CN110621329B - 植物萃取物在制备保护心血管的组合物中的用途 - Google Patents
植物萃取物在制备保护心血管的组合物中的用途 Download PDFInfo
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Abstract
一种植物萃取物在制备调控PDGFC、FGF2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL‑8、ICAM1、VCAM1及CASP8基因的组合物中的用途。植物萃取物包含选自葡萄籽萃取物与四季春茶萃取物、红茶萃取物与菠菜萃取物、葡萄籽萃取物与菠菜萃取物、葡萄籽萃取物与青咖啡豆萃取物、红酒萃取物与普洱茶萃取物,及葡萄籽萃取物与普洱茶萃取物所组成的组。
Description
相关申请的交叉引用
本申请主张在2017年04月03日在美国提交的美国专利申请号No.62/480,860、以及在2017年05月08日在美国提交的美国专利申请号No.62/503,185的优先权,其全部内容通过引用包含于此。
技术领域
本发明涉及一种植物萃取物在制备调控PDGFC、FGF2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL-8、ICAM1、VCAM1及CASP8基因的组合物中的用途。
背景技术
心血管疾病对人类健康的威胁已达不容忽视的程度,其发病之初通常没有明显症状,但等到一旦出现并发症时,例如脑中风、心肌梗塞、心衰竭、肾衰竭或视网膜出血等,患者生命通常已遭受严重的威胁,且为了治疗心血管疾病,心脏血管用药的需求也居高不下,成为医疗资源的庞大负担。因此,本领域的相关技术人员皆致力于开发用于保护心血管的产品(包括食品产品以及医药品),以因应广大人类健康需求。
近年来,利用植物作为原料来开发具有疗效的医药品或用于预防保健的食品产品已逐渐受到市场重视。例如,某些植物常被用来做成食品或饮品的原料,包括茶叶或葡萄等。然而,本领域的技术人员目前并未将前述植物萃取物进行组合并拿来开发医药品或食品产品,因为若为某种植物萃取物,其必须施予相当高的剂量,在使用成本上以及效果上有其局限。因此,若能施予多种萃取物的少量组分,即可产生单一成分的高剂量效果时,将会对本领域的技术带来相当大的突破。
发明内容
本发明的目的为提供一种植物萃取物在制备调控PDGFC、FGF2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL-8、ICAM1、VCAM1及CASP8基因的组合物中的用途,其中植物萃取物包含选自由葡萄籽萃取物与四季春茶萃取物、红茶萃取物与菠菜萃取物、葡萄籽萃取物与菠菜萃取物、葡萄籽萃取物与青咖啡豆萃取物、红酒萃取物与普洱茶萃取物,及葡萄籽萃取物与普洱茶萃取物所组成的组中的至少任一组合。
在本发明的一实施例中,植物萃取物包含至少0.0039mg/mL的葡萄籽萃取物、及至少0.0039mg/mL的四季春茶萃取物、波菜萃取物、青咖啡豆萃取物、或普洱茶萃取物。
在本发明的一实施例中,植物萃取物包含至少0.0625mg/mL的红茶萃取物及至少0.0625mg/mL的菠菜萃取物。
在本发明的一实施例中,植物萃取物包含至少0.0156mg/mL的红酒萃取物及至少0.0156mg/mL的普洱茶萃取物。
在本发明的一实施例中,组合物具有保护心血管的效果。
在本发明的一实施例中,组合物进一步包含医药上可接受的载体。
在本发明的一实施例中,组合物为粉末、颗粒、液体、胶状或膏状的剂型。
在本发明的一实施例中,组合物被制备成医药品或食品产品的形式。
综上所述,本发明的组合物包括葡萄籽萃取物与四季春茶萃取物、红茶萃取物与菠菜萃取物、葡萄籽萃取物与菠菜萃取物、葡萄籽萃取物与青咖啡豆萃取物、红酒萃取物与普洱茶萃取物、及葡萄籽萃取物与普洱茶萃取物等植物萃取物的功效在于:通过调控与心血管相关的基因(包括PDGFC、FGF2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL-8、ICAM1、VCAM1及CASP8)表达来达到保护心血管的功效。
附图说明
图1是一直方图,其显示本发明实施例中植物萃取物的组合在调控与心血管相关的基因表达上的功效。
具体实施方式
以下将配合附图进一步说明本发明的实施方式,下述所列举的实施例用以阐明本发明的发明特点及应用,而非以限定本发明的范围,对于本领域技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,,因此本发明的保护范围应当以本申请权利要求书的内容为准。
定义
本文中所使用数值为近似值,所有实验数据皆表示在20%的范围内,优选为在10%的范围内,最优选为在5%的范围内。
如本文中所使用的用语“基因(gene)”意指DNA序列,包括但不限于:可被转录成mRNA[它可被翻译成多肽链(polypeptide chains)]、被转录成rRNA或tRNA,或者供酶以及其他涉及DNA复制(DNA replication)、转录(transcription)以及调节(regulation)的蛋白质作为识别位点(recognition sites)的DNA序列。这个定义包括各种不同的序列多态性(sequence polymorphisms)、突变和/或序列变异体(sequence variants),其中该等改变(alternation)不会影响基因产物(gene product)的功能。该用语“基因”意欲包括不只编码基因产物的区域还有调节区域包括,例如:启动子、终止区域(termination regions)、翻译调节序列(translational regulatory sequences)[诸如,核糖体结合位点以及内部核糖体进入位点(internal ribosome entry sites)]、增强子(enhancers)、沉默子(silencers)、绝缘子(insulators)、边界要素(boundary elements)、复制起点(replication origins)、基质附着部位(matrix attachment sites),以及基因座控制区域(locus control regions)。该用语“基因”进一步包括所有内含子(intron)以及其他被剪接自mRNA转录本(mRNA transcripts)的DNA序列,还有由选择性剪接位点(alternativesplice site)所导致的变异体。
如本文中所使用的用语“保护心血管(cardiovascular protection)”意指能够治疗心血管疾病、保护心血管系统,或降低心血管疾病发生的风险。
依据本发明,医药品可利用本领域技术人员所详知的技术而被制造成适合于非肠道(parenterally)或口服(orally)投药的剂型(dosage form),这包括但不限于:注射品(injection)[例如,无菌的水性溶液(sterile aqueous solution)或分散液(dispersion)]、无菌的粉末(sterile powder)、锭剂(tablet)、片剂(troche)、口含锭(lozenge)、丸剂(pill)、胶囊(capsule)、分散性粉末(dispersible powder)或细颗粒(granule)、溶液、悬浮液(suspension)、乳剂(emulsion)、糖浆(syrup)、酏剂(elixir)、浓浆(slurry)以及类似的物。
依据本发明的医药品可以选自由下列所组成的组中的非肠道途径(parenteralroutes)来投药:腹膜内注射(intraperitoneal injection)、皮下注射(subcutaneousinjection)、肌肉内注射(intramuscular injection)以及静脉内注射(intravenousinjection)。
依据本发明,医药上可接受的载体可包含一种或多种选自由下列所组成的组中的试剂:溶剂(solvent)、乳化剂(emulsifier)、悬浮剂(suspending agent)、分解剂(decomposer)、黏结剂(binding agent)、赋形剂(excipient)、安定剂(stabilizingagent)、螯合剂(chelating agent)、稀释剂(diluent)、胶凝剂(gelling agent)、防腐剂(preservative)、润滑剂(lubricant)、吸收延迟剂(absorption delaying agent)、脂质体(liposome)以及类似物。有关这些试剂的选用与数量是落在本领域技术人员的专业素养与例行技术范畴内。
依据本发明,医药上可接受的载体可包含选自由下列所组成的群组中的溶剂:水、生理盐水(normal saline)、磷酸盐缓冲生理盐水(phosphate buffered saline,PBS)、含糖溶液、含有醇的水性溶液(aqueous solution containing alcohol)、以及它们的组合。
依据本发明,组合物可被当作食品添加物(food additive),通过公知方法在制备原料时添加,或是在食品的制作过程中添加,而与任一种可食性材料配制成供人类与非人类动物摄食的食品产品。
依据本发明,食品产品的种类包括但不限于:饮料(beverages)、发酵食品(fermented foods)、烘培产品(bakery products)、健康食品(health foods)以及膳食补充品(dietary supplements)。
实施例1.各种植物萃取物的来源或制备
本发明实施例的葡萄籽萃取物是对葡萄属(Vitis spp.)植物种子进行萃取而获得,该萃取物可购自诚鸿生物科技有限公司;普洱茶(Puerh tea)萃取物是对普洱茶茶叶(post-fermented leaves of Camellia sinensis)进行萃取而获得,该萃取物可购自南京泽朗生物科技有限公司;菠菜萃取物是对菠菜(Spinaciaoleracea)进行萃取而获得,该萃取物可购自弘祥农产加工厂;红酒萃取物是对红葡萄酒进行萃取而获得,该萃取物可购自上海博优堂生物技术有限公司;青咖啡豆萃取物是对未经烘焙的咖啡属植物(Coffeaspp.)种子进行萃取而获得,该萃取物可购自ARJUNA NATURAL EXTRACTS有限公司(印度)。
本实施例举例说明本发明红茶(Camellia sinensis leaves)萃取物的制备方法。首先,将红茶洗净及干燥,以粉碎机将红茶粗碎。其次,以水为溶剂对红茶粗碎物进行萃取,该溶剂与红茶粗碎物以液固比5~20∶1~5均匀混合,萃取温度为50℃~100℃,优选为75℃~95℃。本实施例中萃取时间为0.5~3小时。
经上述萃取步骤所得红茶萃取物冷却至室温后,经由400目(mesh)的滤网过滤以移除残余固体物。该过滤后的红茶萃取物可进一步在45℃~70℃进行减压浓缩而获得浓缩产物。
本实施例举例说明本发明四季春茶(Four Seasons Spring tea)萃取物的制备方法。首先,将四季春茶洗净及干燥,以粉碎机将四季春茶粗碎。其次,以水为溶剂对四季春茶粗碎物进行萃取,该溶剂与四季春茶粗碎物以液固比5~20∶1~5均匀混合,萃取温度为50℃~100℃,优选为75℃~95℃。本实施例中萃取时间为0.5~3小时。
经上述萃取步骤所得四季春茶萃取物冷却至室温后,经由400目(mesh)的滤网过滤以移除残余固体物。该过滤后的四季春茶萃取物可进一步在45℃~70℃进行减压浓缩而获得浓缩产物。
实施例2.植物萃取物的组合在调控与心血管相关的基因表达上的功效
首先,将人类脐带静脉内皮细胞(human umbilical vein endothelial cells,HUVEC)[购自中国台湾的食品工业发展研究所(Food Industry Research andDevelopment Institute,FIRDI)的生物资源保存及研究中心(Biosource Collection andResearch Center,BCRC),BCRC编号为H-UV001]培养于EC培养基(EC medium)[添加有培养基200(medium 200,M200)及10%低血清生长添加剂(low serum growth supplement,LSGS)(Gibco;Cat.No.M-200-500)]中。在6孔培养盘的每孔中加入2mL的EC培养基,使每孔具有1.5x105个HUVEC细胞。
之后,将HUVEC细胞分成13组,其中包括7个比较组(即比较组1至7)以及6个实验组(即实验组1至6)。接着,将适量的依据上面实施例1的各个植物萃取物添加至各组细胞中,在培养箱中进行培养,并于6、24小时更换培养液且加入植物萃取物或组合物。有关各组细胞所添加的植物萃取物的种类、浓度,及/或用量比例是显示于下面表1中。
表1
在培养箱中进行培养之后,收集各组细胞培养物并拿来进行基因表达分析。
在本实施例中,用来分析与心血管相关的目标基因包括血小板衍生生长因子C(platelet-derived growth factor C,PDGFC)基因、纤维母细胞生长因子2(fibroblastgrowth factor 2,FGF2)基因、胰岛素样生长因子1受体(insulin-like growth factor 1receptor,IGF1R)基因、前列腺素I2合成酶(prostaglandin I2 synthase,PTGIS)基因、一氧化氮合成酶3(nitric oxide synthase 3,NOS3)基因、内皮素1(endothelin 1,EDN1)基因、组织胞浆素原活化物(plasminogen activator,tissue,PLAT)基因、蛋白质C(proteinC,PROC)基因、冯威里氏因子(von Willebrand factor,VWF)基因、F3基因、丝胺酸蛋白酶抑制蛋白E1(serpin peptidase inhibitor E1,SERPINE1)基因、介白素-8(interleukin-8,IL-8)基因、细胞间粘附分子1(intercellular adhesion molecule 1,ICAM1)基因、血管细胞粘附分子1(vascular cell adhesion molecule 1,VCAM1)基因、及半胱-天冬胺酸蛋白酶8(caspase 8,CASP8)基因。
以RNA萃取试剂盒(RNA extraction kit)(Geneaid)对上面所得到的各组细胞培养物进行RNA的萃取。对由此所得到的各组RNA取2,000ng并以III反转录酶(III Reverse Transcriptase)(Invitrogen)将RNA反转录为cDNA。接着,以cDNA作为模版(template),并且使用用来扩增目标基因的引物对[包括PTGIS、NOS3、EDN1、PLAT、VWF、F3、SERPINE1、ICAM1、VCAM1、IL-8、CASP8、PDGFC、FGF2、IGF2BP3、IGF1R、及ACTB(作为内部对照组),它们的核苷酸序列显示于下面表2],在StepOne Plus实时PCR系统(StepOne Plus Real Time PCR system)(ABI)中利用KAPA SYBR FAST qPCR试剂盒(2x)(KAPA Biosystems)来进行定量实时聚合酶链反应(quantitative real-time polymerasechain reaction,以下简称定量实时PCR),以对目标基因进行扩增及定量。PCR产物的熔化曲线(melting curve)是在定量实时PCR反应期间进行确认。
表2
全部目标基因的相对表达水平是以SCORE法来进行定量,而计算出各组与心血管相关的基因表达的分数。SCORE法是利用ACTB基因(作为内部对照组)及内参基因(reference gene)的循环阈值[cycle threshold(Ct)value]来计算。
目标基因的mRNA相对量是推导自方程式2-ΔCt,其中ΔCt=Ct目标基因-CtACTB(β-肌动蛋白,beta-actin),接着计算上述每个基因的表现量在该六组与空白对照组中的差值,并以此差值的合计作为心血管相关的基因表达的分数。
通过调控心血管相关的基因表达,已确认本发明的组合物具有保护心血管的功效,其中与血管生长有关的基因包括PDGFC基因、FGF2基因,及IGF1R基因;与血管弹性有关的基因包括PTGIS基因、NOS3基因、及EDN1基因;与血栓生成有关的基因包括PLAT基因、PROC基因、VWF基因、F3基因、及SERPINE1基因;与发炎因子有关的基因包括IL-8基因、ICAM1基因,及VCAM1基因;及与细胞凋亡有关的基因包括CASP8基因。
本实施例的结果是显示于图1及表3。图1是一直方图,其显示本发明实施例中植物萃取物的组合在调控与心血管相关的基因表达上的功效。表3对应显示图1的各组所计算出的与心血管相关的基因表达分数数值。其中,分数越高者,代表越具有保护心血管的功效。
表3
由图1及表3可见,与比较组3(即处理葡萄籽萃取物者)及比较组7(即处理四季春茶萃取物者)相较之下,实验组1(即处理葡萄籽萃取物及四季春茶萃取物的组合者)所计算出的分数有显著提升,并且高于比较组3及比较组7的分数总和;与比较组1(即处理红茶萃取物者)及比较组2(亦即处理菠菜萃取物者)相较之下,实验组2(即处理红茶萃取物及菠菜萃取物的组合者)所计算出的分数有显著提升,并且高于比较组1及比较组2的分数总和;与比较组2及比较组3相较之下,实验组3(即处理葡萄籽萃取物及菠菜萃取物的组合者)所计算出的分数有显著提升,并且高于比较组2及比较组3的分数总和;与比较组3及比较组4(即处理青咖啡豆萃取物者)相较之下,实验组4(即处理葡萄籽萃取物及青咖啡豆萃取物的组合者)所计算出的分数有显著提升,并且高于比较组3及比较组4的分数总和;与比较组5(即处理红酒萃取物者)及比较组6(亦即处理普洱茶萃取物者)相较之下,实验组5(即处理红酒萃取物及普洱茶萃取物的组合者)所计算出的分数有显著提升,并且高于比较组5及比较组6的分数总和;以及与比较组3及比较组6相较之下,实验组6(即处理葡萄籽萃取物及普洱茶萃取物的组合者)所计算出的分数有显著提升,并且高于比较组3及比较组6的分数总和。
因此,本发明的实施例的实验结果显示:本发明各个植物萃取物的组合具有调控与心血管相关的基因表达的功效。因此,申请人认为,本发明的组合物能够藉由调控与心血管相关的基因(包括PDGFC、FGE2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL-8、ICAM1、VCAM1及CASP8)表现来达到保护心血管的功效。此外,本发明的组合物也能够制备成医药品或食品产品的形式,并无限制。
以上所述仅为举例性,而非为限制性者。任何未脱离本发明的精神与范畴,而对其进行的等效修改或变更,均应包含于后附的权利要求范围中。
Claims (4)
1.植物萃取物在制备调控PDGFC、FGF2、IGF1R、PTGIS、NOS3、EDN1、PLAT、PROC、VWF、F3、SERPINE1、IL-8、ICAM1、VCAM1及CASP8基因的医药组合物中的用途,其中所述植物萃取物由体积比1:1混合的葡萄籽萃取物与四季春茶萃取物、或体积比1:1混合的葡萄籽萃取物与菠菜萃取物,或体积比1:1混合的葡萄籽萃取物与普洱茶萃取物组成,且葡萄籽萃取物、四季春茶萃取物、菠菜萃取物、普洱茶萃取物的浓度均为0.0039mg/mL。
2.如权利要求1所述的用途,其中所述组合物具有保护心血管的效果。
3.如权利要求1所述的用途,其中所述组合物进一步包含医药上可接受的载体。
4.如权利要求1所述的用途,其中所述组合物为粉末、颗粒、液体、胶状或膏状的剂型。
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Family Cites Families (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5433965A (en) * | 1993-02-16 | 1995-07-18 | The Procter & Gamble Company | Beverage compositions and sweetening compositions which contain juice derived from botanical subfamily Cucurbitaceae |
CN1173991A (zh) * | 1996-08-15 | 1998-02-25 | 夏慧田 | 一种功能型饮品及其制作方法 |
JP4220687B2 (ja) | 1997-05-07 | 2009-02-04 | 豊也 加藤 | テストステロン5α−リダクターゼ阻害剤 |
WO2001026668A1 (en) * | 1999-10-14 | 2001-04-19 | Unilever N.V. | Compositions with anti-prostate cancer activity |
JP2001200238A (ja) * | 2000-01-19 | 2001-07-24 | Pokka Corp | 紫外線吸収剤及びそれを含有した皮膚外用剤 |
WO2004012654A2 (en) * | 2002-08-01 | 2004-02-12 | Gene Cloning, Inc. | Oligonucleotides for treating proliferative disorders |
TW200500013A (en) * | 2003-06-27 | 2005-01-01 | zhen-sheng Li | Method for producing GABA tea |
US7320797B2 (en) | 2003-08-29 | 2008-01-22 | Bioderm Research | Antiaging cosmetic delivery systems |
JP4439900B2 (ja) * | 2003-12-18 | 2010-03-24 | アサヒビール株式会社 | 滋養強壮アルコールドリンク |
CN1569123A (zh) * | 2004-04-30 | 2005-01-26 | 成进学 | 用蛇、蜂、宏、微量元素强化中药方剂的内服功能性药剂及其生产工艺 |
CN1631268A (zh) * | 2004-12-14 | 2005-06-29 | 孙伟 | 绿色保健黄山贡菊花饮料 |
ES2337495T3 (es) * | 2005-02-03 | 2010-04-26 | Dsm Ip Assets B.V. | Composiciones que comprenden galato de epigalocatecina e hidrolizado de proteina. |
KR100728055B1 (ko) * | 2005-02-24 | 2007-06-13 | (주)바이오뉴트리젠 | 비만증 및 고지혈증 예방용 식품 |
CA2546464A1 (en) * | 2005-05-04 | 2006-11-04 | Richard Wachsberg | Sequential application of oral and topical formulations for treating wrinkles and other damage to skin |
CN100366176C (zh) * | 2005-07-10 | 2008-02-06 | 蓝金义 | 一种扁豆保健茶 |
JP2007119373A (ja) * | 2005-10-26 | 2007-05-17 | Arkray Inc | メイラード反応生成物分解剤およびそれを用いた飲食品 |
CN101312660B (zh) * | 2005-11-23 | 2013-07-17 | 可口可乐公司 | 供体重管理之高效甜味剂以及经彼甜化的组成物 |
AT503219B1 (de) * | 2006-02-03 | 2008-07-15 | Annerl Brigitte | Kombinationspräparat auf basis von antioxidanzien zur verbesserung der samenqualität |
WO2007091151A2 (en) * | 2006-02-06 | 2007-08-16 | Indus Biotech Private Limited | A synergistic pharmaceutical and/or neutraceutical flavanoid composition for management of diabetes mellitus |
KR101252553B1 (ko) * | 2006-04-28 | 2013-04-08 | (주)아모레퍼시픽 | 식물 추출물을 함유하는 화장료 조성물 |
KR100853838B1 (ko) * | 2006-05-18 | 2008-08-22 | 전현철 | 새콤달콤한 콜라겐 감귤(柑橘) 비타 침출 녹차 조성물 및 그 제조방법 |
ITBA20060049A1 (it) * | 2006-08-02 | 2008-02-03 | Pierre S R L | Integratore alimentare a base di licopene biologico e procedimento per l'ottenimento del licopene biologico. |
CN101120792A (zh) * | 2006-08-09 | 2008-02-13 | 黄商丽铃 | 含抗氧化成份物质的饮食品制造方法 |
FR2906143B1 (fr) * | 2006-09-21 | 2010-01-22 | Etienne Pierre Dominiq Soudant | Procede de traitement binaire cosmetique, pharmaceutique et dermatologique permettant de synchroniser ou de resynchroniser la peau et l'organisme entier |
TW200816926A (en) | 2006-10-02 | 2008-04-16 | Animal Technology Inst Taiwan | A black tea extract and uses thereof |
US20080138393A1 (en) * | 2006-12-11 | 2008-06-12 | Access To Business Group International Llc | Water soluble extract of spinach for prevention and repair of DNA damage |
CN100560123C (zh) * | 2007-01-30 | 2009-11-18 | 中国人民解放军第三○二医院 | 一种治疗脂肪肝的中药提取物、胶囊剂及制备方法 |
CA2685031A1 (en) * | 2007-03-19 | 2008-09-25 | Atm Metabolics Lllp | Composition for treating diabetes and metabolic disorders with quercetin, myrcetin and chlorogenic acid |
JP2008280310A (ja) | 2007-04-11 | 2008-11-20 | Oriza Yuka Kk | テストステロン生成及び代謝促進剤 |
TW200841826A (en) | 2007-04-20 | 2008-11-01 | Bion Tech Inc | Composition comprising five kinds of process fruit/vegetable |
EP1982604A1 (de) * | 2007-04-20 | 2008-10-22 | Naturheilzentrum Allgäu | Nahrungsergänzungsmittel zum Ausgleich von Nährstoffmangel |
US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
CN101317615B (zh) * | 2007-06-08 | 2011-05-25 | 上海中医药大学 | 一种银棘茶饮料及其制备方法 |
US20090092687A1 (en) * | 2007-10-03 | 2009-04-09 | Stein Daniel S | Prhormone composition and method of use thereof |
JPWO2009066712A1 (ja) | 2007-11-21 | 2011-04-07 | クラシエ製薬株式会社 | アロマターゼ阻害剤 |
US20100273727A1 (en) * | 2007-12-28 | 2010-10-28 | Unitika Ltd. | Oral administration composition |
MX2010010214A (es) * | 2008-03-20 | 2010-12-21 | Virun Inc | Derivados de vitamina e y sus usos. |
CN101254206A (zh) | 2008-04-03 | 2008-09-03 | 上海麟翔生物技术有限公司 | 可改善性功能障碍的组合物 |
CN101589808A (zh) * | 2008-05-26 | 2009-12-02 | 萨哈春食品供应有限公司 | 含姜黄素提取物的饮料制剂 |
CN101623038A (zh) * | 2008-07-08 | 2010-01-13 | 刘泳宏 | 一种天然五色降脂减肥茶饮料及制作方法 |
CN101474304A (zh) * | 2008-12-15 | 2009-07-08 | 北京利千秋科技发展有限公司 | 用于降低血糖与血脂的药物组合物 |
DE202009002126U1 (de) | 2009-02-13 | 2009-04-16 | Orthomol Pharmazeutische Vertriebs Gmbh | Spurenelement enthaltende Zusammensetzung |
US8357382B1 (en) * | 2009-04-02 | 2013-01-22 | Hilt Bethany L | Cosmetic formulations |
JPWO2010134373A1 (ja) * | 2009-05-22 | 2012-11-08 | 株式会社エリナ | メタボリックシンドロームの予防剤及び/又は治療剤 |
KR20100129938A (ko) * | 2009-06-02 | 2010-12-10 | 전태자 | 질환 치료용 미생물 발효 조성물 |
CN102018069B (zh) * | 2009-09-23 | 2013-08-07 | 吉林天士力矿泉饮品有限公司 | 一种蓝莓普洱茶饮料及其制备方法 |
JP2011132150A (ja) * | 2009-12-22 | 2011-07-07 | Kirin Holdings Co Ltd | 濃縮赤ワインエキスを有効成分とする抗うつ剤 |
KR101372037B1 (ko) * | 2010-04-06 | 2014-03-10 | (주)아모레퍼시픽 | 근육 타입 변화를 촉진하는 조성물 |
CN101816360A (zh) | 2010-05-12 | 2010-09-01 | 吉林农业大学 | 人参枸杞速溶茶 |
CN101843298B (zh) * | 2010-06-03 | 2011-08-17 | 湖南省五季风生物科技有限责任公司 | 一种饲料添加剂植物复合提取物及其制备方法与应用 |
DK2585088T3 (da) | 2010-06-25 | 2014-08-25 | Horphag Res Ip Pre Ltd | Sammensætning til forbedring af seksuel sundhed |
CN101984837B (zh) * | 2010-10-29 | 2012-12-26 | 华南农业大学 | 一种柑桔乌龙茶及其加工方法 |
CN102258196B (zh) * | 2010-12-24 | 2013-03-06 | 天津天狮生物发展有限公司 | 一种具有抗氧化功能的保健食品 |
CN102125586B (zh) * | 2011-01-14 | 2013-04-24 | 开曼富丽华德生物医药科技有限公司 | 治疗和预防心脑血管疾病的药物组合物 |
CN102132872B (zh) * | 2011-03-04 | 2012-08-22 | 浙江农林大学 | 一种保健食品及其用途 |
CN102091006B (zh) | 2011-03-28 | 2012-01-25 | 云南龙润茶业集团有限公司 | 一种茶提取物洗面奶及其制备方法 |
CN102204701B (zh) * | 2011-04-20 | 2012-10-10 | 沈阳麦金利食品制造有限公司 | 一种防辐射植物发酵饮料及制造方法 |
CN102273529B (zh) * | 2011-07-24 | 2012-11-21 | 马伟光 | 一种蓝莓养生茶及其制备方法 |
CN102250741B (zh) * | 2011-07-25 | 2012-07-18 | 陈俊杰 | 蓝莓sod红酒及其制备方法 |
CN102258638B (zh) * | 2011-08-17 | 2012-10-03 | 深圳华博生物科技发展有限公司 | 一种抗衰老的植物提取组合物及其制备方法和应用 |
KR20130032625A (ko) * | 2011-09-23 | 2013-04-02 | 주식회사 장원 | 발효차 혼합 조성물 |
CN102552562A (zh) | 2011-10-20 | 2012-07-11 | 宁波海逸生物科技有限公司 | 一种增强免疫力、延缓衰老功能的保健药物配方 |
KR101956155B1 (ko) * | 2011-11-23 | 2019-06-25 | (주)아모레퍼시픽 | 데아닌 유도체를 함유하는 피부 외용제 조성물 |
CN102423374B (zh) * | 2011-11-23 | 2013-08-07 | 桂林莱茵生物科技股份有限公司 | 一种具有减肥作用的药物组合物 |
CN102406592B (zh) * | 2011-11-28 | 2013-05-08 | 广东轻工职业技术学院 | 一种具有美白护肤功能的中药提取物组合物及其应用 |
KR102142311B1 (ko) * | 2011-12-16 | 2020-08-10 | (주)아모레퍼시픽 | 텐저레틴을 함유하는 피부 외용제 조성물 |
KR20130088912A (ko) * | 2012-01-31 | 2013-08-09 | (주)아모레퍼시픽 | 텐저레틴 및 egcg를 함유하는 피부 외용제 조성물 |
CN102524782A (zh) * | 2012-02-07 | 2012-07-04 | 葛志奎 | 一种百病益饿食医食疗配方及其制备方法 |
CN102578645A (zh) * | 2012-02-14 | 2012-07-18 | 陕西理工学院 | 一种柑橘红茶复合果汁茶饮料的制造方法 |
CN102613572A (zh) * | 2012-04-24 | 2012-08-01 | 哈尔滨工业大学 | 黄芪复合提神醒脑制剂及其制备方法 |
CN102669344A (zh) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | 一种食品延缓衰老茶冲剂 |
US20130344215A1 (en) * | 2012-06-26 | 2013-12-26 | Yl Holdings, Inc. | Weight loss beverage |
KR101908346B1 (ko) * | 2012-06-29 | 2018-10-17 | (주)아모레퍼시픽 | 차수를 포함하는 피부 노화 방지용 조성물 |
CN102763885B (zh) * | 2012-08-09 | 2013-12-04 | 颐和美林(天津)生物科技有限公司 | 一种含白藜芦醇的固体饮料的制备方法 |
CN102754725B (zh) * | 2012-08-10 | 2013-08-14 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓红茶 |
CN102783542A (zh) * | 2012-08-10 | 2012-11-21 | 开原景隆现代农业综合开发有限公司 | 一种蓝莓袋泡红茶 |
CN103653085A (zh) * | 2012-09-22 | 2014-03-26 | 青岛道合生物科技有限公司 | 一种滋阴补肾药膳猪骨汤 |
CN104936587A (zh) * | 2012-12-26 | 2015-09-23 | 株式会社Az | 创伤愈合促进剂 |
KR101451872B1 (ko) * | 2013-02-15 | 2014-10-16 | 한국 한의학 연구원 | 알파-스피나스테롤을 유효성분으로 포함하는 안드로겐-관련 질환, 질병 또는 상태 예방 또는 치료용 약제학적 조성물 |
CN103405363B (zh) * | 2013-07-29 | 2015-09-30 | 惠州市博美化妆品有限公司 | 一种防晒修复组合物 |
CN103519267A (zh) | 2013-09-27 | 2014-01-22 | 安徽省林锦记食品工业有限公司 | 一种蜂蜜醋保健饮料及其制作方法 |
CN104543983A (zh) * | 2013-10-15 | 2015-04-29 | 泰运生技有限公司 | 保健食品组合物 |
CN103549061A (zh) * | 2013-10-31 | 2014-02-05 | 合肥康龄养生科技有限公司 | 一种蓝莓普洱凉茶饮料的制备方法 |
KR102176766B1 (ko) * | 2013-11-06 | 2020-11-10 | 목포대학교 산학협력단 | 차나무 잎 아임계수 추출물을 유효성분으로 포함하는 화장료 조성물 |
CN104623670A (zh) | 2013-11-06 | 2015-05-20 | 高松 | 一种含西红花素的组合物及其应用 |
CN103609769B (zh) * | 2013-11-23 | 2015-04-08 | 青岛农业大学 | 蓝莓香型绿茶和蓝莓红茶的制备方法 |
CN103735687B (zh) * | 2013-12-30 | 2016-06-29 | 北京康比特体育科技股份有限公司 | 一种减肥组合物及其制备方法 |
CN103876020A (zh) | 2014-02-21 | 2014-06-25 | 张静 | 一种葡萄红茶养生粥 |
CN103999901B (zh) | 2014-04-23 | 2015-12-09 | 柳培健 | 一种紫苏黑糖玉米酥 |
TW201540294A (zh) | 2014-04-25 | 2015-11-01 | Caliway Biomedical Co Ltd | 用於抑制脂肪細胞、降低體脂肪、減少體重或促進脂肪代謝之植物萃取組成物及其醫藥組合物與用途 |
CN104027762A (zh) * | 2014-05-30 | 2014-09-10 | 陆宇 | 一种具有醒酒解酒功效的感冒药及其制备方法 |
KR20170012485A (ko) * | 2014-05-30 | 2017-02-02 | 샤클리 코포레이션 | 샤도네이 포도 종자 추출물 |
CN104106691A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 椰果荞麦茶饮料及其制备方法 |
CN104109609A (zh) * | 2014-06-20 | 2014-10-22 | 枞阳县新长河食品发展有限责任公司 | 糯米酒荞麦果汁饮料及其制备方法 |
CN104127594A (zh) * | 2014-08-14 | 2014-11-05 | 孙战强 | 应用于糖尿病预防与控制的植物提取组合物 |
CN105454784A (zh) * | 2014-09-03 | 2016-04-06 | 张陈 | 舒缓神经的保健品 |
CN105494827A (zh) * | 2014-10-15 | 2016-04-20 | 王萍 | 一种养生红酒巧克力 |
CN105878087A (zh) * | 2014-10-16 | 2016-08-24 | 王萍 | 一种天然有机植物婴幼儿沐浴露 |
CN104274439A (zh) | 2014-10-21 | 2015-01-14 | 河南牧翔动物药业有限公司 | 原花青素在制备治疗畜禽生殖相关疾病药物的应用 |
CN104365753A (zh) * | 2014-10-28 | 2015-02-25 | 五河童师傅食品有限公司 | 一种花香美酒润肤糕及其制备方法 |
CN105616243A (zh) * | 2014-10-31 | 2016-06-01 | 郁丁丁 | 一种泥状面膜精华液 |
CN104397565A (zh) | 2014-11-19 | 2015-03-11 | 凤阳嘉禾农业科技有限公司 | 一种美容养颜薏仁面粉 |
CN105851308A (zh) * | 2015-01-24 | 2016-08-17 | 苏志力 | 一种保健茶 |
WO2016115765A1 (zh) * | 2015-01-24 | 2016-07-28 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN104782698A (zh) * | 2015-03-27 | 2015-07-22 | 张青杰 | 一种五行植物粉(青色)食品配方及其制备工艺 |
CN104783288A (zh) * | 2015-04-30 | 2015-07-22 | 深圳市前海安测信息技术有限公司 | 基于健康促进的适于肥胖人群饮用的纯天然功能饮料 |
CN104800146A (zh) | 2015-05-13 | 2015-07-29 | 朱敏 | 一种美白淡斑面膜液、制造方法及美白淡斑面膜 |
CN104920692A (zh) * | 2015-06-26 | 2015-09-23 | 王魁兴 | 一种益气补精保健茶 |
CN105146656A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 左旋肉碱与植物提取物的饮品组合物及其制备方法和应用 |
CN105146655A (zh) * | 2015-09-07 | 2015-12-16 | 王保红 | 含有茶树花的饮品组合物及其制备方法和应用 |
CN105194102A (zh) * | 2015-10-30 | 2015-12-30 | 中国科学院昆明植物研究所 | 大叶茶提取物及其制备方法和在化妆品中的应用 |
CN105248820B (zh) * | 2015-11-13 | 2019-07-05 | 福建奥正投资发展有限公司 | 辣木叶与红糖的组合物及其制备方法和应用 |
CN105341939A (zh) * | 2015-11-17 | 2016-02-24 | 界首市菁华科技信息咨询服务有限公司 | 一种含有毛蛋提取物的预防老年心血管疾病的速溶粉 |
CN105248732A (zh) * | 2015-11-20 | 2016-01-20 | 刘书元 | 一种蛋黄果奶茶 |
CN105285211A (zh) * | 2015-11-23 | 2016-02-03 | 刘韶娜 | 一种果蔬奶茶冲剂 |
CN105360528A (zh) * | 2015-11-23 | 2016-03-02 | 刘韶娜 | 一种固体咖啡 |
CN105412354A (zh) * | 2015-12-01 | 2016-03-23 | 苟春虎 | 黑枸杞护眼棒棒糖 |
CN105325608A (zh) * | 2015-12-04 | 2016-02-17 | 广东橘香斋陈皮有限公司 | 一种陈皮老姜茶及其制备方法和应用 |
KR102161179B1 (ko) * | 2015-12-29 | 2020-09-29 | 연세대학교 원주산학협력단 | 홍차줄기 추출물을 함유하는 항산화성 조성물 |
CN105639355A (zh) * | 2016-03-30 | 2016-06-08 | 天地壹号饮料股份有限公司 | 一种苹果果胶膳食纤维饮料及其制备方法 |
CN105851316A (zh) * | 2016-04-21 | 2016-08-17 | 华南农业大学 | 柑橘乌龙茶及其制备方法 |
CN105995696A (zh) * | 2016-05-20 | 2016-10-12 | 安徽省华之慧生态农业发展有限公司 | 一种富含膳食纤维的益生元夹心蔬菜纸及其制备方法 |
CN105941728A (zh) * | 2016-05-24 | 2016-09-21 | 安徽源和堂药业股份有限公司 | 一种橘子皮泡腾茶饮颗粒 |
CN105875963A (zh) * | 2016-06-02 | 2016-08-24 | 江苏丰年果品种植园有限公司 | 一种蓝莓速溶茶的制备方法 |
CN106085749A (zh) * | 2016-06-18 | 2016-11-09 | 吴金珠 | 一种带有减肥功能的保健饮料 |
CN106075179A (zh) * | 2016-06-20 | 2016-11-09 | 威海百合生物技术股份有限公司 | 一种减肥软胶囊 |
CN105963208A (zh) * | 2016-06-29 | 2016-09-28 | 林序彬 | 一种植物多功效洗面奶 |
CN106165869A (zh) * | 2016-07-02 | 2016-11-30 | 马玉玲 | 一种改善记忆功能的保健食品及其制备方法 |
CN106070466A (zh) * | 2016-07-28 | 2016-11-09 | 合肥吴复和食品有限公司 | 一种消脂瘦身山药陈皮糕 |
CN106265415A (zh) | 2016-08-11 | 2017-01-04 | 胡安平 | 一种具有保湿和晒后修护功能的护肤组合物及其应用 |
CN106136066A (zh) | 2016-08-25 | 2016-11-23 | 普安县宏鑫茶业开发有限公司 | 一种绿茶面条及其制作方法 |
CN106418546A (zh) | 2016-09-22 | 2017-02-22 | 上海承煌实业有限公司 | 一种蓝莓叶黄素 |
KR20160126932A (ko) * | 2016-10-12 | 2016-11-02 | 우상호 | 기능성 워터리스 세정제 조성물 및 이를 포함하는 워터리스 세정제 |
CN106492084A (zh) * | 2016-11-16 | 2017-03-15 | 北京澳特舒尔保健品开发有限公司 | 一种纯草本中药减肥产品及其制备方法 |
CN106509235A (zh) * | 2016-12-06 | 2017-03-22 | 广西职业技术学院 | 蜜香橘红茶的制作方法 |
TW202137976A (zh) * | 2017-04-03 | 2021-10-16 | 大江生醫股份有限公司 | 包含植物萃取物的組成物及其修護受損皮膚纖維母細胞之用途 |
CN109706018A (zh) * | 2017-10-23 | 2019-05-03 | 谢玮 | 一种红酒泡腾片及其制备方法 |
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