) * | 2013-10-15 | 2015-04-29 | 泰运生技有限公司 | 保健食品组合物 |
CN103549061A (zh) * | 2013-10-31 | 2014-02-05 | 合肥康龄养生科技有限公司 | 一种蓝莓普洱凉茶饮料的制备方法 |
KR102176766B1 (ko) * | 2013-11-06 | 2020-11-10 | 목포대학교 산학협력단 | 차나무 잎 아임계수 추출물을 유효성분으로 포함하는 화장료 조성물 |
CN104623670A (zh) | 2013-11-06 | 2015-05-20 | 高松 | 一种含西红花素的组合物及其应用 |
CN103609769B (zh) * | 2013-11-23 | 2015-04-08 | 青岛农业大学 | 蓝莓香型绿茶和蓝莓红茶的制备方法 |
CN103735687B (zh) * | 2013-12-30 | 2016-06-29 | 北京康比特体育科技股份有限公司 | 一种减肥组合物及其制备方法 |
CN103876020A (zh) * | 2014-02-21 | 2014-06-25 | 张静 | 一种葡萄红茶养生粥 |
TW201540294A (zh) | 2014-04-25 | 2015-11-01 | Caliway Biomedical Co Ltd | 用於抑制脂肪細胞、降低體脂肪、減少體重或促進脂肪代謝之植物萃取組成物及其醫藥組合物與用途 |
CN104027762A (zh) * | 2014-05-30 | 2014-09-10 | 陆宇 | 一种具有醒酒解酒功效的感冒药及其制备方法 |
TWI782445B (zh) * | 2014-05-30 | 2022-11-01 | 美商嘉康利公司 | 夏多內葡萄籽萃取物 |
CN104106691A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 椰果荞麦茶饮料及其制备方法 |
CN104109609A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 糯米酒荞麦果汁饮料及其制备方法 |
CN104127594A (zh) * | 2014-08-14 | 2014-11-05 | 孙战强 | 应用于糖尿病预防与控制的植物提取组合物 |
CN105454784A (zh) * | 2014-09-03 | 2016-04-06 | 张陈 | 舒缓神经的保健品 |
CN105494827A (zh) * | 2014-10-15 | 2016-04-20 | 王萍 | 一种养生红酒巧克力 |
CN105878087A (zh) * | 2014-10-16 | 2016-08-24 | 王萍 | 一种天然有机植物婴幼儿沐浴露 |
CN104274439A (zh) * | 2014-10-21 | 2015-01-14 | 河南牧翔动物药业有限公司 | 原花青素在制备治疗畜禽生殖相关疾病药物的应用 |
CN104365753A (zh) * | 2014-10-28 | 2015-02-25 | 五河童师傅食品有限公司 | 一种花香美酒润肤糕及其制备方法 |
CN105616243A (zh) * | 2014-10-31 | 2016-06-01 | 郁丁丁 | 一种泥状面膜精华液 |
CN104397565A (zh) * | 2014-11-19 | 2015-03-11 | 凤阳嘉禾农业科技有限公司 | 一种美容养颜薏仁面粉 |
CN105851308A (zh) * | 2015-01-24 | 2016-08-17 | 苏志力 | 一种保健茶 |
WO2016115765A1 (zh) * | 2015-01-24 | 2016-07-28 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN104782698A (zh) * | 2015-03-27 | 2015-07-22 | 张青杰 | 一种五行植物粉(青色)食品配方及其制备工艺 |
CN104783288A (zh) * | 2015-04-30 | 2015-07-22 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN104800146A (zh) | 2015-05-13 | 2015-07-29 | 朱敏 | 一种美白淡斑面膜液、制造方法及美白淡斑面膜 |
CN104920692A (zh) * | 2015-06-26 | 2015-09-23 | 王魁兴 | 一种益气补精保健茶 |
CN105146656A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 左旋肉碱与植物提取物的饮品组合物及其制备方法和应用 |
CN105146655A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 含有茶树花的饮品组合物及其制备方法和应用 |
CN105194102A (zh) * | 2015-10-30 | 2015-12-30 | 中国科学院昆明植物研究所 | 大叶茶提取物及其制备方法和在化妆品中的应用 |
CN105248820B (zh) * | 2015-11-13 | 2019-07-05 | 福建奥正投资发展有限公司 | 辣木叶与红糖的组合物及其制备方法和应用 |
CN105341939A (zh) * | 2015-11-17 | 2016-02-24 | 界首市菁华科技信息咨询服务有限公司 | 一种含有毛蛋提取物的预防老年心血管疾病的速溶粉 |
CN105248732A (zh) * | 2015-11-20 | 2016-01-20 | 刘书元 | 一种蛋黄果奶茶 |
CN105285211A (zh) * | 2015-11-23 | 2016-02-03 | 刘韶娜 | 一种果蔬奶茶冲剂 |
CN105360528A (zh) * | 2015-11-23 | 2016-03-02 | 刘韶娜 | 一种固体咖啡 |
CN105412354A (zh) * | 2015-12-01 | 2016-03-23 | 苟春虎 | 黑枸杞护眼棒棒糖 |
CN105325608A (zh) * | 2015-12-04 | 2016-02-17 | 广东橘香斋陈皮有限公司 | 一种陈皮老姜茶及其制备方法和应用 |
KR102161179B1 (ko) * | 2015-12-29 | 2020-09-29 | 연세대학교 원주산학협력단 | 홍차줄기 추출물을 함유하는 항산화성 조성물 |
CN105639355A (zh) * | 2016-03-30 | 2016-06-08 | 天地壹号饮料股份有限公司 | 一种苹果果胶膳食纤维饮料及其制备方法 |
CN105851316A (zh) * | 2016-04-21 | 2016-08-17 | 华南农业大学 | 柑橘乌龙茶及其制备方法 |
CN105995696A (zh) * | 2016-05-20 | 2016-10-12 | 安徽省华之慧生态农业发展有限公司 | 一种富含膳食纤维的益生元夹心蔬菜纸及其制备方法 |
CN105941728A (zh) * | 2016-05-24 | 2016-09-21 | 安徽源和堂药业股份有限公司 | 一种橘子皮泡腾茶饮颗粒 |
CN105875963A (zh) * | 2016-06-02 | 2016-08-24 | 江苏丰年果品种植园有限公司 | 一种蓝莓速溶茶的制备方法 |
CN106085749A (zh) * | 2016-06-18 | 2016-11-09 | 吴金珠 | 一种带有减肥功能的保健饮料 |
CN106075179A (zh) * | 2016-06-20 | 2016-11-09 | 威海百合生物技术股份有限公司 | 一种减肥软胶囊 |
CN105963208A (zh) * | 2016-06-29 | 2016-09-28 | 林序彬 | 一种植物多功效洗面奶 |
CN106165869A (zh) * | 2016-07-02 | 2016-11-30 | 马玉玲 | 一种改善记忆功能的保健食品及其制备方法 |
CN106070466A (zh) * | 2016-07-28 | 2016-11-09 | 合肥吴复和食品有限公司 | 一种消脂瘦身山药陈皮糕 |
CN106265415A (zh) | 2016-08-11 | 2017-01-04 | 胡安平 | 一种具有保湿和晒后修护功能的护肤组合物及其应用 |
CN106136066A (zh) | 2016-08-25 | 2016-11-23 | 普安县宏鑫茶业开发有限公司 | 一种绿茶面条及其制作方法 |
KR20160126932A (ko) * | 2016-10-12 | 2016-11-02 | 우상호 | 기능성 워터리스 세정제 조성물 및 이를 포함하는 워터리스 세정제 |
CN106492084A (zh) * | 2016-11-16 | 2017-03-15 | 北京澳特舒尔保健品开发有限公司 | 一种纯草本中药减肥产品及其制备方法 |
CN106509235A (zh) * | 2016-12-06 | 2017-03-22 | 广西职业技术学院 | 蜜香橘红茶的制作方法 |
TWI736754B (zh) * | 2017-04-03 | 2021-08-21 | 大江生醫股份有限公司 | 含有植物萃取物之組成物其於促進膠原蛋白增生之用途 |
CN109706018A (zh) * | 2017-10-23 | 2019-05-03 | 谢玮 | 一种红酒泡腾片及其制备方法 |
-
2018
- 2018-04-02 TW TW107111683A patent/TWI736754B/zh active
- 2018-04-02 TW TW107111696A patent/TWI743349B/zh active
- 2018-04-02 TW TW107111690A patent/TWI667036B/zh active
- 2018-04-02 TW TW107111685A patent/TWI671081B/zh active
- 2018-04-02 TW TW107111697A patent/TWI740030B/zh active
- 2018-04-02 TW TW107111687A patent/TWI736755B/zh active
- 2018-04-02 TW TW110118933A patent/TW202137976A/zh unknown
- 2018-04-02 TW TW107111688A patent/TWI754037B/zh active
- 2018-04-03 WO PCT/CN2018/081720 patent/WO2018184527A1/zh unknown
- 2018-04-03 WO PCT/CN2018/081716 patent/WO2018184524A1/zh unknown
- 2018-04-03 CN CN202210511419.8A patent/CN114652776B/zh active Active
- 2018-04-03 EP EP18780313.5A patent/EP3607961B1/en active Active
- 2018-04-03 CN CN201880019596.6A patent/CN110430888B/zh active Active
- 2018-04-03 US US16/500,332 patent/US20200368307A1/en not_active Abandoned
- 2018-04-03 CN CN202210511849.XA patent/CN114832037B/zh active Active
- 2018-04-03 CN CN202111031378.4A patent/CN113769007A/zh active Pending
- 2018-04-03 US US16/499,436 patent/US10918682B2/en active Active
- 2018-04-03 EP EP18781720.0A patent/EP3607958A4/en not_active Withdrawn
- 2018-04-03 EP EP22165424.7A patent/EP4039261A3/en active Pending
- 2018-04-03 US US16/499,666 patent/US11278582B2/en active Active
- 2018-04-03 CN CN202210511635.2A patent/CN114712430A/zh active Pending
- 2018-04-03 WO PCT/CN2018/081719 patent/WO2018184526A1/zh active Application Filing
- 2018-04-03 CN CN202210511675.7A patent/CN114652781B/zh active Active
- 2018-04-03 CN CN201880021296.1A patent/CN110573171A/zh active Pending
- 2018-04-03 WO PCT/CN2018/081709 patent/WO2018184523A1/zh active Application Filing
- 2018-04-03 ES ES18780313T patent/ES2924075T3/es active Active
- 2018-04-03 CN CN202210511769.4A patent/CN114832024B/zh active Active
- 2018-04-03 EP EP18781817.4A patent/EP3613425B1/en active Active
- 2018-04-03 US US16/499,990 patent/US11752183B2/en active Active
- 2018-04-03 CN CN201880021268.XA patent/CN110461347A/zh active Pending
- 2018-04-03 CN CN202210511634.8A patent/CN114652780B/zh active Active
- 2018-04-03 US US16/499,350 patent/US11806317B2/en active Active
- 2018-04-03 CN CN201880021757.5A patent/CN110494150B/zh active Active
- 2018-04-03 WO PCT/CN2018/081717 patent/WO2018184525A1/zh active Application Filing
- 2018-04-03 CN CN202310720393.2A patent/CN116585399A/zh active Pending
- 2018-04-03 CN CN201880021260.3A patent/CN110461348A/zh active Pending
- 2018-04-03 WO PCT/CN2018/081708 patent/WO2018184522A1/zh unknown
- 2018-04-03 CN CN202210511639.0A patent/CN114712412A/zh active Pending
- 2018-04-03 CN CN202210508157.XA patent/CN114712476A/zh active Pending
- 2018-04-03 CN CN201880019606.6A patent/CN110621329B/zh active Active
- 2018-04-03 WO PCT/CN2018/081707 patent/WO2018184521A1/zh active Application Filing
- 2018-04-03 CN CN201880021297.6A patent/CN110545833B/zh active Active
- 2018-04-03 US US16/499,473 patent/US10933107B2/en active Active
- 2018-04-03 US US16/498,737 patent/US10918681B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008280310A (ja) * | 2007-04-11 | 2008-11-20 | Oriza Yuka Kk | テストステロン生成及び代謝促進剤 |
CN103999901A (zh) * | 2014-04-23 | 2014-08-27 | 柳培健 | 一种紫苏黑糖玉米酥 |
CN106418546A (zh) * | 2016-09-22 | 2017-02-22 | 上海承煌实业有限公司 | 一种蓝莓叶黄素 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110494150B (zh) | 一种可促进睾固酮分泌的组合物及其用途 | |
Zhang et al. | Safety evaluation of a triterpenoid-rich extract from bamboo shavings | |
Uboh et al. | Comparative effect of aqueous extract of P. guajava leaves and ascorbic acid on serum sex hormones levels in male and female rats | |
Masuku et al. | Investigation of the effects of Kigelia africana (Lam.) Benth. Extracts on TM3 Leydig cells | |
KR100910259B1 (ko) | 인삼열매가 함유된 미용팩 | |
CN110839760A (zh) | 一种酵母菌饲料添加剂 | |
CN106307491A (zh) | 一种铁皮石斛酵素制备方法 | |
CN105942091A (zh) | 一种雨生红球藻饮料 | |
Ryu et al. | Antioxidant activities of flower, berry and leaf of Panax ginseng CA Meyer | |
Tijjani et al. | Effects of Afromomum melegueta, Zingiber officinale and Piper nigrum on Some Biochemical and Haematological Parameters in Rats Fed with High Lipid Diet | |
CN105901722A (zh) | 一种预防老年痴呆症的南极磷虾油保健胶囊 | |
KR102173430B1 (ko) | 도라지 복합발효추출물과 식물추출물을 포함하는 항염 조성물 및 그 제조방법 | |
CN107164135A (zh) | 一种降脂降压中草药葡萄酒粉及其制备方法 | |
Thakur et al. | Analysis and quantification of anti-obesity compound Quercetin in formulated chocolate with plant based antioxidants | |
CN113509416B (zh) | 一种具有增强过氧化氢酶活力的组合物及其在化妆品中的应用 | |
CN114558083B (zh) | 一种具有抗氧化功能及辅助改善记忆能力的组合物、制备方法及应用 | |
KR102660565B1 (ko) | 진세노사이드 Rg1 및 Rb1이 강화된 산양삼 추출조성물 및 그 제조방법 | |
Roy et al. | Natural Products Chemistry & Research | |
Anyanwu et al. | Effect of Cucurbita pepo (pumpkin) seed extracts on serum prolactin levels of non-lactating female Wistar rats | |
ManasiPatil et al. | Preliminary Phytochemical Evaluation of Passiflora Fruits | |
Tuszynska | Pharmacological and therapeutic application of Asparagus racemosus Willd. | |
Abdo | Sennosides Determination of Senna alexandrina | |
CN109090605A (zh) | 山药提取物烹饪牛肉专用调味品及其制备方法 | |
KR20140120765A (ko) | 인삼 종자유 및 이의 제조방법 | |
Tokuda | Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and'prostate cancer cell lines |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |